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Hangzhou Think Chemical Co. Ltd

Oxacephem nucleus CAS No.:67977-91-7 Name: Oxacephem nucleus Synonyms: (2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphenylmethyl ester Molecular Struct

High purity Oxacephem nucleus CAS No.:67977-91-7

Cas:67977-91-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 67977-91-7 with competitive price

Cas:67977-91-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Leader Biochemical Group

About Product Details

China Biggest factory Supply High Quality Oxacephem nucleus CAS 67977-91-7

Cas:67977-91-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Oxacephem Nucleus 67977-91-7

Cas:67977-91-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

(2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphenylmethyl ester CAS:67977-91-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and develo

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Oxacephem Nucleus

Cas:67977-91-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Oxacephem Nucleus

Cas:67977-91-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(2R,6R,7R)-Benzhydryl 7-benzamido-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylate

Cas:67977-91-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diph

Cas:67977-91-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphenylmethyl ester

Cas:67977-91-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: (2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphenylmethyl ester Synonyms: (2R,6R,7R)-7-(Benzoylamino)-3-methylene-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid diphen

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:White crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide interm

Oxacephem nucleus

Cas:67977-91-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

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JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Oxacephem Nucleus

Cas:67977-91-7

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Oxacephem Nucleus

Cas:67977-91-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

latamoxef oxacephem nucleusAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

latamoxef oxacephem nucleus

Cas:67977-91-7

Min.Order:0

Negotiable

Type:Other

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

67977-91-7

Cas:67977-91-7

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home an

SAGECHEM LIMITED

67977-91-7 Application:intermediate

Oxacephem Nucleus

Cas:67977-91-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

Synthetic route

(R)-3-Hydroxymethyl-2-((1R,5S)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
67977-88-2

(R)-3-Hydroxymethyl-2-((1R,5S)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
boron trifluoride diethyl etherate In ethyl acetate at 25℃;90%
epi-Secopenicillin
67977-61-1

epi-Secopenicillin

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: chlorine / ethyl acetate / 20 - 30 °C
2: NaHCO3 / H2O / 20 - 30 °C
3: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr
4: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C
5: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
Multi-step reaction with 6 steps
1: chlorine / ethyl acetate / 20 - 30 °C
2: NaHCO3 / H2O / 20 - 30 °C
3: PhSNa / acetone; methanol / 35 °C
4: m-chloroperbenzoic acid / CH2Cl2 / -10 °C
5: methanol; benzene / Heating
6: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
(R)-3-chloromethyl-2-((1R)-7-oxo-3-phenyl-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
67977-79-1

(R)-3-chloromethyl-2-((1R)-7-oxo-3-phenyl-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr
2: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C
3: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
Multi-step reaction with 4 steps
1: PhSNa / acetone; methanol / 35 °C
2: m-chloroperbenzoic acid / CH2Cl2 / -10 °C
3: methanol; benzene / Heating
4: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
(R)-2-((1R,5S)-7-Oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-phenylsulfanylmethyl-but-3-enoic acid benzhydryl ester
67977-85-9

(R)-2-((1R,5S)-7-Oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-phenylsulfanylmethyl-but-3-enoic acid benzhydryl ester

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: m-chloroperbenzoic acid / CH2Cl2 / -10 °C
2: methanol; benzene / Heating
3: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
(R)-3-Nitrooxymethyl-2-((1R,5S)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
67977-90-6

(R)-3-Nitrooxymethyl-2-((1R,5S)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C
2: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
C34H28N2O5S

C34H28N2O5S

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol; benzene / Heating
2: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
Diphenylmethyl-2-(3R,4R-3-benzamido-4-chlor-2-oxo-azetidin-1-yl)-3-chlormethyl-3-butenoat
74242-86-7

Diphenylmethyl-2-(3R,4R-3-benzamido-4-chlor-2-oxo-azetidin-1-yl)-3-chlormethyl-3-butenoat

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaHCO3 / H2O / 20 - 30 °C
2: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr
3: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C
4: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
Multi-step reaction with 5 steps
1: NaHCO3 / H2O / 20 - 30 °C
2: PhSNa / acetone; methanol / 35 °C
3: m-chloroperbenzoic acid / CH2Cl2 / -10 °C
4: methanol; benzene / Heating
5: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
6-epipenicillin sulfoxide
69780-18-3

6-epipenicillin sulfoxide

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 80 percent / PPh3 / toluene; CH2Cl2 / Heating
2: chlorine / ethyl acetate / 20 - 30 °C
3: NaHCO3 / H2O / 20 - 30 °C
4: 88 percent / NaNO3, methyl p-toluenesulfonate / dimethylsulfoxide / 55 °C / 50 Torr
5: 85 percent / Zn, AcOH / CH2Cl2 / 0 °C
6: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
Multi-step reaction with 7 steps
1: 80 percent / PPh3 / toluene; CH2Cl2 / Heating
2: chlorine / ethyl acetate / 20 - 30 °C
3: NaHCO3 / H2O / 20 - 30 °C
4: PhSNa / acetone; methanol / 35 °C
5: m-chloroperbenzoic acid / CH2Cl2 / -10 °C
6: methanol; benzene / Heating
7: 90 percent / BF3*Et2O / ethyl acetate / 25 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(2S,6R,7R)-7-Benzoylamino-3-chloro-3-hydroxymethyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
77945-44-9, 112136-32-0

(2S,6R,7R)-7-Benzoylamino-3-chloro-3-hydroxymethyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
With perchloric acid; trichloroisocyanuric acid In acetone at 25℃;100%
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R)-7c-benzoylamino-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
68314-20-5

(6R)-7c-benzoylamino-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 25℃; for 1h;
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(2S,6R,7R)-7-Benzoylamino-3-chloro-3-chloromethyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
1186615-53-1

(2S,6R,7R)-7-Benzoylamino-3-chloro-3-chloromethyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
With chlorine In dichloromethane at -20℃; Irradiation;
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-3-hydroxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
81755-47-7

(6R,7R)-7-Benzoylamino-3-hydroxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
With ozone; acetic acid; zinc 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH; Yield given. Multistep reaction;
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
81755-50-2

(6R,7R)-7-Benzoylamino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: B2H6 / tetrahydrofuran
3: 1.) mesyl chloride, 2.) triethylamine
View Scheme
Multi-step reaction with 3 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran
3: Zn, acetic acid
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(2R,3R,6R,7R)-7-Benzoylamino-3-hydroxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
81755-51-3

(2R,3R,6R,7R)-7-Benzoylamino-3-hydroxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: B2H6 / tetrahydrofuran
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
81755-49-9

(6R,7R)-7-Benzoylamino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
81755-48-8

(6R,7R)-7-Benzoylamino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 100 percent
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7S)-7-Amino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

(6R,7S)-7-Amino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: B2H6 / tetrahydrofuran
3: 1.) mesyl chloride, 2.) triethylamine
4: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
Multi-step reaction with 5 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran
3: Zn, acetic acid
4: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Amino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
81800-15-9

(6R,7R)-7-Amino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: B2H6 / tetrahydrofuran
3: 1.) mesyl chloride, 2.) triethylamine
4: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
Multi-step reaction with 4 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran
3: Zn, acetic acid
4: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7S)-7-Amino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

(6R,7S)-7-Amino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran
3: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Amino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
81800-14-8

(6R,7R)-7-Amino-3-chloro-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 30 percent / chlorine-triphenylphosphine complex, triethylamine / tetrahydrofuran
3: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7S)-7-Amino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

(6R,7S)-7-Amino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 100 percent
3: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Amino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
81800-13-7

(6R,7R)-7-Amino-3-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) O3, 2.) Zn, AcOH / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH
2: 100 percent
3: 1.) PCl5, pyridine, 2.) water / 2.) methanol
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R)-7t-amino-7c-methoxy-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77982-90-2

(6R)-7t-amino-7c-methoxy-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 1 h / 25 °C
3: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0 degC, 2.) from 0 deg C to 25 deg C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R)-7t-benzoylamino-7c-methoxy-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
68313-93-9

(6R)-7t-benzoylamino-7c-methoxy-3-methyl-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 1 h / 25 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

7α-amino-3-methyl-1-oxacephem
77982-88-8

7α-amino-3-methyl-1-oxacephem

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 1 h / 25 °C
2: 1.) PCl5, pyridine, 2.) HCl / 1.) CH2Cl2, 25 deg C, 2.) i-BuOH, CH2Cl2, 25 deg C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Amino-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77930-74-6

(6R,7R)-7-Amino-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: pyridine / CH2Cl2 / 0 °C
3: 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / CH2Cl2 / -30 °C
4: 1.) PCl5, pyridine, 2.) HCl, i-BuOH / 1.) CH2Cl2, 25 deg C, 2.) CH2Cl2, 25 deg C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-3-Acetoxymethyl-7-amino-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
116180-23-5

(6R,7R)-3-Acetoxymethyl-7-amino-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C
4: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0deg C, 2.) from 0 deg C to 25 deg C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-3-Acetoxymethyl-7-benzoylamino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77982-91-3

(6R,7R)-3-Acetoxymethyl-7-benzoylamino-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77930-73-5

(6R,7R)-7-Benzoylamino-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: pyridine / CH2Cl2 / 0 °C
3: 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / CH2Cl2 / -30 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-3-Acetoxymethyl-7-benzoylamino-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77210-18-5

(6R,7R)-3-Acetoxymethyl-7-benzoylamino-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-3-chloro-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-3-chloro-3-(2-chloro-acetoxymethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: pyridine / CH2Cl2 / 0 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-Benzoylamino-8-oxo-3-(2,2,2-trichloro-acetylcarbamoyloxymethyl)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77930-70-2

(6R,7R)-7-Benzoylamino-8-oxo-3-(2,2,2-trichloro-acetylcarbamoyloxymethyl)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: CH2Cl2 / 25 °C
3: 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU) / CH2Cl2 / -35 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-(5-tert-Butoxycarbonylamino-5-carboxy-pentanoylamino)-7-methoxy-3-methyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77930-84-8

(6R,7R)-7-(5-tert-Butoxycarbonylamino-5-carboxy-pentanoylamino)-7-methoxy-3-methyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2 / 1 h / 25 °C
3: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0 degC, 2.) from 0 deg C to 25 deg C
4: Et3N, pyridine / CH2Cl2 / 0 °C
5: Zn, 90percent acetic acid / 25 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(2S,6R,7R)-7-Benzoylamino-3-chloro-8-oxo-3-(2,2,2-trichloro-acetylcarbamoyloxymethyl)-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(2S,6R,7R)-7-Benzoylamino-3-chloro-8-oxo-3-(2,2,2-trichloro-acetylcarbamoyloxymethyl)-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: CH2Cl2 / 25 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-3-Acetoxymethyl-7-(5-tert-butoxycarbonylamino-5-carboxy-pentanoylamino)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77930-85-9

(6R,7R)-3-Acetoxymethyl-7-(5-tert-butoxycarbonylamino-5-carboxy-pentanoylamino)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C
4: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0deg C, 2.) from 0 deg C to 25 deg C
5: Et3N, pyridine / CH2Cl2 / 0 °C
6: Zn, 90percent acetic acid / 25 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-7-[5-tert-Butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-7-methoxy-3-methyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77930-79-1

(6R,7R)-7-[5-tert-Butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-7-methoxy-3-methyl-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Et3N / CH2Cl2 / 1 h / 25 °C
3: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0 degC, 2.) from 0 deg C to 25 deg C
4: Et3N, pyridine / CH2Cl2 / 0 °C
View Scheme
(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester
67977-91-7

(2R,6R,7R)-7-Benzoylamino-3-methylene-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester

(6R,7R)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
77930-80-4

(6R,7R)-3-Acetoxymethyl-7-[5-tert-butoxycarbonylamino-5-(2,2,2-trichloro-ethoxycarbonyl)-pentanoylamino]-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / trichloroisocyanuric acid, aq. HClO4 / acetone / 25 °C
2: 66 percent / pyridine / CH2Cl2 / 0 - 25 °C
4: 1.) PCl5, pyridine, 2.) MeOH / 1.) CH2Cl2, 0deg C, 2.) from 0 deg C to 25 deg C
5: Et3N, pyridine / CH2Cl2 / 0 °C
View Scheme

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