The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
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inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiry(5A)-4,5-EPOXY-3,14-DIHYDROXYMORPHINAN-6-ONE HCLAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryChangzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa
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inquiryMorphinan-6-one,4,5-epoxy-3,14-dihydroxy-, hydrochloride (1:1), (5a)- Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate Transportation:By Sea,by Air,By courier like
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inquirynaloxone hydrochloride
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
With Wilkinson's catalyst In 1,4-dioxane; water at 150℃; for 1h; Microwave irradiation; Inert atmosphere; | 99% |
With Wilkinson's catalyst In water at 200℃; for 1.5h; Microwave irradiation; |
noroxymorphone
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; water at 20℃; Inert atmosphere; Reflux; Large scale; | 93.2% |
With hydrogenchloride In water at 90℃; |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
With acetic acid; tetramethylammonium triacetoxyborohydride In dimethyl sulfoxide at 50℃; for 5h; | 99.5% |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
cyclopropylcarbinyl bromide
Naltrexone
Conditions | Yield |
---|---|
Stage #1: (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With sodium hydrogencarbonate In ISOPROPYLAMIDE at 65 - 69℃; for 0.166667h; Stage #2: cyclopropylcarbinyl bromide In ISOPROPYLAMIDE at 69℃; for 6.5h; Stage #3: With sodium hydroxide; water In ISOPROPYLAMIDE pH=8.6 - 9; | 88.6% |
3-maleimidopropionic acid N-hydroxysuccinimide ester
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: 3-maleimidopropionic acid N-hydroxysuccinimide ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; | 82% |
cyclobutylaldehyde
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
nalbuphine
Conditions | Yield |
---|---|
Stage #1: cyclobutylaldehyde; (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With acetic acid; tetramethylammonium triacetoxyborohydride In dimethyl sulfoxide at 20℃; for 1h; Large scale; Stage #2: With acetic acid; tetramethylammonium triacetoxyborohydride In dimethyl sulfoxide at 60℃; Solvent; Reagent/catalyst; Large scale; | 77.7% |
cyclobutylaldehyde
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
6-ketonalbuphine hydrochloride
Conditions | Yield |
---|---|
Stage #1: cyclobutylaldehyde; (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride In dimethyl sulfoxide at 20℃; for 0.5h; Stage #2: With acetic acid; tetramethylammonium triacetoxyborohydride In dimethyl sulfoxide at 20℃; for 1.16667h; Stage #3: With hydrogenchloride In water; isopropyl alcohol Solvent; Reagent/catalyst; | 67.6% |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With sodium hydroxide In water Stage #2: With Aminoiminomethanesulfinic acid; sodium hydroxide In water at 85℃; for 1h; Inert atmosphere; Stage #3: With hydrogenchloride In water at 20℃; for 3.5h; | 44% |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
bromoacetylglycyne N-hydroxysuccinimide ester
Conditions | Yield |
---|---|
Stage #1: (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Inert atmosphere; Stage #2: bromoacetylglycyne N-hydroxysuccinimide ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1.33333h; Inert atmosphere; | 19.3% |
bromoacetic acid N-hydroxusuccinimidyl ester
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: bromoacetic acid N-hydroxusuccinimidyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; Stage #3: With sodium bromide In acetone at 56℃; for 24h; Inert atmosphere; |
bromoacetic acid N-hydroxusuccinimidyl ester
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Stage #1: (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: bromoacetic acid N-hydroxusuccinimidyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; Overall yield = 8.7 mg; |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere 2: hydrogen; 5%-palladium/activated carbon / ethanol; tetrahydrofuran / 96 h / Inert atmosphere View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere 2: hydrogen; 5%-palladium/activated carbon / ethanol; tetrahydrofuran / 96 h / Inert atmosphere 3: acetic acid; sodium tris(acetoxy)borohydride / 1.5 h / 10 °C / Inert atmosphere View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 70 °C / Inert atmosphere 2: hydrogen; 5%-palladium/activated carbon / ethanol; tetrahydrofuran / 96 h / Inert atmosphere 3: acetic acid; sodium tris(acetoxy)borohydride / 1.5 h / 10 °C / Inert atmosphere 4: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C View Scheme |
3-bromomethyl-2-butenolide
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 70℃; Inert atmosphere; |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
noroxymorphone
Conditions | Yield |
---|---|
With ammonium hydroxide In water at 50℃; pH=8; |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / water / 50 °C / pH 8 2: sulfuric acid / water / 80 °C View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Naloxone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / water / 50 °C / pH 8 2: potassium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 2 h / 30 °C View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Naltrexone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / water / 50 °C / pH 8 2: potassium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 5 h / 50 °C View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
N,O3-bis(cyclobutanecarbonyl)noroxymorphone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / water / 50 °C / pH 8 2: triethylamine / tetrahydrofuran / 1.5 h / 15 °C View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
nalbuphine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: ammonium hydroxide / water / 50 °C / pH 8 2.1: triethylamine / tetrahydrofuran / 1.5 h / 15 °C 3.1: borane-THF / tetrahydrofuran / 8.33 h / 5 °C / Reflux 3.2: 1 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: potassium tri-sec-butyl-borohydride / dimethyl sulfoxide; tetrahydrofuran / 60 °C View Scheme |
cyclobutylaldehyde
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
A
nalbuphine
B
(4R,4aS,7aR,12bS)-3-(cyclobutylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7(7aH)-one
Conditions | Yield |
---|---|
Stage #1: cyclobutylaldehyde; (-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride With acetic acid; tetramethylammonium triacetoxyborohydride In N,N-dimethyl-formamide at 20℃; Stage #2: With acetic acid; tetramethylammonium triacetoxyborohydride In N,N-dimethyl-formamide at 60℃; Solvent; | A 44.83 %Chromat. B 53.64 %Chromat. |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / dimethyl sulfoxide / 1 h / 20 °C / Large scale 1.2: 60 °C / Large scale 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: sodium tetrahydroborate / dimethyl sulfoxide / 60 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: potassium tri-sec-butyl-borohydride / dimethyl sulfoxide; tetrahydrofuran / 60 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / dimethyl sulfoxide / 1 h / 20 °C / Large scale 1.2: 60 °C / Large scale 2.1: phosphoric acid; oxygen / 2160 h / Irradiation View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: phosphoric acid; oxygen / 2160 h / Irradiation View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: sodium tetrahydroborate / dimethyl sulfoxide / 60 °C 3.1: phosphoric acid; oxygen / 2160 h / Irradiation View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: potassium tri-sec-butyl-borohydride / dimethyl sulfoxide; tetrahydrofuran / 60 °C 3.1: phosphoric acid; oxygen / 2160 h / Irradiation View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
A
6β-hydroxy-17-cyclobutylmethyl-4,5α-epoxy-3,14-dihydroxymorphinan
B
nalbuphine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: sodium tetrahydroborate / dimethyl sulfoxide / 60 °C View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
nalbuphine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / dimethyl sulfoxide / 1 h / 20 °C / Large scale 1.2: 60 °C / Large scale 2.1: hydrogenchloride / water / 45 - 60 °C / Large scale View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: hydrogenchloride / water / 45 - 60 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: sodium tetrahydroborate / dimethyl sulfoxide / 60 °C 3.1: hydrogenchloride / water / 45 - 60 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid; tetramethylammonium triacetoxyborohydride / N,N-dimethyl-formamide / 20 °C 1.2: 60 °C 2.1: potassium tri-sec-butyl-borohydride / dimethyl sulfoxide; tetrahydrofuran / 60 °C 3.1: hydrogenchloride / water / 45 - 60 °C / Large scale View Scheme |
(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: dimethyl sulfoxide / 0.5 h / 20 °C 1.2: 1.17 h / 20 °C 2.1: sodium hydroxide / water / Cooling with ice 2.2: 1 h / 85 °C / Inert atmosphere View Scheme |
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