Products

Refine

Country

Business Type

Certificate

Display

Hangzhou Hysen Pharma co.,Ltd.

we are Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well.

Neratinib CAS:698387-09-6

Cas:698387-09-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shangdong Shinning Pharm co.ltd

100% owned factory, regulatory compliance and be audited.Appearance:off- white powder Application:Commercial

Neratinib Cas no.698387-09-6 99.0%+

Cas:698387-09-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Neratinib Manufacturer/High quality/Best price/In stock

Cas:698387-09-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

1. Usage of Neratinib Anti-Cancer 2. Sinoway's advantage: (1) ISO 9001:2008 certificated company (2) 28 years in pharmaceutical industry (3)China office of Fischer Chemicals AG (Switzerland) Appearance: white crystalline powde

Supply High Quality Neratinib CAS No. 698387-09-6

Cas:698387-09-6

Min.Order:10 Gram

FOB Price: $5.0

Type:Trading Company

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:2-8°C Package:1g/vial; 10g/bottle Applic

Good quality Neratinib CAS 698387-09-6 with favorable price

Cas:698387-09-6

Min.Order:1 Gram

FOB Price: $150.0 / 200.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

neratinib

Cas:698387-09-6

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Manufacturers

inquiry

Hangzhou Think Chemical Co. Ltd

Neratinib CAS No.:698387-09-6 Name: Neratinib Synonyms: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide; HKI-2

High purity Neratinib CAS No.:698387-09-6

Cas:698387-09-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Neratinib 698387-09-6 GMP Manufacturer

Cas:698387-09-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

Neratinib

Cas:698387-09-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Hubei DiBo chemical co., LTD

Name:Neratinib The alias:(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide; CAS NO:698387-09-6 Molecular formula:C30H29ClN6O3 Molecular weight:557.0427 Product Quality 12 y

Neratinib/CAS:698387-09-6/Raw material supply

Cas:698387-09-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

Neratinib

Cas:698387-09-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Neratinib 99% Pure CAS 698387-09-6

Cas:698387-09-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 698387-09-6 with competitive price

Cas:698387-09-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Neratinib/HKI 272 698387-09-6

Cas:698387-09-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Neratinib CAS698387-09-6

Cas:698387-09-6

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

High quality MBC Neratinib 698387-09-6 with competitive price

Cas:698387-09-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

Name:Neratinib CAS:698387-09-6 MF:C30H29ClN6O3 MW:557.0427 Purity:98% Density:1.337g/cm3 Boiling Point:756.97°C Flash Point:411.601°C Application:Neratinib(HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of

Hotsale Neratinib 99%

Cas:698387-09-6

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

High Purity Neratinib/ Neratinib (HKI-272) / HKI272 100% Safe Customs Clearance

Cas:698387-09-6

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Neratinib CAS:698387-09-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Neratinib CAS:698387-09-6

Cas:698387-09-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Anti-Cancer chemical 98% powder HKI-272 CAS 698387-09-6 Neratinib

Cas:698387-09-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name: Neratinib Certificates: GMP DMF CAS No.: 698387-09-6 Chemical name: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide; (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)a

Neratinib,698387-09-6

Cas:698387-09-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Neratinib CAS: 698387-09-6 Specification Test Item Analysis Specification Result Description crystalline powder Conforms Melting range 129&

Factory supply Neratinib

Cas:698387-09-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Triumph International Development Limilted

Appearance:off-white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingdao/Shangha

Neratinib|HKI-272 698387-09-6 99% off-white solid

Cas:698387-09-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Neratinib

Cas:698387-09-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Neratinib CAS 698387-09-6 with Fast Shipment

Cas:698387-09-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Neratinib 698387-09-6

Cas:698387-09-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
848139-78-6

6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

4-N,N-dimethylaminocrotonoylchloride Hydrochloride
501332-27-0

4-N,N-dimethylaminocrotonoylchloride Hydrochloride

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 10 - 40℃; for 15h; Solvent;98%
2-(N,N-dimethylamino)ethoxide
52334-92-6

2-(N,N-dimethylamino)ethoxide

diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate
1269662-79-4

diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate With sodium ethanolate; lithium chloride In ethanol at -5℃; for 0.5h;
Stage #2: 2-(N,N-dimethylamino)ethoxide In ethanol for 0.666667h; Temperature; Solvent; Reagent/catalyst;
95.9%
dimethylaminoacetaldehyde diethyl acetal
3616-56-6

dimethylaminoacetaldehyde diethyl acetal

diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate
1269662-79-4

diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride; water at 0 - 40℃; Inert atmosphere;
Stage #2: diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate With sodium ethanolate; lithium chloride In ethanol; water at -20℃; for 3h;
95.2%
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
848139-78-6

6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride

(2E)-4-(dimethylamino)but-2-enoic acid hydrochloride

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 5℃; Inert atmosphere;
Stage #2: 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile In 1-methyl-pyrrolidin-2-one; dichloromethane at 10 - 25℃;
95%
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate
1269662-79-4

diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate

dimethylaminoacetaldehyde-sodium bisulfite adduct

dimethylaminoacetaldehyde-sodium bisulfite adduct

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate With sodium ethanolate; lithium chloride In ethanol at 0℃; for 0.5h;
Stage #2: dimethylaminoacetaldehyde-sodium bisulfite adduct In ethanol for 3h;
94.1%
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
848139-78-6

6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

trans-4-dimethylamino crotonic acid chloride hydrochloride salt
1055943-40-2

trans-4-dimethylamino crotonic acid chloride hydrochloride salt

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 10℃; for 1h; Reagent/catalyst; Inert atmosphere;93%
In 1-methyl-pyrrolidin-2-one at -25 - -20℃; for 5h; Temperature;86.72%
In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 5℃; for 5h; Product distribution / selectivity;68%
neratinib maleate

neratinib maleate

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
With sodium hydroxide In methanol88.7%
With triethylamine In ethanol; acetonitrile at 73℃;
3-chloro-4-(2-pyridylmethoxy)aniline
524955-09-7

3-chloro-4-(2-pyridylmethoxy)aniline

4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile
848133-88-0

4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
With pyridine hydrochloride In isopropyl alcohol Heating;85%
2-chloro 4-aminophenol
3964-52-1

2-chloro 4-aminophenol

2-chloromethylpyridine hydrochloride
6959-47-3

2-chloromethylpyridine hydrochloride

4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile
848133-88-0

4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: 2-chloro 4-aminophenol; 2-chloromethylpyridine hydrochloride; 4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile In tetrahydrofuran at 65℃; for 6h; Inert atmosphere;
Stage #2: With potassium carbonate; potassium iodide In tetrahydrofuran at 60℃; for 16h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
82.73%
4-[4-(2-pyridylmethoxy)-3-chloro]amino-6-amino-3-cyano-7-ethoxyquinoline

4-[4-(2-pyridylmethoxy)-3-chloro]amino-6-amino-3-cyano-7-ethoxyquinoline

(2E)-(N,N-dimethylamino)-2-butenoyl chloride
1056149-69-9

(2E)-(N,N-dimethylamino)-2-butenoyl chloride

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: 4-[4-(2-pyridylmethoxy)-3-chloro]amino-6-amino-3-cyano-7-ethoxyquinoline; (2E)-(N,N-dimethylamino)-2-butenoyl chloride With 1-methyl-pyrrolidin-2-one In tetrahydrofuran for 3 - 16h;
Stage #2: With water In tetrahydrofuran at 40℃;
Stage #3: With sodium hydroxide In tetrahydrofuran; water pH=10 - 11;
80%
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
848139-78-6

6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 30℃; for 2h;
Stage #2: 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 5℃; for 3 - 16h;
80%
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
848139-78-6

6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile

(E)-4-(dimethylamino)-2-butenoic acid hydrochloride

(E)-4-(dimethylamino)-2-butenoic acid hydrochloride

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 30℃; for 2.25h;
Stage #2: 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 10℃; for 20.5h;
52%
(2E)-(N,N-dimethylamino)-2-butenoyl chloride
1056149-69-9

(2E)-(N,N-dimethylamino)-2-butenoyl chloride

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C
2: 85 percent / pyridine hydrochloride / propan-2-ol / Heating
View Scheme
4-Chloro-7-ethoxy-6-nitro-quinoline-3-carbonitrile
214476-09-2

4-Chloro-7-ethoxy-6-nitro-quinoline-3-carbonitrile

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: iron; AcOH; NaOAc / methanol / Heating
2: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C
3: 85 percent / pyridine hydrochloride / propan-2-ol / Heating
View Scheme
4-chloro-6-amino-7-ethoxyquinoline-3-carbonitrile
848133-87-9

4-chloro-6-amino-7-ethoxyquinoline-3-carbonitrile

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C
2: 85 percent / pyridine hydrochloride / propan-2-ol / Heating
View Scheme
(E)-4-(dimethylamino)-2-butenoic acid hydrochloride

(E)-4-(dimethylamino)-2-butenoic acid hydrochloride

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: oxalyl chloride; DMF / acetonitrile / 0.5 h / 60 °C
2: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C
3: 85 percent / pyridine hydrochloride / propan-2-ol / Heating
View Scheme
N-(4-[3-chloro-4-(pyridin-2-ylmethoxy)phenylamino]-3-cyano-7-ethoxyquinoline-6-yl)acetamide

N-(4-[3-chloro-4-(pyridin-2-ylmethoxy)phenylamino]-3-cyano-7-ethoxyquinoline-6-yl)acetamide

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water / Reflux
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C
3.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere
3.2: 3 h / -20 °C
View Scheme
2-chloro-4-nitrophenol
619-08-9

2-chloro-4-nitrophenol

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 50 - 60 °C
2.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux
3.1: methanesulfonic acid / ethanol / 2 h / Reflux
4.1: hydrogenchloride; water / Reflux
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C
6.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere
6.2: 3 h / -20 °C
View Scheme
2-chloromethylpyridine hydrochloride
6959-47-3

2-chloromethylpyridine hydrochloride

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 50 - 60 °C
2.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux
3.1: methanesulfonic acid / ethanol / 2 h / Reflux
4.1: hydrogenchloride; water / Reflux
5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C
6.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere
6.2: 3 h / -20 °C
View Scheme
2-((2-chloro-4-nitrophenoxy)methyl)pyridine
179687-79-7

2-((2-chloro-4-nitrophenoxy)methyl)pyridine

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux
2.1: methanesulfonic acid / ethanol / 2 h / Reflux
3.1: hydrogenchloride; water / Reflux
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C
5.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere
5.2: 3 h / -20 °C
View Scheme
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile
848133-76-6

7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanesulfonic acid / ethanol / 2 h / Reflux
2.1: hydrogenchloride; water / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C
4.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere
4.2: 3 h / -20 °C
View Scheme
Multi-step reaction with 3 steps
1: methanesulfonic acid / N,N-dimethyl-formamide / 70 - 75 °C
2: hydrogenchloride / water / 80 - 85 °C
3: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 15 h / 10 - 40 °C
View Scheme
3-chloro-4-(2-pyridylmethoxy)aniline
524955-09-7

3-chloro-4-(2-pyridylmethoxy)aniline

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: methanesulfonic acid / ethanol / 2 h / Reflux
2.1: hydrogenchloride; water / Reflux
3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C
4.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere
4.2: 3 h / -20 °C
View Scheme
Multi-step reaction with 3 steps
1: methanesulfonic acid / N,N-dimethyl-formamide / 70 - 75 °C
2: hydrogenchloride / water / 80 - 85 °C
3: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 15 h / 10 - 40 °C
View Scheme

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid / methanol / 4 h / 20 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
3-chloro-4-[(pyridin-2-yl)methoxy]-1-p-toluenesulfonyloxybenzene

3-chloro-4-[(pyridin-2-yl)methoxy]-1-p-toluenesulfonyloxybenzene

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / acetonitrile / 6 h / -20 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
4-(4-((pyridin-2-yl)methoxy)-3-chloroaniline)-7-ethoxy-6-nitro-3-cyano quinoline

4-(4-((pyridin-2-yl)methoxy)-3-chloroaniline)-7-ethoxy-6-nitro-3-cyano quinoline

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
2: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
4-amino-7-ethoxy-3-cyano-6-nitro quinoline

4-amino-7-ethoxy-3-cyano-6-nitro quinoline

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / methanol / 4 h / 20 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / acetonitrile / 6 h / -20 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: methanesulfonic acid / ethanol / 2 h / 70 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
2-((4-bromo-2-chlorophenoxy)methyl)pyridine

2-((4-bromo-2-chlorophenoxy)methyl)pyridine

neratinib
698387-09-6

neratinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanesulfonic acid / ethanol / 2 h / 70 °C / Inert atmosphere
2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere
View Scheme
maleic acid
110-16-7

maleic acid

neratinib
698387-09-6

neratinib

(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide maleate

(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide maleate

Conditions
ConditionsYield
In ethanol; water at 20℃; for 1h; Inert atmosphere;98%
With pyrographite In water; acetone at 20 - 40℃; for 0.666667h; Temperature; Solvent;87.7%
In water; isopropyl alcohol Product distribution / selectivity;84%
neratinib
698387-09-6

neratinib

(E)-4-((4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide
1376615-55-2

(E)-4-((4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide

Conditions
ConditionsYield
Stage #1: neratinib With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 4h;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water
10%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 4h;10%
maleic acid
110-16-7

maleic acid

neratinib
698387-09-6

neratinib

neratinib maleate monohydrate
1144516-12-0

neratinib maleate monohydrate

Conditions
ConditionsYield
With water In propan-1-ol at 25 - 60℃; Product distribution / selectivity;

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View