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AstaTech ( Chengdu) BioPharmaceutical Corp.

Chengdu AstaTech Chemical Technology Co., Ltd. is a wholly-owned subsidiary of AstaTech (Chengdu) BioPharmaceutical Co., Ltd. It has overall accountability for AstaTech’s product list and sales and promotion of chemical reagents in China. The c

63095-51-2

Cas:63095-51-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Sinoway Industrial Co., Ltd.

Assay: 99% up; Stable supply with over 10Mt annually; Appearance:transparent liquid Storage:room temprature Package:1kg/bottle, 25kg/drum Application:Intermediate of Brivaracetam Port:Beijing/Shanghai/Shenzhen/Hangzhou

(R)-4-Propyldihydrofuran-2(3H)-one, Intermediate of Brivaracetam

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $100.0 / 110.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product description: Product name (R)-Dihydro-4-propyl-2(3H)-furanone CAS number 63095-51-2 Assay ≥98% Appearance Off-white powder Capacity 200mt/year Application Pharmaceuti

(R)-Dihydro-4-propyl-2(3H)-furanone

Cas:63095-51-2

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply (R)-4-Propyldihydrofuran-2(3H)-one CAS 63095-51-2 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermedia

Factory supply (R)-4-Propyldihydrofuran-2(3H)-one CAS 63095-51-2 with fast delivery

Cas:63095-51-2

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

63095-51-2 2(3H)-Furanone, dihydro-4-propyl-, (R)-

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

(R)-Dihydro-4-propyl-2(3H)-furanone CAS No.:63095-51-2 Name: (R)-Dihydro-4-propyl-2(3H)-furanone Molecular Structure Molecular Formula: C7H12O2 Molecular Weight: 128.17 CAS Registry Number: 63095-51-2

High purity (R)-Dihydro-4-propyl-2(3H)-furanone CAS No.:63095-51-2

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(R)-Dihydro-4-propyl-2(3H)-furanone

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

(R)-4-Propyldihydrofuran-2(3H)-One

Cas:63095-51-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(R)-Dihydro-4-propyl-2(3H)-furanone

Cas:63095-51-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

(R)-4-Propyldihydrofuran-2(3H)-one / LIDE PHARMA- Factory supply / Best price

Cas:63095-51-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

brivaracetam intermediate 1

Cas:63095-51-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 63095-51-2 with best quality

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Henan Sinotech Import&Export Corporation

Name: (R)-4-Propyldihydrofuran-2(3H)-one Synonyms: 2(3H)-Furanone,dihydro-4-propyl-,(R)- CAS: 63095-51-2 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:Syntheses Material Intermediat

(R)-4-Propyldihydrofuran-2(3H)-one

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99% (R)-4-Propyldihydrofuran-2(3H)-one 63095-51-2 Buvaxitan Intermediate

Cas:63095-51-2

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2(3H)-Furanone, dihydro-4-propyl-, (R)- 63095-51-2

Cas:63095-51-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(R)-4-Propyldihydrofuran-2(3H)-one CAS:63095-51-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

(R)-4-Propyldihydrofuran-2(3H)-one CAS:63095-51-2

Cas:63095-51-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2(3H)-Furanone, dihydro-4-propyl-, (R)-

Cas:63095-51-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

(R)-4-Propyldihydrofuran-2(3H)-one

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

2(3H)-Furanone, dihydro-4-propyl-, (R)-

Cas:63095-51-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

BRIVARACETAM INTERMEDIATE 1

Cas:63095-51-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Cas:63095-51-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products brivaracetam intermediate 1

Cas:63095-51-2

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

(R)-4-propyl-dihydro-furan-2-one

Cas:63095-51-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(R)-4-Propyldihydrofuran-2(3H)-one

Cas:63095-51-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Offer fine (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one/(R)-4-Propyldihydrofuran-2(3H)-one CAS NO.63095-51-2

Cas:63095-51-2

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (R)-4-Propyldihydrofuran-2(3H)-One CAS No.:63095-51-2 Molecule Formula:C7H12O2 Molecule Weight:128.17 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality (R)-4-Propyldihydrofuran-2(3H)-One in stock

Cas:63095-51-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(R)-4-Propyldihydrofuran-2(3H)-one

Cas:63095-51-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Offer fine (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one/(R)-4-Propyldihydrofuran-2(3H)-one CAS NO.63095-51-2

Cas:63095-51-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

(4R)-2-oxo-4-propyltetrahydrofuran-3-carboxylic acid

(4R)-2-oxo-4-propyltetrahydrofuran-3-carboxylic acid

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
In toluene at 120℃; for 2h; Time;99%
(R)-3-(hydroxymethyl)hexanenitrile

(R)-3-(hydroxymethyl)hexanenitrile

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride In water at 75℃; for 1h; Reagent/catalyst; Solvent;95.6%
(R)-dihydro-4-(prop-1-enyl)furan-2(3H)-one

(R)-dihydro-4-(prop-1-enyl)furan-2(3H)-one

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol under 750.075 - 1500.15 Torr; Autoclave;95%
(4R)-4-allyldihydrofuran-2(3H)-one
80758-91-4

(4R)-4-allyldihydrofuran-2(3H)-one

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 35℃; for 6h; enantioselective reaction;95%
(3R)-3-(hydroxymethyl)-N-[(1S)-1-phenylethyl]hexanamide

(3R)-3-(hydroxymethyl)-N-[(1S)-1-phenylethyl]hexanamide

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With sulfuric acid In water at 100℃; for 6h;95%
4-propyl-5H-furan-2-one
21963-27-9

4-propyl-5H-furan-2-one

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With bis(η5-cyclopentadienyl)ruthenium; (R,R)-(+)-2,2'-isopropylidene bis(4-isopropyl-2-oxazoline); hydrogen In methanol at 50℃; under 15001.5 Torr; Temperature; Pressure; Solvent; Reagent/catalyst; Autoclave;93%
With water; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); copper(l) chloride; sodium t-butanolate In toluene; tert-butyl alcohol at 0 - 30℃; Inert atmosphere;79.63%
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 9000.9 Torr
2: sodium hydroxide / water / 2 h / 30 °C
View Scheme
Multi-step reaction with 4 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 9 h / 20 °C / 225.02 - 375.04 Torr / Large scale
2: sodium hydroxide / ethanol / 1 h / 20 °C / Large scale
3: 0.5 h / 20 °C / Large scale
4: hydrogenchloride / water / 3 h / 20 - 60 °C / Large scale
View Scheme
cis-4-propyl-5-p-tolylthio-4,5-dihydrofuran-2(3H)-one
123975-96-2

cis-4-propyl-5-p-tolylthio-4,5-dihydrofuran-2(3H)-one

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In toluene at 90 - 100℃; for 0.5h;92%
(S)-3-p-toluenesulfonyl-γ-butyrolactone

(S)-3-p-toluenesulfonyl-γ-butyrolactone

n-propylmagnesium bromide
927-77-5

n-propylmagnesium bromide

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With [2,2]bipyridinyl; copper(l) iodide; lithium methanolate In tetrahydrofuran at 0℃; for 24h; Reagent/catalyst; Solvent;92%
C7H14O3*C14H15NO

C7H14O3*C14H15NO

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride In water at 20 - 60℃; for 3h; Large scale;92%
(2R)-2-propyl-3-(1,3-dithian-2-ylidene)propanol
147725-41-5

(2R)-2-propyl-3-(1,3-dithian-2-ylidene)propanol

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In dichloromethane for 1h; Ambient temperature;90%
(R)-2-(2-methoxy-2-oxoethyl)pentanoic acid

(R)-2-(2-methoxy-2-oxoethyl)pentanoic acid

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With dimethylsulfide borane complex In tetrahydrofuran at -20 - 0℃; for 3h; Reagent/catalyst;90%
3-<(R)-<2-(1,1-dimethylethoxy)-2-oxoethyl>-1-oxopentyl>-4(S)-(phenylmethyl)-2-oxazolidinone
225377-55-9

3-<(R)-<2-(1,1-dimethylethoxy)-2-oxoethyl>-1-oxopentyl>-4(S)-(phenylmethyl)-2-oxazolidinone

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at -25 - 20℃; for 16h; Reagent/catalyst; Temperature;89.25%
Multi-step reaction with 2 steps
1.1: dihydrogen peroxide; lithium hydroxide; water / tetrahydrofuran; water / 15 h / 5 - 25 °C / Cooling with ice
2.1: dimethyl sulfide borane / tetrahydrofuran / 16 h / 10 - 25 °C / Cooling with ice
2.2: 24 h / 0 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran / 2 h / 0 - 5 °C / Large scale
2: sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 5 h / 0 - 5 °C / Large scale
3: trifluoroacetic acid / 6 h / 60 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: lithium hydroxide / tetrahydrofuran / 6 h / 20 °C
2: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
3: trifluoroacetic acid / toluene / 20 - 30 °C
View Scheme
C8H14O4

C8H14O4

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With sodium tetrahydroborate; water; calcium chloride In methanol; ethanol at 0 - 20℃;86.9%
4-propyl-2-furanone

4-propyl-2-furanone

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With copper(II) choride dihydrate; 1,1′-binaphthalene-2,2′-diylbis[bis(4-methylphenyl)phosphine]; sodium t-butanolate In hexane; toluene at -25℃; for 5h; Reagent/catalyst; Inert atmosphere;86.1%
(R)-3-(hydroxymethyl)hexanoic acid tert-butyl ester

(R)-3-(hydroxymethyl)hexanoic acid tert-butyl ester

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; Cooling with ice;85.6%
With trifluoroacetic acid at 60℃; for 6h; Large scale;78%
In water at 25℃; for 1h;n/a
With toluene-4-sulfonic acid In dichloromethane Reflux;
With hydrogenchloride; water at 30℃;
(R)-3-methoxycarbonylhexanoic acid

(R)-3-methoxycarbonylhexanoic acid

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With sodium tetrahydroborate; calcium chloride In methanol; ethanol; water at 0 - 30℃; for 12h;85%
With sodium tetrahydroborate; calcium chloride In methanol; ethanol; water at 0 - 30℃;85%
With sodium tetrahydroborate; calcium chloride In methanol; ethanol; water at 0℃; for 12h;85%
(4R,5R)-5-amino-4-propyldihydrofuran-2(3H)-one

(4R,5R)-5-amino-4-propyldihydrofuran-2(3H)-one

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide In tetrahydrofuran at 0 - 20℃; for 0.5h;85%
(±)-dihydro-4-propyl-2(3H)-furanone
72397-60-5

(±)-dihydro-4-propyl-2(3H)-furanone

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
Stage #1: (±)-dihydro-4-propyl-2(3H)-furanone With titanium(IV) isopropylate In tetrahydrofuran at 75℃;
Stage #2: With sulfuric acid In 1,4-dioxane; water at 80℃;
80%
With sodium hydroxide In water at 30℃; for 2h; Temperature;36%
Multi-step reaction with 3 steps
1: sodium hydroxide / ethanol / 1 h / 20 °C / Large scale
2: 0.5 h / 20 °C / Large scale
3: hydrogenchloride / water / 3 h / 20 - 60 °C / Large scale
View Scheme
Multi-step reaction with 2 steps
1: triethylamine; water / 95 - 100 °C
2: sulfuric acid / water / 6 h / 100 °C
View Scheme
(R)-2-((tert-butoxycarbonyl)methyl)pentanoic acid
112106-16-8

(R)-2-((tert-butoxycarbonyl)methyl)pentanoic acid

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
Stage #1: (R)-2-((tert-butoxycarbonyl)methyl)pentanoic acid With dimethyl sulfide borane In tetrahydrofuran at 10 - 25℃; for 16h; Cooling with ice;
Stage #2: With hydrogenchloride In water at 0 - 25℃; for 24h; Temperature;
78%
Stage #1: (R)-2-((tert-butoxycarbonyl)methyl)pentanoic acid With dimethylsulfide borane complex In tetrahydrofuran at 20℃;
Stage #2: With hydrogenchloride; trifluoroacetic acid In tetrahydrofuran at 50℃; for 12h;
52%
Multi-step reaction with 2 steps
1.1: triethylamine / toluene / 0.58 h / -6 - -5 °C / Inert atmosphere
1.2: 1.63 h / -6.6 - -3.4 °C
1.3: -18.7 °C / Inert atmosphere; Cooling
2.1: water / 1 h / 25 °C
View Scheme
C7H14O3

C7H14O3

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; pH=3;77%
With toluene-4-sulfonic acid In toluene for 20h; Reflux;12 g
With toluene-4-sulfonic acid In toluene Reflux;7.8 g
ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

(1S,5R)-ethyl 2-oxo-3-oxabicycio[3.1.0]hexane-1-carboxylate
145032-58-2

(1S,5R)-ethyl 2-oxo-3-oxabicycio[3.1.0]hexane-1-carboxylate

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
Stage #1: ethylmagnesium bromide With copper(l) iodide In 2-methyltetrahydrofuran at -30 - -20℃; for 0.5h;
Stage #2: ethyl (1S,5R)-2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylate In 2-methyltetrahydrofuran at -30℃; for 0.5h;
75%
n-propylmagnesium bromide
927-77-5

n-propylmagnesium bromide

C5H5F3O5S

C5H5F3O5S

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With zinc(II) chloride In tetrahydrofuran at -5 - 5℃; for 3h; Solvent; Inert atmosphere;73%
diethyl (R)-2-(1-(tert-butyldimethylsilyloxy)pentan-2-yl)malonate

diethyl (R)-2-(1-(tert-butyldimethylsilyloxy)pentan-2-yl)malonate

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With hydrogenchloride; acetic acid In water at 20℃; for 28h; Reflux;70.9%
n-propylmagnesium bromide
927-77-5

n-propylmagnesium bromide

C4H5IO2

C4H5IO2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With zinc(II) chloride In tetrahydrofuran at -5 - 5℃; for 3h; Inert atmosphere;63%
C9H18O3

C9H18O3

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 3h; Time; Reflux;60%
With toluene-4-sulfonic acid In toluene for 3h; Time; Reflux;59%
With toluene-4-sulfonic acid In toluene for 3h; Reflux;
(1S,5R)-3-oxabicyclo[3.1.0]hexan-2-one
75658-86-5

(1S,5R)-3-oxabicyclo[3.1.0]hexan-2-one

ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
Stage #1: ethylmagnesium bromide With copper(l) iodide In tetrahydrofuran at -40 - -30℃; for 1h;
Stage #2: (1S,5R)-3-oxabicyclo[3.1.0]hexan-2-one With ammonium chloride In tetrahydrofuran; water at -20 - 0℃; Reagent/catalyst;
55%
C10H9NO7S

C10H9NO7S

n-propylmagnesium bromide
927-77-5

n-propylmagnesium bromide

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
With zinc(II) chloride In tetrahydrofuran at -5 - 5℃; for 3h; Inert atmosphere;49%
(2R,3S)-3,4-Dimethyl-2-phenyl-6-propyl-3,4,6,7-tetrahydro-2H-furo[3,2-f][1,4]oxazepin-5-one

(2R,3S)-3,4-Dimethyl-2-phenyl-6-propyl-3,4,6,7-tetrahydro-2H-furo[3,2-f][1,4]oxazepin-5-one

A

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

B

(-)-(S)-β-propyl-γ-butyrolactone
63095-60-3

(-)-(S)-β-propyl-γ-butyrolactone

Conditions
ConditionsYield
In sulfuric acid; water; acetic acid Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
(4R,5S)-3-<1-oxo-3-(1,3-dithian-2-ylidene)-2-propylpropyl>-4-methyl-5-phenyl-2-oxazolidinone
147725-30-2

(4R,5S)-3-<1-oxo-3-(1,3-dithian-2-ylidene)-2-propylpropyl>-4-methyl-5-phenyl-2-oxazolidinone

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C
2: 90 percent / TsOH / CH2Cl2 / 1 h / Ambient temperature
View Scheme
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

(R)-γ-bromo-3-propylbutyric acid

(R)-γ-bromo-3-propylbutyric acid

Conditions
ConditionsYield
With hydrogen bromide; acetic acid In dichloromethane at 0 - 30℃; for 16h; Temperature;100%
With hydrogen bromide In acetic acid at 40 - 50℃; for 4h; Large scale;93%
With hydrogen bromide; acetic acid at 5 - 80℃; for 2.83h; Inert atmosphere;91.95%
With hydrogen bromide In acetic acid at 5 - 80℃; for 3.16667h; Inert atmosphere; Large scale;81%
With hydrogen bromide; acetic acid at 20 - 55℃;
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

C7H13IO2

C7H13IO2

Conditions
ConditionsYield
With trimethylsilyl iodide In dichloromethane at 0 - 30℃; for 2h; Inert atmosphere;99.5%
With trimethylsilyl iodide In dichloromethane at 0 - 30℃; for 2h; Inert atmosphere;99.5%
With trimethylsilyl iodide In dichloromethane at 0 - 30℃; for 2h; Inert atmosphere;99.5%
With trimethylsilyl iodide In dichloromethane at 0 - 25℃; for 2h; Inert atmosphere;97%
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

3-(hydroxymethyl)hexanoyloxy sodium

3-(hydroxymethyl)hexanoyloxy sodium

Conditions
ConditionsYield
With sodium hydroxide for 2h;95%
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

C6H11IO2

C6H11IO2

Conditions
ConditionsYield
With trimethylsilyl iodide In dichloromethane at 20℃; for 3h;94%
With trimethylsilyl iodide In dichloromethane at 20℃; for 3h;94%
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

ethanol
64-17-5

ethanol

ethyl (R)-γ-bromo-3-propylbutyrate

ethyl (R)-γ-bromo-3-propylbutyrate

Conditions
ConditionsYield
With trimethylsilyl bromide In dichloromethane at 30℃; for 8h; Temperature; Solvent; Cooling with ice;93%
With trimethylsilyl bromide In dichloromethane at 0 - 20℃;87%
With trimethylsilyl bromide In dichloromethane at 20℃; for 6h; Inert atmosphere;
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

L-2-aminobutyric acid
1492-24-6

L-2-aminobutyric acid

C11H21NO4

C11H21NO4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 15h; Reagent/catalyst; Temperature;90%
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

C7H12Br2O

C7H12Br2O

Conditions
ConditionsYield
With thionyl chloride; hydrogen bromide In toluene at 20℃; for 8h; Reagent/catalyst;90%
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

C6H11BrO2

C6H11BrO2

Conditions
ConditionsYield
With trimethylsilyl bromide; zinc(II) chloride In dichloromethane at 20℃; for 28h;89%
With trimethylsilyl bromide; zinc(II) chloride In dichloromethane at 20℃; for 28h;89%
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

(R)-3-hydroxymethylhexanoic acid [(S)-1-carbamoylpropyl]amide

(R)-3-hydroxymethylhexanoic acid [(S)-1-carbamoylpropyl]amide

Conditions
ConditionsYield
With titanium(IV) isopropylate In tetrahydrofuran at 10 - 35℃; for 5h; Temperature; Solvent; Reagent/catalyst; Green chemistry;84.15%
In ethanol for 24h; Solvent; Reflux;
(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
63095-51-2

(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one

(R)-3-(chloromethyl)hexanoyl chloride

(R)-3-(chloromethyl)hexanoyl chloride

Conditions
ConditionsYield
With thionyl chloride; zinc(II) chloride at 85℃; Concentration; Temperature;79.7%
With thionyl chloride; zinc(II) chloride at 85℃;66.5%

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