Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a
Cas:706779-91-1
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:706779-91-1
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inquiryPimavanserin CAS No.:706779-91-1 Name: Pimavanserin Synonyms 1-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea Molecular Structure Molecular Formula: C25H34FN3O2
Cas:706779-91-1
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:706779-91-1
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inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Pimavanserin Basic information Parkinson's treatment Uses Product Name: Pimavanserin Synonyms: Pimavanserin;PIMAVANSERIN/1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1-METHYLPIPERIDIN-4-YL)UREA;Unii-jz963p0dik;Pimavamserin;1-[(4-fluorophenyl
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inquiryTIANFUCHEM-- 706779-91-1--High purity Pimavanserin in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business
Cas:706779-91-1
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:706779-91-1
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:706779-91-1
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,
Pimavanserin CAS:706779-91-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:706779-91-1
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:706779-91-1
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
Cas:706779-91-1
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:706779-91-1
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inquiryPimavanserinAppearance:White fine powder Storage:Kept in a cool,dry and ventilated place Package:according to customers' requirements Application:Meets the requirements Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in
Cas:706779-91-1
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Product name: Pimavanserin CAS No.:706779-91-1 Molecule Formula:C25H34FN3O2 Molecule Weight:427.55 Purity: 98% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SP
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:706779-91-1
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inquiryHangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:706779-91-1
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inquiryN-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
In toluene at 50℃; for 15h; | 100% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
1-[4-(2-methylpropyloxy)phenyl]methanamine
1,1'-carbonyldiimidazole
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In toluene at 20℃; for 1h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 50℃; for 15h; | 96% |
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 18 - 22℃; for 12h; Temperature; | 85% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With potassium carbonate at 65 - 70℃; for 18h; | 95.6% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
di(succinimido) carbonate
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine; di(succinimido) carbonate With 4-methyl-morpholine In dichloromethane at -5 - 25℃; for 5h; Stage #2: 1-[4-(2-methylpropyloxy)phenyl]methanamine In dichloromethane at 25℃; for 10h; Solvent; Temperature; Time; | 95% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With silver carbonate In acetonitrile at 20℃; for 24h; Reagent/catalyst; Green chemistry; | 94.2% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With potassium carbonate In toluene at 90℃; for 24h; Reagent/catalyst; Temperature; | 92% |
With triethylamine In ethanol for 6h; Reflux; | 91% |
With triethylamine In ethanol for 12h; Reflux; Green chemistry; | 84.5% |
4-isobutoxybenzaldehyde
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea; 4-isobutoxybenzaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 10h; Stage #2: With sodium tetrahydroborate at -5 - 0℃; for 6h; | 92% |
With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid In toluene for 24h; Reagent/catalyst; Solvent; Time; Inert atmosphere; | 82% |
1,1'-carbonyldiimidazole
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; for 10h; | 90.4% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
1,1'-carbonyldiimidazole
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With triethylamine In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 15 - 25℃; for 8h; | 90.3% |
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With N,N'-bis(4-isobutoxybenzyl)urea; potassium carbonate In toluene at 65 - 80℃; for 5h; Reagent/catalyst; Temperature; | 90% |
With triethylamine In acetonitrile at 50 - 60℃; for 12h; | 75% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
(4-Isobutoxy-phenyl)-acetic acid hydrazide
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium nitrite In dichloromethane; water at 15 - 110℃; under 11251.1 Torr; for 0.0611111h; Time; Solvent; Temperature; | 90% |
potassium cyanate
4-isobutoxybenzaldehyde
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: potassium cyanate; N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride In methanol for 4h; Stage #2: 4-isobutoxybenzaldehyde With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid for 4h; Reflux; | 88% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
In toluene at 25 - 55℃; for 15h; | 83.19% |
In tetrahydrofuran at 60℃; for 4h; | 70% |
In toluene Solvent; Reflux; | |
In N,N-dimethyl-formamide; acetonitrile at 60℃; for 2h; Temperature; Solvent; Sealed tube; | 704.3 mg |
With potassium tert-butylate In toluene at 25 - 55℃; for 15h; Reflux; | 16 g |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
at 120 - 130℃; for 12h; Green chemistry; | 83.1% |
In toluene |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
In toluene at 50℃; for 15h; | 100% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
1-[4-(2-methylpropyloxy)phenyl]methanamine
1,1'-carbonyldiimidazole
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In toluene at 20℃; for 1h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 50℃; for 15h; | 96% |
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 18 - 22℃; for 12h; Temperature; | 85% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With potassium carbonate at 65 - 70℃; for 18h; | 95.6% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
di(succinimido) carbonate
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine; di(succinimido) carbonate With 4-methyl-morpholine In dichloromethane at -5 - 25℃; for 5h; Stage #2: 1-[4-(2-methylpropyloxy)phenyl]methanamine In dichloromethane at 25℃; for 10h; Solvent; Temperature; Time; | 95% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With silver carbonate In acetonitrile at 20℃; for 24h; Reagent/catalyst; Green chemistry; | 94.2% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With potassium carbonate In toluene at 90℃; for 24h; Reagent/catalyst; Temperature; | 92% |
With triethylamine In ethanol for 6h; Reflux; | 91% |
With triethylamine In ethanol for 12h; Reflux; Green chemistry; | 84.5% |
4-isobutoxybenzaldehyde
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea; 4-isobutoxybenzaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 10h; Stage #2: With sodium tetrahydroborate at -5 - 0℃; for 6h; | 92% |
With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid In toluene for 24h; Reagent/catalyst; Solvent; Time; Inert atmosphere; | 82% |
1,1'-carbonyldiimidazole
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; for 10h; | 90.4% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
1,1'-carbonyldiimidazole
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With triethylamine In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 15 - 25℃; for 8h; | 90.3% |
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With N,N'-bis(4-isobutoxybenzyl)urea; potassium carbonate In toluene at 65 - 80℃; for 5h; Reagent/catalyst; Temperature; | 90% |
With triethylamine In acetonitrile at 50 - 60℃; for 12h; | 75% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
(4-Isobutoxy-phenyl)-acetic acid hydrazide
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium nitrite In dichloromethane; water at 15 - 110℃; under 11251.1 Torr; for 0.0611111h; Time; Solvent; Temperature; | 90% |
potassium cyanate
4-isobutoxybenzaldehyde
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: potassium cyanate; N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride In methanol for 4h; Stage #2: 4-isobutoxybenzaldehyde With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid for 4h; Reflux; | 88% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
In toluene at 25 - 55℃; for 15h; | 83.19% |
In tetrahydrofuran at 60℃; for 4h; | 70% |
In toluene Solvent; Reflux; | |
In N,N-dimethyl-formamide; acetonitrile at 60℃; for 2h; Temperature; Solvent; Sealed tube; | 704.3 mg |
With potassium tert-butylate In toluene at 25 - 55℃; for 15h; Reflux; | 16 g |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
at 120 - 130℃; for 12h; Green chemistry; | 83.1% |
In toluene |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
1-[4-(2-methylpropyloxy)phenyl]methanamine
phenyl chloroformate
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; phenyl chloroformate With triethylamine In acetonitrile at 0 - 20℃; for 2h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine With triethylamine In acetonitrile at 60℃; for 12h; | 83% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
di-tert-butyl dicarbonate
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: di-tert-butyl dicarbonate; 1-[4-(2-methylpropyloxy)phenyl]methanamine With dmap; triethylamine In dichloromethane at -18 - -5℃; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at -5 - 35℃; for 0.5h; | 83% |
Stage #1: di-tert-butyl dicarbonate; 1-[4-(2-methylpropyloxy)phenyl]methanamine With dmap In acetonitrile at -10℃; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 50℃; for 15h; |
bis(trichloromethyl) carbonate
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: bis(trichloromethyl) carbonate; 4-isobutoxybenzylamine hydrochloride With N-ethyl-N,N-diisopropylamine In chloroform at -5 - 5℃; for 1h; Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In chloroform at 15 - 25℃; for 6h; | 82.4% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With potassium carbonate In Isopropyl acetate at 50 - 60℃; for 6h; Solvent; Temperature; | 82% |
at 80℃; for 3h; | 20.3 g |
1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; Large scale; | 81.6% |
In tetrahydrofuran at 25℃; for 16h; Solvent; | 63.8% |
In tetrahydrofuran at 20℃; for 16h; | 60.4% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
bis(trichloromethyl) carbonate
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: bis(trichloromethyl) carbonate; 1-[4-(2-methylpropyloxy)phenyl]methanamine With triethylamine In dichloromethane at -5 - 5℃; for 1h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 15 - 25℃; for 5h; Temperature; Solvent; | 81.6% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 0 - 20℃; for 2h; | 81% |
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With dmap In 1,4-dioxane at 75℃; for 15h; Solvent; Reagent/catalyst; Temperature; | 78.5% |
4-Nitrophenyl chloroformate
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 4-isobutoxybenzylamine acetate; 4-Nitrophenyl chloroformate With triethylamine In dichloromethane at 0 - 5℃; for 0.5h; Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate With triethylamine In dichloromethane at 15 - 25℃; for 10h; | 78.1% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: N-(4-isobutoxybenzyl)formamide With bis(trichloromethyl) carbonate; triethylamine In dichloromethane at 0 - 20℃; Green chemistry; Stage #2: With trifluoromethylsulfonic anhydride; dimethyl sulfoxide at -65 - -60℃; Inert atmosphere; Green chemistry; Stage #3: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at -65 - 20℃; Inert atmosphere; Green chemistry; | 77.7% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
1-[4-(2-methylpropyloxy)phenyl]methanamine
4-Nitrophenyl chloroformate
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 4-Nitrophenyl chloroformate With triethylamine In acetonitrile at 0 - 20℃; for 2h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine With triethylamine In acetonitrile at 0 - 20℃; for 12h; Cooling with ice; | 74% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid In acetonitrile at 50℃; for 24h; Inert atmosphere; | 74% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine With dmap; di-tert-butyl dicarbonate; triethylamine In dichloromethane at -5 - 5℃; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 0 - 5℃; for 2h; Reagent/catalyst; Further stages; | 72% |
1-[4-(2-methylpropyloxy)phenyl]methanamine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 40℃; for 10h; | 71.8% |
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
Conditions | Yield |
---|---|
Stage #1: methyl (4-isobutoxybenzyl)carbamate With triethylamine In toluene at 0 - 10℃; for 0.5h; Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 80℃; for 12h; | 71% |
at 120℃; for 0.24h; Time; Temperature; | 22% |
With potassium tert-butylate In toluene for 5h; Reflux; | 14 g |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
L-Tartaric acid
Conditions | Yield |
---|---|
In n-heptane; acetone at 20 - 50℃; for 10h; Solvent; | 99% |
In ethanol at -5 - 50℃; for 16h; | 85% |
In ethanol at 20 - 50℃; for 17h; | 104.6 g |
In ethanol at 20 - 50℃; for 2h; | 21.9 g |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
toluene-4-sulfonic acid
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 42℃; for 5h; | 97.9% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
L-Tartaric acid
Conditions | Yield |
---|---|
In tert-butyl methyl ether; acetone at 50 - 55℃; for 1h; | 95% |
In dichloromethane; isopropyl alcohol at 70℃; for 5h; Inert atmosphere; | 93% |
In dichloromethane; isopropyl alcohol at 0 - 70℃; for 7h; Inert atmosphere; | 93% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
cyclohexylsulfamic acid
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 42℃; for 5h; | 93.7% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
L-Tartaric acid
Conditions | Yield |
---|---|
In ethanol at 30 - 50℃; for 2h; | 85% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
D-tartaric acid
Conditions | Yield |
---|---|
In ethanol | 85% |
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