Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Aztreonam

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

99% up GMP DMF Aztreonam 78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Hangzhou Dingyan Chem is a leading manufacturer and supplier of

High purity 78110-38-0 Aztreonam

Cas:78110-38-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

Aztreonam API Cas No.78110-38-0 USP

Cas:78110-38-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Aztreonam Cas 78110-38-0 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage: 0-5°C Package:1kg/foil bag, 25kg/drum or as you requir

Trade Assurance Aztreonam Cas 78110-38-0 with high quality low price

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $90.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Aztreonam

Cas:78110-38-0

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Aztreonam 78110-38-0 GMP Manufacturer

Cas:78110-38-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Aztreonam

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Aztreonam

Cas:78110-38-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Aztreonam

Cas:78110-38-0

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 78110-38-0 with competitive price

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

AztreonamCAS78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Aztreonam/ LIDE PHARMA- Factory supply / Best price

Cas:78110-38-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Chemical Name: Aztreonam Other name: Aztreonam sterile Molecular Formula: C13H17N5O8S2 Formula Weight: 435.43 CAS No.: 78110-38-0;80951-91-3;149496-40-2 EINECS号: 278-839-9 Appearance:white to off-white crystals Assay: 92.0% ~105.

Aztreonam 78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Aztreonam

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White, odorless crystalline powder Storage:Store in sealed c

98% Pharmaceutical USP Powder Aztreonam For Anti-Infective CAS 78110-38-0

Cas:78110-38-0

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Antibacterial Agents Aztreonam CAS 78110-38-0 with Good Quality

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Aztreonam 78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antibiotic drugs Aztreonam CAS:78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $254.0 / 280.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Aztreonam CAS: 78110-38-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Aztreonam CAS: 78110-38-0

Cas:78110-38-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Aztreonam 78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of h

Aztreonam (Azactam) CAS 78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:78110-38-0

Cas:78110-38-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Main Service 1.Own made fine chemical products 2.Out sourcing and quality controlling service in China 3. COM for Chemical synthesis 4.Lab custom synthesis of API and intermadiates Quality Assurance 1. NMR,HPLC and COA can be suppli

Aztreonam

Cas:78110-38-0

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Aztreonam

Cas:78110-38-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Aztreonam CAS 78110-38-0 White Crystalline Powder Pharmaceutical Aztreonam

Cas:78110-38-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Aztreonam CAS 78110-38-0

Cas:78110-38-0

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

SQ 26776 Aztreonam 78110-38-0

Cas:78110-38-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Aztreonam

Cas:78110-38-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Aztreonam

Cas:78110-38-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid
80082-65-1

(3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid

(Z)-2-<<<1-(2-amino-4-thiazolyl)-2-<(2-benzothiazolyl)thio>-2-oxoethylidene>amino>oxy>-2-methyl propanoic acid 1,1-dimethylethyl ester
89604-92-2

(Z)-2-<<<1-(2-amino-4-thiazolyl)-2-<(2-benzothiazolyl)thio>-2-oxoethylidene>amino>oxy>-2-methyl propanoic acid 1,1-dimethylethyl ester

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Stage #1: (3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid; (Z)-2-<<<1-(2-amino-4-thiazolyl)-2-<(2-benzothiazolyl)thio>-2-oxoethylidene>amino>oxy>-2-methyl propanoic acid 1,1-dimethylethyl ester With pyridine In acetonitrile at -5℃; for 4h;
Stage #2: With nitric acid at 35℃; for 2h; pH=1; Solvent; Reagent/catalyst; Temperature;
86.9%
(Z)-2-[[[1-(2-amino-4-thiazolyl)-2-(3-oxido-1H-benzotriazol-1-yl)-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid methanesulfonate (1:1) salt
139714-28-6

(Z)-2-[[[1-(2-amino-4-thiazolyl)-2-(3-oxido-1H-benzotriazol-1-yl)-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid methanesulfonate (1:1) salt

(3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid
80082-65-1

(3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Stage #1: (Z)-2-[[[1-(2-amino-4-thiazolyl)-2-(3-oxido-1H-benzotriazol-1-yl)-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid methanesulfonate (1:1) salt; (3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid With triethylamine In ethanol; water at -6 - -3℃; for 3h;
Stage #2: With hydrogenchloride In ethanol; water at -3 - 0℃;
81%
[3S-[3α(Z),4β]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid
330944-50-8

[3S-[3α(Z),4β]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With hydrogenchloride; water at 0 - 65℃; for 4.75h;72%
With water; trifluoroacetic acid at 0 - 63℃; for 1 - 21.75h;63%
With hydrogenchloride In water at 60℃; for 5h;
3-<<(2-amino-4-thiazolyl)-<<1-(diphenylmethoxycarbonyl)-1-methyl ethoxy>-imino>-acetyl>-amino>-4-methyl-2-oxoazetidi-ne-1-sulfonic acid
123539-91-3

3-<<(2-amino-4-thiazolyl)-<<1-(diphenylmethoxycarbonyl)-1-methyl ethoxy>-imino>-acetyl>-amino>-4-methyl-2-oxoazetidi-ne-1-sulfonic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With methoxybenzene; trifluoroacetic acid In dichloromethane
2-[1-(2-Amino-thiazol-4-yl)-2-(diphenoxy-phosphoryloxy)-2-oxo-eth-(Z)-ylideneaminooxy]-2-methyl-propionic acid benzhydryl ester

2-[1-(2-Amino-thiazol-4-yl)-2-(diphenoxy-phosphoryloxy)-2-oxo-eth-(Z)-ylideneaminooxy]-2-methyl-propionic acid benzhydryl ester

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O
2: trifluoroacetic acid, anisole / CH2Cl2
View Scheme
aztreonam

aztreonam

6,7-Dihydroxy-2,3-quinolinedicarboxylic anhydride

6,7-Dihydroxy-2,3-quinolinedicarboxylic anhydride

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
In water; N,N-dimethyl-formamide; acetonitrile
azthreonam dipotassium salt

azthreonam dipotassium salt

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With hydrogenchloride In methanol; water
With hydrogenchloride In methanol; water
water
7732-18-5

water

3-<<(2-amino-4-thiazolyl)-<<1-(diphenylmethoxycarbonyl)-1-methyl ethoxy>-imino>-acetyl>-amino>-4-methyl-2-oxoazetidi-ne-1-sulfonic acid
123539-91-3

3-<<(2-amino-4-thiazolyl)-<<1-(diphenylmethoxycarbonyl)-1-methyl ethoxy>-imino>-acetyl>-amino>-4-methyl-2-oxoazetidi-ne-1-sulfonic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With trifluoroacetic acid In acetone-denatured alcohol; ethanol; dichloromethane; methoxybenzene
(Z)-2-Amino-α-[[2-(diphenylmethoxy)-1,1-dimethyl-2-oxoethoxy]-imino]-4-thiazoleacetic acid
80542-76-3

(Z)-2-Amino-α-[[2-(diphenylmethoxy)-1,1-dimethyl-2-oxoethoxy]-imino]-4-thiazoleacetic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 2 h / 30 °C
2.1: methoxybenzene / dichloromethane / 1 h / 0 - 3 °C
3.1: triethylamine / water; methanol / 0 °C / pH 8 - 8.5
3.2: 10 °C / pH 1.3
View Scheme
Multi-step reaction with 3 steps
1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / acetonitrile / 3 h / 20 - 24 °C
1.2: 15 h / 20 °C
2.1: methanesulfonic acid; methoxybenzene / dichloromethane / 5 h / 0 °C
3.1: triethylamine / ethanol; water / 3 h / -6 - -3 °C
3.2: -3 - 0 °C
View Scheme
(Z)-2-[[[1-(2-amino-4-thiazolyl)-2-(3-oxido-1H-benzotriazol-1-yl)-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid diphenylmethyl ester methanesulfonate (1:1) salt
139714-26-4

(Z)-2-[[[1-(2-amino-4-thiazolyl)-2-(3-oxido-1H-benzotriazol-1-yl)-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid diphenylmethyl ester methanesulfonate (1:1) salt

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: methanesulfonic acid; methoxybenzene / dichloromethane / 5 h / 0 °C
2.1: triethylamine / ethanol; water / 3 h / -6 - -3 °C
2.2: -3 - 0 °C
View Scheme
2-{[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethylidene]amino]oxy}-2-methylpropionic acid benzhydryl ester

2-{[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethylidene]amino]oxy}-2-methylpropionic acid benzhydryl ester

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: methoxybenzene / dichloromethane / 1 h / 0 - 3 °C
2.1: triethylamine / water; methanol / 0 °C / pH 8 - 8.5
2.2: 10 °C / pH 1.3
View Scheme
2-amino-4-[(1-carboxy-1-methyl-ethoxyimino)-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-methyl]-thiazol-3-ium methanesulfonate
477528-80-6

2-amino-4-[(1-carboxy-1-methyl-ethoxyimino)-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-methyl]-thiazol-3-ium methanesulfonate

(3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid
80082-65-1

(3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Stage #1: 2-amino-4-[(1-carboxy-1-methyl-ethoxyimino)-(2,5-dioxo-pyrrolidin-1-yloxycarbonyl)-methyl]-thiazol-3-ium methanesulfonate; (3S-trans)-3-Amino-4-methyl-2-oxo-1-azetidinesulfonic acid With triethylamine In methanol; water at 0℃; pH=8 - 8.5;
Stage #2: With hydrogenchloride In methanol; water at 10℃; pH=1.3;
174.2 g
C16H22N4O7SSi*ClH

C16H22N4O7SSi*ClH

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / N,N-dimethyl-formamide; ethyl acetate / 0.02 h / 10 °C
1.2: 10 °C
2.1: triethylamine / water; methanol / 0 °C / pH 8 - 8.5
2.2: 10 °C / pH 1.3
View Scheme
2-amino-α-[(1-carboxy-1-methylethoxy)imino]-4-thiazoleacetic acid

2-amino-α-[(1-carboxy-1-methylethoxy)imino]-4-thiazoleacetic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide / 0.25 h / 50 °C
1.2: 3 h / -5 - 5 °C
2.1: triethylamine / N,N-dimethyl-formamide; ethyl acetate / 0.02 h / 10 °C
2.2: 10 °C
3.1: triethylamine / water; methanol / 0 °C / pH 8 - 8.5
3.2: 10 °C / pH 1.3
View Scheme
3-(3-amino-2-methyl-4-oxo-azetidine-1-sulfonyloxy)-2,2-dimethylpropionic acid ethyl ester methanesulfonic acid salt

3-(3-amino-2-methyl-4-oxo-azetidine-1-sulfonyloxy)-2,2-dimethylpropionic acid ethyl ester methanesulfonic acid salt

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
2.1: dichloromethane / 20 °C
2.2: 0.5 h
3.1: carboxylesterase 1 (CES1) / acetonitrile / 0.5 h / 37 °C / pH 4.7 / Enzymatic reaction
View Scheme
4-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-3,3-dimethylbutyl pivalate mesylate

4-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-3,3-dimethylbutyl pivalate mesylate

A

azthreonam
78110-38-0

azthreonam

B

3,3-dimethyltetrahydrofuran
15833-75-7

3,3-dimethyltetrahydrofuran

C

Trimethylacetic acid
75-98-9

Trimethylacetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
2.1: dichloromethane / 20 °C
2.2: 0.5 h
3.1: sodium dihydrogenphosphate / water-d2; [D3]acetonitrile / 1.17 h / 37 °C / Enzymatic reaction
View Scheme
4-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-3,3-dimethylbutyl pivalate mesylate

4-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-3,3-dimethylbutyl pivalate mesylate

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
2.1: dichloromethane / 20 °C
2.2: 0.5 h
3.1: carboxylesterase 1 (CES1) / acetonitrile / 0.03 h / 37 °C / pH 4.7 / Enzymatic reaction
View Scheme
5-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate mesylate

5-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate mesylate

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
2.1: dichloromethane / 20 °C
2.2: 0.5 h
3.1: carboxylesterase 1 (CES1) / acetonitrile / 0.33 h / 37 °C / pH 4.7 / Enzymatic reaction
View Scheme
5-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate mesylate

5-((((2S,3S)-3-amino-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate mesylate

A

γ,γ-dimethyl-δ-valerolactone
1679-55-6

γ,γ-dimethyl-δ-valerolactone

B

5-hydroxy-4,4-dimethylpentanoic acid
1148130-26-0

5-hydroxy-4,4-dimethylpentanoic acid

C

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
2.1: dichloromethane / 20 °C
2.2: 0.5 h
3.1: sodium dihydrogenphosphate / water-d2; [D3]acetonitrile / 19 h / 37 °C / Enzymatic reaction
View Scheme
(Z)-2-(2-aminothiazol-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxy)iminoacetic acid
86299-47-0

(Z)-2-(2-aminothiazol-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxy)iminoacetic acid

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C
2.1: dichloromethane / 20 °C
2.2: 0.5 h
3.1: carboxylesterase 1 (CES1) / acetonitrile / 0.5 h / 37 °C / pH 4.7 / Enzymatic reaction
View Scheme
C24H37N5O10S2*C2HF3O2

C24H37N5O10S2*C2HF3O2

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane / 20 °C
1.2: 0.5 h
2.1: carboxylesterase 1 (CES1) / acetonitrile / 0.5 h / 37 °C / pH 4.7 / Enzymatic reaction
View Scheme
2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-((3-ethoxy-2,2-dimethyl-3-oxopropoxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetic acid salt

2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-((3-ethoxy-2,2-dimethyl-3-oxopropoxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetic acid salt

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With carboxylesterase 1 (CES1) In acetonitrile at 37℃; for 0.5h; pH=4.7; Enzymatic reaction;28 %Chromat.
4-((((2S,3S)-3-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-3,3-dimethylbutyl pivalate trifluoroacetate

4-((((2S,3S)-3-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-3,3-dimethylbutyl pivalate trifluoroacetate

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane / 20 °C
1.2: 0.5 h
2.1: carboxylesterase 1 (CES1) / acetonitrile / 0.03 h / 37 °C / pH 4.7 / Enzymatic reaction
View Scheme
Multi-step reaction with 2 steps
1.1: dichloromethane / 20 °C
1.2: 0.5 h
2.1: sodium dihydrogenphosphate / water-d2; [D3]acetonitrile / 1.17 h / 37 °C / Enzymatic reaction
View Scheme
2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-((2,2-dimethyl-4-(pivaloyloxy)butoxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-((2,2-dimethyl-4-(pivaloyloxy)butoxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

A

azthreonam
78110-38-0

azthreonam

B

3,3-dimethyltetrahydrofuran
15833-75-7

3,3-dimethyltetrahydrofuran

C

Trimethylacetic acid
75-98-9

Trimethylacetic acid

Conditions
ConditionsYield
With sodium dihydrogenphosphate In [D3]acetonitrile; water-d2 at 37℃; for 1.16667h; Mechanism; Enzymatic reaction;
2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-((2,2-dimethyl-4-(pivaloyloxy)butoxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-((2,2-dimethyl-4-(pivaloyloxy)butoxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With carboxylesterase 1 (CES1) In acetonitrile at 37℃; for 0.0333333h; pH=4.7; Enzymatic reaction;> 95 %Chromat.
ethyl 5-((((2S,3S)-3-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate trifluoroacetate

ethyl 5-((((2S,3S)-3-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate trifluoroacetate

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane / 20 °C
1.2: 0.5 h
2.1: carboxylesterase 1 (CES1) / acetonitrile / 0.33 h / 37 °C / pH 4.7 / Enzymatic reaction
View Scheme
ethyl 5-((((2S,3S)-3-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate trifluoroacetate

ethyl 5-((((2S,3S)-3-((Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetamido)-2-methyl-4-oxoazetidin-1-yl)sulfonyl)oxy)-4,4-dimethylpentanoate trifluoroacetate

A

γ,γ-dimethyl-δ-valerolactone
1679-55-6

γ,γ-dimethyl-δ-valerolactone

B

5-hydroxy-4,4-dimethylpentanoic acid
1148130-26-0

5-hydroxy-4,4-dimethylpentanoic acid

C

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane / 20 °C
1.2: 0.5 h
2.1: sodium dihydrogenphosphate / water-d2; [D3]acetonitrile / 19 h / 37 °C / Enzymatic reaction
View Scheme
2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-(((5-ethoxy-2,2-dimethyl-5-oxopentyl)oxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-(((5-ethoxy-2,2-dimethyl-5-oxopentyl)oxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With carboxylesterase 1 (CES1) In acetonitrile at 37℃; for 0.333333h; pH=4.7; Enzymatic reaction;90 %Chromat.
2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-(((5-ethoxy-2,2-dimethyl-5-oxopentyl)oxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

2-(((Z)-(1-(2-aminothiazol-4-yl)-2-(((2S,3S)-1-(((5-ethoxy-2,2-dimethyl-5-oxopentyl)oxy)sulfonyl)-2-methyl-4-oxoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid trifluoroacetate

A

γ,γ-dimethyl-δ-valerolactone
1679-55-6

γ,γ-dimethyl-δ-valerolactone

B

5-hydroxy-4,4-dimethylpentanoic acid
1148130-26-0

5-hydroxy-4,4-dimethylpentanoic acid

C

azthreonam
78110-38-0

azthreonam

Conditions
ConditionsYield
With sodium dihydrogenphosphate In [D3]acetonitrile; water-d2 at 37℃; for 19h; Mechanism; Enzymatic reaction;
L-lysine
56-87-1

L-lysine

azthreonam
78110-38-0

azthreonam

aztreonam lysinate
827611-49-4

aztreonam lysinate

Conditions
ConditionsYield
In water at 0 - 5℃; Conversion of starting material;77%
In water at 0 - 5℃; Conversion of starting material;62%
In water for 0.1h; pH=4.34; Cooling with ice;56%
In water at 0 - 5℃; Conversion of starting material;
ethanol
64-17-5

ethanol

azthreonam
78110-38-0

azthreonam

aztreonam ethyl ester

aztreonam ethyl ester

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine; triethylamine; diisopropyl-carbodiimide at 0 - 32℃; for 48h; Reagent/catalyst;71.6%
azthreonam
78110-38-0

azthreonam

(2S,3S)-2-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-1-carboxy-1-methyl-ethoxyimino]-acetylamino}-3-sulfoamino-butyric acid

(2S,3S)-2-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-1-carboxy-1-methyl-ethoxyimino]-acetylamino}-3-sulfoamino-butyric acid

Conditions
ConditionsYield
With citrate buffer at 35℃; Rate constant; other aqueous buffer;
With Zn2+-Tris In water at 35℃; Rate constant; other metal ions;
azthreonam
78110-38-0

azthreonam

C12H14N3O5S(1-)*Na(1+)

C12H14N3O5S(1-)*Na(1+)

Conditions
ConditionsYield
With phosphoric acid In water at 35℃; Rate constant; various pH;
azthreonam
78110-38-0

azthreonam

aztreonam

aztreonam

Conditions
ConditionsYield
With water at 59.85℃; Kinetics; Thermodynamic data; Further Variations:; Temperatures;
azthreonam
78110-38-0

azthreonam

[2S-[2α,3β(Z)]]-2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid, 2-[(1,4-dihydro-6,7-dihydroxy-4-oxo-3-quinolinyl)carbonyl]hydrazide, monopotassium salt

[2S-[2α,3β(Z)]]-2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid, 2-[(1,4-dihydro-6,7-dihydroxy-4-oxo-3-quinolinyl)carbonyl]hydrazide, monopotassium salt

Conditions
ConditionsYield
In N-methyl-acetamide

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View