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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powder 2. Fact

Orellanine II CAS72016-31-0

Cas:72016-31-0

Min.Order:1 Kilogram

FOB Price: $5.0 / 30.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Orellanine II

Cas:72016-31-0

Min.Order:1 Gram

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Qingdao Beluga Import and Export Co., LTD

Orellanine II CAS:72016-31-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Orellanine II CAS:72016-31-0

Cas:72016-31-0

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Orellanine II

Cas:72016-31-0

Min.Order:1 Kilogram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Orellanine II

Cas:72016-31-0

Min.Order:0

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-hydroxy-2-(3-hydroxy-4-oxo-1H-pyridin-2-yl)-1H-pyridin-4-one

Cas:72016-31-0

Min.Order:10 Gram

FOB Price: $100.0

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

Min.Order:1 Gram

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

Min.Order:1 Metric Ton

FOB Price: $1.5

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

Min.Order:1 Metric Ton

FOB Price: $1.0

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

3-hydroxy-2-(3-hydroxy-4-oxo-1H-pyridin-2-yl)-1H-pyridin-4-one

Cas:72016-31-0

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

Orellanine II

Cas:72016-31-0

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Orellanine II

Cas:72016-31-0

Min.Order:0

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

Orellanine II

Cas:72016-31-0

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Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Orellanine II

Cas:72016-31-0

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Hubei Langyou International Trading Co., Ltd

Orellanine II CAS NO.72016-31-0 Application:Orellanine II CAS NO.72016-31-0

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

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DB BIOTECH CO., LTD

best seller Application:API

Orellanine II

Cas:72016-31-0

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Hangzhou Fandachem Co.,Ltd

ORELLANINEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

ORELLANINE

Cas:72016-31-0

Min.Order:0

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Type:Other

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Orellanine II

Cas:72016-31-0

Min.Order:0

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

72016-31-0

Cas:72016-31-0

Min.Order:0

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Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

Orellanine II

Cas:72016-31-0

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Hunan Longxianng Runhui Trading Co.,Ltd

Orellanine II CAS NO.72016-31-0Appearance:off-white fine crystalline powder Storage:Dry and ventilated Package:Standard or as customer's require Application:intermediates Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amou

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

Min.Order:0

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Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

Min.Order:0

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

Orellanine II

Cas:72016-31-0

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QINGDAO SUN TECH INDUSTRIES & TRADING CO., LTD

3,3'-dihydroxy-2,2'-bipyridine-4,4'(1H,1'H)-dione CAS 72016-31-0 Orellanine II Appearance:White powder. Storage:Stool in cool and dry place. Package:as per customers' request. Application:Reagents, intermediates, laboratory and

3,3'-dihydroxy-2,2'-bipyridine-4,4'(1H,1'H)-dione

Cas:72016-31-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

Orellanine II

Cas:72016-31-0

Min.Order:0

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Type:Lab/Research institutions

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Chungking Joyinchem Co., Ltd.

Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

Orellanine II

Cas:72016-31-0

Min.Order:0

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Shandong Jiashisheng Biotechnolgy Co.,Ltd

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

Orellanine II CAS NO.72016-31-0

Cas:72016-31-0

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Synthetic route

3,3',4,4'-tetramethoxy-2,2'-bipyridine
101664-55-5

3,3',4,4'-tetramethoxy-2,2'-bipyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
With hydrogen bromide In acetic acid for 5h; Heating;77%
With hydrogen bromide at 150℃; sealed tube, overnight;60%
With hydrogen bromide at 120℃;60%
3,3'-Bis<<2-(trimethylsilyl)ethoxy>methoxy>-2,2'-bipyridin-4,4'-diol
119767-30-5

3,3'-Bis<<2-(trimethylsilyl)ethoxy>methoxy>-2,2'-bipyridin-4,4'-diol

orelline
72016-31-0

orelline

Conditions
ConditionsYield
With hydrogenchloride In methanol for 1h; Heating;75%
4,4'-dihydroxy-3,3'-dimethoxy-2,2'-bipyridine
405137-22-6

4,4'-dihydroxy-3,3'-dimethoxy-2,2'-bipyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
With hydrogen bromide In acetic acid for 5h; Heating;71%
3,3'-dihyroxy-4,4'-dimethoxy-2,2'-bipyridyl
104819-53-6

3,3'-dihyroxy-4,4'-dimethoxy-2,2'-bipyridyl

orelline
72016-31-0

orelline

Conditions
ConditionsYield
With hydrogen bromide In acetic acid for 5h; Heating;70%
3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide
37338-80-0

3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide

orelline
72016-31-0

orelline

Conditions
ConditionsYield
at 220℃; under 0.01 Torr; sublimation;50%
for 336h; Irradiation;
3,3'-Dihydroxy-2,2'-bipyridin-4,4'-dicarbaldehyd
119767-37-2

3,3'-Dihydroxy-2,2'-bipyridin-4,4'-dicarbaldehyd

orelline
72016-31-0

orelline

Conditions
ConditionsYield
With dihydrogen peroxide In potassium hydroxide at 60 - 70℃; for 1h;36%
C22H34Li2N2O4Si2

C22H34Li2N2O4Si2

orelline
72016-31-0

orelline

Conditions
ConditionsYield
With bis-trimethylsilanyl peroxide In diethyl ether for 0.5h; Ambient temperature;11%
Multi-step reaction with 3 steps
1: 45 percent / 0.5 h / -20 - -15 °C
2: 75 percent / conc. HCl / H2O / 30 h / Heating
3: 36 percent / 30percent H2O2 / aq. KOH / 1 h / 60 - 70 °C
View Scheme
Multi-step reaction with 2 steps
1: 10 percent / 0.5 h / -5 °C
2: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 10 percent / bis(trimethylsilyl)-peroxide / 0.5 h / -5 °C
2: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
2-iodo-3-hydroxypyridine
40263-57-8

2-iodo-3-hydroxypyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 70 percent / NaH / dimethylsulfoxide / 15 h / 0 - 20 °C
2.1: 2,2,6,6-tetramethylpiperidine; BuLi / tetrahydrofuran; hexane / 1 h / -50 °C
2.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -75 °C
2.3: 78 percent / aq. AcOH; AcOOH / tetrahydrofuran; hexane / -75 - 20 °C
3.1: 71 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
4.1: [Pd(PPh3)4]; CuBr / dioxane / 15 h / Heating
5.1: aq. HCl / diethyl ether / 15 h / 20 °C
6.1: 70 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
Multi-step reaction with 6 steps
1.1: 85 percent / MeONa / dimethylformamide / 15 h / 0 - 20 °C
2.1: 2,2,6,6-tetramethylpiperidine; BuLi / tetrahydrofuran; hexane / 1 h / -50 °C
2.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -75 °C
2.3: 63 percent / aq. AcOH; AcOOH / tetrahydrofuran; hexane / -75 - 20 °C
3.1: 69 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
4.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
4.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
4.3: [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
5.1: aq. HCl / tetrahydrofuran / 7 h / 50 °C
6.1: 71 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
Multi-step reaction with 5 steps
1.1: 85 percent / MeONa / dimethylformamide / 15 h / 0 - 20 °C
2.1: 2,2,6,6-tetramethylpiperidine; BuLi / tetrahydrofuran; hexane / 1 h / -50 °C
2.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -75 °C
2.3: 63 percent / aq. AcOH; AcOOH / tetrahydrofuran; hexane / -75 - 20 °C
3.1: 71 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
4.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
4.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
4.3: 59 percent / [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
5.1: 77 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
2-iodo-3-methoxy-pyridine
93560-55-5

2-iodo-3-methoxy-pyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 2,2,6,6-tetramethylpiperidine; BuLi / tetrahydrofuran; hexane / 1 h / -50 °C
1.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -75 °C
1.3: 63 percent / aq. AcOH; AcOOH / tetrahydrofuran; hexane / -75 - 20 °C
2.1: 69 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
3.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
3.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
3.3: [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
4.1: aq. HCl / tetrahydrofuran / 7 h / 50 °C
5.1: 71 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
Multi-step reaction with 4 steps
1.1: 2,2,6,6-tetramethylpiperidine; BuLi / tetrahydrofuran; hexane / 1 h / -50 °C
1.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -75 °C
1.3: 63 percent / aq. AcOH; AcOOH / tetrahydrofuran; hexane / -75 - 20 °C
2.1: 71 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
3.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
3.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
3.3: 59 percent / [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
4.1: 77 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
2-iodo-3-(methoxymethoxy)pyridine
87905-88-2

2-iodo-3-(methoxymethoxy)pyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 2,2,6,6-tetramethylpiperidine; BuLi / tetrahydrofuran; hexane / 1 h / -50 °C
1.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h / -75 °C
1.3: 78 percent / aq. AcOH; AcOOH / tetrahydrofuran; hexane / -75 - 20 °C
2.1: 71 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
3.1: [Pd(PPh3)4]; CuBr / dioxane / 15 h / Heating
4.1: aq. HCl / diethyl ether / 15 h / 20 °C
5.1: 70 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
2-iodo-3,4-dimethoxypyridine
153199-59-8

2-iodo-3,4-dimethoxypyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
1.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
1.3: 59 percent / [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
2.1: 77 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
2-iodo-3-methoxypyridin-4-ol
405137-17-9

2-iodo-3-methoxypyridin-4-ol

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 69 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
2.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
2.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
2.3: [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
3.1: aq. HCl / tetrahydrofuran / 7 h / 50 °C
4.1: 71 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1.1: 71 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
2.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
2.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
2.3: 59 percent / [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
3.1: 77 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
2-iodo-3-methoxy-4-(methoxymethoxy)pyridine
405137-19-1

2-iodo-3-methoxy-4-(methoxymethoxy)pyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -75 °C
1.2: ZnCl2 / tetrahydrofuran; hexane / -75 - 20 °C
1.3: [Pd(PPh3)4] / tetrahydrofuran; hexane / 20 h / Heating
2.1: aq. HCl / tetrahydrofuran / 7 h / 50 °C
3.1: 71 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
2-iodo-4-methoxy-3-(methoxymethoxy)pyridine
405137-18-0

2-iodo-4-methoxy-3-(methoxymethoxy)pyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: [Pd(PPh3)4]; CuBr / dioxane / 15 h / Heating
2: aq. HCl / diethyl ether / 15 h / 20 °C
3: 70 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
2-iodo-3-(methoxymethoxy)pyridin-4-ol
405137-24-8

2-iodo-3-(methoxymethoxy)pyridin-4-ol

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 71 percent / Ag2CO3 / tetrahydrofuran / 15 h / 20 °C
2: [Pd(PPh3)4]; CuBr / dioxane / 15 h / Heating
3: aq. HCl / diethyl ether / 15 h / 20 °C
4: 70 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
3,3'-dimethoxy-4,4'-bis-methoxymethoxy-[2,2']bipyridinyl

3,3'-dimethoxy-4,4'-bis-methoxymethoxy-[2,2']bipyridinyl

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HCl / tetrahydrofuran / 7 h / 50 °C
2: 71 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
4,4'-dimethoxy-3,3'-bis(methoxymethoxy)-2,2'-bipyridine

4,4'-dimethoxy-3,3'-bis(methoxymethoxy)-2,2'-bipyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HCl / diethyl ether / 15 h / 20 °C
2: 70 percent / aq. HBr / acetic acid / 5 h / Heating
View Scheme
3-HYDROXYPYRIDINE
109-00-2

3-HYDROXYPYRIDINE

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 52 percent / Br2, HCl / aq. NaOH / 20 °C
2: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) 1.5 h
3: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
4: 22 percent / 1.) 1.5 M BuLi; 2.) 2-(phenylsulfonyl)-3-phenyloxaziridine / 1.) Et2O, -50 deg C, hexan, 2h; 2.) -20 deg C, THF, 75 min
5: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 7 steps
1: 52 percent / Br2, HCl / aq. NaOH / 20 °C
2: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) 1.5 h
3: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
4: 1.5 M BuLi / diethyl ether / -50 - -20 °C
5: 45 percent / 0.5 h / -20 - -15 °C
6: 75 percent / conc. HCl / H2O / 30 h / Heating
7: 36 percent / 30percent H2O2 / aq. KOH / 1 h / 60 - 70 °C
View Scheme
Multi-step reaction with 6 steps
1: 52 percent / Br2, HCl / aq. NaOH / 20 °C
2: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) 1.5 h
3: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
4: 1.5 M BuLi / diethyl ether / -50 - -20 °C
5: 10 percent / 0.5 h / -5 °C
6: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
2-bromo-pyridin-3-ol
6602-32-0

2-bromo-pyridin-3-ol

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) 1.5 h
2: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
3: 22 percent / 1.) 1.5 M BuLi; 2.) 2-(phenylsulfonyl)-3-phenyloxaziridine / 1.) Et2O, -50 deg C, hexan, 2h; 2.) -20 deg C, THF, 75 min
4: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) 1.5 h
2: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
3: 1.5 M BuLi / diethyl ether / -50 - -20 °C
4: 45 percent / 0.5 h / -20 - -15 °C
5: 75 percent / conc. HCl / H2O / 30 h / Heating
6: 36 percent / 30percent H2O2 / aq. KOH / 1 h / 60 - 70 °C
View Scheme
Multi-step reaction with 5 steps
1: 1.) NaH / 1.) DMF, 25 deg C, 1 h; 2.) 1.5 h
2: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
3: 1.5 M BuLi / diethyl ether / -50 - -20 °C
4: 10 percent / 0.5 h / -5 °C
5: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
2-bromo-3-(β-trimethylsilyl ethoxymethoxy)pyridine
118399-88-5

2-bromo-3-(β-trimethylsilyl ethoxymethoxy)pyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
2: 22 percent / 1.) 1.5 M BuLi; 2.) 2-(phenylsulfonyl)-3-phenyloxaziridine / 1.) Et2O, -50 deg C, hexan, 2h; 2.) -20 deg C, THF, 75 min
3: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
2: 1.5 M BuLi / diethyl ether / -50 - -20 °C
3: 45 percent / 0.5 h / -20 - -15 °C
4: 75 percent / conc. HCl / H2O / 30 h / Heating
5: 36 percent / 30percent H2O2 / aq. KOH / 1 h / 60 - 70 °C
View Scheme
Multi-step reaction with 4 steps
1: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
2: 1.5 M BuLi / diethyl ether / -50 - -20 °C
3: 10 percent / 0.5 h / -5 °C
4: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
2: 1.5 M BuLi / diethyl ether / -50 - -20 °C
3: 10 percent / bis(trimethylsilyl)-peroxide / 0.5 h / -5 °C
4: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 79 percent / NiCl2*6H2O, triphenylphosphine, Zn / dimethylformamide / 0.42 h / 60 °C
2: 1.5 M BuLi / diethyl ether / -50 - -20 °C
3: 11 percent / bis(trimethylsilyl)-peroxide / diethyl ether / 0.5 h / Ambient temperature
View Scheme
3,3'-Bis<<2-(trimethylsilyl)ethoxy>methoxy>-2,2'-bipyridin
119767-27-0

3,3'-Bis<<2-(trimethylsilyl)ethoxy>methoxy>-2,2'-bipyridin

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 22 percent / 1.) 1.5 M BuLi; 2.) 2-(phenylsulfonyl)-3-phenyloxaziridine / 1.) Et2O, -50 deg C, hexan, 2h; 2.) -20 deg C, THF, 75 min
2: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: 1.5 M BuLi / diethyl ether / -50 - -20 °C
2: 45 percent / 0.5 h / -20 - -15 °C
3: 75 percent / conc. HCl / H2O / 30 h / Heating
4: 36 percent / 30percent H2O2 / aq. KOH / 1 h / 60 - 70 °C
View Scheme
Multi-step reaction with 3 steps
1: 1.5 M BuLi / diethyl ether / -50 - -20 °C
2: 10 percent / 0.5 h / -5 °C
3: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 1.5 M BuLi / diethyl ether / -50 - -20 °C
2: 10 percent / bis(trimethylsilyl)-peroxide / 0.5 h / -5 °C
3: 75 percent / 2N HCl / methanol / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 1.5 M BuLi / diethyl ether / -50 - -20 °C
2: 11 percent / bis(trimethylsilyl)-peroxide / diethyl ether / 0.5 h / Ambient temperature
View Scheme
3,3'-Bis<<2-(trimethylsilyl)ethoxy>methoxy>-2,2'-bipyridin-4,4'-dicarbaldehyd
119767-36-1

3,3'-Bis<<2-(trimethylsilyl)ethoxy>methoxy>-2,2'-bipyridin-4,4'-dicarbaldehyd

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 75 percent / conc. HCl / H2O / 30 h / Heating
2: 36 percent / 30percent H2O2 / aq. KOH / 1 h / 60 - 70 °C
View Scheme
2-bromo-3,4-dimethoxy pyridine
104819-52-5

2-bromo-3,4-dimethoxy pyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 87 percent / NiCl2, P(Ph)3, Zn / dimethylformamide / 50 °C
2: 60 percent / 48percent HBr / 120 °C
View Scheme
Multi-step reaction with 4 steps
1: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
2: 85 percent / m-chloroperbenzoic acid / CHCl3 / 8 h / Ambient temperature
3: 60 percent / 48percent aq. HBr / 5 h / 120 °C
4: 50 percent / 220 °C / 0.01 Torr / sublimation
View Scheme
Multi-step reaction with 2 steps
1: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
2: 60 percent / 48percent aq. HBr / 150 °C / sealed tube, overnight
View Scheme
2-bromo-3,4-dimethoxy pyridine-N-oxide
105011-83-4

2-bromo-3,4-dimethoxy pyridine-N-oxide

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus tribromide
2: 87 percent / NiCl2, P(Ph)3, Zn / dimethylformamide / 50 °C
3: 60 percent / 48percent HBr / 120 °C
View Scheme
Multi-step reaction with 5 steps
1: 85 percent / PBr3 / CHCl3 / 0.5 h / 60 °C
2: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
3: 85 percent / m-chloroperbenzoic acid / CHCl3 / 8 h / Ambient temperature
4: 60 percent / 48percent aq. HBr / 5 h / 120 °C
5: 50 percent / 220 °C / 0.01 Torr / sublimation
View Scheme
Multi-step reaction with 3 steps
1: 85 percent / PBr3 / CHCl3 / 0.5 h / 60 °C
2: 1.) NiCl2*6H2O, Ph3P, Zn powder / 1.) DMF, 50 deg C, 1 h; 2.) DMF, 50 deg C, 2 h; other cond.: Cu, KI, DMF or Pd/C, phase transfer conditions
3: 60 percent / 48percent aq. HBr / 150 °C / sealed tube, overnight
View Scheme
4-methoxypyridin-3-amine
33631-09-3

4-methoxypyridin-3-amine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 80 percent / Br2, conc. HCl / 1 h
3: 42 percent / NiCl2*6H2O/(C6H5)3P, Zn / 4 h / 50 °C
4: 27 percent / 30percent H2O2, (CH3CO)2O / 14 h / 100 °C
5: 92 percent / Na / 0.25 h / Heating
6: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
7: 336 h / Irradiation
View Scheme
2-chloro-3-fluoropyridine
17282-04-1

2-chloro-3-fluoropyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 64 percent / (CH3CO)2O, 30percent H2O2 / 12 h / 80 °C
2: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
3: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
4: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
5: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
6: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
7: 336 h / Irradiation
View Scheme
Multi-step reaction with 5 steps
1: 64 percent / (CH3CO)2O, 30percent H2O2 / 12 h / 80 °C
2: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
3: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
4: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
5: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 8 steps
1: 64 percent / (CH3CO)2O, 30percent H2O2 / 12 h / 80 °C
2: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
3: 83 percent / Na / methanol / 72 h / Ambient temperature
4: 80 percent / PCl3 / CHCl3 / 2 h / Heating
5: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
6: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
7: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
8: 336 h / Irradiation
View Scheme
Multi-step reaction with 6 steps
1: 64 percent / (CH3CO)2O, 30percent H2O2 / 12 h / 80 °C
2: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
3: 83 percent / Na / methanol / 72 h / Ambient temperature
4: 80 percent / PCl3 / CHCl3 / 2 h / Heating
5: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
6: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 54 percent / acetic anhydride, 30percent H2O2
2: 42 percent / 100percent HNO3/ 100percent H2SO4 containing 10percent SO3
3: Ambient temperature
4: PCl3
5: 25 percent / dimethylformamide / 4 h / 50 °C
6: 46 percent / 33percent HBr / acetic acid / 4 h
View Scheme
2-Chlor-3-fluorpyridin-1-oxid
85386-94-3

2-Chlor-3-fluorpyridin-1-oxid

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
2: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
3: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
4: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
5: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
6: 336 h / Irradiation
View Scheme
Multi-step reaction with 4 steps
1: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
2: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
3: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
4: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 7 steps
1: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
2: 83 percent / Na / methanol / 72 h / Ambient temperature
3: 80 percent / PCl3 / CHCl3 / 2 h / Heating
4: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
5: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
6: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
7: 336 h / Irradiation
View Scheme
Multi-step reaction with 5 steps
1: 44 percent / conc. H2SO4/H2SO4 (20percent SO3) (1:1); H2SO4 (20percent SO3)/100percent HNO3 / 1 h / Heating
2: 83 percent / Na / methanol / 72 h / Ambient temperature
3: 80 percent / PCl3 / CHCl3 / 2 h / Heating
4: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
5: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 42 percent / 100percent HNO3/ 100percent H2SO4 containing 10percent SO3
2: Ambient temperature
3: PCl3
4: 25 percent / dimethylformamide / 4 h / 50 °C
5: 46 percent / 33percent HBr / acetic acid / 4 h
View Scheme
2-chloro-3,4-dimethoxypyridine
101664-59-9

2-chloro-3,4-dimethoxypyridine

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
2: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
3: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
4: 336 h / Irradiation
View Scheme
Multi-step reaction with 2 steps
1: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
2: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 25 percent / dimethylformamide / 4 h / 50 °C
2: 46 percent / 33percent HBr / acetic acid / 4 h
View Scheme
2-Chlor-3,4-dimethoxypyridin-1-oxid
101664-58-8

2-Chlor-3,4-dimethoxypyridin-1-oxid

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / PCl3 / CHCl3 / 2 h / Heating
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
3: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
4: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
5: 336 h / Irradiation
View Scheme
Multi-step reaction with 3 steps
1: 80 percent / PCl3 / CHCl3 / 2 h / Heating
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
3: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: PCl3
2: 25 percent / dimethylformamide / 4 h / 50 °C
3: 46 percent / 33percent HBr / acetic acid / 4 h
View Scheme
2-Chlor-3-fluor-4-nitropyridin-1-oxid
101664-56-6

2-Chlor-3-fluor-4-nitropyridin-1-oxid

orelline
72016-31-0

orelline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
3: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
4: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
5: 336 h / Irradiation
View Scheme
Multi-step reaction with 3 steps
1: 1.) Na, 2.) PCl3 / 1.) MeOH, 24 h, room temp. 2.) chloroform, 2 h, reflux
2: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
3: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 83 percent / Na / methanol / 72 h / Ambient temperature
2: 80 percent / PCl3 / CHCl3 / 2 h / Heating
3: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
4: 53 percent / 30percent H2O2, (CH3CO)2O, / 14 h / 100 °C
5: 77 percent / 33percent HBr/CH3COOH / 5 h / Heating
6: 336 h / Irradiation
View Scheme
Multi-step reaction with 4 steps
1: 83 percent / Na / methanol / 72 h / Ambient temperature
2: 80 percent / PCl3 / CHCl3 / 2 h / Heating
3: 52 percent / NiCl2*6H2O/(C6H5)3P, Zn, KI / dimethylformamide / 12 h / 50 °C
4: 46 percent / 33percent HBr/CH3COOH / 5 h / Heating
View Scheme
Multi-step reaction with 4 steps
1: Ambient temperature
2: PCl3
3: 25 percent / dimethylformamide / 4 h / 50 °C
4: 46 percent / 33percent HBr / acetic acid / 4 h
View Scheme
orelline
72016-31-0

orelline

3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide
37338-80-0

3,3',4,4'-tetrahydroxy-2,2'-bipyridine-1,1'-dioxide

Conditions
ConditionsYield
With dihydrogen peroxide for 8h; Ambient temperature;87%
for 336h; Irradiation; isomerisation also without irradiation;
orelline
72016-31-0

orelline

3,3'-dihyroxy-4,4'-dimethoxy-2,2'-bipyridyl
104819-53-6

3,3'-dihyroxy-4,4'-dimethoxy-2,2'-bipyridyl

Conditions
ConditionsYield
In diethyl ether Ambient temperature;

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