Oxacephem nucleus CAS No.:67977-91-7 Name: Oxacephem nucleus Synonyms: (2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphenylmethyl ester Molecular Struct
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiry(2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphenylmethyl ester CAS:67977-91-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and develo
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Name: (2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphenylmethyl ester Synonyms: (2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphen
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inquirySuperior quality, moderate price & quick delivery. Appearance:White crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide interm
Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquirylatamoxef oxacephem nucleusAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryOur mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical
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inquiry(R)-3-Hydroxymethyl-2-((1R,5S)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
boron trifluoride diethyl etherate In ethyl acetate at 25℃; | 90% |
epi-Secopenicillin
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: chlorine / ethyl acetate / 20 - 30 °C 2: NaHCO3 / H2O / 20 - 30 °C 3: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr 4: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C 5: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme | |
Multi-step reaction with 6 steps 1: chlorine / ethyl acetate / 20 - 30 °C 2: NaHCO3 / H2O / 20 - 30 °C 3: PhSNa / acetone; methanol / 35 °C 4: m-chloroperbenzoic acid / CH2Cl2 / -10 °C 5: methanol; benzene / Heating 6: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme |
(R)-3-chloromethyl-2-((1R)-7-oxo-3-phenyl-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr 2: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C 3: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme | |
Multi-step reaction with 4 steps 1: PhSNa / acetone; methanol / 35 °C 2: m-chloroperbenzoic acid / CH2Cl2 / -10 °C 3: methanol; benzene / Heating 4: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme |
(R)-2-((1R,5S)-7-Oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-phenylsulfanylmethyl-but-3-enoic acid benzhydryl ester
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: m-chloroperbenzoic acid / CH2Cl2 / -10 °C 2: methanol; benzene / Heating 3: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme |
(R)-3-Nitrooxymethyl-2-((1R,5S)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C 2: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanol; benzene / Heating 2: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme |
Diphenylmethyl-2-(3R,4R-3-benzamido-4-chlor-2-oxo-azetidin-1-yl)-3-chlormethyl-3-butenoat
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: NaHCO3 / H2O / 20 - 30 °C 2: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr 3: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C 4: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme | |
Multi-step reaction with 5 steps 1: NaHCO3 / H2O / 20 - 30 °C 2: PhSNa / acetone; methanol / 35 °C 3: m-chloroperbenzoic acid / CH2Cl2 / -10 °C 4: methanol; benzene / Heating 5: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme |
6-epipenicillin sulfoxide
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 80 percent / PPh3 / toluene; CH2Cl2 / Heating 2: chlorine / ethyl acetate / 20 - 30 °C 3: NaHCO3 / H2O / 20 - 30 °C 4: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr 5: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C 6: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme | |
Multi-step reaction with 7 steps 1: 80 percent / PPh3 / toluene; CH2Cl2 / Heating 2: chlorine / ethyl acetate / 20 - 30 °C 3: NaHCO3 / H2O / 20 - 30 °C 4: PhSNa / acetone; methanol / 35 °C 5: m-chloroperbenzoic acid / CH2Cl2 / -10 °C 6: methanol; benzene / Heating 7: 90 percent / BF3*Et2O / ethyl acetate / 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(2S,6R,7R)-7-Benzoylamino-3-chloro-3-hydroxymethyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With perchloric acid; trichloroisocyanuric acid In acetone at 25℃; | 100% |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R)-7c-benzoylamino-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 25℃; for 1h; |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(2S,6R,7R)-7-Benzoylamino-3-chloro-3-chloromethyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With chlorine In dichloromethane at -20℃; Irradiation; |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Benzoylamino-3-hydroxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
With ozone; acetic acid; zinc 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH; Yield given. Multistep reaction; |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Benzoylamino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: B2H6 / tetrahydrofuran 3: 1.) mesyl chloride, 2.) triethylamine View Scheme | |
Multi-step reaction with 3 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran 3: Zn, acetic acid View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(2R,3R,6R,7R)-7-Benzoylamino-3-hydroxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: B2H6 / tetrahydrofuran View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Benzoylamino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Benzoylamino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 100 percent View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: B2H6 / tetrahydrofuran 3: 1.) mesyl chloride, 2.) triethylamine 4: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme | |
Multi-step reaction with 5 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran 3: Zn, acetic acid 4: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Amino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: B2H6 / tetrahydrofuran 3: 1.) mesyl chloride, 2.) triethylamine 4: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme | |
Multi-step reaction with 4 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran 3: Zn, acetic acid 4: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran 3: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Amino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran 3: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 100 percent 3: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Amino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH 2: 100 percent 3: 1.) PCl5, pyridine, 2.) water / 2.) methanol View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R)-7t-amino-7c-methoxy-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 1 h / 25 °C 3: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0 degC, 2.) from 0 deg C to 25 deg C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R)-7t-benzoylamino-7c-methoxy-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1 h / 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
7α-amino-3-methyl-1-oxacephem
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1 h / 25 °C 2: 1.) PCl5, pyridine, 2.) HCl / 1.) CH2Cl2, 25 deg C, 2.) i-BuOH, CH2Cl2, 25 deg C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Amino-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: pyridine / CH2Cl2 / 0 °C 3: 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / CH2Cl2 / -30 °C 4: 1.) PCl5, pyridine, 2.) HCl, i-BuOH / 1.) CH2Cl2, 25 deg C, 2.) CH2Cl2, 25 deg C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-3-Acetoxymethyl-7-amino-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C 4: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0deg C, 2.) from 0 deg C to 25 deg C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-3-Acetoxymethyl-7-benzoylamino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Benzoylamino-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: pyridine / CH2Cl2 / 0 °C 3: 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / CH2Cl2 / -30 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-3-Acetoxymethyl-7-benzoylamino-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: pyridine / CH2Cl2 / 0 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-Benzoylamino-8-oxo-3-(2,2,2-trichloro-acetylcarbamoyloxymethyl)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: CH2Cl2 / 25 °C 3: 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / CH2Cl2 / -35 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-(5-tert-Butoxycarbonylamino-5-carboxy-pentanoylamino)-7-methoxy-3-methyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Et3N / CH2Cl2 / 1 h / 25 °C 3: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0 degC, 2.) from 0 deg C to 25 deg C 4: Et3N, pyridine / CH2Cl2 / 0 °C 5: Zn, 90percent acetic acid / 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: CH2Cl2 / 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-3-Acetoxymethyl-7-(5-tert-butoxycarbonylamino-5-carboxy-pentanoylamino)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C 4: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0deg C, 2.) from 0 deg C to 25 deg C 5: Et3N, pyridine / CH2Cl2 / 0 °C 6: Zn, 90percent acetic acid / 25 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-7-[5-tert-Butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-7-methoxy-3-methyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Et3N / CH2Cl2 / 1 h / 25 °C 3: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0 degC, 2.) from 0 deg C to 25 deg C 4: Et3N, pyridine / CH2Cl2 / 0 °C View Scheme |
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
(6R,7R)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C 2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C 4: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0deg C, 2.) from 0 deg C to 25 deg C 5: Et3N, pyridine / CH2Cl2 / 0 °C View Scheme |
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