Product Name: Maytansinol CAS No.: 57103-68-1 Chemical formula:C28H37ClN2O8 Molecular weight: 565.05 Product Usage: Apply in Anti-cancer drugs Packaging and Shipping: 25kgs /drum, or customized. Storage: Notes: Keep stored in coo
Cas:57103-68-1
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:57103-68-1
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:57103-68-1
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:57103-68-1
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:57103-68-1
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inquiryTIANFUCHEM-- 57103-68-1--High purity Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl- in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And
Cas:57103-68-1
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:57103-68-1
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:57103-68-1
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inquiryAbout Product Details
Cas:57103-68-1
Min.Order:1 Kilogram
FOB Price: $1.0 / 2.0
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:57103-68-1
Min.Order:1 Kilogram
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inquiryMaytansinol CAS:57103-68-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:57103-68-1
Min.Order:1 Gram
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:57103-68-1
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:57103-68-1
Min.Order:1 Gram
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Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:57103-68-1
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:57103-68-1
Min.Order:4 Kilogram
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inquiryAppearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/A
Cas:57103-68-1
Min.Order:100 Metric Ton
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:57103-68-1
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
High quality Low price Appearance:White Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:pharmaceutical intermediate Transportation:shipping,land,air P
Cas:57103-68-1
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:57103-68-1
Min.Order:10 Gram
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:57103-68-1
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
Cas:57103-68-1
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:57103-68-1
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:57103-68-1
Min.Order:1 Kilogram
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:57103-68-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:57103-68-1
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryansamitocin P-3
maytansinol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at -20℃; for 2h; | |
With lithium (hydro)trimethoxyaluminate | |
With lithium (hydro)trimethoxyaluminate | |
With lithium (hydro)trimethoxyaluminate In tetrahydrofuran at -40℃; | |
With lithium (hydro)trimethoxyaluminate In tetrahydrofuran at -40℃; for 1.5h; Inert atmosphere; |
maytanbutine
maytansinol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at -23℃; for 3h; |
(-)-maytansinol
maytansinol
Conditions | Yield |
---|---|
hydrolysis; |
4-deoxymaytansinol
maytansinol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C 2: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C 3: hydrolysis View Scheme |
(3E,5E,14E)-(7R,8S,12S,13S,16S)-21-Chloro-16-hydroxy-7,8,22-trimethoxy-3,13,15,19-tetramethyl-11-oxa-9,19-diaza-tricyclo[18.3.1.18,12]pentacosa-1(24),3,5,14,20,22-hexaene-10,18-dione
maytansinol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C 2: hydrolysis View Scheme |
C36H56ClNO5S2Si
maytansinol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) pyridine, 2.) aq. ammonium hydroxide / 1.) 27 deg C, 20 min, 2.) tert-butyl alcohol, 27 deg C, 2 h 2: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C 3: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C 4: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C 5: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C 6: hydrolysis View Scheme |
3-O-(tert-butyldimethylsilyl)-4,5-deoxymaytansinol
maytansinol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C 2: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C 3: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C 4: hydrolysis View Scheme |
C37H57ClN2O6S2Si
maytansinol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C 2: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C 3: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C 4: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C 5: hydrolysis View Scheme |
maytansinol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 1.) 2-propanethiol, boron trifluoride etherate, 2.) silver nitrate, aq. 2,6-lutidine / 1.) methylene chloride, - 78 deg C, 5 min, 2.) THF, 25 deg C, 1.75 h 2: 1.) pyridine, 2.) aq. ammonium hydroxide / 1.) 27 deg C, 20 min, 2.) tert-butyl alcohol, 27 deg C, 2 h 3: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C 4: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C 5: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C 6: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C 7: hydrolysis View Scheme |
maytansinol
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 71 percent / mesitylenesulfonyl chloride, diisopropylethylamine / benzene / 28 h / 40 °C 2: 1.) 2-propanethiol, boron trifluoride etherate, 2.) silver nitrate, aq. 2,6-lutidine / 1.) methylene chloride, - 78 deg C, 5 min, 2.) THF, 25 deg C, 1.75 h 3: 1.) pyridine, 2.) aq. ammonium hydroxide / 1.) 27 deg C, 20 min, 2.) tert-butyl alcohol, 27 deg C, 2 h 4: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C 5: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C 6: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C 7: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C 8: hydrolysis View Scheme |
maytansinol
(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione
(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate
Conditions | Yield |
---|---|
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere; | 95% |
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere; | |
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide for 24h; |
N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine
maytansinol
Conditions | Yield |
---|---|
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Stage #2: With diisopropyl-carbodiimide at -8 - 20℃; for 0.5h; | 90.5% |
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Stage #2: With diisopropyl-carbodiimide at -8 - 20℃; for 0.5h; | 90.5% |
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 0.5h; | 90.5% |
maytansinol
(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione
Conditions | Yield |
---|---|
With zinc(II) trifluoroacetate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 40h; Product distribution / selectivity; | 84% |
Stage #1: maytansinol; (L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 0.0333333 - 0.05h; Stage #2: With zinc(II) trifluoroacetate In tetrahydrofuran at 50 - 55℃; for 28h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With zinc(II) chloride; diisopropyl-carbodiimide In diethyl ether; dichloromethane at 20℃; for 2h; Inert atmosphere; | 74% |
Conditions | Yield |
---|---|
Stage #1: C8H14N4O3; maytansinol With diisopropyl-carbodiimide In dichloromethane for 0.0166667h; Inert atmosphere; Stage #2: With zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; Inert atmosphere; | 74% |
maytansinol
Conditions | Yield |
---|---|
With zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 18h; Sealed tube; Inert atmosphere; | 67% |
2-chloro-1-isocyanato-4-nitro-benzene
maytansinol
Conditions | Yield |
---|---|
With zinc(II) chloride In diethyl ether; dichloromethane at 20 - 50℃; Sealed tube; Inert atmosphere; | 58% |
N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine
maytansinol
A
Fmoc-N-Me-D-Ala-maytansinol
B
Fmoc-N-Me-L-Ala-maytansinol
Conditions | Yield |
---|---|
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; | A 43.1% B 46% |
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 0.5h; | A 43.1% B 46% |
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 0.5h; | A 43.1% B 46% |
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Inert atmosphere; Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8℃; for 0.5h; Inert atmosphere; Overall yield = 90.5 %; Overall yield = 0.8385 g; | A 43.1% B 46% |
Multi-step reaction with 2 steps 1.1: dmap; scandium tris(trifluoromethanesulfonate) / dichloromethane / 0.5 h / -8 °C 1.2: 0.5 h / -8 - 20 °C 2.1: silica gel / dichloromethane; methanol / Resolution of racemate View Scheme |
N-methyl-N-[(4-(R,S)-methyldithio)-1-oxopentyl]-L-alanine
maytansinol
A
N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; | A 36% B 30% |
N-methyl-N-[4-methyl-(4-methyldithio)-1-oxopentyl]-L-alanine
maytansinol
A
N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine
B
N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-D-maytansine
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; | A 36% B n/a |
Conditions | Yield |
---|---|
With zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 18h; Inert atmosphere; Sealed tube; | 34% |
N-methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine
maytansinol
A
N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; | A 32% B 30% |
maytansinol
A
(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate
B
N-Me-D-Ala-maytansinol
Conditions | Yield |
---|---|
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 50℃; for 4h; Glovebox; Inert atmosphere; Sealed tube; | A 21% B 20% |
maytansinol
(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate
Conditions | Yield |
---|---|
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In 2-methyltetrahydrofuran; N,N-dimethyl-formamide at 20 - 50℃; for 44h; Sealed tube; Glovebox; | 21% |
maytansinol
Conditions | Yield |
---|---|
Stage #1: N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h; Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h; | A 16% B 14% |
maytansinol
Conditions | Yield |
---|---|
Stage #1: N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h; Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h; | A 12% B 14.2% |
maytansinol
Conditions | Yield |
---|---|
Stage #1: N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h; Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h; | A 10.6% B 10.7% |
Stage #1: N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h; Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h; | A 10.7% B 10.6% |
bromoacetic anhydride
maytansinol
(3E,5E,7R,84S)-12c-bromoacetoxy-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
Conditions | Yield |
---|---|
With pyridine at 45℃; for 18h; |
Conditions | Yield |
---|---|
With pyridine at 53℃; for 18h; | |
With pyridine for 18h; Ambient temperature; |
crotonic anhydride
maytansinol
(3E,5E,7R,84S)-12c-but-2t-enoyloxy-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
Conditions | Yield |
---|---|
With pyridine at 65℃; for 20h; |
propionic acid anhydride
maytansinol
(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-12c-propionyloxy-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
Conditions | Yield |
---|---|
With pyridine at 45℃; for 72h; |
maytansinol
trifluoroacetic anhydride
(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-12c-trifluoroacetoxy-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at -10℃; for 0.25h; |
maytansinol
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; |
N-methyl-N-[(3-methyldithio)-1-oxobutyl]-L-alanine
maytansinol
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; |
N-methyl-N-[(4-(S)-methyldithio)-1-oxopentyl]-S-alanine
maytansinol
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; |
N-methyl-N-[(4-(R)-methyldithio)-1-oxopentyl]-S-alanine
maytansinol
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; |
N-methyl-N-(3-phenyldithio-propanoyl)-L-alanine
maytansinol
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; |
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