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GIHI CHEMICALS CO.,LIMITED

Product Name: Maytansinol CAS No.: 57103-68-1 Chemical formula:C28H37ClN2O8 Molecular weight: 565.05 Product Usage: Apply in Anti-cancer drugs Packaging and Shipping: 25kgs /drum, or customized. Storage: Notes: Keep stored in coo

Biggest manufacturer of Maytansinol,higher purity, lower price, sample available from gihichem

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $4.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Maytansine,3-O-de[2-(acetylmethylamino)-1-oxopropyl]-

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 57103-68-1

Cas:57103-68-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Maytansinol

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Maytansinol

Cas:57103-68-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Maytansinol

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 57103-68-1--High purity Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl- in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And

TIANFUCHEM-- 57103-68-1--High purity Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl- in stock

Cas:57103-68-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Maytansinol CAS No. 57103-68-1

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 57103-68-1 with competitive price

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Leader Biochemical Group

About Product Details

Supply High Quality Maytansinol CAS 57103-68-1 For research use only

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Maytansine,3-O-de[2-(acetylmethylamino)-1-oxopropyl]- 57103-68-1

Cas:57103-68-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Maytansinol CAS:57103-68-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Maytansinol CAS:57103-68-1

Cas:57103-68-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Maytansine,3-O-de[2-(acetylmethylamino)-1-oxopropyl]-

Cas:57103-68-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

MAYTANSINOL manufacturer with low price

Cas:57103-68-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Maytansine,3-O-de[2-(acetylmethylamino)-1-oxopropyl]-

Cas:57103-68-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Maytansine;Ansamitocin P-0

Cas:57103-68-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/A

57103-68-1

Cas:57103-68-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

API Research Maytansinol Powder Dosage Usage Effect and Benefit

Cas:57103-68-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

MAYTANSINOL

Cas:57103-68-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

MAYTANSINOL

Cas:57103-68-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Send Pharmaceutical Technology Co., Ltd.

High quality Low price Appearance:White Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:pharmaceutical intermediate Transportation:shipping,land,air P

Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-

Cas:57103-68-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Maytansine,3-O-de[2-(acetylmethylamino)-1-oxopropyl]-

Cas:57103-68-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

API Research Maytansinol Powder Dosage Usage Effect and Benefit

Cas:57103-68-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Maytansine

Cas:57103-68-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Factory SupplierMaytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-

Cas:57103-68-1

Min.Order:0

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

MAYTANSINOL

Cas:57103-68-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

MAYTANSINOL

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Maytansine, O3-de2-(acetylmethylamino)-1-oxopropyl-

Cas:57103-68-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

API Research Maytansinol Powder Dosage Usage Effect and Benefit

Cas:57103-68-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

API Research Maytansinol Powder Dosage Usage Effect and Benefit

Cas:57103-68-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

ansamitocin P-3
66584-72-3, 93221-27-3

ansamitocin P-3

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at -20℃; for 2h;
With lithium (hydro)trimethoxyaluminate
With lithium (hydro)trimethoxyaluminate
With lithium (hydro)trimethoxyaluminate In tetrahydrofuran at -40℃;
With lithium (hydro)trimethoxyaluminate In tetrahydrofuran at -40℃; for 1.5h; Inert atmosphere;
maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at -23℃; for 3h;
Conditions
ConditionsYield
hydrolysis;
4-deoxymaytansinol
75340-67-9

4-deoxymaytansinol

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C
2: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
3: hydrolysis
View Scheme
(3E,5E,14E)-(7R,8S,12S,13S,16S)-21-Chloro-16-hydroxy-7,8,22-trimethoxy-3,13,15,19-tetramethyl-11-oxa-9,19-diaza-tricyclo[18.3.1.18,12]pentacosa-1(24),3,5,14,20,22-hexaene-10,18-dione
75349-70-1

(3E,5E,14E)-(7R,8S,12S,13S,16S)-21-Chloro-16-hydroxy-7,8,22-trimethoxy-3,13,15,19-tetramethyl-11-oxa-9,19-diaza-tricyclo[18.3.1.18,12]pentacosa-1(24),3,5,14,20,22-hexaene-10,18-dione

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
2: hydrolysis
View Scheme
C36H56ClNO5S2Si
75340-66-8

C36H56ClNO5S2Si

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) pyridine, 2.) aq. ammonium hydroxide / 1.) 27 deg C, 20 min, 2.) tert-butyl alcohol, 27 deg C, 2 h
2: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C
3: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C
4: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C
5: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
6: hydrolysis
View Scheme
3-O-(tert-butyldimethylsilyl)-4,5-deoxymaytansinol
75349-69-8

3-O-(tert-butyldimethylsilyl)-4,5-deoxymaytansinol

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C
2: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C
3: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
4: hydrolysis
View Scheme
C37H57ClN2O6S2Si
75349-68-7

C37H57ClN2O6S2Si

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C
2: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C
3: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C
4: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
5: hydrolysis
View Scheme
C40H64ClNO6S2Si

C40H64ClNO6S2Si

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.) 2-propanethiol, boron trifluoride etherate, 2.) silver nitrate, aq. 2,6-lutidine / 1.) methylene chloride, - 78 deg C, 5 min, 2.) THF, 25 deg C, 1.75 h
2: 1.) pyridine, 2.) aq. ammonium hydroxide / 1.) 27 deg C, 20 min, 2.) tert-butyl alcohol, 27 deg C, 2 h
3: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C
4: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C
5: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C
6: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
7: hydrolysis
View Scheme
(E)-(3S,6S,7S)-3-(tert-Butyl-dimethyl-silanyloxy)-8-{2-[(2E,4E)-(R)-6-(4-chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-propoxy)-4,6-dimethyl-oct-4-enoatetetrabutyl-ammonium;

(E)-(3S,6S,7S)-3-(tert-Butyl-dimethyl-silanyloxy)-8-{2-[(2E,4E)-(R)-6-(4-chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-propoxy)-4,6-dimethyl-oct-4-enoatetetrabutyl-ammonium;

maytansinol
57103-68-1

maytansinol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 71 percent / mesitylenesulfonyl chloride, diisopropylethylamine / benzene / 28 h / 40 °C
2: 1.) 2-propanethiol, boron trifluoride etherate, 2.) silver nitrate, aq. 2,6-lutidine / 1.) methylene chloride, - 78 deg C, 5 min, 2.) THF, 25 deg C, 1.75 h
3: 1.) pyridine, 2.) aq. ammonium hydroxide / 1.) 27 deg C, 20 min, 2.) tert-butyl alcohol, 27 deg C, 2 h
4: mercuric chloride, aq. calcium carbonate / acetonitrile / 12 h / 25 °C
5: 83 percent / aq. HF / acetonitrile / 0.75 h / 0 °C
6: 0.1 percent p-toluenesulfonic acid / 0.5 h / 25 °C
7: 87 percent / tert-butyl hydroperoxide, oxyvanadium(IV) bis(acetylacetonate), 2,6-lutidine / benzene; toluene / 3.5 h / 25 °C
8: hydrolysis
View Scheme
maytansinol
57103-68-1

maytansinol

(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione
58311-53-8

(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione

(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate
77668-69-0

(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;95%
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere;
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide for 24h;
N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine
84000-07-7

N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine

maytansinol
57103-68-1

maytansinol

Fmoc-N-Me-D/L-Ala-maytansinol

Fmoc-N-Me-D/L-Ala-maytansinol

Conditions
ConditionsYield
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h;
Stage #2: With diisopropyl-carbodiimide at -8 - 20℃; for 0.5h;
90.5%
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h;
Stage #2: With diisopropyl-carbodiimide at -8 - 20℃; for 0.5h;
90.5%
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h;
Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 0.5h;
90.5%
maytansinol
57103-68-1

maytansinol

(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione
58311-53-8

(L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione

maytansinol 3-(S)-α-N-methylaminopropionate

maytansinol 3-(S)-α-N-methylaminopropionate

Conditions
ConditionsYield
With zinc(II) trifluoroacetate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 40h; Product distribution / selectivity;84%
Stage #1: maytansinol; (L)-3,4-dimethyl-1,3-oxazolidine-2,5-dione With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 0.0333333 - 0.05h;
Stage #2: With zinc(II) trifluoroacetate In tetrahydrofuran at 50 - 55℃; for 28h; Product distribution / selectivity;
C8H14N4O3

C8H14N4O3

maytansinol
57103-68-1

maytansinol

C36H49ClN6O10

C36H49ClN6O10

Conditions
ConditionsYield
With zinc(II) chloride; diisopropyl-carbodiimide In diethyl ether; dichloromethane at 20℃; for 2h; Inert atmosphere;74%
C8H14N4O3

C8H14N4O3

maytansinol
57103-68-1

maytansinol

C36H49ClN6O10

C36H49ClN6O10

Conditions
ConditionsYield
Stage #1: C8H14N4O3; maytansinol With diisopropyl-carbodiimide In dichloromethane for 0.0166667h; Inert atmosphere;
Stage #2: With zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h; Inert atmosphere;
74%
1-isocyanato-3-methoxy-4-nitrobenzene

1-isocyanato-3-methoxy-4-nitrobenzene

maytansinol
57103-68-1

maytansinol

maytan-3-O-carbamoyl-N-(3-methoxy-4-nitrobenzene)

maytan-3-O-carbamoyl-N-(3-methoxy-4-nitrobenzene)

Conditions
ConditionsYield
With zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 18h; Sealed tube; Inert atmosphere;67%
2-chloro-1-isocyanato-4-nitro-benzene
40397-95-3

2-chloro-1-isocyanato-4-nitro-benzene

maytansinol
57103-68-1

maytansinol

maytan-3-O-carbamoyl-N-(2-chloro-4-nitrobenzene)

maytan-3-O-carbamoyl-N-(2-chloro-4-nitrobenzene)

Conditions
ConditionsYield
With zinc(II) chloride In diethyl ether; dichloromethane at 20 - 50℃; Sealed tube; Inert atmosphere;58%
N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine
84000-07-7

N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine

maytansinol
57103-68-1

maytansinol

A

Fmoc-N-Me-D-Ala-maytansinol
1452404-53-3

Fmoc-N-Me-D-Ala-maytansinol

B

Fmoc-N-Me-L-Ala-maytansinol
1452404-52-2

Fmoc-N-Me-L-Ala-maytansinol

Conditions
ConditionsYield
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h;
Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃;
A 43.1%
B 46%
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h;
Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 0.5h;
A 43.1%
B 46%
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h;
Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8 - 20℃; for 0.5h;
A 43.1%
B 46%
Stage #1: N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine; maytansinol With dmap; scandium tris(trifluoromethanesulfonate) In dichloromethane at -8℃; for 0.5h; Inert atmosphere;
Stage #2: With diisopropyl-carbodiimide In dichloromethane at -8℃; for 0.5h; Inert atmosphere; Overall yield = 90.5 %; Overall yield = 0.8385 g;
A 43.1%
B 46%
Multi-step reaction with 2 steps
1.1: dmap; scandium tris(trifluoromethanesulfonate) / dichloromethane / 0.5 h / -8 °C
1.2: 0.5 h / -8 - 20 °C
2.1: silica gel / dichloromethane; methanol / Resolution of racemate
View Scheme
N-methyl-N-[(4-(R,S)-methyldithio)-1-oxopentyl]-L-alanine
796073-60-4

N-methyl-N-[(4-(R,S)-methyldithio)-1-oxopentyl]-L-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine
796073-70-6

N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine

B

C38H54ClN3O10S2

C38H54ClN3O10S2

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;A 36%
B 30%
N-methyl-N-[4-methyl-(4-methyldithio)-1-oxopentyl]-L-alanine
796073-57-9

N-methyl-N-[4-methyl-(4-methyldithio)-1-oxopentyl]-L-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine
796073-68-2

N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine

B

N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-D-maytansine
902768-55-2

N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-D-maytansine

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;A 36%
B n/a
4-Nitrophenyl isocyanate
100-28-7

4-Nitrophenyl isocyanate

maytansinol
57103-68-1

maytansinol

maytan-3-O-carbamoyl-N-(4-nitrobenzene)

maytan-3-O-carbamoyl-N-(4-nitrobenzene)

Conditions
ConditionsYield
With zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 18h; Inert atmosphere; Sealed tube;34%
N-methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine
138148-62-6

N-methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine
138148-68-2

N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]maytansine

B

N2'-deacetyl-N2'-[2-(methyldithio)-1-oxopropyl]maytansine

N2'-deacetyl-N2'-[2-(methyldithio)-1-oxopropyl]maytansine

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;A 32%
B 30%
3,4-dimethyl-2-thioxo-oxazolidin-5-one

3,4-dimethyl-2-thioxo-oxazolidin-5-one

maytansinol
57103-68-1

maytansinol

A

(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate
77668-69-0

(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate

B

N-Me-D-Ala-maytansinol
77714-98-8

N-Me-D-Ala-maytansinol

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 50℃; for 4h; Glovebox; Inert atmosphere; Sealed tube;A 21%
B 20%
3,4-dimethyl-2-thioxo-oxazolidin-5-one

3,4-dimethyl-2-thioxo-oxazolidin-5-one

maytansinol
57103-68-1

maytansinol

(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate
77668-69-0

(14S,16S,32R,33R,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl methyl-L-alaninate

Conditions
ConditionsYield
With zinc trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In 2-methyltetrahydrofuran; N,N-dimethyl-formamide at 20 - 50℃; for 44h; Sealed tube; Glovebox;21%
N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine

N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine

maytansinol
57103-68-1

maytansinol

A

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alaninate

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alaninate

B

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-D-alaninate

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-D-alaninate

Conditions
ConditionsYield
Stage #1: N-((1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h;
Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h;
A 16%
B 14%
N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine

N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine

maytansinol
57103-68-1

maytansinol

A

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alaninate

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alaninate

B

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-D-alaninate

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-D-alaninate

Conditions
ConditionsYield
Stage #1: N-((5-(S)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h;
Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h;
A 12%
B 14.2%
N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine

N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine

maytansinol
57103-68-1

maytansinol

A

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy- 85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-D-alaninate

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy- 85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-D-alaninate

B

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alaninate

(14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alaninate

Conditions
ConditionsYield
Stage #1: N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h;
Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h;
A 10.6%
B 10.7%
Stage #1: N-((5-(R)-1,2-dithiolan-3-yl)pentanoyl)-N-methyl-L-alanine; maytansinol With dicyclohexyl-carbodiimide In dichloromethane for 0.0166667h;
Stage #2: With zinc(II) chloride In dichloromethane at 20℃; for 24h;
A 10.7%
B 10.6%
bromoacetic anhydride
13094-51-4

bromoacetic anhydride

maytansinol
57103-68-1

maytansinol

(3E,5E,7R,84S)-12c-bromoacetoxy-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
57103-71-6

(3E,5E,7R,84S)-12c-bromoacetoxy-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione

Conditions
ConditionsYield
With pyridine at 45℃; for 18h;
acetic anhydride
108-24-7

acetic anhydride

maytansinol
57103-68-1

maytansinol

ansamitocin P1
57103-69-2

ansamitocin P1

Conditions
ConditionsYield
With pyridine at 53℃; for 18h;
With pyridine for 18h; Ambient temperature;
crotonic anhydride
623-68-7

crotonic anhydride

maytansinol
57103-68-1

maytansinol

(3E,5E,7R,84S)-12c-but-2t-enoyloxy-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
57103-72-7

(3E,5E,7R,84S)-12c-but-2t-enoyloxy-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione

Conditions
ConditionsYield
With pyridine at 65℃; for 20h;
propionic acid anhydride
123-62-6

propionic acid anhydride

maytansinol
57103-68-1

maytansinol

(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-12c-propionyloxy-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
57103-70-5

(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-12c-propionyloxy-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione

Conditions
ConditionsYield
With pyridine at 45℃; for 72h;
maytansinol
57103-68-1

maytansinol

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-12c-trifluoroacetoxy-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione
57103-73-8

(3E,5E,7R,84S)-14-chloro-10t,11c-epoxy-84-hydroxy-15,7r-dimethoxy-3,9c,11t,15-tetramethyl-12c-trifluoroacetoxy-(84r'H,86c'H)-15-aza-1(1,3)-benzena-8(4,6)-[1,3]oxazinana-cyclopentadecaphane-3,5-diene-82,14-dione

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at -10℃; for 0.25h;
N-methyl-N-[(2-methyldithio)-1-oxoethyl]-L-alanine

N-methyl-N-[(2-methyldithio)-1-oxoethyl]-L-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[2-(methyldithio)-1-oxoethyl]maytansine

N2'-deacetyl-N2'-[2-(methyldithio)-1-oxoethyl]maytansine

B

N2'-deacetyl-N2'-[2-(methyldithio)-1-oxoethyl]maytansine

N2'-deacetyl-N2'-[2-(methyldithio)-1-oxoethyl]maytansine

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;
N-methyl-N-[(3-methyldithio)-1-oxobutyl]-L-alanine
138148-63-7

N-methyl-N-[(3-methyldithio)-1-oxobutyl]-L-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[3-(methyldithio)-1-oxobutyl]maytansine

N2'-deacetyl-N2'-[3-(methyldithio)-1-oxobutyl]maytansine

B

C37H52ClN3O10S2

C37H52ClN3O10S2

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;
N-methyl-N-[(4-(S)-methyldithio)-1-oxopentyl]-S-alanine
796073-78-4

N-methyl-N-[(4-(S)-methyldithio)-1-oxopentyl]-S-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[4-(S)-(methyldithio)-1-oxopentyl]maytansine

N2'-deacetyl-N2'-[4-(S)-(methyldithio)-1-oxopentyl]maytansine

B

N2'-deacetyl-N2'-[4-(S)-(methyldithio)-1-oxopentyl]-D-maytansine

N2'-deacetyl-N2'-[4-(S)-(methyldithio)-1-oxopentyl]-D-maytansine

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;
N-methyl-N-[(4-(R)-methyldithio)-1-oxopentyl]-S-alanine
796073-74-0

N-methyl-N-[(4-(R)-methyldithio)-1-oxopentyl]-S-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[4-(R)-(methyldithio)-1-oxopentyl]maytansine

N2'-deacetyl-N2'-[4-(R)-(methyldithio)-1-oxopentyl]maytansine

B

C38H54ClN3O10S2

C38H54ClN3O10S2

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;
N-methyl-N-(3-phenyldithio-propanoyl)-L-alanine
382599-34-0

N-methyl-N-(3-phenyldithio-propanoyl)-L-alanine

maytansinol
57103-68-1

maytansinol

A

N2'-deacetyl-N2'-[3-(phenyldithio)-1-oxopropyl]maytansine

N2'-deacetyl-N2'-[3-(phenyldithio)-1-oxopropyl]maytansine

B

C41H52ClN3O10S2

C41H52ClN3O10S2

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; zinc(II) chloride In diethyl ether; dichloromethane at 20℃; for 2h;

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