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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Cefdinir Manufacturer/High quality/Best price/In stock

Cas:91832-40-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance It should be a yellowish to yellow crystalline powder with a slight odor. Yellowish crystalline powde

High quality Cefdinir with best price cas:91832-40-5

Cas:91832-40-5

Min.Order:1 Kilogram

FOB Price: $250.0 / 350.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Cefdinir Cas 91832-40-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to light yellow crystalline powder Storage:Cool dry place Package:25k

Factory supply high quality Cefdinir Cas 91832-40-5 with best price

Cas:91832-40-5

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Hefei TNJ chemical industry co.,ltd

Cefdinir Structural formula: CAS NO.:91832-40-5 Standard:JP14 Test Results: Assay≥98%,the rest specifications conform to JP 14 standard

Cefdinir

Cas:91832-40-5

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

Cefdinir English name: Cefdinir Chemical name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Categor

Cefdinir

Cas:91832-40-5

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Cefdinir

Cas:91832-40-5

Min.Order:1

Negotiable

Type:Other

inquiry

HANGZHOU CLAKE BIOTECH CO.,LTD

1. ISO AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:25kg/drum / 25kg/bag Application:active pharmaceutical ingredient Transportation:sea/air both ok Port:any

CEFDINIR

Cas:91832-40-5

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Cefdinir 91832-40-5 GMP Manufacturer

Cas:91832-40-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Cefdinir

Cas:91832-40-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Cefdinir

Cas:91832-40-5

Min.Order:5 Milligram

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Cefdinir

Cas:91832-40-5

Min.Order:1000 Gram

FOB Price: $700.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Cefdinir Manufacturer/supplier in China Chinese Name: Cefdinir English Name: cefdinir English aliases: Omnice; Cefdinir; Cefzon; Novacef; cefdinyl; CAS No. 91832-40-5 Molecular formula: C14H13N5O5S2 Molecula

Cefdinir Manufacturer/supplier in China/High quality

Cas:91832-40-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Cefdinir

Cas:91832-40-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--91832-40-5--High purity Cefdinir factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business

TIANFUCHEM--91832-40-5--High purity Cefdinir factory price

Cas:91832-40-5

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 91832-40-5 with best quality

Cas:91832-40-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Cefdinir/ LIDE PHARMA- Factory supply / Best price

Cas:91832-40-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Synonyms: 8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid CAS NO.: 91832-40-5 MF: C14H13N5O5S2 MW: 395.41 InChI: 1/C14H13N5O5S2/c1-2-5-3-25-12-8(11(

Cefdinir

Cas:91832-40-5

Min.Order:5 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed containers a

Cefdinir CAS NO.91832-40-5 C14H13N5O5S2 Human antibiotics

Cas:91832-40-5

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Cefdinir 91832-40-5

Cas:91832-40-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Cefdinir Structure: Formula: C14H13N5O5S2 Molecular Weight : 395.41 Synonyms: (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-hydroxyimino-1-oxoethyl]amino]-3-e

Factory Supply Cefdinir

Cas:91832-40-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:Pale yellow solid Storage:Keep in dark place,Sealed in dry,2-8°C Package:25kg/Barrel Application:API Transportation:Express/Sea/Air Port:Any port in china

TOP quality Cefdinir with best price cas:91832-40-5

Cas:91832-40-5

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Cefdinir cephalosporins

Cas:91832-40-5

Min.Order:1 Kilogram

FOB Price: $165.0 / 200.0

Type:Trading Company

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Cefdinir CAS91832-40-5

Cas:91832-40-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available;

Factory Supply High Quality Cefdinir CAS 91832-40-5

Cas:91832-40-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:Pale Yellow Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/C

Cefdinir

Cas:91832-40-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Cefdinir

Cas:91832-40-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

FK-482 Cefdinir 91832-40-5

Cas:91832-40-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cefdinir

Cas:91832-40-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

high quality of CefdinirAppearance:powder Storage:store in a cool dry place and keep away from strong Package:according to customers' requirements Application:in research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF o

high quality of Cefdinir

Cas:91832-40-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Pale yellow solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:A Cephalospori

cefdinir

Cas:91832-40-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Synthetic route

7-amino-3-vinylcephalosporin-4-carboxylic acid p-nitrobenzyl ester

7-amino-3-vinylcephalosporin-4-carboxylic acid p-nitrobenzyl ester

1-[(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetoxy]benzotriazole

1-[(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetoxy]benzotriazole

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Stage #1: 7-amino-3-vinylcephalosporin-4-carboxylic acid p-nitrobenzyl ester With N-cyclohexyl-cyclohexanamine In water; isopropyl alcohol; acetonitrile at 5 - 10℃; for 0.166667h;
Stage #2: 1-[(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetoxy]benzotriazole In water; isopropyl alcohol; acetonitrile at 20℃; Further stages;
98%
potassium syn-7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate tetrahydrate

potassium syn-7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate tetrahydrate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With hydrogenchloride In water at 25 - 30℃; for 2h; pH=2.4 - 2.5;90%
S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate
104797-47-9

S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate

(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
79349-82-9

(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Stage #1: S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate; (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In tetrahydrofuran at 20 - 23℃; for 5h;
Stage #2: With hydrogenchloride; methoxybenzene In tetrahydrofuran; dichloromethane at -25 - -20℃; for 1.5h;
88.6%
Stage #1: S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate; (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In tetrahydrofuran; water at 20℃; for 4 - 6h;
Stage #2: With potassium carbonate In water at 20℃; for 0.5 - 0.75h; pH=8.0 - 8.2;
Stage #3: With sulfuric acid In water pH=2 - 2.5;
Stage #1: S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate; (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid In tetrahydrofuran for 0.166667h;
Stage #2: With water; triethylamine In tetrahydrofuran; dichloromethane at 15 - 25℃; for 3 - 4h;
Stage #3: With sulfuric acid; water In tetrahydrofuran; dichloromethane at 35 - 40℃; for 2h; pH=2.4 - 2.5;
(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
79349-82-9

(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

S-(2-benzothiazolyl) 2-(2-aminothiazol-4-yl)-2(Z)-trityloxyiminothioacetate
143183-03-3

S-(2-benzothiazolyl) 2-(2-aminothiazol-4-yl)-2(Z)-trityloxyiminothioacetate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Stage #1: (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; S-(2-benzothiazolyl) 2-(2-aminothiazol-4-yl)-2(Z)-trityloxyiminothioacetate With triethylamine In N,N-dimethyl acetamide at 15 - 20℃; for 4h;
Stage #2: With hydrogenchloride; methoxybenzene In dichloromethane; N,N-dimethyl acetamide at -15 - -10℃; for 2h;
85.8%
7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(trityloxyamino)acetamido]-3-vinylcephem-4-carboxylic acid
128454-32-0

7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(trityloxyamino)acetamido]-3-vinylcephem-4-carboxylic acid

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With formic acid at 20℃; for 3h;2.54 g
C16H15N5O6S2
127770-93-8

C16H15N5O6S2

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With ammonium chloride; water; potassium carbonate at 18 - 22℃; pH=8 - 8.2;
7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(trityloxyamino)acetamido]-3-vinylcephem-4-carboxylic acid
128454-32-0

7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(trityloxyamino)acetamido]-3-vinylcephem-4-carboxylic acid

A

3-methyl cefdinir

3-methyl cefdinir

B

Cefdinir sulfoxide

Cefdinir sulfoxide

C

(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(hydroxyimino)acetamido]-3-vinyl-2-cephem-4-carboxylic acid

(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(hydroxyimino)acetamido]-3-vinyl-2-cephem-4-carboxylic acid

D

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With trifluoroacetic acid at 10 - 15℃; for 4h; Further byproducts.;A n/a
B n/a
C n/a
D 39.5 g
C16H15N5O6S2*C6H15N

C16H15N5O6S2*C6H15N

A

3-methyl cefdinir

3-methyl cefdinir

B

C14H15N5O6S2

C14H15N5O6S2

C

cefdinir
91832-40-5

cefdinir

D

7β-[(E)-2-(2-amino-4-thiazolyl)-2-(hydroxyimino)acetamido]-3-vinylcephem-4-carboxylic acid

7β-[(E)-2-(2-amino-4-thiazolyl)-2-(hydroxyimino)acetamido]-3-vinylcephem-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: C16H15N5O6S2*C6H15N With ammonium chloride; potassium carbonate In tetrahydrofuran at 20 - 25℃; for 0.166667h; pH=5;
Stage #2: With sulfuric acid at 20 - 40℃; pH=2.5 - 2.6; Further stages. Title compound not separated from byproducts.;
A n/a
B n/a
C 160 g
D n/a
S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate
104797-47-9

S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran; H2O / 6 h / 15 - 20 °C
2: ammonium chloride; potassium carbonate; water / 18 - 22 °C / pH 8 - 8.2
View Scheme
(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetic acid

(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetic acid

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / triphenylphosphine; triethylamine / CH2Cl2 / 0.5 h / 10 - 30 °C
2: triethylamine / tetrahydrofuran; H2O / 6 h / 15 - 20 °C
3: ammonium chloride; potassium carbonate; water / 18 - 22 °C / pH 8 - 8.2
View Scheme
(6R,7R)-benzhydryl 3-(hydroxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
35246-64-1

(6R,7R)-benzhydryl 3-(hydroxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: PBr / tetrahydrofuran / 0.33 h / -5 °C
2.1: ethyl acetate / 5 h / 20 °C
3.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C
4.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C
4.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C
4.3: 90 percent / H2O / -50 °C
5.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
6.1: TFA; anisole / CH2Cl2 / 0 - 5 °C
7.1: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate
94796-13-1

diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C
1.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C
1.3: 90 percent / H2O / -50 °C
2.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
3.1: TFA; anisole / CH2Cl2 / 0 - 5 °C
4.1: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino)acetate
69689-86-7

ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino)acetate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97.6 percent / aq. NaOH / dioxane / 2 h / 100 - 110 °C
2: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
3: TFA; anisole / CH2Cl2 / 0 - 5 °C
4: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
15690-38-7

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: N,O-bis(trimethylsilyl)acetamide / N,N-dimethyl-acetamide / 0.5 h / 20 °C
1.2: 51.9 percent / N,N-dimethyl-acetamide / 1.5 h / -20 - -10 °C
2.1: ethyl acetate / 1 h / 20 °C
3.1: PBr / tetrahydrofuran / 0.33 h / -5 °C
4.1: ethyl acetate / 5 h / 20 °C
5.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C
6.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C
6.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C
6.3: 90 percent / H2O / -50 °C
7.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
8.1: TFA; anisole / CH2Cl2 / 0 - 5 °C
9.1: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1.1: ethyl acetate / 1 h / 20 °C
2.1: PBr / tetrahydrofuran / 0.33 h / -5 °C
3.1: ethyl acetate / 5 h / 20 °C
4.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C
5.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C
5.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C
5.3: 90 percent / H2O / -50 °C
6.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
7.1: TFA; anisole / CH2Cl2 / 0 - 5 °C
8.1: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
3-hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
28240-15-5

3-hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: ethyl acetate / 1 h / 20 °C
2.1: PBr / tetrahydrofuran / 0.33 h / -5 °C
3.1: ethyl acetate / 5 h / 20 °C
4.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C
5.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C
5.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C
5.3: 90 percent / H2O / -50 °C
6.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
7.1: TFA; anisole / CH2Cl2 / 0 - 5 °C
8.1: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
Diphenylmethyl 7β-amino-3-vinyl-3-cephem-4-carboxylate hydrochloride

Diphenylmethyl 7β-amino-3-vinyl-3-cephem-4-carboxylate hydrochloride

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
2: TFA; anisole / CH2Cl2 / 0 - 5 °C
3: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
(Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate
64485-82-1

(Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 52.2 percent / TEA / CHCl3 / 1.5 h / 20 °C
2: 97.6 percent / aq. NaOH / dioxane / 2 h / 100 - 110 °C
3: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
4: TFA; anisole / CH2Cl2 / 0 - 5 °C
5: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
(6R,7R)-3-Bromomethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
64276-70-6

(6R,7R)-3-Bromomethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: ethyl acetate / 5 h / 20 °C
2.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C
3.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C
3.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C
3.3: 90 percent / H2O / -50 °C
4.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
5.1: TFA; anisole / CH2Cl2 / 0 - 5 °C
6.1: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
sodium 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino)acetate

sodium 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino)acetate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
2: TFA; anisole / CH2Cl2 / 0 - 5 °C
3: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
diphenylmethyl 7β-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-tritylhydroxyimino]-3-vinyl-3-cephem-4-carboxylate
123201-39-8

diphenylmethyl 7β-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-tritylhydroxyimino]-3-vinyl-3-cephem-4-carboxylate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA; anisole / CH2Cl2 / 0 - 5 °C
2: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
((6R,7R)-2-Benzhydryloxycarbonyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl)-triphenyl-phosphonium; bromide

((6R,7R)-2-Benzhydryloxycarbonyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl)-triphenyl-phosphonium; bromide

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C
2.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C
2.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C
2.3: 90 percent / H2O / -50 °C
3.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C
4.1: TFA; anisole / CH2Cl2 / 0 - 5 °C
5.1: 2.54 g / aq. HCOOH / 3 h / 20 °C
View Scheme
2-(Z)-(2-aminothiazol-4-yl)-2-hydroxyiminoacetic acid chloride/hydrochloride

2-(Z)-(2-aminothiazol-4-yl)-2-hydroxyiminoacetic acid chloride/hydrochloride

(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
79349-82-9

(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 0 - 20℃; for 3.5h;
potassium 7-(Z)-[2-(2-aminothiazol-4-yl)-2-hydroxylminoacetimido]-3-vinyl-3-cephem-4-carboxylate
91832-41-6

potassium 7-(Z)-[2-(2-aminothiazol-4-yl)-2-hydroxylminoacetimido]-3-vinyl-3-cephem-4-carboxylate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With hydrogenchloride In water at 3 - 4℃; for 5 - 6h; pH=2.4 - 2.6; Purification / work up;
With hydrogenchloride In methanol; water at 0 - 14℃; for 5 - 6h; pH=2.2 - 2.3; Product distribution / selectivity;
With ethylenediaminetetraacetic acid In water at 25 - 30℃; for 0.25 - 0.5h; pH=1.8 - 2.4; Product distribution / selectivity; Active carbon;
With ethylenediaminetetraacetic acid In water at 8 - 30℃; for 0.25 - 0.5h; pH=1.8 - 2.4; Product distribution / selectivity; Active carbon;
N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid
865411-26-3

N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Stage #1: N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid With hydrogenchloride In water; acetone at 35 - 38℃; for 0.0833333 - 0.166667h; pH=1.2 - 1.8;
Stage #2: With ammonia; pyrographite In water; acetone at 35 - 38℃; for 0.5h; pH=6.0;
Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages;
Stage #1: N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid With hydrogenchloride In water; ethyl acetate at 35 - 38℃; for 0.0833333 - 0.166667h; pH=1.2 - 1.8;
Stage #2: With ammonia; pyrographite In water; ethyl acetate at 35 - 38℃; for 0.5h; pH=6.0;
Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages;
Stage #1: N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid With hydrogenchloride In water; isopropyl alcohol at 35 - 38℃; for 0.0833333 - 0.166667h; pH=1.2 - 1.8;
Stage #2: With ammonia; pyrographite In water; isopropyl alcohol at 35 - 38℃; for 0.5h; pH=6.0;
Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages;
benzhydryl 7-[2-(-aminothiazaol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrobromide (syn isomer)
1056963-31-5

benzhydryl 7-[2-(-aminothiazaol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrobromide (syn isomer)

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With trifluoroacetic acid In methoxybenzene at 5℃; for 1h; Product distribution / selectivity;
With boron trifluoride diethyl etherate In acetic acid; methoxybenzene at 10℃; for 0.333333h; Product distribution / selectivity;
Stage #1: benzhydryl 7-[2-(-aminothiazaol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrobromide (syn isomer) With trifluoroacetic acid In methoxybenzene at 5 - 7℃; for 1h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate at 0℃; for 1h; pH=2.2; Product distribution / selectivity;
Stage #1: benzhydryl 7-[2-(-aminothiazaol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrobromide (syn isomer) With boron trifluoride diethyl etherate; acetic acid In methoxybenzene at 10℃; for 0.333333h;
Stage #2: With hydrogenchloride In water pH=2.0; Product distribution / selectivity;
With trifluoroacetic acid In methoxybenzene at 5 - 7℃; for 1h; Product distribution / selectivity;
p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate
146667-80-3

p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Stage #1: p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate With trifluoroacetic acid In toluene at 5 - 20℃; for 3.5h;
Stage #2: With water In toluene at 0 - 5℃; for 0.75 - 1h;
C55H49N5O5S2Si

C55H49N5O5S2Si

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
Stage #1: C55H49N5O5S2Si With trifluoroacetic acid In toluene at 5 - 20℃; for 3.5h;
Stage #2: With water In toluene at 0 - 50℃; Product distribution / selectivity;
7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) monohydrate

7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) monohydrate

cefdinir
91832-40-5

cefdinir

Conditions
ConditionsYield
With water for 0.0833333h;
In methanol Purification / work up;
Stage #1: 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) monohydrate at -20℃; freezing;
Stage #2: at 20℃; under 0.01 Torr; for 158h; Product distribution / selectivity; vacuum drying;
With phosphorus pentoxide at 60℃; for 1h; Product distribution / selectivity;
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium hydrogen sulfate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium hydrogen sulfate

Conditions
ConditionsYield
Stage #1: cefdinir With sulfuric acid In methanol Cooling with ice;
Stage #2: With sodium methylate In methanol for 0.25h; Product distribution / selectivity;
99%
With sulfuric acid; sodium methylate In methanol for 0.25h; Product distribution / selectivity; Cooling with ice;99%
cefdinir
91832-40-5

cefdinir

2C14H13N5O5S2*HO4S(1-)*H2O4S*K(1+)

2C14H13N5O5S2*HO4S(1-)*H2O4S*K(1+)

Conditions
ConditionsYield
With sulfuric acid; potassium propylate In ethanol for 0.25h; Product distribution / selectivity;98.3%
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium dihydrogen phosphate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sodium dihydrogen phosphate

Conditions
ConditionsYield
Stage #1: cefdinir With phosphoric acid In ethanol
Stage #2: With sodium t-butanolate In ethanol for 0.25h; Product distribution / selectivity;
98.1%
With phosphoric acid; sodium t-butanolate In ethanol for 0.25h; Product distribution / selectivity;98.1%
cefdinir
91832-40-5

cefdinir

2C14H13N5O5S2*HO4S(1-)*H2O4S*Na(1+)

2C14H13N5O5S2*HO4S(1-)*H2O4S*Na(1+)

Conditions
ConditionsYield
With sulfuric acid; sodium methylate In ethanol for 0.25h; Product distribution / selectivity; Cooling with ice;98.1%
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid potassium hydrogen sulfate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid potassium hydrogen sulfate

Conditions
ConditionsYield
Stage #1: cefdinir With sulfuric acid In methanol Cooling with ice;
Stage #2: With potassium methanolate In methanol for 0.25h; Product distribution / selectivity;
98%
With sulfuric acid; sodium methylate In metahanol for 0.25h; Product distribution / selectivity; Cooling with ice;98%
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid ammonium hydrogen sulfate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid ammonium hydrogen sulfate

Conditions
ConditionsYield
With ammonium bisulphate In methanol Product distribution / selectivity;98%
With ammonium bisulphate In methanol Product distribution / selectivity;98%
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino) 8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid potassium dihydrogen phosphate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino) 8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid potassium dihydrogen phosphate

Conditions
ConditionsYield
Stage #1: cefdinir With phosphoric acid In methanol
Stage #2: With potassium isopropoxide In methanol for 0.25h; Product distribution / selectivity;
97.5%
With phosphoric acid; potassium isopropoxide In methanol for 0.25h; Product distribution / selectivity;97.5%
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid cesium hydrogen sulfate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid cesium hydrogen sulfate

Conditions
ConditionsYield
Stage #1: cefdinir With sulfuric acid In acetone
Stage #2: With cesium butoxide In acetone for 0.25h; Product distribution / selectivity;
97.3%
With sulfuric acid; cesium butoxide In acetone for 0.25h; Product distribution / selectivity;97.3%
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0)oct-2-ene-2-carboxylic acid cesium dihydrogen phosphate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo (4.2.0)oct-2-ene-2-carboxylic acid cesium dihydrogen phosphate

Conditions
ConditionsYield
Stage #1: cefdinir With phosphoric acid In ethanol
Stage #2: With cesium butoxide In ethanol for 0.25h; Product distribution / selectivity;
96.8%
With phosphoric acid; cesium butoxide In ethanol for 0.25h; Product distribution / selectivity;96.8%
cefdinir
91832-40-5

cefdinir

2C14H13N5O5S2*2H2O4S*H3N

2C14H13N5O5S2*2H2O4S*H3N

Conditions
ConditionsYield
With sulfuric acid; ammonia In ethanol for 0.25h; Product distribution / selectivity; Cooling with ice;96.7%
cefdinir
91832-40-5

cefdinir

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid ammonium dihydrogen phosphate

(-)-(6R,7R)-7-((Z)-2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetylamino)-8-oxo-3-vinyl-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid ammonium dihydrogen phosphate

Conditions
ConditionsYield
With ammonium dihydrogen phosphate In ethanol Product distribution / selectivity;96.4%
With ammonium dihydrogen phosphate In ethanol Product distribution / selectivity;96.4%
cefdinir
91832-40-5

cefdinir

potassium syn-7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate tetrahydrate

potassium syn-7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate tetrahydrate

Conditions
ConditionsYield
With water; potassium acetate In acetone at 10 - 30℃; for 5h; Product distribution / selectivity;94.5%
cefdinir
91832-40-5

cefdinir

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

C14H13N5O5S2*C42H70O35
1372167-37-7

C14H13N5O5S2*C42H70O35

Conditions
ConditionsYield
at 60℃; for 0.025h; Microwave irradiation; Alcohol solution;72.9%
cefdinir
91832-40-5

cefdinir

(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(hydroxyimino)acetamido]-3-vinyl-2-cephem-4-carboxylic acid

(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(hydroxyimino)acetamido]-3-vinyl-2-cephem-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: cefdinir With N-Trimethylsilylacetamide In dichloromethane for 0.5h;
Stage #2: With triethylamine In dichloromethane at 25 - 30℃; for 24h;
Stage #3: With sulfuric acid at 2 - 5℃; for 2h; pH=3.0; Further stages.;
48%
cefdinir
91832-40-5

cefdinir

cefdinir lactone

cefdinir lactone

Conditions
ConditionsYield
With trifluoroacetic acid In water at 35 - 40℃; for 1h;1%

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