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Hangzhou Hysen Pharma co.,Ltd.

Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We own a

Pimavanserin factory

Cas:706779-91-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 706779-91-1 Pimavanserin

Cas:706779-91-1

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Pimavanserin CAS No.:706779-91-1 Name: Pimavanserin Synonyms 1-(4-Fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea Molecular Structure Molecular Formula: C25H34FN3O2

High purity Pimavanserin CAS No.:706779-91-1

Cas:706779-91-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Pimavanserin Manufacturer/High quality/Best price/In stock

Cas:706779-91-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Pimavanserin

Cas:706779-91-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

High purity 99% Pimavanserin powder

Cas:706779-91-1

Min.Order:1 Kilogram

FOB Price: $450.0 / 800.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Pimavanserin

Cas:706779-91-1

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

inquiry

Ality Chemical Corporation

Pimavanserin Basic information Parkinson's treatment Uses Product Name: Pimavanserin Synonyms: Pimavanserin;PIMAVANSERIN/1-(4-FLUOROBENZYL)-3-(4-ISOBUTOXYBENZYL)-1-(1-METHYLPIPERIDIN-4-YL)UREA;Unii-jz963p0dik;Pimavamserin;1-[(4-fluorophenyl

Factory Supply Pimavanserin

Cas:706779-91-1

Min.Order:1 Gram

FOB Price: $1.0 / 3.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 706779-91-1--High purity Pimavanserin in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business

TIANFUCHEM-- 706779-91-1--High purity Pimavanserin in stock

Cas:706779-91-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 706779-91-1 with competitive price

Cas:706779-91-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

ACP-103 Pimavanserin Raw Powder CAS: 706779-91-1

Cas:706779-91-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present,

Pimavanserin

Cas:706779-91-1

Min.Order:1 Gram

FOB Price: $120.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Pimavanserin CAS:706779-91-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Pimavanserin CAS:706779-91-1

Cas:706779-91-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Urea,N-[(4-fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]-

Cas:706779-91-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Treating Parkinson API Of Pimavanserin Powder With High Quality 99% Pimavanserin

Cas:706779-91-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:706779-91-1

Cas:706779-91-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--Pimavanserin

Cas:706779-91-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Pimavanserin 706779-91-1

Cas:706779-91-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

PIMAVANSERIN

Cas:706779-91-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Urea,N-[(4-fluorophenyl)methyl]-N-(1-methyl-4-piperidinyl)-N'-[[4-(2-methylpropoxy)phenyl]methyl]-

Cas:706779-91-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Pimavanserin

Cas:706779-91-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

PimavanserinAppearance:White fine powder Storage:Kept in a cool,dry and ventilated place Package:according to customers' requirements Application:Meets the requirements Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or

Pimavanserin

Cas:706779-91-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in

Pimavanserin

Cas:706779-91-1

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Pimavanserin

Cas:706779-91-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Pimavanserin CAS No.:706779-91-1 Molecule Formula:C25H34FN3O2 Molecule Weight:427.55 Purity: 98% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SP

High Quality Pimavanserin in stock

Cas:706779-91-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Pimavanserin

Cas:706779-91-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--Pimavanserin

Cas:706779-91-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Pimavanserin

Cas:706779-91-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--Pimavanserin

Cas:706779-91-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-[4-(2-methylpropyloxy)phenyl]methanamino acetate

1-[4-(2-methylpropyloxy)phenyl]methanamino acetate

C18H24FN4O(1+)*I(1-)

C18H24FN4O(1+)*I(1-)

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
In toluene at 50℃; for 15h;100%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In toluene at 20℃; for 1h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 50℃; for 15h;
96%
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 18 - 22℃; for 12h; Temperature;
85%
N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With potassium carbonate at 65 - 70℃; for 18h;95.6%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine; di(succinimido) carbonate With 4-methyl-morpholine In dichloromethane at -5 - 25℃; for 5h;
Stage #2: 1-[4-(2-methylpropyloxy)phenyl]methanamine In dichloromethane at 25℃; for 10h; Solvent; Temperature; Time;
95%
1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)thiourea

1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)thiourea

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With silver carbonate In acetonitrile at 20℃; for 24h; Reagent/catalyst; Green chemistry;94.2%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

N-(4-isobutoxybenzyl)carbamic acid phenyl ester

N-(4-isobutoxybenzyl)carbamic acid phenyl ester

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With potassium carbonate In toluene at 90℃; for 24h; Reagent/catalyst; Temperature;92%
With triethylamine In ethanol for 6h; Reflux;91%
With triethylamine In ethanol for 12h; Reflux; Green chemistry;84.5%
1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea

1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea

4-isobutoxybenzaldehyde
18962-07-7

4-isobutoxybenzaldehyde

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea; 4-isobutoxybenzaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 10h;
Stage #2: With sodium tetrahydroborate at -5 - 0℃; for 6h;
92%
With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid In toluene for 24h; Reagent/catalyst; Solvent; Time; Inert atmosphere;82%
4-isobutoxybenzylamine acetate

4-isobutoxybenzylamine acetate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; for 10h;
90.4%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

4-isobutoxybenzylamine acetate

4-isobutoxybenzylamine acetate

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With triethylamine In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 15 - 25℃; for 8h;
90.3%
1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

phenyl (4-fluorobenzyl)(1-methylpiperidin-4-yl)carbamate

phenyl (4-fluorobenzyl)(1-methylpiperidin-4-yl)carbamate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With N,N'-bis(4-isobutoxybenzyl)urea; potassium carbonate In toluene at 65 - 80℃; for 5h; Reagent/catalyst; Temperature;90%
With triethylamine In acetonitrile at 50 - 60℃; for 12h;75%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

(4-Isobutoxy-phenyl)-acetic acid hydrazide
61904-59-4

(4-Isobutoxy-phenyl)-acetic acid hydrazide

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; sodium nitrite In dichloromethane; water at 15 - 110℃; under 11251.1 Torr; for 0.0611111h; Time; Solvent; Temperature;90%
potassium cyanate
590-28-3

potassium cyanate

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

4-isobutoxybenzaldehyde
18962-07-7

4-isobutoxybenzaldehyde

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: potassium cyanate; N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride In methanol for 4h;
Stage #2: 4-isobutoxybenzaldehyde With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid for 4h; Reflux;
88%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
In toluene at 25 - 55℃; for 15h;83.19%
In tetrahydrofuran at 60℃; for 4h;70%
In toluene Solvent; Reflux;
In N,N-dimethyl-formamide; acetonitrile at 60℃; for 2h; Temperature; Solvent; Sealed tube;704.3 mg
With potassium tert-butylate In toluene at 25 - 55℃; for 15h; Reflux;16 g
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

1-(4-isobutoxybenzyl)urea

1-(4-isobutoxybenzyl)urea

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
at 120 - 130℃; for 12h; Green chemistry;83.1%
In toluene
1-[4-(2-methylpropyloxy)phenyl]methanamino acetate

1-[4-(2-methylpropyloxy)phenyl]methanamino acetate

C18H24FN4O(1+)*I(1-)

C18H24FN4O(1+)*I(1-)

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
In toluene at 50℃; for 15h;100%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In toluene at 20℃; for 1h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 50℃; for 15h;
96%
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 18 - 22℃; for 12h; Temperature;
85%
N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With potassium carbonate at 65 - 70℃; for 18h;95.6%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine; di(succinimido) carbonate With 4-methyl-morpholine In dichloromethane at -5 - 25℃; for 5h;
Stage #2: 1-[4-(2-methylpropyloxy)phenyl]methanamine In dichloromethane at 25℃; for 10h; Solvent; Temperature; Time;
95%
1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)thiourea

1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)thiourea

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With silver carbonate In acetonitrile at 20℃; for 24h; Reagent/catalyst; Green chemistry;94.2%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

N-(4-isobutoxybenzyl)carbamic acid phenyl ester

N-(4-isobutoxybenzyl)carbamic acid phenyl ester

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With potassium carbonate In toluene at 90℃; for 24h; Reagent/catalyst; Temperature;92%
With triethylamine In ethanol for 6h; Reflux;91%
With triethylamine In ethanol for 12h; Reflux; Green chemistry;84.5%
1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea

1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea

4-isobutoxybenzaldehyde
18962-07-7

4-isobutoxybenzaldehyde

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea; 4-isobutoxybenzaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 10h;
Stage #2: With sodium tetrahydroborate at -5 - 0℃; for 6h;
92%
With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid In toluene for 24h; Reagent/catalyst; Solvent; Time; Inert atmosphere;82%
4-isobutoxybenzylamine acetate

4-isobutoxybenzylamine acetate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate With N-ethyl-N,N-diisopropylamine In dichloromethane at 15 - 25℃; for 10h;
90.4%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

4-isobutoxybenzylamine acetate

4-isobutoxybenzylamine acetate

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 4-isobutoxybenzylamine acetate; 1,1'-carbonyldiimidazole With triethylamine In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 15 - 25℃; for 8h;
90.3%
1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

phenyl (4-fluorobenzyl)(1-methylpiperidin-4-yl)carbamate

phenyl (4-fluorobenzyl)(1-methylpiperidin-4-yl)carbamate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With N,N'-bis(4-isobutoxybenzyl)urea; potassium carbonate In toluene at 65 - 80℃; for 5h; Reagent/catalyst; Temperature;90%
With triethylamine In acetonitrile at 50 - 60℃; for 12h;75%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

(4-Isobutoxy-phenyl)-acetic acid hydrazide
61904-59-4

(4-Isobutoxy-phenyl)-acetic acid hydrazide

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; sodium nitrite In dichloromethane; water at 15 - 110℃; under 11251.1 Torr; for 0.0611111h; Time; Solvent; Temperature;90%
potassium cyanate
590-28-3

potassium cyanate

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride

4-isobutoxybenzaldehyde
18962-07-7

4-isobutoxybenzaldehyde

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: potassium cyanate; N-(4-fluorobenzyl)-1-methylpiperidine-4-amine dihydrochloride In methanol for 4h;
Stage #2: 4-isobutoxybenzaldehyde With 1,1,3,3-Tetramethyldisiloxane; trifluoroacetic acid for 4h; Reflux;
88%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(4-(2-methylpropyloxy)phenylmethyl)imidazol-1-ylcarboxamide

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
In toluene at 25 - 55℃; for 15h;83.19%
In tetrahydrofuran at 60℃; for 4h;70%
In toluene Solvent; Reflux;
In N,N-dimethyl-formamide; acetonitrile at 60℃; for 2h; Temperature; Solvent; Sealed tube;704.3 mg
With potassium tert-butylate In toluene at 25 - 55℃; for 15h; Reflux;16 g
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

1-(4-isobutoxybenzyl)urea

1-(4-isobutoxybenzyl)urea

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
at 120 - 130℃; for 12h; Green chemistry;83.1%
In toluene
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

phenyl chloroformate
1885-14-9

phenyl chloroformate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; phenyl chloroformate With triethylamine In acetonitrile at 0 - 20℃; for 2h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine With triethylamine In acetonitrile at 60℃; for 12h;
83%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: di-tert-butyl dicarbonate; 1-[4-(2-methylpropyloxy)phenyl]methanamine With dmap; triethylamine In dichloromethane at -18 - -5℃;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at -5 - 35℃; for 0.5h;
83%
Stage #1: di-tert-butyl dicarbonate; 1-[4-(2-methylpropyloxy)phenyl]methanamine With dmap In acetonitrile at -10℃;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 50℃; for 15h;
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine p-toluenesulfonate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine p-toluenesulfonate

4-isobutoxybenzylamine hydrochloride

4-isobutoxybenzylamine hydrochloride

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; 4-isobutoxybenzylamine hydrochloride With N-ethyl-N,N-diisopropylamine In chloroform at -5 - 5℃; for 1h;
Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine p-toluenesulfonate With N-ethyl-N,N-diisopropylamine In chloroform at 15 - 25℃; for 6h;
82.4%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

C16H20N2O5

C16H20N2O5

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With potassium carbonate In Isopropyl acetate at 50 - 60℃; for 6h; Solvent; Temperature;82%
at 80℃; for 3h;20.3 g
1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene
639863-75-5

1-(isocyanatomethyl)-4-(2-methylpropoxy)benzene

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 2h; Large scale;81.6%
In tetrahydrofuran at 25℃; for 16h; Solvent;63.8%
In tetrahydrofuran at 20℃; for 16h;60.4%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; 1-[4-(2-methylpropyloxy)phenyl]methanamine With triethylamine In dichloromethane at -5 - 5℃; for 1h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 15 - 25℃; for 5h; Temperature; Solvent;
81.6%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

4-nitrophenyl (4-isobutoxybenzyl)carbamate

4-nitrophenyl (4-isobutoxybenzyl)carbamate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With triethylamine In acetonitrile at 0 - 20℃; for 2h;81%
1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

(4-fluorobenzyl)(1-methylpiperidin-4-yl)carbamoyl chloride

(4-fluorobenzyl)(1-methylpiperidin-4-yl)carbamoyl chloride

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With dmap In 1,4-dioxane at 75℃; for 15h; Solvent; Reagent/catalyst; Temperature;78.5%
4-isobutoxybenzylamine acetate

4-isobutoxybenzylamine acetate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate

N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 4-isobutoxybenzylamine acetate; 4-Nitrophenyl chloroformate With triethylamine In dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: N-(4-fluorobenzyl)-1-methylpiperidin-4-amine oxalate With triethylamine In dichloromethane at 15 - 25℃; for 10h;
78.1%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

N-(4-isobutoxybenzyl)formamide

N-(4-isobutoxybenzyl)formamide

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: N-(4-isobutoxybenzyl)formamide With bis(trichloromethyl) carbonate; triethylamine In dichloromethane at 0 - 20℃; Green chemistry;
Stage #2: With trifluoromethylsulfonic anhydride; dimethyl sulfoxide at -65 - -60℃; Inert atmosphere; Green chemistry;
Stage #3: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at -65 - 20℃; Inert atmosphere; Green chemistry;
77.7%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine; 4-Nitrophenyl chloroformate With triethylamine In acetonitrile at 0 - 20℃; for 2h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine With triethylamine In acetonitrile at 0 - 20℃; for 12h; Cooling with ice;
74%
1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea

1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)urea

sodium hydroxy(4-isobutoxyphenyl)methanesulfonate

sodium hydroxy(4-isobutoxyphenyl)methanesulfonate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With triethylsilane; trifluoroacetic acid In acetonitrile at 50℃; for 24h; Inert atmosphere;74%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: 1-[4-(2-methylpropyloxy)phenyl]methanamine With dmap; di-tert-butyl dicarbonate; triethylamine In dichloromethane at -5 - 5℃;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In dichloromethane at 0 - 5℃; for 2h; Reagent/catalyst; Further stages;
72%
1-[4-(2-methylpropyloxy)phenyl]methanamine
4734-09-2

1-[4-(2-methylpropyloxy)phenyl]methanamine

4-((-4-fluorobenzyl)benzyloxycarbonylamino)-1-methylpiperidine

4-((-4-fluorobenzyl)benzyloxycarbonylamino)-1-methylpiperidine

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 40℃; for 10h;71.8%
N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine
359878-47-0

N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine

methyl (4-isobutoxybenzyl)carbamate

methyl (4-isobutoxybenzyl)carbamate

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

Conditions
ConditionsYield
Stage #1: methyl (4-isobutoxybenzyl)carbamate With triethylamine In toluene at 0 - 10℃; for 0.5h;
Stage #2: N- [(4-fluorophenyl)methyl]-1-methylpiperidin-4-amine In toluene at 80℃; for 12h;
71%
at 120℃; for 0.24h; Time; Temperature;22%
With potassium tert-butylate In toluene for 5h; Reflux;14 g
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

L-Tartaric acid
87-69-4

L-Tartaric acid

1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea L-hemitartrate

1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea L-hemitartrate

Conditions
ConditionsYield
In n-heptane; acetone at 20 - 50℃; for 10h; Solvent;99%
In ethanol at -5 - 50℃; for 16h;85%
In ethanol at 20 - 50℃; for 17h;104.6 g
In ethanol at 20 - 50℃; for 2h;21.9 g
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

C25H34FN3O2*C7H8O3S*H2O

C25H34FN3O2*C7H8O3S*H2O

Conditions
ConditionsYield
In ethyl acetate at 20 - 42℃; for 5h;97.9%
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

L-Tartaric acid
87-69-4

L-Tartaric acid

Pimavanserin tartrate

Pimavanserin tartrate

Conditions
ConditionsYield
In tert-butyl methyl ether; acetone at 50 - 55℃; for 1h;95%
In dichloromethane; isopropyl alcohol at 70℃; for 5h; Inert atmosphere;93%
In dichloromethane; isopropyl alcohol at 0 - 70℃; for 7h; Inert atmosphere;93%
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

cyclohexylsulfamic acid
100-88-9

cyclohexylsulfamic acid

C25H34FN3O2*H2O*C6H13NO3S

C25H34FN3O2*H2O*C6H13NO3S

Conditions
ConditionsYield
In ethyl acetate at 20 - 42℃; for 5h;93.7%
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

L-Tartaric acid
87-69-4

L-Tartaric acid

pimavanserin tartrate

pimavanserin tartrate

Conditions
ConditionsYield
In ethanol at 30 - 50℃; for 2h;85%
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

D-tartaric acid
147-71-7

D-tartaric acid

N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropoxy)phenylmethyl)urea hemi-tartrate

N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropoxy)phenylmethyl)urea hemi-tartrate

Conditions
ConditionsYield
In ethanol85%

Raw Materials

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