Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:847445-81-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)- CAS:847445-81-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research
Cas:847445-81-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:847445-81-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:847445-81-2
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryEnterprise standard Application:Pharma Intermediate
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Type:Lab/Research institutions
inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
Cas:847445-81-2
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Type:Lab/Research institutions
inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
Cas:847445-81-2
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Type:Lab/Research institutions
inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
Cas:847445-81-2
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Type:Lab/Research institutions
inquiryProduct Description Description & Specification Category Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard
Cas:847445-81-2
Min.Order:1 Kilogram
FOB Price: $112.0
Type:Trading Company
inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
Cas:847445-81-2
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Negotiable
Type:Trading Company
inquiry1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceuti
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Other
inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Trading Company
inquiry1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G
Cas:847445-81-2
Min.Order:10 Milligram
Negotiable
Type:Lab/Research institutions
inquiryWatson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L
Cas:847445-81-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryBetterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in
Cas:847445-81-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi
Cas:847445-81-2
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Type:Other
inquiryUnited Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryNanjing Chemlin Chemical Industry Co., Ltd was established in Aug,1999, located in the industrial park of Nanjing University of Technology, It is a private enterprises in Jiangsu Province with 1200 square meters’ R&D center. Our R&D center has a well
Enterprise standard Application:Pharma Intermediate
Cas:847445-81-2
Min.Order:0 Metric Ton
Negotiable
Type:Other
inquiry(2E/Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine Storage:Store in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/Pharm
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryFINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the (2Z)-3-Amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryCas:847445-81-2
Min.Order:0
Negotiable
Type:Trading Company
inquiryDebyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen
Cas:847445-81-2
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Negotiable
Type:Lab/Research institutions
inquiryhigh purity Application:Drug intermediates Materials intermediates and active molecules
Cas:847445-81-2
Min.Order:0
Negotiable
Type:Trading Company
inquirydehydrositagliptin
Conditions | Yield |
---|---|
With ammonium hydroxide; ammonium acetate; acetic acid In methanol; water at 60 - 65℃; for 6h; Product distribution / selectivity; Reflux; | 88.4% |
With ammonium hydroxide; ammonium acetate; acetic acid In methanol; water at 60 - 65℃; for 6h; Product distribution / selectivity; |
1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
dehydrositagliptin
Conditions | Yield |
---|---|
With ammonium acetate; ammonia In methanol; water at 55℃; for 6h; | 75% |
With ammonium acetate; ammonia In methanol; water at 0 - 45℃; | |
With ammonium acetate |
ammonia
1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione
dehydrositagliptin
Conditions | Yield |
---|---|
With ammonium acetate In methanol; water at 0 - 45℃; for 0.25 - 0.5h; |
(2,4,5-trifluorophenyl)acetic acid
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: dmap / acetonitrile / 25 - 30 °C 1.2: 30 - 50 °C 2.1: ammonium hydroxide; ammonium acetate; acetic acid / water; methanol / 6 h / 60 - 65 °C View Scheme |
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: dmap / acetonitrile / 25 - 30 °C 1.2: 30 - 50 °C 2.1: ammonium hydroxide; ammonium acetate; acetic acid / water; methanol / 6 h / 60 - 65 °C View Scheme |
4-(2,4,5-trifluorophenyl)-3-oxobutanoic acid
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C / Molecular sieve 2.1: benzotriazol-1-ol / dichloromethane / 0.17 h / 0 °C 2.2: 14 h / 20 °C 3.1: hydrogenchloride / isopropyl alcohol / 4 h / 35 - 40 °C View Scheme |
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: benzotriazol-1-ol / dichloromethane / 0.17 h / 0 °C 1.2: 14 h / 20 °C 2.1: hydrogenchloride / isopropyl alcohol / 4 h / 35 - 40 °C View Scheme |
dehydrositagliptin
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol at 35 - 40℃; for 4h; | 0.9 g |
dehydrositagliptin
(R/S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Conditions | Yield |
---|---|
Stage #1: dehydrositagliptin With methanesulfonic acid; dimethylsulfide borane complex In tetrahydrofuran; isopropyl alcohol at -10 - -5℃; for 4h; Stage #2: With ammonium hydroxide In tetrahydrofuran; water; isopropyl alcohol Product distribution / selectivity; | 100% |
Stage #1: dehydrositagliptin With methanesulfonic acid; dimethylsulfide borane complex In tetrahydrofuran; isopropyl alcohol at -10 - -5℃; for 4h; Stage #2: With ammonia In tetrahydrofuran; water; isopropyl alcohol Product distribution / selectivity; | 100% |
With hydrogenchloride; sodium cyanoborohydride In methanol at 30℃; for 5h; pH=4.5; | 99.9% |
With sodium cyanoborohydride; acetic acid In methanol; dichloromethane at -5 - 30℃; | |
Stage #1: dehydrositagliptin With sodium cyanoborohydride; acetic acid In methanol; dichloromethane at -5 - 30℃; Inert atmosphere; Stage #2: With ammonia In water |
dehydrositagliptin
sitagliptin
Conditions | Yield |
---|---|
With C44H42O8P2Ru; hydrogen; ammonium salicylate; salicylic acid In toluene at 75℃; under 12153.3 Torr; for 20h; Solvent; Reagent/catalyst; Pressure; Temperature; Inert atmosphere; | 62% |
Multi-step reaction with 3 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol 3: sodium hydrogencarbonate / water; methanol View Scheme | |
Multi-step reaction with 3 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol / 3 h / 60 - 65 °C 3: sodium hydrogencarbonate / ethyl acetate; water View Scheme |
Conditions | Yield |
---|---|
With hydrogen In water; isopropyl alcohol at 20 - 25℃; under 760.051 - 1520.1 Torr; for 4h; Autoclave; Inert atmosphere; | 35.6% |
dehydrositagliptin
A
(R/S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
B
(R/S)-3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Conditions | Yield |
---|---|
With sodium tetrahydroborate; methanesulfonic acid In tetrahydrofuran; isopropyl alcohol at -5 - 5℃; |
dehydrositagliptin
acetic acid
A
(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[ 4,3-a]pyrazin-7(8H)yl)-4-(2,4,5-trifluoro phenyl)butan-1-one acetate
Conditions | Yield |
---|---|
With Ru(OAc)2(S)-DM-SegPhos; hydrogen In methanol at 80℃; under 14997.7 Torr; for 15h; optical yield given as %ee; enantioselective reaction; | A 32 %Chromat. B n/a |
Conditions | Yield |
---|---|
With Ru(OAc)2(S)-DM-SegPhos; hydrogen; ammonium salicylate In methanol at 80℃; under 14997.7 Torr; for 15h; optical yield given as %ee; enantioselective reaction; | 96 %Chromat. |
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol / 2 h / 20 °C 3: sodium hydrogencarbonate / water; methanol View Scheme | |
With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; 1,1-bis[(2R,5R)-2,5-diethylphospholano]ferrocene; hydrogen; ammonium chloride In methanol at 70℃; under 22502.3 Torr; for 24h; Catalytic behavior; Pressure; Reagent/catalyst; Temperature; Solvent; Schlenk technique; Autoclave; enantioselective reaction; | A n/a B n/a |
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol / 2 h / 20 °C View Scheme |
dehydrositagliptin
A
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine (-)dibenzolyl-L-tartaric acid salt
B
(2S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine (-)dibenzolyl-L-tartaric acid salt
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: isopropyl alcohol; methanol / 1 h / 60 - 65 °C View Scheme |
dehydrositagliptin
A
dibenzoyl-D-tartaric acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
B
dibenzoyl-D-tartaric acid (2S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: isopropyl alcohol; methanol / 1 h / 60 - 65 °C View Scheme |
dehydrositagliptin
L-tartaric acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol / 3 h / 60 - 65 °C View Scheme |
dehydrositagliptin
A
(S)-(+)-O-acetylmandelic acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
B
(S)-(+)-O-acetylmandelic acid (2S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: water / 17 h / 60 - 65 °C View Scheme |
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol View Scheme |
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol 3: sodium hydrogencarbonate / water; methanol 4: phosphoric acid / isopropyl alcohol / 70 - 75 °C View Scheme | |
Multi-step reaction with 4 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol / 2 h / 20 °C 3: sodium hydrogencarbonate / water; methanol 4: phosphoric acid / isopropyl alcohol / 70 - 75 °C View Scheme | |
Multi-step reaction with 4 steps 1: dimethylsulfide borane complex; methanesulfonic acid / isopropyl alcohol; tetrahydrofuran / 4 h / -10 - -5 °C 2: methanol / 3 h / 60 - 65 °C 3: sodium hydrogencarbonate / ethyl acetate; water 4: phosphoric acid / isopropyl alcohol / 70 - 75 °C View Scheme |
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen; ammonium salicylate / [RhCl2(p-cymene)]2; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthalene / 2,2,2-trifluoroethanol / 24 h / 50 °C / 22502.3 Torr / Autoclave 2: phosphoric acid / methanol View Scheme |
Conditions | Yield |
---|---|
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; hydrogen; ammonium chloride In methanol at 50℃; under 5947.36 Torr; for 16h; enantioselective reaction; |
dehydrositagliptin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; (2S)-1-[(1S)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferrocene; hydrogen; ammonium chloride / methanol / 16 h / 50 °C / 5947.36 Torr 2: phosphoric acid / water; isopropyl alcohol View Scheme |
dehydrositagliptin
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride In N,N-dimethyl-formamide at 60 - 70℃; for 6h; | 0.5 g |
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