we are Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well.
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inquiry100% owned factory, regulatory compliance and be audited.Appearance:off- white powder Application:Commercial
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiry1. Usage of Neratinib Anti-Cancer 2. Sinoway's advantage: (1) ISO 9001:2008 certificated company (2) 28 years in pharmaceutical industry (3)China office of Fischer Chemicals AG (Switzerland) Appearance: white crystalline powde
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White powder Storage:2-8°C Package:1g/vial; 10g/bottle Applic
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inquirySleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric
Neratinib CAS No.:698387-09-6 Name: Neratinib Synonyms: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide; HKI-2
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryHigh quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce
Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:698387-09-6
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inquiryName:Neratinib The alias:(2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide; CAS NO:698387-09-6 Molecular formula:C30H29ClN6O3 Molecular weight:557.0427 Product Quality 12 y
Cas:698387-09-6
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inquiryCompetitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me
With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:698387-09-6
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:698387-09-6
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inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam
Cas:698387-09-6
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:698387-09-6
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inquiryName:Neratinib CAS:698387-09-6 MF:C30H29ClN6O3 MW:557.0427 Purity:98% Density:1.337g/cm3 Boiling Point:756.97°C Flash Point:411.601°C Application:Neratinib(HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of
Cas:698387-09-6
Min.Order:10 Gram
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:698387-09-6
Min.Order:10 Gram
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Type:Trading Company
inquiryNeratinib CAS:698387-09-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:698387-09-6
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:698387-09-6
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inquiryAPI name: Neratinib Certificates: GMP DMF CAS No.: 698387-09-6 Chemical name: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide; (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)a
Cas:698387-09-6
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inquiryNeratinib CAS: 698387-09-6 Specification Test Item Analysis Specification Result Description crystalline powder Conforms Melting range 129&
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:698387-09-6
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inquiryAppearance:off-white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingdao/Shangha
Cas:698387-09-6
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:698387-09-6
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:698387-09-6
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inquiry6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
4-N,N-dimethylaminocrotonoylchloride Hydrochloride
neratinib
Conditions | Yield |
---|---|
With sodium hydroxide In 1-methyl-pyrrolidin-2-one; water at 10 - 40℃; for 15h; Solvent; | 98% |
2-(N,N-dimethylamino)ethoxide
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate
neratinib
Conditions | Yield |
---|---|
Stage #1: diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate With sodium ethanolate; lithium chloride In ethanol at -5℃; for 0.5h; Stage #2: 2-(N,N-dimethylamino)ethoxide In ethanol for 0.666667h; Temperature; Solvent; Reagent/catalyst; | 95.9% |
dimethylaminoacetaldehyde diethyl acetal
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate
neratinib
Conditions | Yield |
---|---|
Stage #1: dimethylaminoacetaldehyde diethyl acetal With hydrogenchloride; water at 0 - 40℃; Inert atmosphere; Stage #2: diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate With sodium ethanolate; lithium chloride In ethanol; water at -20℃; for 3h; | 95.2% |
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
Stage #1: (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 5℃; Inert atmosphere; Stage #2: 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile In 1-methyl-pyrrolidin-2-one; dichloromethane at 10 - 25℃; | 95% |
diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate
neratinib
Conditions | Yield |
---|---|
Stage #1: diethyl ({[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]carbamoyl}methyl)phosphonate With sodium ethanolate; lithium chloride In ethanol at 0℃; for 0.5h; Stage #2: dimethylaminoacetaldehyde-sodium bisulfite adduct In ethanol for 3h; | 94.1% |
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
trans-4-dimethylamino crotonic acid chloride hydrochloride salt
neratinib
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 10℃; for 1h; Reagent/catalyst; Inert atmosphere; | 93% |
In 1-methyl-pyrrolidin-2-one at -25 - -20℃; for 5h; Temperature; | 86.72% |
In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 5℃; for 5h; Product distribution / selectivity; | 68% |
neratinib
Conditions | Yield |
---|---|
With sodium hydroxide In methanol | 88.7% |
With triethylamine In ethanol; acetonitrile at 73℃; |
3-chloro-4-(2-pyridylmethoxy)aniline
4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
With pyridine hydrochloride In isopropyl alcohol Heating; | 85% |
2-chloro 4-aminophenol
2-chloromethylpyridine hydrochloride
4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
Stage #1: 2-chloro 4-aminophenol; 2-chloromethylpyridine hydrochloride; 4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile In tetrahydrofuran at 65℃; for 6h; Inert atmosphere; Stage #2: With potassium carbonate; potassium iodide In tetrahydrofuran at 60℃; for 16h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 82.73% |
(2E)-(N,N-dimethylamino)-2-butenoyl chloride
neratinib
Conditions | Yield |
---|---|
Stage #1: 4-[4-(2-pyridylmethoxy)-3-chloro]amino-6-amino-3-cyano-7-ethoxyquinoline; (2E)-(N,N-dimethylamino)-2-butenoyl chloride With 1-methyl-pyrrolidin-2-one In tetrahydrofuran for 3 - 16h; Stage #2: With water In tetrahydrofuran at 40℃; Stage #3: With sodium hydroxide In tetrahydrofuran; water pH=10 - 11; | 80% |
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 30℃; for 2h; Stage #2: 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 5℃; for 3 - 16h; | 80% |
6-amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 30℃; for 2.25h; Stage #2: 6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 10℃; for 20.5h; | 52% |
(2E)-(N,N-dimethylamino)-2-butenoyl chloride
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C 2: 85 percent / pyridine hydrochloride / propan-2-ol / Heating View Scheme |
4-Chloro-7-ethoxy-6-nitro-quinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: iron; AcOH; NaOAc / methanol / Heating 2: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C 3: 85 percent / pyridine hydrochloride / propan-2-ol / Heating View Scheme |
4-chloro-6-amino-7-ethoxyquinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C 2: 85 percent / pyridine hydrochloride / propan-2-ol / Heating View Scheme |
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: oxalyl chloride; DMF / acetonitrile / 0.5 h / 60 °C 2: 7.97 g / 1-methyl-pyrrolidin-2-one / 2.5 h / 0 - 20 °C 3: 85 percent / pyridine hydrochloride / propan-2-ol / Heating View Scheme |
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride; water / Reflux 2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C 3.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere 3.2: 3 h / -20 °C View Scheme |
2-chloro-4-nitrophenol
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 50 - 60 °C 2.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux 3.1: methanesulfonic acid / ethanol / 2 h / Reflux 4.1: hydrogenchloride; water / Reflux 5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C 6.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere 6.2: 3 h / -20 °C View Scheme |
2-chloromethylpyridine hydrochloride
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 50 - 60 °C 2.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux 3.1: methanesulfonic acid / ethanol / 2 h / Reflux 4.1: hydrogenchloride; water / Reflux 5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C 6.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere 6.2: 3 h / -20 °C View Scheme |
2-((2-chloro-4-nitrophenoxy)methyl)pyridine
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: iron; ammonium chloride / ethanol; water / 1 h / Reflux 2.1: methanesulfonic acid / ethanol / 2 h / Reflux 3.1: hydrogenchloride; water / Reflux 4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C 5.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere 5.2: 3 h / -20 °C View Scheme |
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanesulfonic acid / ethanol / 2 h / Reflux 2.1: hydrogenchloride; water / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C 4.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere 4.2: 3 h / -20 °C View Scheme | |
Multi-step reaction with 3 steps 1: methanesulfonic acid / N,N-dimethyl-formamide / 70 - 75 °C 2: hydrogenchloride / water / 80 - 85 °C 3: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 15 h / 10 - 40 °C View Scheme |
3-chloro-4-(2-pyridylmethoxy)aniline
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanesulfonic acid / ethanol / 2 h / Reflux 2.1: hydrogenchloride; water / Reflux 3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 5 h / 40 °C 4.1: hydrogenchloride; water / 0 - 40 °C / Inert atmosphere 4.2: 3 h / -20 °C View Scheme | |
Multi-step reaction with 3 steps 1: methanesulfonic acid / N,N-dimethyl-formamide / 70 - 75 °C 2: hydrogenchloride / water / 80 - 85 °C 3: sodium hydroxide / water; 1-methyl-pyrrolidin-2-one / 15 h / 10 - 40 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trifluoroacetic acid / methanol / 4 h / 20 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme |
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / acetonitrile / 6 h / -20 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme |
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 2: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme |
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid / N,N-dimethyl-formamide / 1 h / 150 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: trifluoroacetic acid / methanol / 4 h / 20 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: toluene-4-sulfonic acid / acetonitrile / 6 h / -20 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: methanesulfonic acid / ethanol / 2 h / 70 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme |
neratinib
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanesulfonic acid / ethanol / 2 h / 70 °C / Inert atmosphere 2: platinum on carbon; hydrogen / tetrahydrofuran / 6 h / 25 - 30 °C / 1292.9 Torr 3: triethylamine / tetrahydrofuran / 1 h / 0 - 10 °C / Inert atmosphere View Scheme |
maleic acid
neratinib
Conditions | Yield |
---|---|
In ethanol; water at 20℃; for 1h; Inert atmosphere; | 98% |
With pyrographite In water; acetone at 20 - 40℃; for 0.666667h; Temperature; Solvent; | 87.7% |
In water; isopropyl alcohol Product distribution / selectivity; | 84% |
neratinib
(E)-4-((4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide
Conditions | Yield |
---|---|
Stage #1: neratinib With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 4h; Stage #2: With sodium hydrogencarbonate In dichloromethane; water | 10% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 4h; | 10% |
Conditions | Yield |
---|---|
With water In propan-1-ol at 25 - 60℃; Product distribution / selectivity; |
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