As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryIdelalisib CAS No.:870281-82-6 Name: 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone Molecular Structure Molecular Fo
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Product Name: CAL-101 Synonyms: CAL-101;GS1101;CAL-101 (GS-1101);5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone;CAL101,CAL-101;CAL-101 (Idelalisib, GS-1101);(S)-2-(1-((9H-Purin-6-yl)aMino)propyl)-5-fluoro-3-phenylquina
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inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiryName: 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAS:870281-82-6 MF: C22H18FN7O Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25KG Application:APIS Transportation:By sea or by
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:870281-82-6
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
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inquiryCAL-101 CAS:870281-82-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:870281-82-6
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:870281-82-6
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:870281-82-6
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inquiryCAL-101 CAS NO.870281-82-6Appearance:Powder and crystal Storage:Kept in a cool,dry and ventilated place Package:according to customers' requirements Application:For chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(
We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:870281-82-6
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inquiryProduct name: CAL-101(CAS:870281-82-6) CAS No.: 870281-82-6 Molecule Formula:C22H18FN7O Molecule Weight:415.42 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard
Cas:870281-82-6
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryWe are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiry5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With iodine; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 30℃; for 6h; Solvent; Temperature; | 88% |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane; zinc(II) chloride In acetonitrile for 4h; Reagent/catalyst; Solvent; Reflux; | 60% |
aniline
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.2: 20.5 h / 5 - 30 °C 3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C 4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.2: 20.5 h / 5 - 30 °C 3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C 4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C 6.1: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: Chloro-oxo-acetic acid / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C 1.2: 1.5 h / 0 - 20 °C 2.1: zinc; ammonium formate / dichloromethane; water; methanol / 20 °C 3.1: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C 4.1: trifluoroacetic acid / dichloromethane / 3 h 5.1: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C 6.1: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux View Scheme |
9-(triphenylmethyl)adenine
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: dmap / tetrahydrofuran / 17 h / 25 - 50 °C 2: methanol; potassium carbonate / 6 h / 50 °C 3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C 4: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: pyridine / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere 2: dmap / tetrahydrofuran / 17 h / 25 - 50 °C 3: methanol; potassium carbonate / 6 h / 50 °C 4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C 5: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C View Scheme |
di-tert-butyl (9-trityl-9H-purin-6-yl)-di-carbamate
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol; potassium carbonate / 6 h / 50 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C 3: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C View Scheme |
tert-butyl (9-trityl-9H-purin-6-yl)carbamate
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C 2: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: phosphorus trichloride / acetonitrile / 8.17 h / 25 - 50 °C 2: potassium carbonate / methanol / 1 h / 25 °C 3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C 4: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / methanol / 1 h / 25 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C 3: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 0 - 25℃; for 2.25h; | 525 mg |
2-fluoro-6-nitro-N-phenyl-benzamide
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 1.2: 20.5 h / 5 - 30 °C 2.1: acetic acid; zinc / 20.5 h / 15 - 20 °C 3.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 4.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 1.2: 20.5 h / 5 - 30 °C 2.1: acetic acid; zinc / 20.5 h / 15 - 20 °C 3.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 4.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C 5.1: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C View Scheme | |
Multi-step reaction with 5 steps 1: zinc; ammonium formate / dichloromethane; water; methanol / 20 °C 2: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C 3: trifluoroacetic acid / dichloromethane / 3 h 4: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C 5: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux View Scheme |
6-fluoro-2-nitrobenzoic acid
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.2: 20.5 h / 5 - 30 °C 3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C 4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C 2.2: 20.5 h / 5 - 30 °C 3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C 4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C 6.1: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C View Scheme |
(S)-[1-(2-fluoro-6-nitro-benzoy)phenylaminocarbonyl]propyl carbamic acid tert-butyl ester
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetic acid; zinc / 20.5 h / 15 - 20 °C 2: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 3: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C View Scheme | |
Multi-step reaction with 4 steps 1: acetic acid; zinc / 20.5 h / 15 - 20 °C 2: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 3: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C 4: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C View Scheme |
(S)-(1-(5-fluoro-4-carbonyl-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamic acid tert-butyl ester
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 2: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C 2: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C 3: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen; sodium acetate In ethanol at 30℃; for 16h; |
(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
6-chloro-7H-purine
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With triethylamine In tert-butyl alcohol at 30 - 85℃; for 24h; Concentration; Reagent/catalyst; | 3.1 g |
(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
2,6-dichloro-7H-purine
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C 2: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C View Scheme |
(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
6-bromopurine
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tert-butyl alcohol at 85 - 90℃; | 62.5 g |
5-fluoro-2H-benzo[d][1,3]-oxazine-2,4(1H)-dione
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetonitrile / 40 - 82 °C 2: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 20 h / -5 - 28 °C 3: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr 4: trifluoroacetic acid / dichloromethane / 8 - 28 °C 5: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C View Scheme |
2-amino-6-fluorobenzoic acid
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: pyridine / acetonitrile; dichloromethane / 50 - 60 °C 2: acetonitrile / 40 - 82 °C 3: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 20 h / -5 - 28 °C 4: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr 5: trifluoroacetic acid / dichloromethane / 8 - 28 °C 6: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 20 h / -5 - 28 °C 2: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr 3: trifluoroacetic acid / dichloromethane / 8 - 28 °C 4: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C View Scheme | |
Multi-step reaction with 4 steps 1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 4 h / 0 - 60 °C 2: 1,1,1,3,3,3-hexamethyl-disilazane; iodine / dichloromethane / 36 h / Reflux 3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 6 h / 50 °C 4: hydrogenchloride / water; ethanol / 4 h / 50 °C View Scheme | |
Multi-step reaction with 4 steps 1: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C 2: trifluoroacetic acid / dichloromethane / 3 h 3: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C 4: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr 2: trifluoroacetic acid / dichloromethane / 8 - 28 °C 3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1,1,1,3,3,3-hexamethyl-disilazane; iodine / dichloromethane / 36 h / Reflux 2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 6 h / 50 °C 3: hydrogenchloride / water; ethanol / 4 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: trifluoroacetic acid / dichloromethane / 3 h 2: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C 3: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux View Scheme |
6-chloro-7H-purine
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dichloromethane / 2 h / 30 °C 2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 6 h / 50 °C 3: hydrogenchloride / water; ethanol / 4 h / 50 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 50℃; for 4h; | 28 g |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C 2: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux View Scheme |
2-fluoro-5-nitrobenzoic acid
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Chloro-oxo-acetic acid / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C 1.2: 1.5 h / 0 - 20 °C 2.1: zinc; ammonium formate / dichloromethane; water; methanol / 20 °C 3.1: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C 4.1: trifluoroacetic acid / dichloromethane / 3 h 5.1: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C 6.1: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux View Scheme |
aniline
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With acetic anhydride In toluene at 80 - 120℃; |
9-tert-butoxycarbonyl-6-chloro-9H-purine
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol; ethanol / 30 h / 90 °C / Inert atmosphere 2.1: sodium hydroxide; water / tetrahydrofuran / 10 h / Reflux 3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 3 h / -10 °C / Inert atmosphere 3.2: -10 - 60 °C 4.1: iodine; 1,1,1,3,3,3-hexamethyl-disilazane / dichloromethane / 6 h / 30 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydroxide; water / tetrahydrofuran / 10 h / Reflux 2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 3 h / -10 °C / Inert atmosphere 2.2: -10 - 60 °C 3.1: iodine; 1,1,1,3,3,3-hexamethyl-disilazane / dichloromethane / 6 h / 30 °C View Scheme |
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
Conditions | Yield |
---|---|
With deuterium In N,N-dimethyl acetamide at 80℃; under 1500.15 Torr; for 36h; Reagent/catalyst; Glovebox; |
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