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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino) Manufacturer/High quality/Best price/In stock

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

Idelalisib CAS No.:870281-82-6 Name: 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone Molecular Structure Molecular Fo

High purity Idelalisib CAS No.:870281-82-6

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% CAL-101 870281-82-6 GMP Manufacturer

Cas:870281-82-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Idelalisib

Cas:870281-82-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

idelalisib

Cas:870281-82-6

Min.Order:1000 Gram

FOB Price: $500.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Product Name: CAL-101 Synonyms: CAL-101;GS1101;CAL-101 (GS-1101);5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone;CAL101,CAL-101;CAL-101 (Idelalisib, GS-1101);(S)-2-(1-((9H-Purin-6-yl)aMino)propyl)-5-fluoro-3-phenylquina

870281-82-6 CAL-101

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

CAL-101

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 870281-82-6 with competitive price

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-

Cas:870281-82-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAS:870281-82-6 MF: C22H18FN7O Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25KG Application:APIS Transportation:By sea or by

5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 870281-82-6 CAL-101 with best price

Cas:870281-82-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]- 870281-82-6

Cas:870281-82-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Antineoplastic Agents, CAL-101 CAS:870281-82-6

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $81.0 / 86.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

CAL-101 CAS:870281-82-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

CAL-101 CAS:870281-82-6

Cas:870281-82-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Idelalisib manufacturer with low price

Cas:870281-82-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Idelalisib

Cas:870281-82-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

CAL-101CAS. 870281-82-6

Cas:870281-82-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

CAL-101 Idelalisib 870281-82-6

Cas:870281-82-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Good Quality Idelalisib CAS 870281-82-6

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

IDELALISIB

Cas:870281-82-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

CAL-101

Cas:870281-82-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

CAL-101/High quality/Best price

Cas:870281-82-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino) Manufacturer

Cas:870281-82-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

CAL-101 CAS NO.870281-82-6Appearance:Powder and crystal Storage:Kept in a cool,dry and ventilated place Package:according to customers' requirements Application:For chemical research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(

CAL-101 CAS NO.870281-82-6

Cas:870281-82-6

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

CAL-101CAS. 870281-82-6

Cas:870281-82-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: CAL-101(CAS:870281-82-6) CAS No.: 870281-82-6 Molecule Formula:C22H18FN7O Molecule Weight:415.42 Purity: 99.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Standard

Lower Price CAL-101(CAS:870281-82-6)

Cas:870281-82-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

CAL-101 USP/EP/BP

Cas:870281-82-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)

CAL-101 CAS NO.: 870281-82-6

Cas:870281-82-6

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Synthetic route

C27H28FN7O4

C27H28FN7O4

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With iodine; 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 30℃; for 6h; Solvent; Temperature;88%
2-{[(2S)-2-amino(7H-purin)butanoyl]amino}-6-fluoro-N-phenylbenzamide

2-{[(2S)-2-amino(7H-purin)butanoyl]amino}-6-fluoro-N-phenylbenzamide

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane; zinc(II) chloride In acetonitrile for 4h; Reagent/catalyst; Solvent; Reflux;60%
aniline
62-53-3

aniline

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.2: 20.5 h / 5 - 30 °C
3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C
4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.2: 20.5 h / 5 - 30 °C
3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C
4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C
6.1: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C
View Scheme
Multi-step reaction with 6 steps
1.1: Chloro-oxo-acetic acid / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
1.2: 1.5 h / 0 - 20 °C
2.1: zinc; ammonium formate / dichloromethane; water; methanol / 20 °C
3.1: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C
4.1: trifluoroacetic acid / dichloromethane / 3 h
5.1: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C
6.1: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux
View Scheme
9-(triphenylmethyl)adenine
21802-46-0

9-(triphenylmethyl)adenine

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dmap / tetrahydrofuran / 17 h / 25 - 50 °C
2: methanol; potassium carbonate / 6 h / 50 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C
4: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C
View Scheme
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine / N,N-dimethyl-formamide / 16 h / 25 °C / Inert atmosphere
2: dmap / tetrahydrofuran / 17 h / 25 - 50 °C
3: methanol; potassium carbonate / 6 h / 50 °C
4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C
5: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C
View Scheme
di-tert-butyl (9-trityl-9H-purin-6-yl)-di-carbamate
1229622-81-4

di-tert-butyl (9-trityl-9H-purin-6-yl)-di-carbamate

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol; potassium carbonate / 6 h / 50 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C
3: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C
View Scheme
tert-butyl (9-trityl-9H-purin-6-yl)carbamate
1229622-72-3

tert-butyl (9-trityl-9H-purin-6-yl)carbamate

(R)-5-fluoro-2-(1-hydroxypropyl)-3-phenylquinazolin-4(3H)-one

(R)-5-fluoro-2-(1-hydroxypropyl)-3-phenylquinazolin-4(3H)-one

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C
2: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C
View Scheme
(R)-2-(2-acetoxybutanamido)-6-fluorobenzoic acid

(R)-2-(2-acetoxybutanamido)-6-fluorobenzoic acid

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: phosphorus trichloride / acetonitrile / 8.17 h / 25 - 50 °C
2: potassium carbonate / methanol / 1 h / 25 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C
4: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C
View Scheme
(R)-1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl acetate

(R)-1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl acetate

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / methanol / 1 h / 25 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 21 h / 25 - 45 °C
3: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 25 °C
View Scheme
(S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)(9-trityl-9H-purin-6-yl)carbamate

(S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)(9-trityl-9H-purin-6-yl)carbamate

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 25℃; for 2.25h;525 mg
2-fluoro-6-nitro-N-phenyl-benzamide
870281-83-7

2-fluoro-6-nitro-N-phenyl-benzamide

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
1.2: 20.5 h / 5 - 30 °C
2.1: acetic acid; zinc / 20.5 h / 15 - 20 °C
3.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
4.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
1.2: 20.5 h / 5 - 30 °C
2.1: acetic acid; zinc / 20.5 h / 15 - 20 °C
3.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
4.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C
5.1: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C
View Scheme
Multi-step reaction with 5 steps
1: zinc; ammonium formate / dichloromethane; water; methanol / 20 °C
2: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C
3: trifluoroacetic acid / dichloromethane / 3 h
4: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C
5: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux
View Scheme
6-fluoro-2-nitrobenzoic acid
385-02-4

6-fluoro-2-nitrobenzoic acid

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.2: 20.5 h / 5 - 30 °C
3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C
4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 85 °C
2.2: 20.5 h / 5 - 30 °C
3.1: acetic acid; zinc / 20.5 h / 15 - 20 °C
4.1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
5.1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C
6.1: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C
View Scheme
(S)-[1-(2-fluoro-6-nitro-benzoy)phenylaminocarbonyl]propyl carbamic acid tert-butyl ester
870281-84-8

(S)-[1-(2-fluoro-6-nitro-benzoy)phenylaminocarbonyl]propyl carbamic acid tert-butyl ester

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; zinc / 20.5 h / 15 - 20 °C
2: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
3: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C
View Scheme
Multi-step reaction with 4 steps
1: acetic acid; zinc / 20.5 h / 15 - 20 °C
2: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
3: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C
4: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C
View Scheme
(S)-(1-(5-fluoro-4-carbonyl-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamic acid tert-butyl ester
870281-85-9

(S)-(1-(5-fluoro-4-carbonyl-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamic acid tert-butyl ester

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
2: triethylamine / tert-butyl alcohol / 24 h / 30 - 85 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water; tetrahydrofuran / 2.25 h / 10 - 30 °C
2: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C
3: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C
View Scheme
(S)-2-(1-((2-chloro-7H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one (Chloro-idelalisib)

(S)-2-(1-((2-chloro-7H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one (Chloro-idelalisib)

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; sodium acetate In ethanol at 30℃; for 16h;
(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0

(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

6-chloro-7H-purine
87-42-3

6-chloro-7H-purine

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With triethylamine In tert-butyl alcohol at 30 - 85℃; for 24h; Concentration; Reagent/catalyst;3.1 g
(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0

(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

2,6-dichloro-7H-purine
5451-40-1

2,6-dichloro-7H-purine

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / tert-butyl alcohol / 24 h / 30 - 80 °C
2: palladium 10% on activated carbon; hydrogen; sodium acetate / ethanol / 16 h / 30 °C
View Scheme
(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
870281-86-0

(S)-2-(1-((9H-purin-6-yl-2,8-d2)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

6-bromopurine
767-69-1

6-bromopurine

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tert-butyl alcohol at 85 - 90℃;62.5 g
5-fluoro-2H-benzo[d][1,3]-oxazine-2,4(1H)-dione
78755-94-9

5-fluoro-2H-benzo[d][1,3]-oxazine-2,4(1H)-dione

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: acetonitrile / 40 - 82 °C
2: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 20 h / -5 - 28 °C
3: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr
4: trifluoroacetic acid / dichloromethane / 8 - 28 °C
5: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C
View Scheme
2-amino-6-fluorobenzoic acid
434-76-4

2-amino-6-fluorobenzoic acid

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: pyridine / acetonitrile; dichloromethane / 50 - 60 °C
2: acetonitrile / 40 - 82 °C
3: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 20 h / -5 - 28 °C
4: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr
5: trifluoroacetic acid / dichloromethane / 8 - 28 °C
6: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C
View Scheme
2-amino-6-fluoro-N-phenyl-benzamide

2-amino-6-fluoro-N-phenyl-benzamide

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 20 h / -5 - 28 °C
2: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr
3: trifluoroacetic acid / dichloromethane / 8 - 28 °C
4: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 4 h / 0 - 60 °C
2: 1,1,1,3,3,3-hexamethyl-disilazane; iodine / dichloromethane / 36 h / Reflux
3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 6 h / 50 °C
4: hydrogenchloride / water; ethanol / 4 h / 50 °C
View Scheme
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C
2: trifluoroacetic acid / dichloromethane / 3 h
3: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C
4: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux
View Scheme
(S)-N-[2-[[3-fluoro-2-[(phenylamino)carbonyl]phenyl]amino]-1-ethyl-2-oxoethyl]-carbamic acid tert-butyl ester

(S)-N-[2-[[3-fluoro-2-[(phenylamino)carbonyl]phenyl]amino]-1-ethyl-2-oxoethyl]-carbamic acid tert-butyl ester

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine; chloro-trimethyl-silane / acetonitrile / 24 h / 15 - 95 °C / 750.08 - 1500.15 Torr
2: trifluoroacetic acid / dichloromethane / 8 - 28 °C
3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 85 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1: 1,1,1,3,3,3-hexamethyl-disilazane; iodine / dichloromethane / 36 h / Reflux
2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 6 h / 50 °C
3: hydrogenchloride / water; ethanol / 4 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 3 h
2: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C
3: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux
View Scheme
6-chloro-7H-purine
87-42-3

6-chloro-7H-purine

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane / 2 h / 30 °C
2: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 6 h / 50 °C
3: hydrogenchloride / water; ethanol / 4 h / 50 °C
View Scheme
5-fluoro-3-phenyl-2-[(1S)-1-[[9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]amino]propyl]-3,4-dihydroquinazolin-4-one

5-fluoro-3-phenyl-2-[(1S)-1-[[9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]amino]propyl]-3,4-dihydroquinazolin-4-one

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 50℃; for 4h;28 g
2-{[(2S)-2-aminobutanoyl]amino}-6-fluoro-N-phenylbenzamide

2-{[(2S)-2-aminobutanoyl]amino}-6-fluoro-N-phenylbenzamide

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C
2: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux
View Scheme
2-fluoro-5-nitrobenzoic acid
7304-32-7

2-fluoro-5-nitrobenzoic acid

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Chloro-oxo-acetic acid / dichloromethane; N,N-dimethyl-formamide / 3 h / 20 °C
1.2: 1.5 h / 0 - 20 °C
2.1: zinc; ammonium formate / dichloromethane; water; methanol / 20 °C
3.1: benzotriazol-1-ol; 1,1'-carbonyldiimidazole / toluene / 8 - 15 °C
4.1: trifluoroacetic acid / dichloromethane / 3 h
5.1: N-ethyl-N,N-diisopropylamine; zinc(II) chloride / acetonitrile / 80 - 100 °C
6.1: zinc(II) chloride; 1,1,1,3,3,3-hexamethyl-disilazane / acetonitrile / 4 h / Reflux
View Scheme
C16H15FN6O3

C16H15FN6O3

aniline
62-53-3

aniline

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
With acetic anhydride In toluene at 80 - 120℃;
9-tert-butoxycarbonyl-6-chloro-9H-purine
851165-38-3

9-tert-butoxycarbonyl-6-chloro-9H-purine

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol; ethanol / 30 h / 90 °C / Inert atmosphere
2.1: sodium hydroxide; water / tetrahydrofuran / 10 h / Reflux
3.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 3 h / -10 °C / Inert atmosphere
3.2: -10 - 60 °C
4.1: iodine; 1,1,1,3,3,3-hexamethyl-disilazane / dichloromethane / 6 h / 30 °C
View Scheme
C16H23N5O4

C16H23N5O4

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / tetrahydrofuran / 10 h / Reflux
2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 3 h / -10 °C / Inert atmosphere
2.2: -10 - 60 °C
3.1: iodine; 1,1,1,3,3,3-hexamethyl-disilazane / dichloromethane / 6 h / 30 °C
View Scheme
5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one
870281-82-6

5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-3,4-dihydroquinazolin-4-one

C22H16(2)H2FN7O

C22H16(2)H2FN7O

Conditions
ConditionsYield
With deuterium In N,N-dimethyl acetamide at 80℃; under 1500.15 Torr; for 36h; Reagent/catalyst; Glovebox;

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