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Hebei Muhuang Technology Co., Ltd

Good day! I am May Zhang from Hebei Muhuang Technology Co., Ltd. We can provide you with chemical raw materials, chemical products, pharmaceutical intermediates, veterinary intermediates, dye intermediates, pigments, cosmetic raw materials and chem

Met-Enkephaline58569-55-4Sufficient supply high-quality Manufactor

Cas:58569-55-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Trading Company

inquiry

Sichuan Jisheng BioPharmaceutical Co., Ltd.

Name:Met-Enkephaline Type: Pharmaceutical Peptide CAS:58569-55-4 Purity:98% Appearance:White powder Packing Specification:1g, 10g, 100g Storage:2 ℃ to 8 ℃ Molecular Formula:C27H35N5O7S Molecular Weight:573.66 Appearance:Whit

Met-Enkephaline58569-55-4Sufficient supply high-quality Manufactor

Cas:58569-55-4

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Tyrosylglycyl-glycyl-phenylalanyl-methionine

Cas:58569-55-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Methionine enkephalin manufacturer/supplier

Cas:58569-55-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% H-TYR-GLY-GLY-PHE-MET-OH 58569-55-4 GMP Manufacturer

Cas:58569-55-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Met-Enkephaline

Cas:58569-55-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Met-Enkephaline CAS NO: 58569-55-4 Grade:Medical scientific research and export Molecular formula:C27H35N5O7S Molecular weight:573.66 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabilit

Met-Enkephaline/ CAS:58569-55-4/Met-Enkephaline raw material/ high-quality

Cas:58569-55-4

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

H-TYR-GLY-GLY-PHE-MET-OH

Cas:58569-55-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 58569-55-4 with best quality

Cas:58569-55-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

H-TYR-GLY-GLY-PHE-MET-OHCAS58569-55-4

Cas:58569-55-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-5-Adrenorphin (human)(9CI) 58569-55-4

Cas:58569-55-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Met-Enkephalin acetate salt/Met-Enkephaline/58569-55-4 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Ma

Met-Enkephalin acetate salt/Met-Enkephaline/58569-55-4

Cas:58569-55-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-5-Adrenorphin (human)(9CI)

Cas:58569-55-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Pharma Grade PeptideTop Quality Cas 58569-55-4 Met-Enkephaline

Cas:58569-55-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Met-Enkephalin acetate salt

Cas:58569-55-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Lab/Research institutions

inquiry

Lonwin Chemical Group Limited

Tyrosylglycyl-glycyl-phenylalanyl-methionine CAS: 58569-55-4 Specification Item Standard Structural data confirmation 1. H-NMR: The data of structure are identical with reference standard

Factory supply Tyrosylglycyl-glycyl-phenylalanyl-methionine

Cas:58569-55-4

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-5-Adrenorphin (human)(9CI)

Cas:58569-55-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Factory direct supply H-TYR-GLY-GLY-PHE-MET-OH CAS 58569-55-4 AKS

Cas:58569-55-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Met-Enkephaline

Cas:58569-55-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Met-Enkephaline

Cas:58569-55-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Met-Enkephalin

Cas:58569-55-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Met-Enkephalin

Cas:58569-55-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Jisheng Biopharmaceutical Co.,Ltd is specializing of peptide and pharmaceutical intermediates. all of our products are produced in accordance with GMP standard and are exceeded in international quality standards. We are a leading peptide

Met-Enkephaline

Cas:58569-55-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Siwei Development Group Ltd.

Product name: Met-Enkephalin CAS No.: 58569-55-4 Molecule Formula:C27H35N5O7S Molecule Weight:573.66 Purity: 98.0% Package: 1g/bag Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price Met-Enkephalin

Cas:58569-55-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

H-TYR-GLY-GLY-PHE-MET-OH

Cas:58569-55-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Met-Enkephalin|[MET5]

Cas:58569-55-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Met-Enkephaline

Cas:58569-55-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Met-Enkephaline

Cas:58569-55-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Met-Enkephaline

Cas:58569-55-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Tyrosylglycyl-glycyl-phenylalanyl-methionine

Cas:58569-55-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-2-{(S)-2-[2-(2-{(S)-3-[4-(4-Bromo-phenoxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methanesulfinyl-butyric acid

(S)-2-{(S)-2-[2-(2-{(S)-3-[4-(4-Bromo-phenoxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionylamino}-acetylamino)-acetylamino]-3-phenyl-propionylamino}-4-methanesulfinyl-butyric acid

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With p-cresol; dimethylsulfide; hydrogen fluoride at 0℃; for 1h;92%
boc-Tyr-Gly-Gly-Phe-Met-OH
59481-77-5

boc-Tyr-Gly-Gly-Phe-Met-OH

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride; acetic acid for 1h;90%
With hydrogenchloride In acetic acid for 0.5h;85%
Boc-Tyr-Gly-Gly-Phe-Met-OBut
82362-16-1

Boc-Tyr-Gly-Gly-Phe-Met-OBut

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With methyl-phenyl-thioether; trifluoroacetic acid for 1h; Ambient temperature;74%
C17H13NO10S2(2-)*2Na(1+)

C17H13NO10S2(2-)*2Na(1+)

C20H19NO10S3(2-)*2Na(1+)

C20H19NO10S3(2-)*2Na(1+)

C24H19NO10S2(2-)*2Na(1+)

C24H19NO10S2(2-)*2Na(1+)

C24H19NO11S2(2-)*2Na(1+)

C24H19NO11S2(2-)*2Na(1+)

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Stage #1: C20H19NO10S3(2-)*2Na(1+) With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; acetonitrile at 20℃; for 0.75h;
Stage #2: With ethanolamine In water for 0.166667h;
Stage #3: C17H13NO10S2(2-)*2Na(1+); C24H19NO10S2(2-)*2Na(1+); C24H19NO11S2(2-)*2Na(1+) Further stages;
63%
Boc-Tyr(Mtb)-Gly-Gly-Phe-Met-OMtb
129398-74-9

Boc-Tyr(Mtb)-Gly-Gly-Phe-Met-OMtb

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With 3,5-dimethylmethoxybenzene; ethane-1,2-dithiol; trifluoroacetic acid 1) 0 deg C, 120 min, 2) 20 deg C, 60 min;57%
Boc-Tyr(Cl2Bzl)-Gly-Gly-Phe-Met-OBzl
129398-68-1

Boc-Tyr(Cl2Bzl)-Gly-Gly-Phe-Met-OBzl

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; methyl-phenyl-thioether; ethane-1,2-dithiol; 3-methyl-phenol; trifluoroacetic acid at 0℃; for 1.5h;49%
N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine
148715-90-6

N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 6h;40%
Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met
62530-43-2

Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride; ethane-1,2-dithiol; methoxybenzene In 1,4-dioxane for 1h; Ambient temperature; Yield given;
Z-Tyr(Bzl)-Gly-Gly-Phe-Met
74937-32-9

Z-Tyr(Bzl)-Gly-Gly-Phe-Met

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With methyl-phenyl-thioether In trifluoroacetic acid at 25℃; for 4h; Yield given;
methyl ester of N,O-di-t-butyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine
81649-52-7

methyl ester of N,O-di-t-butyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide 1.) methanol, water, 4 h, 2.) AcOH, 45 min; Yield given. Multistep reaction;
Z-Tyr-Gly-Gly-Phe-Hcy(Bzl)-OBzl
97512-82-8

Z-Tyr-Gly-Gly-Phe-Hcy(Bzl)-OBzl

methyl iodide
74-88-4

methyl iodide

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With sodium 1.) NH3 liq., -70 deg C, 2.) hexane-NH3, -70 -> -25 deg C, 1 h; Yield given. Multistep reaction;
methionine-enkephalin sulfoxide
60283-51-4

methionine-enkephalin sulfoxide

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With ammonium iodide; dimethylsulfide In trifluoroacetic acid at 0℃;
BocMet-R, Boc-amino acids

BocMet-R, Boc-amino acids

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Yield given; Multistep reaction;
phospho-Tyr-Gly-Gly-Phe-Met-OH

phospho-Tyr-Gly-Gly-Phe-Met-OH

A

met-enkephalin
58569-55-4

met-enkephalin

B

O-phosphono-L-tyrosine
21820-51-9

O-phosphono-L-tyrosine

C

L-tyrosine
60-18-4

L-tyrosine

D

[des-tyr1]-methionine enkephalin
61370-88-5

[des-tyr1]-methionine enkephalin

Conditions
ConditionsYield
With aminopeptidase M (EC3.4.11.2); 2-amino-2-hydroxymethyl-1,3-propanediol at 37℃; for 1h; pH=7.02; Kinetics; Hydrolysis;
-enkephalyl-arg6-phe7

-enkephalyl-arg6-phe7

A

L-arginyl-L-phenylalanine
2047-13-4

L-arginyl-L-phenylalanine

B

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
With angiotensin I converting enzyme In various solvent(s) at 37℃; pH=7.75; Kinetics;
-enkephalyl-arg6-phe7

-enkephalyl-arg6-phe7

A

YG
673-08-5

YG

B

met-enkephalin
58569-55-4

met-enkephalin

C

tyrosylglycylglycine
21778-69-8

tyrosylglycylglycine

D

L-tyrosine
60-18-4

L-tyrosine

Conditions
ConditionsYield
With membrane fraction In various solvents at 37℃; for 1h; pH=7.4; Product distribution; Further Variations:; Reagents;
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Val

Boc-Pro, Boc-Cys(Bzl), Boc-Asn NPE, Boc-Val

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: NMM / dimethylformamide / 0.17 h / -15 °C
2: NMM / dimethylformamide / 20 h / -20 °C
3: 90 percent / 1.5 N HCl/AcOH
4: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
5: 95 percent / 1.5 N HCl/AcOH / 1 h
6: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
7: 86 percent / 0.5 M NaOH / acetone / 1.5 h
8: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine
40290-63-9

Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 90 percent / 1.5 N HCl/AcOH
2: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
3: 95 percent / 1.5 N HCl/AcOH / 1 h
4: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
5: 86 percent / 0.5 M NaOH / acetone / 1.5 h
6: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Multi-step reaction with 5 steps
1: 98 percent / 4 M HCl / dioxane / 0.75 h
2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
3: 91 percent / 2 M HCl / acetic acid / 0.75 h
4: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
5: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 8 steps
1: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl / 1.) room temp., 5 h, 2.) Et2O
2: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h
3: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
4: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h
5: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
6: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
7: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
8: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate
60566-44-1

methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 86 percent / 0.5 M NaOH / acetone / 1.5 h
2: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester
70035-45-9

N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 95 percent / 1.5 N HCl/AcOH / 1 h
2: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
3: 86 percent / 0.5 M NaOH / acetone / 1.5 h
4: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Multi-step reaction with 3 steps
1: 91 percent / 2 M HCl / acetic acid / 0.75 h
2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
3: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 4 steps
1: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
2: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
3: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
4: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
Boc-Phe-O-COO-isoBu
67729-36-6, 60398-40-5

Boc-Phe-O-COO-isoBu

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: NMM / dimethylformamide / 20 h / -20 °C
2: 90 percent / 1.5 N HCl/AcOH
3: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
4: 95 percent / 1.5 N HCl/AcOH / 1 h
5: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
6: 86 percent / 0.5 M NaOH / acetone / 1.5 h
7: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine
70035-46-0

hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
2: 86 percent / 0.5 M NaOH / acetone / 1.5 h
3: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
Multi-step reaction with 2 steps
1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
2: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 3 steps
1: N-methylmorpholine, 2,6-luditine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h
2: 91 percent / aq. NaOH / dimethylformamide / 6 h
3: 40 percent / aq. HCl / dioxane / 6 h
View Scheme
Multi-step reaction with 3 steps
1: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
2: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
3: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
L-phenylalaninyl-L-methionine methyl ether p-toluenesulfonate

L-phenylalaninyl-L-methionine methyl ether p-toluenesulfonate

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h
2: 95 percent / 1.5 N HCl/AcOH / 1 h
3: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h
4: 86 percent / 0.5 M NaOH / acetone / 1.5 h
5: 90 percent / 1.3 M HCl/AcOH / 1 h
View Scheme
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 90 percent / N,N'-dicyclohexylcarbodiimide (DCCI) / tetrahydrofuran / Ambient temperature
2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
3: 98 percent / 4 M HCl / dioxane / 0.75 h
4: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
5: 91 percent / 2 M HCl / acetic acid / 0.75 h
6: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
7: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 4 steps
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 1 min, 2.) -10 deg C, 30 min; 20 deg C, 2 h
2: 95 percent / 4.1 M HCl / dioxane / 4 h / 20 °C
3: 1.) 4.1 M HCl, isopentyl nitrite, 2.) Et3N / 1.) DMF, -20 deg C, 1 h, 2.) -30 deg C, 1 h; 4 deg C, 21 h
4: 1.) Na / 1.) NH3 liq., -70 deg C, 2.) hexane-NH3, -70 -> -25 deg C, 1 h
View Scheme
Multi-step reaction with 9 steps
1: 1)N-methylmorpholine, 1-β-napthalenesulphonyloxybenzotriazole / 1)EtOAc, RT, 1.5h 2) 12h RT
2: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl / 1.) room temp., 5 h, 2.) Et2O
3: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h
4: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
5: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h
6: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
7: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
8: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
9: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
Multi-step reaction with 8 steps
1.1: N,N-dimethyl-formamide / 20 °C
2.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / pH 7
2.2: 4 h / 0 - 20 °C
3.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 0.25 h / 20 °C
4.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / pH 7
4.2: 0 °C
4.3: 4 h / 0 - 20 °C
5.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 1 h / 20 °C
6.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C
6.3: 4 h / 0 - 20 °C
7.1: palladium 10% on activated carbon / methanol / 0.33 h / 20 °C
8.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 0.5 h / 0 °C
View Scheme
hydrochloride of methyl ester of L-phenylalanyl-L-methionine
40290-65-1

hydrochloride of methyl ester of L-phenylalanyl-L-methionine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
2: 91 percent / 2 M HCl / acetic acid / 0.75 h
3: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
4: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
Multi-step reaction with 7 steps
1: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h
2: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
3: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h
4: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl
5: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h
6: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature
7: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature
View Scheme
O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime
81638-94-0

O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
2: 98 percent / 4 M HCl / dioxane / 0.75 h
3: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h
4: 91 percent / 2 M HCl / acetic acid / 0.75 h
5: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h
6: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min
View Scheme
N-benzyloxycarbonyl-O-benzyl-L-tyrosine
86827-18-1, 92455-53-3, 16677-29-5

N-benzyloxycarbonyl-O-benzyl-L-tyrosine

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dicyclohexylcarbodi-imide
4: thioanisole / trifluoroacetic acid / 4 h / 25 °C
View Scheme
N-(O-benzyl-N-benzyloxycarbonyl-L-tyrosyl)-glycine ethyl ester
21869-36-3

N-(O-benzyl-N-benzyloxycarbonyl-L-tyrosyl)-glycine ethyl ester

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
3: thioanisole / trifluoroacetic acid / 4 h / 25 °C
View Scheme
Z-Tyr(Bzl)-Gly-N2H3
74916-75-9

Z-Tyr(Bzl)-Gly-N2H3

met-enkephalin
58569-55-4

met-enkephalin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: thioanisole / trifluoroacetic acid / 4 h / 25 °C
View Scheme
fluorescein isothiocyanate
3326-32-7, 27072-45-3

fluorescein isothiocyanate

met-enkephalin
58569-55-4

met-enkephalin

C48H46N6O12S2

C48H46N6O12S2

Conditions
ConditionsYield
With N-ethylmorpholine; In N,N-dimethyl-formamide at 20℃; for 24h;

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