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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. High quality and competitive price: 1) Standard: BP/USP/EP/ enterprise standard 2) All purity ≥99% 3) We are manufacturers and can provide high quality products at factory prices. 2. Fast and safe delivery 1) The package c

2-Bromo-5-trifluoromethoxypyridine CAS:888327-36-4

Cas:888327-36-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Pyridine,2-bromo-5-(trifluoromethoxy)-

Cas:888327-36-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2-Bromo-5-trifluoromethoxypyridine CAS:888327-36-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual

2-Bromo-5-trifluoromethoxypyridine CAS:888327-36-4

Cas:888327-36-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Bromo-5-trifluoromethoxypyridine CAS NO.888327-36-4

Cas:888327-36-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Pyridine,2-bromo-5-(trifluoromethoxy)-

Cas:888327-36-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Pyridine,2-bromo-5-(trifluoromethoxy)-;2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Manufacturers

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

best price good quality Storage:Room Temperature Application:For pharmacy chemiacals Transportation:By sea air

Pyridine,2-bromo-5-(trifluoromethoxy)-;2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

Pyridine,2-bromo-5-(trifluoromethoxy)-

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2-BroMo-5-trifluoroMethoxy-pyridine CAS No.888327-36-4

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

2-BROMO-5-(TRIFLUOROMETHOXY)PYRIDINEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-BROMO-5-(TRIFLUOROMETHOXY)PYRIDINE

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Other

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SAGECHEM LIMITED

laboratory Application:Synthetic building block

Pyridine,2-bromo-5-(trifluoromethoxy)-

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Other

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Trading Company

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NUTROCHEM- MANUFACTURE PLACE

best seller Application:API

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Trading Company

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Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Other

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ENAO Chemical Co, Limited

For quick quotation, please send us the inquiry include CAS#, Structure, Chemical Name, quantity, purity, as well as any additional specifications you require, we will try to get back to you within 24 hours. Our Services Besides manufacturing,

2-Bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:S

2-Bromo-5-(trifluoromethoxy)pyridine888327-36-4

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Trading Company

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Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Other

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Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

High quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS

2-bromo-5-(trifluoromethoxy)pyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Finetech Industry Limited

FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the 2-Bromo-5-trifluoromethoxypyridine, CAS:888327-36-4 with the most competitive price a

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changzhou Hopschain Chemical Co.,Ltd

We did before and have a mature technology.If you need NMR/HPLC,please contact with us Package:As your requrement Application:Intermediate Transportation:By Express

2-Bromo-5-trifluoromethoxypyridine

Cas:888327-36-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-chloro-5-(trifluoromethoxy)pyridine
1206972-45-3

2-chloro-5-(trifluoromethoxy)pyridine

2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

Conditions
ConditionsYield
With trimethylsilyl bromide In propiononitrile for 24h; Reflux;81%
With trimethylsilyl bromide In propiononitrile at 100℃; for 72h;81%
6-bromo-pyridin-3-ol
55717-45-8

6-bromo-pyridin-3-ol

tetrachloromethane
56-23-5

tetrachloromethane

2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

Conditions
ConditionsYield
Stage #1: 6-bromo-pyridin-3-ol; tetrachloromethane With antimony pentafluoride at 150℃; for 8h;
Stage #2: With potassium hydroxide In water
2.9%
6-bromopyridin-3-ylboronic acid
223463-14-7

6-bromopyridin-3-ylboronic acid

2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dihydrogen peroxide; acetic acid / tetrahydrofuran / 0 - 20 °C
2: antimony pentafluoride / 8 h / 150 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

2-bromo-5-(trifluoromethoxy)pyridin-1-ium-1-olate

2-bromo-5-(trifluoromethoxy)pyridin-1-ium-1-olate

Conditions
ConditionsYield
With dihydrogen peroxide In dichloromethane; water at 0℃; for 18h;100%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

2,2-dimethyl-1-(2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(pyrimidin-5-yl)propan-1-ol

2,2-dimethyl-1-(2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(pyrimidin-5-yl)propan-1-ol

2,2-dimethyl-1-(2-methyl-4-(5-(trifluoromethoxy)pyridin-2-yl)phenyl)-1-(pyrimidin-5-yl)propan-1-ol

2,2-dimethyl-1-(2-methyl-4-(5-(trifluoromethoxy)pyridin-2-yl)phenyl)-1-(pyrimidin-5-yl)propan-1-ol

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In water; N,N-dimethyl-formamide at 120℃; for 0.5h; Suzuki Coupling; Inert atmosphere; Microwave irradiation;93%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

Ethyl bromodifluoroacetate
667-27-6

Ethyl bromodifluoroacetate

ethyl 2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)acetate

ethyl 2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)acetate

Conditions
ConditionsYield
With copper In dimethyl sulfoxide at 80℃;62%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

carbon dioxide
124-38-9

carbon dioxide

5-(trifluoromethoxy)picolinic acid

5-(trifluoromethoxy)picolinic acid

Conditions
ConditionsYield
Stage #1: 2-bromo-5-(trifluoromethoxy)pyridine With n-butyllithium In hexane; toluene at -100 - -78℃;
Stage #2: carbon dioxide In hexane; toluene
Stage #3: With hydrogenchloride In water pH=4;
60%
Stage #1: 2-bromo-5-(trifluoromethoxy)pyridine With n-butyllithium In hexane; toluene at -78℃; for 2h;
Stage #2: carbon dioxide In hexane; toluene
Stage #3: With hydrogenchloride In hexane; water; toluene pH=4;
60%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

ethyl (2E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acrylate
1009307-13-4

ethyl (2E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acrylate

(E)-ethyl 3-(5-(trifluoromethoxy)pyridin-2-yl)acrylate

(E)-ethyl 3-(5-(trifluoromethoxy)pyridin-2-yl)acrylate

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,2-dimethoxyethane; water at 110℃; for 0.5h; Microwave irradiation; Sealed tube; Inert atmosphere;56%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,2-dimethoxyethane; water at 110℃; for 0.5h; Microwave irradiation;56%
3-bromo-1H-1,2,4-triazole
7343-33-1

3-bromo-1H-1,2,4-triazole

2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

2-(3-bromo-1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)pyridine

2-(3-bromo-1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)pyridine

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 1h; Inert atmosphere; Microwave irradiation;31%
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide at 100℃; for 1h; Sealed tube; Microwave irradiation;31%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

methyl 5-chloro-2-hydroxybenzoate
4068-78-4

methyl 5-chloro-2-hydroxybenzoate

methyl 5-chloro-2-[[5-(trifluoromethoxy)-2-pyridyl]oxy]benzoate

methyl 5-chloro-2-[[5-(trifluoromethoxy)-2-pyridyl]oxy]benzoate

Conditions
ConditionsYield
With 2-Picolinic acid; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 80℃; for 19h; Inert atmosphere;31%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-[5-(trifluoromethoxy)pyridin-2-yl]piperazine-1-carboxylate

tert-butyl 4-[5-(trifluoromethoxy)pyridin-2-yl]piperazine-1-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 80℃; for 16h;28%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

C14H20N2O3

C14H20N2O3

C20H22F3N3O4

C20H22F3N3O4

Conditions
ConditionsYield
With 15-crown-5; sodium hydride In N,N-dimethyl-formamide; mineral oil at 80℃; for 16h;19%
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)oxazole
942070-84-0

5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)oxazole

2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

5-(5-(trifluoromethoxy)pyridin-2-yl)oxazole

5-(5-(trifluoromethoxy)pyridin-2-yl)oxazole

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran for 16h; Suzuki Coupling; Reflux;5.1%
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-(2-amino-2-methylcyclopentyl)-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride

N-(2-amino-2-methylcyclopentyl)-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride

N-(2-methyl-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl)-2-(2H-1,2,3-triazol-2-yl)benzamide

N-(2-methyl-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl)-2-(2H-1,2,3-triazol-2-yl)benzamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 140℃; for 17h; Inert atmosphere;
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-[(1S,2S)-2-aminocyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride

N-[(1S,2S)-2-aminocyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride

2-(2H-1,2,3-triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl]benzamide

2-(2H-1,2,3-triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl]benzamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 110℃; for 17h; Sealed tube; Inert atmosphere;
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-[(1S,2S)-2-aminocyclopentyl]-5-chloro-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride

N-[(1S,2S)-2-aminocyclopentyl]-5-chloro-2-(2H-1,2,3-triazol-2-yl)benzamide hydrochloride

5-chloro-2-(2H-1,2,3-triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl]benzamide

5-chloro-2-(2H-1,2,3-triazol-2-yl)-N-[(1S,2S)-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl]benzamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 120℃; for 0.25h; Inert atmosphere;
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-[(1S,2S)-2-amino-4,4-difluorocyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide

N-[(1S,2S)-2-amino-4,4-difluorocyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide

N-[(1S,2S)-4,4-difluoro-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide

N-[(1S,2S)-4,4-difluoro-2-{[5-(trifluoromethoxy)pyridin-2-yl]amino}cyclopentyl]-2-(2H-1,2,3-triazol-2-yl)benzamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 120℃; for 17h; Inert atmosphere;
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethanol

2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper / dimethyl sulfoxide / 80 °C
2: sodium tetrahydroborate; ethanol / 0.5 h / 20 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyltrifluoromethanesulfonate

2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyltrifluoromethanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper / dimethyl sulfoxide / 80 °C
2: sodium tetrahydroborate; ethanol / 0.5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-(1-(2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyl)piperidin-4-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-(1-(2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyl)piperidin-4-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: copper / dimethyl sulfoxide / 80 °C
2: sodium tetrahydroborate; ethanol / 0.5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 60 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-(1-(2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyl)piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-(1-(2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyl)piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: copper / dimethyl sulfoxide / 80 °C
2: sodium tetrahydroborate; ethanol / 0.5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 60 °C
5: sodium hydroxide / water; tetrahydrofuran / 3 h / 60 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-(1-(2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyl)piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

N-(1-(2,2-difluoro-2-(5-(trifluoromethoxy)pyridin-2-yl)ethyl)piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: copper / dimethyl sulfoxide / 80 °C
2: sodium tetrahydroborate; ethanol / 0.5 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 60 °C
5: sodium hydroxide / water; tetrahydrofuran / 3 h / 60 °C
6: hydrogenchloride / methanol / 0.5 h / 20 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-[2-(1-benzylpiperidin-4-yl)ethyl]piperidine-4-carboxamide

N-[2-(1-benzylpiperidin-4-yl)ethyl]piperidine-4-carboxamide

N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-[5-(trifluoromethoxy)pyridin-2-yl]piperidine-4-carboxamide

N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-[5-(trifluoromethoxy)pyridin-2-yl]piperidine-4-carboxamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃;
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

6-bromo-(3-trifluoromethoxy)pyridine-2-carbonitrile

6-bromo-(3-trifluoromethoxy)pyridine-2-carbonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dihydrogen peroxide / dichloromethane; water / 18 h / 0 °C
2: triethylamine / acetonitrile / 40 h / 80 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

1-[5-(trifluoromethoxy)pyridin-2-yl]piperazine

1-[5-(trifluoromethoxy)pyridin-2-yl]piperazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 16 h / 80 °C
2: hydrogenchloride / water; 1,4-dioxane / 4 h / 20 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-[5-[(tert-butyldimethylsilyl)oxy]pyridin-2-yl]-4-[5-(trifluoromethoxy)pyridin-2-yl]piperazine-1-carboxamide

N-[5-[(tert-butyldimethylsilyl)oxy]pyridin-2-yl]-4-[5-(trifluoromethoxy)pyridin-2-yl]piperazine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 16 h / 80 °C
2: hydrogenchloride / water; 1,4-dioxane / 4 h / 20 °C
3: triethylamine / dichloromethane / 16 h / 20 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

N-(5-hydroxypyridin-2-yl)-4-[5-(trifluoromethoxy)pyridin-2-yl]piperazine-1-carboxamide

N-(5-hydroxypyridin-2-yl)-4-[5-(trifluoromethoxy)pyridin-2-yl]piperazine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 16 h / 80 °C
2: hydrogenchloride / water; 1,4-dioxane / 4 h / 20 °C
3: triethylamine / dichloromethane / 16 h / 20 °C
4: hydrogenchloride / water; tetrahydrofuran / 2 h / 20 °C
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

5-(trifluoromethoxy)-2-(3-vinyl-1H-1,2,4-triazol-1-yl)pyridine

5-(trifluoromethoxy)-2-(3-vinyl-1H-1,2,4-triazol-1-yl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 100 °C / Sealed tube; Microwave irradiation
2: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 0.5 h / 90 °C / Sealed tube; Microwave irradiation
View Scheme
2-bromo-5-(trifluoromethoxy)pyridine
888327-36-4

2-bromo-5-(trifluoromethoxy)pyridine

4,4-difluoroazepane
1094073-72-9

4,4-difluoroazepane

4,4-difluoro-1-(5-(trifluoromethoxy)pyridin-2-yl)azepane

4,4-difluoro-1-(5-(trifluoromethoxy)pyridin-2-yl)azepane

Conditions
ConditionsYield
With [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate; sodium t-butanolate In tetrahydrofuran at 60℃; for 12h; Inert atmosphere;
With [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate; sodium t-butanolate In tetrahydrofuran at 25 - 60℃; for 12h; Inert atmosphere;

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