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inquiryName:Met-Enkephaline Type: Pharmaceutical Peptide CAS:58569-55-4 Purity:98% Appearance:White powder Packing Specification:1g, 10g, 100g Storage:2 ℃ to 8 ℃ Molecular Formula:C27H35N5O7S Molecular Weight:573.66 Appearance:Whit
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inquiryName:Met-Enkephaline CAS NO: 58569-55-4 Grade:Medical scientific research and export Molecular formula:C27H35N5O7S Molecular weight:573.66 Product Quality 12 years of chemical raw materials Mature operation of the industry System stabilit
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Cas:58569-55-4
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inquiryTyrosylglycyl-glycyl-phenylalanyl-methionine CAS: 58569-55-4 Specification Item Standard Structural data confirmation 1. H-NMR: The data of structure are identical with reference standard
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Product name: Met-Enkephalin CAS No.: 58569-55-4 Molecule Formula:C27H35N5O7S Molecule Weight:573.66 Purity: 98.0% Package: 1g/bag Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquirymet-enkephalin
Conditions | Yield |
---|---|
With p-cresol; dimethylsulfide; hydrogen fluoride at 0℃; for 1h; | 92% |
boc-Tyr-Gly-Gly-Phe-Met-OH
met-enkephalin
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid for 1h; | 90% |
With hydrogenchloride In acetic acid for 0.5h; | 85% |
Boc-Tyr-Gly-Gly-Phe-Met-OBut
met-enkephalin
Conditions | Yield |
---|---|
With methyl-phenyl-thioether; trifluoroacetic acid for 1h; Ambient temperature; | 74% |
met-enkephalin
Conditions | Yield |
---|---|
Stage #1: C20H19NO10S3(2-)*2Na(1+) With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; acetonitrile at 20℃; for 0.75h; Stage #2: With ethanolamine In water for 0.166667h; Stage #3: C17H13NO10S2(2-)*2Na(1+); C24H19NO10S2(2-)*2Na(1+); C24H19NO11S2(2-)*2Na(1+) Further stages; | 63% |
Boc-Tyr(Mtb)-Gly-Gly-Phe-Met-OMtb
met-enkephalin
Conditions | Yield |
---|---|
With 3,5-dimethylmethoxybenzene; ethane-1,2-dithiol; trifluoroacetic acid 1) 0 deg C, 120 min, 2) 20 deg C, 60 min; | 57% |
Boc-Tyr(Cl2Bzl)-Gly-Gly-Phe-Met-OBzl
met-enkephalin
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; methyl-phenyl-thioether; ethane-1,2-dithiol; 3-methyl-phenol; trifluoroacetic acid at 0℃; for 1.5h; | 49% |
N-(diphenylphosphinoyl)tyrosylglycylglycylphenylalanylmethionine
met-enkephalin
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane for 6h; | 40% |
Boc-Tyr(tert.-Bu)-Gly-Gly-Phe-Met
met-enkephalin
Conditions | Yield |
---|---|
With hydrogenchloride; ethane-1,2-dithiol; methoxybenzene In 1,4-dioxane for 1h; Ambient temperature; Yield given; |
Z-Tyr(Bzl)-Gly-Gly-Phe-Met
met-enkephalin
Conditions | Yield |
---|---|
With methyl-phenyl-thioether In trifluoroacetic acid at 25℃; for 4h; Yield given; |
methyl ester of N,O-di-t-butyloxycarbonyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine
met-enkephalin
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide 1.) methanol, water, 4 h, 2.) AcOH, 45 min; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With sodium 1.) NH3 liq., -70 deg C, 2.) hexane-NH3, -70 -> -25 deg C, 1 h; Yield given. Multistep reaction; |
methionine-enkephalin sulfoxide
met-enkephalin
Conditions | Yield |
---|---|
With ammonium iodide; dimethylsulfide In trifluoroacetic acid at 0℃; |
met-enkephalin
Conditions | Yield |
---|---|
Yield given; Multistep reaction; |
A
met-enkephalin
B
O-phosphono-L-tyrosine
C
L-tyrosine
D
[des-tyr1]-methionine enkephalin
Conditions | Yield |
---|---|
With aminopeptidase M (EC3.4.11.2); 2-amino-2-hydroxymethyl-1,3-propanediol at 37℃; for 1h; pH=7.02; Kinetics; Hydrolysis; |
Conditions | Yield |
---|---|
With angiotensin I converting enzyme In various solvent(s) at 37℃; pH=7.75; Kinetics; |
Conditions | Yield |
---|---|
With membrane fraction In various solvents at 37℃; for 1h; pH=7.4; Product distribution; Further Variations:; Reagents; |
N-tert-butoxycarbonyl-L-phenylalanine
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: NMM / dimethylformamide / 0.17 h / -15 °C 2: NMM / dimethylformamide / 20 h / -20 °C 3: 90 percent / 1.5 N HCl/AcOH 4: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h 5: 95 percent / 1.5 N HCl/AcOH / 1 h 6: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h 7: 86 percent / 0.5 M NaOH / acetone / 1.5 h 8: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme |
Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 90 percent / 1.5 N HCl/AcOH 2: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h 3: 95 percent / 1.5 N HCl/AcOH / 1 h 4: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h 5: 86 percent / 0.5 M NaOH / acetone / 1.5 h 6: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme | |
Multi-step reaction with 5 steps 1: 98 percent / 4 M HCl / dioxane / 0.75 h 2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h 3: 91 percent / 2 M HCl / acetic acid / 0.75 h 4: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h 5: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min View Scheme | |
Multi-step reaction with 8 steps 1: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl / 1.) room temp., 5 h, 2.) Et2O 2: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h 3: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl 4: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h 5: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl 6: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h 7: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature 8: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature View Scheme |
methyl N-tert-butoxycarbonyl-L-tyrosyldiglycyl-L-phenylalanyl-L-methioninate
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / 0.5 M NaOH / acetone / 1.5 h 2: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme |
N-tert-Butyloxycarbonyl-glycyl-glycyl-L-phenylalanyl-L-methionin-methylester
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 95 percent / 1.5 N HCl/AcOH / 1 h 2: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h 3: 86 percent / 0.5 M NaOH / acetone / 1.5 h 4: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme | |
Multi-step reaction with 3 steps 1: 91 percent / 2 M HCl / acetic acid / 0.75 h 2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h 3: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min View Scheme | |
Multi-step reaction with 4 steps 1: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl 2: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h 3: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature 4: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature View Scheme |
Boc-Phe-O-COO-isoBu
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: NMM / dimethylformamide / 20 h / -20 °C 2: 90 percent / 1.5 N HCl/AcOH 3: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h 4: 95 percent / 1.5 N HCl/AcOH / 1 h 5: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h 6: 86 percent / 0.5 M NaOH / acetone / 1.5 h 7: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme |
hydrochloride of methyl ester of glycylglycyl-L-phenylalanyl-L-methionine
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h 2: 86 percent / 0.5 M NaOH / acetone / 1.5 h 3: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme | |
Multi-step reaction with 2 steps 1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h 2: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min View Scheme | |
Multi-step reaction with 3 steps 1: N-methylmorpholine, 2,6-luditine / CH2Cl2; dimethylformamide / 1.) 0 deg C, 1 h, 2.) r. t., 1 h 2: 91 percent / aq. NaOH / dimethylformamide / 6 h 3: 40 percent / aq. HCl / dioxane / 6 h View Scheme | |
Multi-step reaction with 3 steps 1: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h 2: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature 3: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature View Scheme |
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 97 percent / HOBt*H2O, NEt3 / dimethylformamide / 23 h 2: 95 percent / 1.5 N HCl/AcOH / 1 h 3: 90 percent / HOBt*H2O, NEt3, DCC / dimethylformamide / a) -5 deg C to 0 deg C, 1 h, b) 20 deg C, 24 h 4: 86 percent / 0.5 M NaOH / acetone / 1.5 h 5: 90 percent / 1.3 M HCl/AcOH / 1 h View Scheme |
N-tert-butoxycarbonyl-L-phenylalanine
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 90 percent / N,N'-dicyclohexylcarbodiimide (DCCI) / tetrahydrofuran / Ambient temperature 2: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h 3: 98 percent / 4 M HCl / dioxane / 0.75 h 4: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h 5: 91 percent / 2 M HCl / acetic acid / 0.75 h 6: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h 7: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min View Scheme | |
Multi-step reaction with 4 steps 1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) THF, -15 deg C, 1 min, 2.) -10 deg C, 30 min; 20 deg C, 2 h 2: 95 percent / 4.1 M HCl / dioxane / 4 h / 20 °C 3: 1.) 4.1 M HCl, isopentyl nitrite, 2.) Et3N / 1.) DMF, -20 deg C, 1 h, 2.) -30 deg C, 1 h; 4 deg C, 21 h 4: 1.) Na / 1.) NH3 liq., -70 deg C, 2.) hexane-NH3, -70 -> -25 deg C, 1 h View Scheme | |
Multi-step reaction with 9 steps 1: 1)N-methylmorpholine, 1-β-napthalenesulphonyloxybenzotriazole / 1)EtOAc, RT, 1.5h 2) 12h RT 2: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl / 1.) room temp., 5 h, 2.) Et2O 3: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h 4: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl 5: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h 6: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl 7: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h 8: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature 9: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature View Scheme | |
Multi-step reaction with 8 steps 1.1: N,N-dimethyl-formamide / 20 °C 2.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / pH 7 2.2: 4 h / 0 - 20 °C 3.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 0.25 h / 20 °C 4.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / pH 7 4.2: 0 °C 4.3: 4 h / 0 - 20 °C 5.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 1 h / 20 °C 6.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C 6.3: 4 h / 0 - 20 °C 7.1: palladium 10% on activated carbon / methanol / 0.33 h / 20 °C 8.1: hydrogenchloride; methyl-phenyl-thioether; 2-hydroxyethanethiol / 1,4-dioxane / 0.5 h / 0 °C View Scheme |
hydrochloride of methyl ester of L-phenylalanyl-L-methionine
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h 2: 91 percent / 2 M HCl / acetic acid / 0.75 h 3: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h 4: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min View Scheme | |
Multi-step reaction with 7 steps 1: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h 2) RT 12h 2: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl 3: 1) N-methylmorpholine, 1-β-naphthalenesulphonyloxybenzotriazole / 1) EtOAc, DMF, 1.5h, 2) RT, 12h 4: 1.) HCO2H, PhOMe, HS-(CH2)2-SH, 2.) HCl 5: 1) 1-β-naphthalenesulphonyloxybenzotriazole, 2) N-methylmorpholine / 1) EtOAc, 1.5h, DMF, RT, 2) RT, 15h 6: 92.23 percent / 2N NaOH / methanol; H2O / 1 h / Ambient temperature 7: 10percentHCl, C6H5OCH3, HS-(CH2)2-SH / dioxane / 1 h / Ambient temperature View Scheme |
O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h 2: 98 percent / 4 M HCl / dioxane / 0.75 h 3: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) THF, 24 h 4: 91 percent / 2 M HCl / acetic acid / 0.75 h 5: 1.) NH3, 2.) AcOH / 1.) CHCl3, 5 min, 2.) DMF, THF, 24 h 6: 1.) 2 M NaOH, 2.) 2M HCl / 1.) methanol, water, 4 h, 2.) AcOH, 45 min View Scheme |
N-benzyloxycarbonyl-O-benzyl-L-tyrosine
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dicyclohexylcarbodi-imide 4: thioanisole / trifluoroacetic acid / 4 h / 25 °C View Scheme |
N-(O-benzyl-N-benzyloxycarbonyl-L-tyrosyl)-glycine ethyl ester
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 3: thioanisole / trifluoroacetic acid / 4 h / 25 °C View Scheme |
Z-Tyr(Bzl)-Gly-N2H3
met-enkephalin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: thioanisole / trifluoroacetic acid / 4 h / 25 °C View Scheme |
Conditions | Yield |
---|---|
With N-ethylmorpholine; In N,N-dimethyl-formamide at 20℃; for 24h; |
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