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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

17-Aag Manufacturer/High quality/Best price/In stock

Cas:75747-14-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Tanespimycin manufacturer/supplier

Cas:75747-14-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% 17-AAG 75747-14-7 GMP Manufacturer

Cas:75747-14-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

17-(Allylamino)-geldanamycin

Cas:75747-14-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Telatinib

Cas:75747-14-7

Min.Order:1 Gram

FOB Price: $260.0 / 300.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 75747-14-7 with best quality

Cas:75747-14-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

17-AAG

Cas:75747-14-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

17-AAG Tinib antitumor drugs

Cas:75747-14-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:75747-14-7

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Telatinib 17aag 75747-14-7

Cas:75747-14-7

Min.Order:200 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Telatinib

Cas:75747-14-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

17-Aag

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

17-AAG

Cas:75747-14-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

TelatinibAppearance:appearance White powder Storage:Dry and ventilated Package:according to customers' requirements Application:Widely used in cosmetics, medicine, beauty health food and other industries Transportation:By air(EMS or EUB or FedEx or T

Telatinib

Cas:75747-14-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Telatinib

Cas:75747-14-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Lyander (Xiamen) Medical Technology Co., LTD

Lyander’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Lyander can provide different quantities of cu

CB1195912

Cas:75747-14-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Telatinib Synonyms: GELDANAMYCIN,17-DEMETHOXY-17-(2-PROPENYLAMINO)-;CP 127374;ALLYLAMINOGELDANAMYCIN;17-(ALLYLAMINO)-17-DEMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DESMETHOXYGELDANAMYCIN;17-(ALLYLAMINO)-17-DIMETHOXYGELDANAMYCIN;17

TIANFU-CHEM CAS NO.75747-14-7 Telatinib

Cas:75747-14-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Telatinib

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

17-Allylaminogeldanamycin

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

99% up by HPLC 17-AAG 75747-14-7

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Stable stock and competitive priceAppearance:powder Storage:available Package:1KG 5KG 25KG Application:As Pharm raw material Transportation:By Courier,Sea or air

75747-14-7

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

17-AAG

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

17-AAG

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. https:

17-AAG

Cas:75747-14-7

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

17-(AllylaMino)-17-deMethoxygeldanaMycin

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

17-AAG

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

17-Aag cas 75747-14-7Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

17-Aag cas 75747-14-7

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Telatinib

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

75747-14-7

Cas:75747-14-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

1-amino-2-propene
107-11-9

1-amino-2-propene

geldanmycin
30562-34-6

geldanmycin

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃;99%
In chloroform at 20℃; for 18h;99%
In dichloromethane at 23℃;95%
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

17-(allylamino)-11-oxogeldanamycin

17-(allylamino)-11-oxogeldanamycin

Conditions
ConditionsYield
With Dess-Martin periodane In chloroform for 1h; Heating;96%
With Dess-Martin periodane In dichloromethane at 20℃;
C5H10ClNO*ClH
51250-92-1

C5H10ClNO*ClH

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C5H11NO2*C31H45N3O8*ClH
857402-51-8

C5H11NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: C5H10ClNO*ClH In dichloromethane for 2h;
Stage #3: With water In dichloromethane
92%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: C5H10ClNO*ClH In dichloromethane for 2h;
92%
C3H6ClNO*ClH
146751-69-1

C3H6ClNO*ClH

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C3H7NO2*C31H45N3O8*ClH
857402-33-6

C3H7NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: C3H6ClNO*ClH In dichloromethane for 2h;
Stage #3: With water In dichloromethane
91%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: C3H6ClNO*ClH In dichloromethane for 2h;
91%
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)‐19‐(allylamino)‐13,20,22‐trihydroxy‐8,14‐dimethoxy‐4,10,12,16‐tetramethyl‐3‐oxo‐2‐azabicyclo[1 6.3.1]docosa‐1(22),4,6,10,18,20‐hexaen‐9‐yl carbamate
857402-23-4

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)‐19‐(allylamino)‐13,20,22‐trihydroxy‐8,14‐dimethoxy‐4,10,12,16‐tetramethyl‐3‐oxo‐2‐azabicyclo[1 6.3.1]docosa‐1(22),4,6,10,18,20‐hexaen‐9‐yl carbamate

Conditions
ConditionsYield
With sodium dithionite; water In ethyl acetate for 0.5h;90%
With sodium dithionite; water In ethyl acetate at 20℃; for 2h;85%
With sodium dithionite; water In ethyl acetate at 22℃; for 1h; Product distribution / selectivity;74%
β-Alanine acid chloride hydrochloride
65247-00-9

β-Alanine acid chloride hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C3H7NO2*C31H45N3O8*ClH
857402-30-3

C3H7NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: β-Alanine acid chloride hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
83%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: β-Alanine acid chloride hydrochloride In dichloromethane for 2h;
83%
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

Trichloroacetyl isocyanate
3019-71-4

Trichloroacetyl isocyanate

11-carbamate-17-(allylamino)-17-demethoxygeldanamycin
163112-96-7

11-carbamate-17-(allylamino)-17-demethoxygeldanamycin

Conditions
ConditionsYield
In dichloromethane at 20℃; for 1.5h;80%
dimethylaminoacetyl chloride hydrochloride
59660-95-6

dimethylaminoacetyl chloride hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C4H9NO2*C31H45N3O8*ClH
857402-27-8

C4H9NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane Product distribution / selectivity;
79%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h;
79%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In MeTHF for 0.75h;
Stage #2: dimethylaminoacetyl chloride hydrochloride In MeTHF at 0℃; for 3h; Product distribution / selectivity;
N,N-dimethylaminoacetyl chloride hydrochloride
60853-81-8

N,N-dimethylaminoacetyl chloride hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C4H9NO2*C31H45N3O8*ClH
857402-24-5

C4H9NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: N,N-dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
66%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: N,N-dimethylaminoacetyl chloride hydrochloride In dichloromethane for 2h;
66%
1-aminocyclopropanecarbonyl chloride hydrochloride
874154-69-5

1-aminocyclopropanecarbonyl chloride hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C4H7NO2*C31H45N3O8*ClH
857402-47-2

C4H7NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: 1-aminocyclopropanecarbonyl chloride hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
62%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: 1-aminocyclopropanecarbonyl chloride hydrochloride In dichloromethane for 2h;
62%
Ac-Cys-OMe
7652-46-2

Ac-Cys-OMe

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

(R)-methyl-2-acetamido-3-((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(allylamino)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-21-ylthio)propanoate
1427297-13-9

(R)-methyl-2-acetamido-3-((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(allylamino)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-21-ylthio)propanoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃;62%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20℃; for 2h;62%
C6H10ClNO*ClH
874154-72-0

C6H10ClNO*ClH

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C6H11NO2*C31H45N3O8*ClH
857402-54-1

C6H11NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: C6H10ClNO*ClH In dichloromethane for 2h;
Stage #3: With water In dichloromethane
60%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: C6H10ClNO*ClH In dichloromethane for 2h;
60%
4-chloro-carbonyl piperidine hydrochloride

4-chloro-carbonyl piperidine hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C6H11NO2*C31H45N3O8*ClH
857402-36-9

C6H11NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: 4-chloro-carbonyl piperidine hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
60%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: 4-chloro-carbonyl piperidine hydrochloride In dichloromethane for 2h;
60%
N-chlorobetainyl chloride
53684-57-4

N-chlorobetainyl chloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C5H11NO2*C31H45N3O8*ClH
857402-60-9, 1256359-49-5

C5H11NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: N-chlorobetainyl chloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
57%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: N-chlorobetainyl chloride In dichloromethane for 2h;
57%
1-methylpiperidine-4-carbonyl chloride hydrochloride
7462-84-2

1-methylpiperidine-4-carbonyl chloride hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C7H13NO2*C31H45N3O8*ClH
857402-57-4

C7H13NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: 1-methylpiperidine-4-carbonyl chloride hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
56%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: 1-methylpiperidine-4-carbonyl chloride hydrochloride In dichloromethane for 2h;
56%
diethylamino-acetyl chloride hydrochloride

diethylamino-acetyl chloride hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C6H13NO2*C31H45N3O8*ClH
857402-43-8

C6H13NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: diethylamino-acetyl chloride hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
41%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: diethylamino-acetyl chloride hydrochloride In dichloromethane for 2h;
41%
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13S,14S,16R)-19-allylamino-13-fluoro-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl ester

Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13S,14S,16R)-19-allylamino-13-fluoro-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-aza-bicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl ester

Conditions
ConditionsYield
With diethylamino-sulfur trifluoride In dichloromethane at -68℃; for 1h;35%
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

BrH*C31H45N3O8

BrH*C31H45N3O8

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In ethyl acetate at 20℃; for 0.5h;
Stage #2: With hydrogen bromide In ethyl acetate at 0 - 20℃; for 0.5h;
31%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In water; ethyl acetate at 20℃; for 0.5h;
Stage #2: With hydrogen bromide In water; ethyl acetate at 0 - 20℃; for 0.5h;
31%
UDP-glucose
133-89-1

UDP-glucose

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

17-allylamino-17-demethoxygeldanamycin glucoside

17-allylamino-17-demethoxygeldanamycin glucoside

Conditions
ConditionsYield
With UDP-glycosyltransferase YjiC In aq. buffer at 28℃; for 16h; pH=8; Enzymatic reaction;25.5%
glycinyl chloride hydrochloride
2184-96-5

glycinyl chloride hydrochloride

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C2H5NO2*C31H45N3O8*ClH
857402-39-2

C2H5NO2*C31H45N3O8*ClH

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: glycinyl chloride hydrochloride In dichloromethane for 2h;
19%
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: glycinyl chloride hydrochloride In dichloromethane for 2h;
Stage #3: With water In dichloromethane
azetidine
503-29-7

azetidine

isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

17-(allylamino)-11-<(azetidinylsulfamyl)carbonyl>geldanamycin

17-(allylamino)-11-<(azetidinylsulfamyl)carbonyl>geldanamycin

Conditions
ConditionsYield
1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, from 0 deg C to RT, 1 h; Yield given. Multistep reaction;
isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

isopropylamine
75-31-0

isopropylamine

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

17-(allylamino)-11-<(isopropylsulfamyl)carbonyl>geldanamycin

17-(allylamino)-11-<(isopropylsulfamyl)carbonyl>geldanamycin

Conditions
ConditionsYield
1.) CH2Cl2, 0 deg C, 1 h, 2.) CH2Cl2, from 0 deg C to RT, 1 h; Yield given. Multistep reaction;
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

retaspimycin hydrochloride

retaspimycin hydrochloride

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: With hydrogenchloride In 1,4-dioxane; dichloromethane; water for 0.5h;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 0.5h;
Stage #2: With hydrogenchloride In 1,4-dioxane; dichloromethane for 0.5h; Product distribution / selectivity;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In ethyl acetate for 1.16667h;
Stage #2: With hydrogenchloride In ethyl acetate; acetone at 20℃; for 0.383333h; pH=2.5; Product distribution / selectivity;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In ethyl acetate at 20℃; for 2h;
Stage #2: With hydrogenchloride In ethyl acetate at 20℃; for 1.83333h; pH=2; Product distribution / selectivity;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 0.5h;
Stage #2: With hydrogenchloride In 1,4-dioxane; dichloromethane; water for 0.5h; Inert atmosphere;
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C31H45N3O8*H2O4S

C31H45N3O8*H2O4S

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In tert-butyl methyl ether for 1h;
Stage #2: With sulfuric acid In ethanol; tert-butyl methyl ether at -5 - 20℃; for 0.5h;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In tert-butyl methyl ether; water for 1h;
Stage #2: With sulfuric acid In ethanol; tert-butyl methyl ether; water at -5 - 20℃; Inert atmosphere;
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C31H45N3O8*H3O4P

C31H45N3O8*H3O4P

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 1h;
Stage #2: With phosphoric acid In dichloromethane; isopropyl alcohol for 1h;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 1h;
Stage #2: With phosphoric acid In dichloromethane; water; isopropyl alcohol Inert atmosphere;
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C7H8O3S*C31H45N3O8

C7H8O3S*C31H45N3O8

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 1h;
Stage #2: toluene-4-sulfonic acid In dichloromethane; isopropyl alcohol for 1h;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 1h;
Stage #2: toluene-4-sulfonic acid In dichloromethane; water; isopropyl alcohol Inert atmosphere;
methanesulfonic acid
75-75-2

methanesulfonic acid

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

CH4O3S*C31H45N3O8

CH4O3S*C31H45N3O8

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 1h;
Stage #2: methanesulfonic acid In dichloromethane; isopropyl alcohol for 1h;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 1h;
Stage #2: methanesulfonic acid In dichloromethane; water; isopropyl alcohol Inert atmosphere;
(+)-10-camphorsulfonic acid
76-26-6, 3144-16-9, 5872-08-2, 35963-20-3

(+)-10-camphorsulfonic acid

17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

C10H16O4S*C31H45N3O8

C10H16O4S*C31H45N3O8

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 1h;
Stage #2: (+)-10-camphorsulfonic acid In dichloromethane; isopropyl alcohol for 1h;
17-allylamino-17-demethoxygeldanamycin
75747-14-7

17-allylamino-17-demethoxygeldanamycin

benzenesulfonic acid
98-11-3

benzenesulfonic acid

C6H6O3S*C31H45N3O8

C6H6O3S*C31H45N3O8

Conditions
ConditionsYield
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite; water In dichloromethane for 1h;
Stage #2: benzenesulfonic acid In dichloromethane; isopropyl alcohol for 1h;
Stage #1: 17-allylamino-17-demethoxygeldanamycin With sodium dithionite In dichloromethane; water for 1h;
Stage #2: benzenesulfonic acid In dichloromethane; water; isopropyl alcohol Inert atmosphere;

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