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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Tacalcitol Manufacturer/High quality/Best price/In stock

Cas:57333-96-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tacalcitol

Cas:57333-96-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 57333-96-7 with competitive price

Cas:57333-96-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Tacalcitol

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Tacalcitol manufaacturer 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and e

High quality Tacalcitol manufaacturer

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tacalcitol

Cas:57333-96-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Tacalcitol manufacturer with low price

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Tacalcitol powder 57333-96-7

Cas:57333-96-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Tianjin Kind Pharma Co., Ltd.

Factory direct sales, accept customization. Tacalcitol, the second vitamin D analog developed as a topical antipsoriatic, was introduced for keratosis, psoriasis, ichthyosis, pityriasis rubra pilaris and palmoplantar pustulosis and keratoderma. It s

Tacalcitol

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

TACALCITOL

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

cas:57333-96-7

Cas:57333-96-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

High Quality Tacalcitol 98% 57333-96-7 in stock fast delivery good supplierAppearance:Powder Storage:Dry and ventilated Package:according to customers' requirements Application:APIs Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(F

High Quality Tacalcitol 98% 57333-96-7 in stock fast delivery good supplier

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Tacalcitol

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Tacalcitol CAS No.:57333-96-7 Molecule Formula:C27H44O3 Molecule Weight:416.64 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPECIF

Best Quality Tacalcitol with good supplier

Cas:57333-96-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

Tacalcitol 57333-96-7

Cas:57333-96-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Tacalcitol

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tacalcitol

Cas:57333-96-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Tacalcitol

Cas:57333-96-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

57333-96-7 CAS NO.57333-96-7

Cas:57333-96-7

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

High Quality Tacalcitol 98% 57333-96-7 in stock fast delivery good supplier

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Stable stock and competitive priceAppearance:powder Storage:available Package:1KG 5KG 25KG Application:As Pharm raw material Transportation:By Courier,Sea or air

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Tacalcitol 5mg

Cas:57333-96-7

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Joyochem Co., Ltd.

JP16 Application:API

Tacalcitol

Cas:57333-96-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea

Tacalcitol

Cas:57333-96-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

((1R,3S,Z)-5-((E)-2-((1R,7aR)-7a-methyl-1((2R,5R)-6-methyl-5-(triethylsilyloxy)heptan-2-yl)dihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy)bis(tert-butyldimethylsilane)

((1R,3S,Z)-5-((E)-2-((1R,7aR)-7a-methyl-1((2R,5R)-6-methyl-5-(triethylsilyloxy)heptan-2-yl)dihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy)bis(tert-butyldimethylsilane)

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; Darkness;98%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 40h; Darkness;98%
(1R,3S)-5-[2-[(1R,3aS,7aR)-1-((1R,4R)-4-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexane-1,3-diol

(1R,3S)-5-[2-[(1R,3aS,7aR)-1-((1R,4R)-4-Methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-methylene-cyclohexane-1,3-diol

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
With hydrogen fluoride In water; acetonitrile at 20℃; for 24h;76%
With methanol; AG 50W-X4 resin at 20℃; methanolysis;33 mg
C41H74O4Si2

C41H74O4Si2

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Stage #1: C41H74O4Si2 With potassium carbonate In methanol at 20℃; for 5h;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran for 2h; Reflux;
75%
C46H76O4Si2

C46H76O4Si2

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Stage #1: C46H76O4Si2 With potassium carbonate In methanol at 20℃; for 5h;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran for 2h; Reflux;
75%
C39H72O3Si2

C39H72O3Si2

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
With (1S)-10-camphorsulfonic acid In methanol; chloroform at 20℃; for 2.5h;65%
Stage #1: C39H72O3Si2 With tetrabutyl ammonium fluoride In tetrahydrofuran at 50 - 55℃; for 2h;
Stage #2: With maleic anhydride In ethyl acetate at 30 - 35℃; for 24h;
300 mg
1α,3β,24(R)-trihydroxycholesta-5,7-diene
57701-47-0

1α,3β,24(R)-trihydroxycholesta-5,7-diene

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
In diethyl ether Irradiation;
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate
66774-80-9

(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1.1: 91 percent / dimethylsulfoxide / 2 h / 90 °C
2.1: 98 percent / imidazole / dimethylformamide / 12 h / 80 °C
3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
3.2: 91 percent / hexamethylphosphoramide / tetrahydrofuran; hexane / 7 h / -60 - 20 °C
4.1: 94 percent / tert-butanol; potassium; hexamethylphosphoramide / diethyl ether / 13 h / 0 - 20 °C
5.1: 93 percent / N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C
6.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / Heating
7.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
8.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
8.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
9.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
10.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
11.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
12.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
13.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol
64190-52-9

(8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1.1: 93 percent / pyridine / 12 h / 0 °C
2.1: 91 percent / dimethylsulfoxide / 2 h / 90 °C
3.1: 98 percent / imidazole / dimethylformamide / 12 h / 80 °C
4.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
4.2: 91 percent / hexamethylphosphoramide / tetrahydrofuran; hexane / 7 h / -60 - 20 °C
5.1: 94 percent / tert-butanol; potassium; hexamethylphosphoramide / diethyl ether / 13 h / 0 - 20 °C
6.1: 93 percent / N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C
7.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / Heating
8.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
9.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
9.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
10.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
11.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
12.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
13.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
14.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
Multi-step reaction with 11 steps
1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 96 h / 20 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 0 - 20 °C
5: lithium hexamethyldisilazane / tetrahydrofuran / 15 h / -78 - 20 °C
6: tetrabutyl ammonium fluoride / tetrahydrofuran / 17 h / 65 °C
7: hydrogen; palladium 10% on activated carbon / methanol / 15 h
8: dipyridinium dichromate / dichloromethane / 20 °C
9: n-butyllithium / tetrahydrofuran / 18 h / -78 °C
10: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Darkness
11: hydrogen fluoride / acetonitrile; water / 24 h / 20 °C
View Scheme
Multi-step reaction with 10 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 50 - 55 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / -5 - 5 °C
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0.17 h / -5 - 5 °C
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -70 - -60 °C
4.2: -70 - 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 55 - 60 °C
6.1: pyridinium chlorochromate / dichloromethane / 20 °C
7.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 2280.15 - 2660.18 Torr
8.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C
9.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -60 °C
9.2: 1.5 h / -65 - -10 °C
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Darkness
View Scheme
Multi-step reaction with 10 steps
1.1: 1H-imidazole; ammonium chloride / N,N-dimethyl-formamide / 50 - 55 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 4 h / 20 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere
4.2: -70 - 20 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 °C / Inert atmosphere
6.1: dipyridinium dichromate / dichloromethane / 20 °C
7.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 24 h / 2280.15 - 2660.18 Torr
8.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
9.1: n-butyllithium / tetrahydrofuran / 1 h / -65 °C / Inert atmosphere
9.2: 1.5 h / -65 - -10 °C / Inert atmosphere
10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 40 h / 20 °C / Darkness
View Scheme
<1R-<1β(R*),3aα,4β,7aβ>>-octahydro-4-hydroxy-β,7a-dimethyl-1H-indene-1-propanenitrile
93489-60-2

<1R-<1β(R*),3aα,4β,7aβ>>-octahydro-4-hydroxy-β,7a-dimethyl-1H-indene-1-propanenitrile

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: 98 percent / imidazole / dimethylformamide / 12 h / 80 °C
2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
2.2: 91 percent / hexamethylphosphoramide / tetrahydrofuran; hexane / 7 h / -60 - 20 °C
3.1: 94 percent / tert-butanol; potassium; hexamethylphosphoramide / diethyl ether / 13 h / 0 - 20 °C
4.1: 93 percent / N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C
5.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / Heating
6.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
7.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
7.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
8.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
9.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
10.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
11.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
12.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
De-A,B-(24R)-8β-[(tert-butyldimethylsilyl)oxy]-cholestan-24-ol
145223-31-0

De-A,B-(24R)-8β-[(tert-butyldimethylsilyl)oxy]-cholestan-24-ol

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: 93 percent / N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C
2.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / Heating
3.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
4.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
4.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
5.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
6.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
7.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
8.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
9.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
(R)-3-((1R,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)butanenitrile
145223-29-6

(R)-3-((1R,3aR,4S,7aR)-4-((tert-butyldimethylsilyl)oxy)-7a-methyloctahydro-1H-inden-1-yl)butanenitrile

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
1.2: 91 percent / hexamethylphosphoramide / tetrahydrofuran; hexane / 7 h / -60 - 20 °C
2.1: 94 percent / tert-butanol; potassium; hexamethylphosphoramide / diethyl ether / 13 h / 0 - 20 °C
3.1: 93 percent / N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C
4.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / Heating
5.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
6.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
6.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
7.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
8.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
9.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
10.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
11.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
De-A,B-(24R,22ξ)-8β-[(tert-butyldimethylsilyl)oxy]-24-hydroxy-cholestane-22-carbonitrile
145223-30-9

De-A,B-(24R,22ξ)-8β-[(tert-butyldimethylsilyl)oxy]-24-hydroxy-cholestane-22-carbonitrile

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 94 percent / tert-butanol; potassium; hexamethylphosphoramide / diethyl ether / 13 h / 0 - 20 °C
2.1: 93 percent / N,N-diisopropylethylamine / CH2Cl2 / 0 - 20 °C
3.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / Heating
4.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
5.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
5.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
6.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
7.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
8.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
9.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
10.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
De-A,B-(24R)-24-[(methoxymethyl)oxy]-cholestan-8-one
188949-00-0

De-A,B-(24R)-24-[(methoxymethyl)oxy]-cholestan-8-one

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
1.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
3.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
4.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
5.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
6.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: n-butyllithium / tetrahydrofuran / 18 h / -78 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Darkness
3: hydrogen fluoride / acetonitrile; water / 24 h / 20 °C
View Scheme
De-A,B-(24R)-8β-hydroxy-cholestan-24-ol methoxymethyl ether
188948-99-4

De-A,B-(24R)-8β-hydroxy-cholestan-24-ol methoxymethyl ether

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
2.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
2.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
4.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
5.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
6.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
7.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: dipyridinium dichromate / dichloromethane / 20 °C
2: n-butyllithium / tetrahydrofuran / 18 h / -78 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Darkness
4: hydrogen fluoride / acetonitrile; water / 24 h / 20 °C
View Scheme
De-A,B-(24R)-24-[(methoxymethyl)oxy]-cholest-8-en-8-yl trifluoromethanesulfonate
188948-96-1

De-A,B-(24R)-24-[(methoxymethyl)oxy]-cholest-8-en-8-yl trifluoromethanesulfonate

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
2: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
3: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
4: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
5: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
De-A,B-(24R)-8β-[(tert-butyldimethylsilyl)oxy]-cholestan-24-ol methoxymethyl ether
188948-98-3

De-A,B-(24R)-8β-[(tert-butyldimethylsilyl)oxy]-cholestan-24-ol methoxymethyl ether

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 18 h / Heating
2.1: 96 percent / pyridinium dichromate; pyridinium p-toluenesulfonate / CH2Cl2 / 40 h / 0 °C
3.1: lithium diisopropylamide / hexane; tetrahydrofuran / 2 h / -78 - 20 °C
3.2: 76 percent / tetrahydrofuran; hexane / -78 - 20 °C
4.1: 92 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 2 h / 70 °C
5.1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
6.1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
7.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
8.1: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
(24R)-1α-[(tert-butyldimethylsilyl)oxy]-6,7-didehydro-24-[(methoxymethyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether
188948-95-0

(24R)-1α-[(tert-butyldimethylsilyl)oxy]-6,7-didehydro-24-[(methoxymethyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 83 percent / hydrogen; quinoline / Lindlar catalyst / hexane / 0.5 h
2: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
3: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
4: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
1α-[(tert-butyldimethylsilyl)oxy]-24R-[(methoxymethyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether
188949-01-1

1α-[(tert-butyldimethylsilyl)oxy]-24R-[(methoxymethyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / 2,2,4-trimethyl-pentane / 4 h / Heating
2: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
3: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
1α-[(tert-butyldimethylsilyl)oxy]-24R-[(methoxymethyl)oxy]-vitamin D3 tert-butyldimethylsilyl ether
188949-02-2

1α-[(tert-butyldimethylsilyl)oxy]-24R-[(methoxymethyl)oxy]-vitamin D3 tert-butyldimethylsilyl ether

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 20 °C
2: 33 mg / AG 50W-X4 resin; methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Darkness
2: hydrogen fluoride / acetonitrile; water / 24 h / 20 °C
View Scheme
1α, 3β, 24-trihydroxycholest-5-ene
59780-19-7

1α, 3β, 24-trihydroxycholest-5-ene

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Py
3: diethyl ether / Irradiation
View Scheme
1α, 2α-epoxy-24-keto-cholesta-4,6-dien-3-one
57701-42-5

1α, 2α-epoxy-24-keto-cholesta-4,6-dien-3-one

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Li, NH4Cl, liq. NH3
2: Py
4: diethyl ether / Irradiation
View Scheme
1α-Hydroxy-3β,24(R)-dibenzoyloxy-cholest-5-ene
57333-97-8

1α-Hydroxy-3β,24(R)-dibenzoyloxy-cholest-5-ene

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: diethyl ether / Irradiation
View Scheme
C24H46O2Si

C24H46O2Si

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere
2.1: palladium on activated charcoal; hydrogen / methanol / 760.05 Torr
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / Reflux
4.1: pyridinium dichromate; aluminum oxide / dichloromethane / 20 h / 20 °C
5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
5.2: 2 h / 20 °C
6.1: potassium carbonate / methanol / 5 h / 20 °C
6.2: 2 h / Reflux
View Scheme
C34H50O2Si

C34H50O2Si

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: pyridine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere
2.1: palladium on activated charcoal; hydrogen / methanol / 760.05 Torr
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / Reflux
4.1: pyridinium dichromate / dichloromethane / 20 h / 20 °C / Inert atmosphere
5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
5.2: 2 h / 20 °C
6.1: potassium carbonate / methanol / 5 h / 20 °C
6.2: 2 h / Reflux
View Scheme
C26H48O3Si

C26H48O3Si

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: palladium on activated charcoal; hydrogen / methanol / 760.05 Torr
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / Reflux
3.1: pyridinium dichromate; aluminum oxide / dichloromethane / 20 h / 20 °C
4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
4.2: 2 h / 20 °C
5.1: potassium carbonate / methanol / 5 h / 20 °C
5.2: 2 h / Reflux
View Scheme
C41H54O3Si

C41H54O3Si

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: palladium on activated charcoal; hydrogen / methanol / 760.05 Torr
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / Reflux
3.1: pyridinium dichromate / dichloromethane / 20 h / 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
4.2: 2 h / 20 °C
5.1: potassium carbonate / methanol / 5 h / 20 °C
5.2: 2 h / Reflux
View Scheme
C26H50O3Si

C26H50O3Si

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / Reflux
2.1: pyridinium dichromate; aluminum oxide / dichloromethane / 20 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
3.2: 2 h / 20 °C
4.1: potassium carbonate / methanol / 5 h / 20 °C
4.2: 2 h / Reflux
View Scheme
C41H56O3Si

C41H56O3Si

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 10 h / Reflux
2.1: pyridinium dichromate / dichloromethane / 20 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
3.2: 2 h / 20 °C
4.1: potassium carbonate / methanol / 5 h / 20 °C
4.2: 2 h / Reflux
View Scheme
C20H36O3

C20H36O3

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridinium dichromate; aluminum oxide / dichloromethane / 20 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
2.2: 2 h / 20 °C
3.1: potassium carbonate / methanol / 5 h / 20 °C
3.2: 2 h / Reflux
View Scheme
C25H38O3

C25H38O3

tacalcitol
57333-96-7

tacalcitol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: pyridinium dichromate / dichloromethane / 20 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere
2.2: 2 h / 20 °C
3.1: potassium carbonate / methanol / 5 h / 20 °C
3.2: 2 h / Reflux
View Scheme
tacalcitol
57333-96-7

tacalcitol

1α,24(R)-dihydroxy-6,19-dihydro-6,19-epidioxyvitamin D3

1α,24(R)-dihydroxy-6,19-dihydro-6,19-epidioxyvitamin D3

Conditions
ConditionsYield
With oxygen; rose bengal In ethanol for 1h; Irradiation; Yield given;

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