Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Tetrabenazine Manufacturer/High quality/Best price/In stock

Cas:58-46-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Tetrabenazine CAS:58-46-8

Cas:58-46-8

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Name: TETRABENAZINE Synonyms: (3R,11BR)-REL-1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-2H-BENZO[A]QUINOLIZIN-2-ONE;TETRABENAZI… Founded in 2014, as a professional international pharmaceutical corporation, headquarter

Tetrabenazine

Cas:58-46-8

Min.Order:1 Metric Ton

FOB Price: $2.0 / 10.0

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Tetrabenazine manufacturer/supplier

Cas:58-46-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tetrabenazine

Cas:58-46-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 58-46-8 with best quality

Cas:58-46-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Tetrabenazine 58-46-8 CAS Registry Number 58-46-8 EINECS 200-383-6 Appearance:White powder Storage:Stored in dry and cool place, keeping out of moisture and sunshine, shelf life is two year. Package:on request Application:Central Nervous Sy

Tetrabenazine 58-46-8

Cas:58-46-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:Off-white crystal Storage:R.T Package:100G/Bottle, 500G/Bottle, 1KG/Bottle or at customers reqirement. Application:Antipsychotics Transportation:Express/Sea/Air Port:Any port in China

Tetrabenazine cas 58-46-8

Cas:58-46-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

58-46-8 Tetrabenazine

Cas:58-46-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 58-46-8 TETRABENAZINE with best price

Cas:58-46-8

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Tetrabenazine 58-46-8

Cas:58-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Tetrabenazine/CAS:58-46-8

Cas:58-46-8

Min.Order:200 Milligram

FOB Price: $106.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

TETRABENAZINE CAS:58-46-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

TETRABENAZINE CAS:58-46-8

Cas:58-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Tetrabenazine

Cas:58-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Tetrabenazine

Cas:58-46-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TETRABENAZINE

Cas:58-46-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

TETRABENAZINE

Cas:58-46-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

TETRABENAZINE

Cas:58-46-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

TETRABENAZINE

Cas:58-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

TETRABENAZINE

Cas:58-46-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Tetrabenazine

Cas:58-46-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Tetrabenazine CAS No.:58-46-8 Molecule Formula:C19H27NO3 Molecule Weight:317.42 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SPECI

Best Quality Tetrabenazine with good supplier

Cas:58-46-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

58-46-8 TETRABENAZINE

Cas:58-46-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferTetrabenazine

Cas:58-46-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Tetrabenazine

Cas:58-46-8

Min.Order:100 Kilogram

Negotiable

Type:Other

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TETRABENAZINE

Cas:58-46-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Tetrabenazine

Cas:58-46-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Tetrabenazine

Cas:58-46-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TETRABENAZINE

Cas:58-46-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Tetrabenazine

Cas:58-46-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methanol
67-56-1

methanol

(+/-)-9,10-dihydroxy-3c-isobutyl-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one
89929-27-1

(+/-)-9,10-dihydroxy-3c-isobutyl-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 25 - 30℃; Mitsunobu Displacement; Large scale;96%
6,7-dimethoxy-3,4-dihydro-isoquinoline
3382-18-1

6,7-dimethoxy-3,4-dihydro-isoquinoline

2-acetyl-N,N,N,4-tetramethyl-1-pentanaminium iodide
1069-62-1

2-acetyl-N,N,N,4-tetramethyl-1-pentanaminium iodide

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Stage #1: 6,7-dimethoxy-3,4-dihydro-isoquinoline; 2-acetyl-N,N,N,4-tetramethyl-1-pentanaminium iodide In ethanol at 80℃;
Stage #2: With sodium hydroxide; water In dichloromethane
75%
6,7-dimethoxy-3,4-dihydro-isoquinoline
3382-18-1

6,7-dimethoxy-3,4-dihydro-isoquinoline

C12H18O3

C12H18O3

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Stage #1: 6,7-dimethoxy-3,4-dihydro-isoquinoline; C12H18O3 In ethanol at 60℃; for 72h; Diels-Alder Cycloaddition; Inert atmosphere;
Stage #2: With morpholine; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; ethanol at 20℃; for 3h; Inert atmosphere;
69%
3-isobutyl-9,10-dimethoxy-2-methylene-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline

3-isobutyl-9,10-dimethoxy-2-methylene-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Stage #1: 3-isobutyl-9,10-dimethoxy-2-methylene-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline With osmium(VIII) oxide; water In tetrahydrofuran at 0℃; for 0.25h; Inert atmosphere;
Stage #2: With sodium periodate; 4-methylmorpholine N-oxide In tetrahydrofuran; water at 0℃; for 5h; Inert atmosphere;
61%
3-isobutyl-9,10-dimethoxy-2-oxo-1,3,4,6,7,11b-tetrahydro-2H-pyrido<2,1-a>isoquinoline-1,3-carboxylic acid diethyl ester

3-isobutyl-9,10-dimethoxy-2-oxo-1,3,4,6,7,11b-tetrahydro-2H-pyrido<2,1-a>isoquinoline-1,3-carboxylic acid diethyl ester

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
With hydrogenchloride
4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentyl-4-methylbenzenesulfonate
1346909-18-9

4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentyl-4-methylbenzenesulfonate

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
2.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
3.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 5 h / 0 °C / Inert atmosphere
View Scheme
6,7-dimethoxy-2-(4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentyl)-1,2,3,4-tetrahydroisoquinoline
1346909-10-1

6,7-dimethoxy-2-(4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentyl)-1,2,3,4-tetrahydroisoquinoline

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 5 h / 0 °C / Inert atmosphere
View Scheme
methyl 4-methyl-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pentanoate
1346909-36-1

methyl 4-methyl-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pentanoate

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.58 h / -20 - -5 °C / Inert atmosphere
2.1: diethyl ether; hexane / 2 h / -78 - 20 °C / Inert atmosphere
3.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
3.2: 0.67 h / Inert atmosphere
4.1: toluene-4-sulfonic acid / methanol / 0.5 h / 20 °C / Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / diethyl ether / 0 °C / Inert atmosphere
5.2: 1 h / Inert atmosphere
6.1: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere
7.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
8.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
9.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
9.2: 5 h / 0 °C / Inert atmosphere
View Scheme
N-methoxy-N,4-dimethyl-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pentane amide
1346909-38-3

N-methoxy-N,4-dimethyl-2-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)pentane amide

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: diethyl ether; hexane / 2 h / -78 - 20 °C / Inert atmosphere
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
2.2: 0.67 h / Inert atmosphere
3.1: toluene-4-sulfonic acid / methanol / 0.5 h / 20 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / diethyl ether / 0 °C / Inert atmosphere
4.2: 1 h / Inert atmosphere
5.1: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere
6.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
7.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
8.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
8.2: 5 h / 0 °C / Inert atmosphere
View Scheme
5-methyl-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)hexan-2-one
1346909-30-5

5-methyl-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)hexan-2-one

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
1.2: 0.67 h / Inert atmosphere
2.1: toluene-4-sulfonic acid / methanol / 0.5 h / 20 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / diethyl ether / 0 °C / Inert atmosphere
3.2: 1 h / Inert atmosphere
4.1: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere
5.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
6.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
7.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
7.2: 5 h / 0 °C / Inert atmosphere
View Scheme
5-methyl-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)hex-1-ene-2-yl trifluoromethanesulfonate
1346909-40-7

5-methyl-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)hex-1-ene-2-yl trifluoromethanesulfonate

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / methanol / 0.5 h / 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / diethyl ether / 0 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere
4.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
5.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
6.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
6.2: 5 h / 0 °C / Inert atmosphere
View Scheme
3-(hydroxymethyl)-5-methylhex-1-ene-2-yl trifluoromethanesulfonate
1346909-31-6

3-(hydroxymethyl)-5-methylhex-1-ene-2-yl trifluoromethanesulfonate

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / diethyl ether / 0 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere
3.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
4.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
5.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
5.2: 5 h / 0 °C / Inert atmosphere
View Scheme
4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentan-1-ol
1346909-44-1

4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentan-1-ol

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere
2.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
3.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
4.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
4.2: 5 h / 0 °C / Inert atmosphere
View Scheme
rac-2-(hydroxymethyl)-4-methylpentanoic acid methyl ester
403804-65-9

rac-2-(hydroxymethyl)-4-methylpentanoic acid methyl ester

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere
2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.58 h / -20 - -5 °C / Inert atmosphere
3.1: diethyl ether; hexane / 2 h / -78 - 20 °C / Inert atmosphere
4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
4.2: 0.67 h / Inert atmosphere
5.1: toluene-4-sulfonic acid / methanol / 0.5 h / 20 °C / Inert atmosphere
6.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / diethyl ether / 0 °C / Inert atmosphere
6.2: 1 h / Inert atmosphere
7.1: dmap; triethylamine / dichloromethane / 0 °C / Inert atmosphere
8.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 80 °C / Inert atmosphere
9.1: lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere
10.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
10.2: 5 h / 0 °C / Inert atmosphere
View Scheme
methyl 2-acetyl-4-methylpentanoate
51756-09-3

methyl 2-acetyl-4-methylpentanoate

C19H27NO3

C19H27NO3

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / toluene / 18 h / Reflux; Dean-Stark
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
3.2: 1 h / -78 - 20 °C
4.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 20 °C
5.1: acetic acid / toluene / 15 h / Molecular sieve; Reflux
View Scheme
C11H20O4

C11H20O4

C19H27NO3

C19H27NO3

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 20 °C
4.1: acetic acid / toluene / 15 h / Molecular sieve; Reflux
View Scheme
4-methyl-2-(2-methyl-1,3-dioxolan-2-yl)pentan-1-ol

4-methyl-2-(2-methyl-1,3-dioxolan-2-yl)pentan-1-ol

C19H27NO3

C19H27NO3

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
1.2: 1 h / -78 - 20 °C
2.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 20 °C
3.1: acetic acid / toluene / 15 h / Molecular sieve; Reflux
View Scheme
C10H18O3

C10H18O3

C19H27NO3

C19H27NO3

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / tetrahydrofuran; water / 12 h / 20 °C
2: acetic acid / toluene / 15 h / Molecular sieve; Reflux
View Scheme
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
1745-07-9

6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

2-acetyl-4-methylpentanal

2-acetyl-4-methylpentanal

C19H27NO3

C19H27NO3

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
With acetic acid In toluene for 15h; Molecular sieve; Reflux; Overall yield = 50 %; diastereoselective reaction;A n/a
B n/a
6,7-dihydroxy-3,4-dihydroisoquinoline hydrochloride

6,7-dihydroxy-3,4-dihydroisoquinoline hydrochloride

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / methanol; water / 30 h / 65 - 70 °C / Large scale
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 - 30 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / methanol; water
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 - 30 °C / Large scale
View Scheme
2-acetyl-N,N,N,4-tetramethyl-1-pentanaminium iodide
1069-62-1

2-acetyl-N,N,N,4-tetramethyl-1-pentanaminium iodide

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / methanol; water / 30 h / 65 - 70 °C / Large scale
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 - 30 °C / Large scale
View Scheme
3-methylene-5-methyl-2-hexanone
1187-87-7

3-methylene-5-methyl-2-hexanone

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / methanol; water
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 25 - 30 °C / Large scale
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2α-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine
3466-75-9, 7744-53-8, 7744-54-9, 85081-18-1, 113627-25-1

2α-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol at 0 - 20℃; for 1h; Inert atmosphere;80%
With sodium tetrahydroborate In ethanol at 20℃; for 12h; Inert atmosphere;51%
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2β-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine
3466-75-9, 7744-53-8, 7744-54-9, 85081-18-1, 113627-25-1

2β-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran; ethanol at 0 - 20℃; for 0.5 - 6.5h; Product distribution / selectivity;67%
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2α-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine
3466-75-9, 7744-53-8, 7744-54-9, 85081-18-1, 113627-25-1

2α-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2β-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine
3466-75-9, 7744-53-8, 7744-54-9, 85081-18-1, 113627-25-1

2β-hydroxy-3-isobutyl-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
Stage #1: (3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo<a>quinolizin-2-one</a> With sodium tetrahydroborate In ethanol at 0 - 3℃; for 3h; Inert atmosphere;
Stage #2: With water In dichloromethane
A n/a
B 8%
With sodium tetrahydroborate In ethanol at 0℃;
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

(+/-)-cyano-((2Ξ)-3t-isobutyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-yliden)-acetic acid ethyl ester
118660-30-3

(+/-)-cyano-((2Ξ)-3t-isobutyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-yliden)-acetic acid ethyl ester

Conditions
ConditionsYield
With ammonium acetate; acetic acid; toluene
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

malononitrile
109-77-3

malononitrile

(+/-)-(3t-isobutyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-ylidene)-malononitrile

(+/-)-(3t-isobutyl-9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-ylidene)-malononitrile

Conditions
ConditionsYield
With ammonium acetate; acetic acid; benzene
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(+/-)-9,10-dihydroxy-3c-isobutyl-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one
89929-27-1

(+/-)-9,10-dihydroxy-3c-isobutyl-(11br)-1,3,4,6,7,11b-hexahydro-pyrido[2,1-a]isoquinolin-2-one

Conditions
ConditionsYield
With hydrogen bromide
isopropyllithium
1888-75-1

isopropyllithium

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2α-isopropyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2α-isopropyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
With water 1.) THF, a) 0 deg C, 2.5 h, b) from 0 deg C to RT, 12 h; Yield given. Multistep reaction;
methyllithium
917-54-4

methyllithium

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2α-hydroxy-2-methyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2α-hydroxy-2-methyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2β-hydroxy-2-methyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2β-hydroxy-2-methyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
With water 1.) THF, a) 0 deg C, 2.5 h, b) from 0 deg C to RT, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
ethyllithium
811-49-4

ethyllithium

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2α-ethyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2α-ethyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
With water 1.) THF, a) 0 deg C, 2.5 h, b) from 0 deg C to RT, 12 h; Yield given. Multistep reaction;
propyllithium
2417-93-8

propyllithium

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2α-n-propyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2α-n-propyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
With water 1.) THF, a) 0 deg C, 2.5 h, b) from 0 deg C to RT, 12 h; Yield given. Multistep reaction;
(2-methylpropyl)lithium
920-36-5, 90269-51-5

(2-methylpropyl)lithium

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

2α-isobutyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

2α-isobutyl-2β-hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine

Conditions
ConditionsYield
With water 1.) THF, a) 0 deg C, 2.5 h, b) from 0 deg C to RT, 12 h; Yield given. Multistep reaction;
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(3-isobutyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinolin-2-yl)-acetic acid
115985-36-9

(3-isobutyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinolin-2-yl)-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonium acetate; acetic acid; benzene
2: aqueous HCl
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

A

(2R,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
924854-62-6

(2R,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

B

(+)-α-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
924854-60-4

(+)-α-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran; ethanol at 0℃; for 1h; Product distribution / selectivity;
With L-Selectride In tetrahydrofuran at 0 - 20℃; for 6.5h; Product distribution / selectivity;
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

A

(3S,11bS)-tetrabenazine
1026016-84-1

(3S,11bS)-tetrabenazine

B

((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one)
1026016-83-0

((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one)

Conditions
ConditionsYield
Purification / work up; Resolution of racemate;
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(3S,11bS)-tetrabenazine
1026016-84-1

(3S,11bS)-tetrabenazine

Conditions
ConditionsYield
Stage #1: (3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo<a>quinolizin-2-one</a> With (R)-10-camphorsulfonic acid In acetone Heating; Resolution of racemate;
Stage #2: With ammonium hydroxide In methanol
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one)
1026016-83-0

((3R,11bR)-3-isobutyl-9.10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one)

Conditions
ConditionsYield
Stage #1: (3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo<a>quinolizin-2-one</a> With (1S)-10-camphorsulfonic acid In acetone Heating; Resolution of racemate;
Stage #2: With ammonium hydroxide In methanol
3.4 g
Stage #1: (3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo<a>quinolizin-2-one</a> With (1S)-10-camphorsulfonic acid In acetone at 16 - 31℃; for 24h;
Stage #2: With sodium carbonate In diethyl ether; water pH=8;
83.12 g
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

RU 350
862377-27-3

RU 350

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: sodium tetrahydroborate
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 48 h / 0 - 15 °C
4.2: 1.5 h / pH 12 / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 48 h / 0 - 15 °C
4.2: 1.5 h / pH 12 / Reflux
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(2R,3R,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
862377-29-5

(2R,3R,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (R)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 48 h / 0 - 15 °C
4.2: 1.5 h / pH 12 / Reflux
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(11bR)-1,6,7,11b-tetrahydro-9,10-dimethoxy-3-(2-methylpropyl)-4H-benzo[a]quinolizine
920265-21-0

(11bR)-1,6,7,11b-tetrahydro-9,10-dimethoxy-3-(2-methylpropyl)-4H-benzo[a]quinolizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2: sodium tetrahydroborate
3: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(11bS)-1,6,7,11b-tetrahydro-9,10-dimethoxy-3-(2-methylpropyl)-4H-benzo[a]quinolizine
1215167-80-8

(11bS)-1,6,7,11b-tetrahydro-9,10-dimethoxy-3-(2-methylpropyl)-4H-benzo[a]quinolizine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: (R)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(8aS,9aR,10aR)-5,8,8a,9a,10,10a-hexahydro-2,3-dimethoxy-8a-(2-methylpropyl)-6H-benz[a]oxireno[g]quinolizine
1300639-86-4

(8aS,9aR,10aR)-5,8,8a,9a,10,10a-hexahydro-2,3-dimethoxy-8a-(2-methylpropyl)-6H-benz[a]oxireno[g]quinolizine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: sodium tetrahydroborate
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: perchloric acid / methanol
4.2: 38 h / 20 °C / Darkness
View Scheme
Multi-step reaction with 4 steps
1.1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: perchloric acid / methanol
4.2: 38 h / 20 °C / Darkness
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(8aR,9aS,10aS)-5,8,8a,9a,10,10a-hexahydro-2,3-dimethoxy-8a-(2-methylpropyl)-6H-benz[a]oxireno[g]quinolizine
1300639-88-6

(8aR,9aS,10aS)-5,8,8a,9a,10,10a-hexahydro-2,3-dimethoxy-8a-(2-methylpropyl)-6H-benz[a]oxireno[g]quinolizine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (R)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: perchloric acid / methanol
4.2: 38 h / 20 °C / Darkness
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(2R,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
924854-62-6

(2R,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (R)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

(2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
862377-31-9

(2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-methoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: sodium tetrahydroborate
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: perchloric acid / methanol
4.2: 38 h / 20 °C / Darkness
5.1: dimethylsulfide borane complex / tetrahydrofuran / 48 h / 0 - 15 °C
5.2: 0.5 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: (1S)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: perchloric acid / methanol
4.2: 38 h / 20 °C / Darkness
5.1: dimethylsulfide borane complex / tetrahydrofuran / 48 h / 0 - 15 °C
5.2: 0.5 h / Reflux
View Scheme
(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one
58-46-8

(3R*,11bR*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzoquinolizin-2-one

RU 346
862377-33-1

RU 346

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: (R)-10-camphorsulfonic acid / acetone / Heating; Resolution of racemate
2.1: ethanol; L-Selectride / tetrahydrofuran / 0.67 h / 0 °C
2.2: 20 °C
3.1: phosphorus pentachloride / dichloromethane / 0.5 h / 0 °C
4.1: perchloric acid / methanol
4.2: 38 h / 20 °C / Darkness
5.1: dimethylsulfide borane complex / tetrahydrofuran / 48 h / 0 - 15 °C
5.2: 0.5 h / Reflux
View Scheme

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View