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Ningjiang Chemical Factory

We are one of the sub-factories of NINGJIANG GROUP PHARMACEUTICAL AND CHEMICAL CORPORATION. Process Capability : WE HAVE ONE RESEARCH & DEVELOPMENT INSTITUTE. OUR COMPANY HAS THE ABILITY TO TEST THE QUALITY BY MEANS OF HPLC TESTING SYS

1,2-Cyclopentane dicarboximide

Cas:5763-44-0

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Cyclopentane-1,2-dicarboximude CAS number 5763-44-0 Assay ≥99% Appearance White powder Capacity 100mt/year Application Gliclazide intermedia

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

High quality Cyclopentane-1,2-dicarboximude CAS 5763-44-0 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Fo

High quality Cyclopentane-1,2-dicarboximude CAS 5763-44-0 with factory price

Cas:5763-44-0

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Cas:5763-44-0

Min.Order:1

Negotiable

Type:Other

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Cas:5763-44-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

1,2-Cyclopentanedicarboximide

Cas:5763-44-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM- Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 5763-44-0 with best quality

Cas:5763-44-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione Molecular Formula:C7H9NO2 Molecular Weight:139.15 CAS No.:5763-44-0 Appearance:Similar White To Slight Yellow Crystal Appearance:Similar White To Slight Yellow Crystal Storage:Store in cool a

tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Cas:5763-44-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Cyclopentane-1,2-dicarboximude Manufacturer CAS:5763-44-0

Cas:5763-44-0

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Tetrahydrocyclopenta(c)pyrrole-1,3(2H,3aH)-dione 5763-44-0

Cas:5763-44-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

Cyclopentane-1,2-dicarboximude WITH BEST PRICE

Cas:5763-44-0

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Cyclopentane-1,2-dicarboximude CAS:5763-44-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality org

Cyclopentane-1,2-dicarboximude CAS:5763-44-0

Cas:5763-44-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tetrahydrocyclopenta(c)pyrrole-1,3(2H,3aH)-dione

Cas:5763-44-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Tetrahydrocyclopenta(c)pyrrole-1,3(2H,3aH)-dione/ LIDE PHARMA- Factory supply / Best price

Cas:5763-44-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 5763-44-0 Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Tetrahydrocyclopenta(c)pyrrole-1,3(2H,3aH)-dione

Cas:5763-44-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Cabazitaxel

Cas:5763-44-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developmen

1,2-Cyclopentane dicarboximide CAS NO.5763-44-0

Cas:5763-44-0

Min.Order:1 Kilogram

FOB Price: $2.0 / 6.0

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 1,2-Cyclopentane Dicarboximide CAS No.:5763-44-0 Molecule Formula:C7H9NO2 Molecule Weight:139.15 Purity: 99.0% Package: 25kg/drum Description:Off-white crystalline powder Manufacture Standards:Enterprise Standard

High Quality 1,2-Cyclopentane Dicarboximide on stock

Cas:5763-44-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferCyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

Cyclopentane-1,2-dicarboximude Chemical Properties Melting point 168 °C (dec.) Boiling point 322.2±11.0 °C(Predicted) density 1.242±0.06 g/cm3(Predicted) pka 11.

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Cyclopentane-1,2-dicarboximude

Cas:5763-44-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

diethyl cyclopentane-1,2-dicarboxylate
90474-13-8

diethyl cyclopentane-1,2-dicarboxylate

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Conditions
ConditionsYield
With ammonia at 130 - 280℃; for 5h; Product distribution / selectivity; autoclave; Pyrolysis; Industry scale;96%
trans-DL-1,2-cyclopentanedicarboxylic acid
50483-99-3

trans-DL-1,2-cyclopentanedicarboxylic acid

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Conditions
ConditionsYield
at 170℃; Temperature; Inert atmosphere;93.5%
cyclopentane-1,2-dicarboxamide

cyclopentane-1,2-dicarboxamide

2-carbamylcyclopentane-1-carboxylic acid

2-carbamylcyclopentane-1-carboxylic acid

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Conditions
ConditionsYield
In diphenylether at 240℃; for 2.5h; Temperature; Inert atmosphere; Industrial scale;92.6%
cyclopentane-dicarboxylic acid-(1.2)-anhydride

cyclopentane-dicarboxylic acid-(1.2)-anhydride

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Conditions
ConditionsYield
With ammonia at 180℃;
C13H20N2O

C13H20N2O

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid / toluene; water / 4 h / 120 °C
2: chlorine / 1,2-dichloro-ethane / 10 h / -10 - 0 °C
3: ammonium hydroxide / 5 h / -10 - 0 °C
4: trans-DL-1,2-cyclopentanedicarboxylic acid / 2 h / 220 - 240 °C
View Scheme
cyclohexanone-2-carboxamide
22945-27-3

cyclohexanone-2-carboxamide

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorine / 1,2-dichloro-ethane / 10 h / -10 - 0 °C
2: ammonium hydroxide / 5 h / -10 - 0 °C
3: trans-DL-1,2-cyclopentanedicarboxylic acid / 2 h / 220 - 240 °C
View Scheme
cyclopentane-1,2-dicarboxamide

cyclopentane-1,2-dicarboxamide

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

Conditions
ConditionsYield
With trans-DL-1,2-cyclopentanedicarboxylic acid at 220 - 240℃; for 2h;
4-chlorobutyl bromide
6940-78-9

4-chlorobutyl bromide

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

2-(4-chlorobutyl)tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

2-(4-chlorobutyl)tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;98%
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

tert-butyl 4-[4-chloro-2-[2-(hydroxymethyl)thieno[3,2-b]pyridin-7-yl]-6-methyl-phenoxy]piperidine-1-carboxylate

tert-butyl 4-[4-chloro-2-[2-(hydroxymethyl)thieno[3,2-b]pyridin-7-yl]-6-methyl-phenoxy]piperidine-1-carboxylate

tert-butyl 4-(4-chloro-2-(2-((1,3-dioxohexahydrocyclopenta[c]pyrrol-2(1H)-yl)methyl)thieno[3,2-b]pyridin-7-yl)-6-methylphenoxy)piperidine-1-carboxylate

tert-butyl 4-(4-chloro-2-(2-((1,3-dioxohexahydrocyclopenta[c]pyrrol-2(1H)-yl)methyl)thieno[3,2-b]pyridin-7-yl)-6-methylphenoxy)piperidine-1-carboxylate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 60℃; for 2h; Mitsunobu Displacement;69%
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

C7H8ClNO2

C7H8ClNO2

Conditions
ConditionsYield
With trichloroisocyanuric acid In dichloromethane at 0 - 20℃; for 4h; Inert atmosphere; Schlenk technique;64%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

N-(4-bromobutyl)-2,4-dioxo-3-azabicyclo [3.3.0]octane
138278-16-7

N-(4-bromobutyl)-2,4-dioxo-3-azabicyclo [3.3.0]octane

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 60℃; for 6h;58%
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

sulfate solution

sulfate solution

lactam of/the/ 2-aminomethyl-cyclopentane-carboxylic acid-(1)

lactam of/the/ 2-aminomethyl-cyclopentane-carboxylic acid-(1)

Conditions
ConditionsYield
at 0 - 5℃; elektrolytische Reduktion;
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azabicyclo[3.3.0]Octane
138277-79-9

3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azabicyclo[3.3.0]Octane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 58 percent / KI, K2CO3 / acetonitrile / 6 h / 60 °C
2: 66 percent / triethylamine, KI / dimethylformamide / 24 h / 60 °C
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

3-{4-[N-PROPYL-N-(5-METHOXY-3-CHROMANYL)AMINO]-BUTYL}-2,4-DIOXO-3-AZABICYCLO[3.3.0]OCTANE

3-{4-[N-PROPYL-N-(5-METHOXY-3-CHROMANYL)AMINO]-BUTYL}-2,4-DIOXO-3-AZABICYCLO[3.3.0]OCTANE

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 58 percent / KI, K2CO3 / acetonitrile / 6 h / 60 °C
2: 66 percent / triethylamine, KI / dimethylformamide / 24 h / 60 °C
3: 78 percent / K2CO3 / dimethylformamide / 24 h / 60 °C
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

cis-octahydrocyclopenta[c]pyrrole

cis-octahydrocyclopenta[c]pyrrole

Conditions
ConditionsYield
With hydrogen; copper chromite In 1,4-dioxane at 265℃; under 153765 Torr; Product distribution / selectivity; Industry scale;
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

cis-octahydrocyclopenta[c]pyrrole hydrochloride

cis-octahydrocyclopenta[c]pyrrole hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / copper chromite / 1,4-dioxane / 265 °C / 153765 Torr / Industry scale
2: ethanol; water / 0.5 h / 0 - 20 °C
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide hydrochloride

4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen / copper chromite / 1,4-dioxane / 265 °C / 153765 Torr / Industry scale
2.1: ethanol; water / 0.5 h / 0 - 20 °C
3.1: trimethyl orthoformate; sodium tris(acetoxy)borohydride / tetrahydrofuran / 0.83 h / 40 °C
3.3: 40 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogen / copper chromite / 1,4-dioxane / 265 °C / 153765 Torr / Industry scale
2: triethylamine / isopropyl alcohol; water / Industry scale; Reflux
3: hydrogenchloride / water / 2.5 h / 20 - 60 °C / Industry scale
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide

4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / copper chromite / 1,4-dioxane / 265 °C / 153765 Torr / Industry scale
2: triethylamine / isopropyl alcohol; water / Industry scale; Reflux
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

hexahydrocyclopenta[c]pyrrole-1(2H)-one
56593-76-1

hexahydrocyclopenta[c]pyrrole-1(2H)-one

Conditions
ConditionsYield
With hexarhodium hexadecacarbonyl; hydrogen; molybdenum hexacarbonyl In 2-methyltetrahydrofuran at 160℃; under 75007.5 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Pressure; Autoclave; Inert atmosphere;94 %Chromat.
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

A

octahydrocyclopenta[c]pyrrole
1468-87-7, 5661-03-0, 10268-00-5

octahydrocyclopenta[c]pyrrole

B

hexahydrocyclopenta[c]pyrrole-1(2H)-one
56593-76-1

hexahydrocyclopenta[c]pyrrole-1(2H)-one

Conditions
ConditionsYield
With hexarhodium hexadecacarbonyl; hydrogen; molybdenum hexacarbonyl In 1,4-dioxane at 160℃; under 75007.5 Torr; for 15h; Autoclave; Inert atmosphere;A 71 %Chromat.
B 14 %Chromat.
With hydrogen; molybdenum hexacarbonyl In 1,2-dimethoxyethane at 160℃; under 75007.5 Torr; for 48h; Reagent/catalyst; Autoclave; Inert atmosphere;A 48 %Chromat.
B 52 %Chromat.
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

octahydrocyclopenta[c]pyrrole
1468-87-7, 5661-03-0, 10268-00-5

octahydrocyclopenta[c]pyrrole

Conditions
ConditionsYield
With hexarhodium hexadecacarbonyl; hydrogen; molybdenum hexacarbonyl In 1,2-dimethoxyethane at 160℃; under 75007.5 Torr; for 24h; Reagent/catalyst; Autoclave; Inert atmosphere;100 %Chromat.
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione hydrochloride

2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 95 °C
2.2: 0.5 h
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

1-bromo-2-cyclopropylbenzene
57807-28-0

1-bromo-2-cyclopropylbenzene

3-(2-cyclopropylphenyl)hexahydrocyclopenta[c]pyrrol-1(2H)-one

3-(2-cyclopropylphenyl)hexahydrocyclopenta[c]pyrrol-1(2H)-one

Conditions
ConditionsYield
Stage #1: 1-bromo-2-cyclopropylbenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: 4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
Stage #3: With hydrogenchloride; sodium cyanoborohydride In tetrahydrofuran; hexane; water at 0 - 20℃; for 1h; Inert atmosphere;
2.8 g
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

C12H11FO2

C12H11FO2

A

C19H20FNO4

C19H20FNO4

B

C19H20FNO4

C19H20FNO4

Conditions
ConditionsYield
With 2,6-dibromophenol; C21H23F5NOPS In toluene at 0℃; Overall yield = 86 percent;A n/a
B n/a
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

C13H15NO

C13H15NO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice
2: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 1 h / 50 °C
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

C19H19NO

C19H19NO

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice
2: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 1 h / 50 °C
3: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

C19H18N2O3

C19H18N2O3

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice
2: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 1 h / 50 °C
3: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

C13H14ClNO

C13H14ClNO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice
2: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 1 h / 50 °C
View Scheme
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione
5763-44-0

4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

C19H18ClNO

C19H18ClNO

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Cooling with ice
2: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 1 h / 50 °C
3: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere
View Scheme

Raw Materials

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