As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:91832-40-5
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Appearance It should be a yellowish to yellow crystalline powder with a slight odor. Yellowish crystalline powde
Cas:91832-40-5
Min.Order:1 Kilogram
FOB Price: $250.0 / 350.0
Type:Trading Company
inquiryUnique advantages of Cefdinir Cas 91832-40-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to light yellow crystalline powder Storage:Cool dry place Package:25k
Cas:91832-40-5
Min.Order:25 Kilogram
Negotiable
Type:Trading Company
inquiryCefdinir Structural formula: CAS NO.:91832-40-5 Standard:JP14 Test Results: Assay≥98%,the rest specifications conform to JP 14 standard
Cefdinir English name: Cefdinir Chemical name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Categor
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. ISO AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:25kg/drum / 25kg/bag Application:active pharmaceutical ingredient Transportation:sea/air both ok Port:any
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:91832-40-5
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Cefdinir Manufacturer/supplier in China Chinese Name: Cefdinir English Name: cefdinir English aliases: Omnice; Cefdinir; Cefzon; Novacef; cefdinyl; CAS No. 91832-40-5 Molecular formula: C14H13N5O5S2 Molecula
Cas:91832-40-5
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
TIANFUCHEM--91832-40-5--High purity Cefdinir factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable business
Cas:91832-40-5
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:91832-40-5
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:91832-40-5
Min.Order:0
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Type:Lab/Research institutions
inquirySynonyms: 8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid CAS NO.: 91832-40-5 MF: C14H13N5O5S2 MW: 395.41 InChI: 1/C14H13N5O5S2/c1-2-5-3-25-12-8(11(
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Solid Storage:Store in sealed containers a
Cas:91832-40-5
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:91832-40-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Cefdinir Structure: Formula: C14H13N5O5S2 Molecular Weight : 395.41 Synonyms: (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-hydroxyimino-1-oxoethyl]amino]-3-e
Appearance:Pale yellow solid Storage:Keep in dark place,Sealed in dry,2-8°C Package:25kg/Barrel Application:API Transportation:Express/Sea/Air Port:Any port in china
Cas:91832-40-5
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:91832-40-5
Min.Order:1 Kilogram
FOB Price: $165.0 / 200.0
Type:Trading Company
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:91832-40-5
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. 3) OEM/ODM Available;
Cas:91832-40-5
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryAppearance:Pale Yellow Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/C
Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:91832-40-5
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
high quality of CefdinirAppearance:powder Storage:store in a cool dry place and keep away from strong Package:according to customers' requirements Application:in research Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF o
Superior quality, moderate price & quick delivery. Appearance:Pale yellow solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:A Cephalospori
cefdinir
Conditions | Yield |
---|---|
Stage #1: 7-amino-3-vinylcephalosporin-4-carboxylic acid p-nitrobenzyl ester With N-cyclohexyl-cyclohexanamine In water; isopropyl alcohol; acetonitrile at 5 - 10℃; for 0.166667h; Stage #2: 1-[(Z)-2-(2-amino-4-thiazolyl)-2-(acetoxyimino)acetoxy]benzotriazole In water; isopropyl alcohol; acetonitrile at 20℃; Further stages; | 98% |
cefdinir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 25 - 30℃; for 2h; pH=2.4 - 2.5; | 90% |
S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate
(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefdinir
Conditions | Yield |
---|---|
Stage #1: S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate; (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In tetrahydrofuran at 20 - 23℃; for 5h; Stage #2: With hydrogenchloride; methoxybenzene In tetrahydrofuran; dichloromethane at -25 - -20℃; for 1.5h; | 88.6% |
Stage #1: S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate; (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid With triethylamine In tetrahydrofuran; water at 20℃; for 4 - 6h; Stage #2: With potassium carbonate In water at 20℃; for 0.5 - 0.75h; pH=8.0 - 8.2; Stage #3: With sulfuric acid In water pH=2 - 2.5; | |
Stage #1: S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate; (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid In tetrahydrofuran for 0.166667h; Stage #2: With water; triethylamine In tetrahydrofuran; dichloromethane at 15 - 25℃; for 3 - 4h; Stage #3: With sulfuric acid; water In tetrahydrofuran; dichloromethane at 35 - 40℃; for 2h; pH=2.4 - 2.5; |
(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
S-(2-benzothiazolyl) 2-(2-aminothiazol-4-yl)-2(Z)-trityloxyiminothioacetate
cefdinir
Conditions | Yield |
---|---|
Stage #1: (6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; S-(2-benzothiazolyl) 2-(2-aminothiazol-4-yl)-2(Z)-trityloxyiminothioacetate With triethylamine In N,N-dimethyl acetamide at 15 - 20℃; for 4h; Stage #2: With hydrogenchloride; methoxybenzene In dichloromethane; N,N-dimethyl acetamide at -15 - -10℃; for 2h; | 85.8% |
7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(trityloxyamino)acetamido]-3-vinylcephem-4-carboxylic acid
cefdinir
Conditions | Yield |
---|---|
With formic acid at 20℃; for 3h; | 2.54 g |
C16H15N5O6S2
cefdinir
Conditions | Yield |
---|---|
With ammonium chloride; water; potassium carbonate at 18 - 22℃; pH=8 - 8.2; |
7β-[(Z)-2-(2-amino-4-thiazolyl)-2-(trityloxyamino)acetamido]-3-vinylcephem-4-carboxylic acid
D
cefdinir
Conditions | Yield |
---|---|
With trifluoroacetic acid at 10 - 15℃; for 4h; Further byproducts.; | A n/a B n/a C n/a D 39.5 g |
C
cefdinir
Conditions | Yield |
---|---|
Stage #1: C16H15N5O6S2*C6H15N With ammonium chloride; potassium carbonate In tetrahydrofuran at 20 - 25℃; for 0.166667h; pH=5; Stage #2: With sulfuric acid at 20 - 40℃; pH=2.5 - 2.6; Further stages. Title compound not separated from byproducts.; | A n/a B n/a C 160 g D n/a |
S-2-benzothiazolyl (Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyimino thioacetate
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran; H2O / 6 h / 15 - 20 °C 2: ammonium chloride; potassium carbonate; water / 18 - 22 °C / pH 8 - 8.2 View Scheme |
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / triphenylphosphine; triethylamine / CH2Cl2 / 0.5 h / 10 - 30 °C 2: triethylamine / tetrahydrofuran; H2O / 6 h / 15 - 20 °C 3: ammonium chloride; potassium carbonate; water / 18 - 22 °C / pH 8 - 8.2 View Scheme |
(6R,7R)-benzhydryl 3-(hydroxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: PBr / tetrahydrofuran / 0.33 h / -5 °C 2.1: ethyl acetate / 5 h / 20 °C 3.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C 4.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C 4.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C 4.3: 90 percent / H2O / -50 °C 5.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 6.1: TFA; anisole / CH2Cl2 / 0 - 5 °C 7.1: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
diphenylmethyl 7β-phenylacetamido-3-vinyl-3-cephem-4-carboxylate
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C 1.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C 1.3: 90 percent / H2O / -50 °C 2.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 3.1: TFA; anisole / CH2Cl2 / 0 - 5 °C 4.1: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino)acetate
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 97.6 percent / aq. NaOH / dioxane / 2 h / 100 - 110 °C 2: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 3: TFA; anisole / CH2Cl2 / 0 - 5 °C 4: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: N,O-bis(trimethylsilyl)acetamide / N,N-dimethyl-acetamide / 0.5 h / 20 °C 1.2: 51.9 percent / N,N-dimethyl-acetamide / 1.5 h / -20 - -10 °C 2.1: ethyl acetate / 1 h / 20 °C 3.1: PBr / tetrahydrofuran / 0.33 h / -5 °C 4.1: ethyl acetate / 5 h / 20 °C 5.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C 6.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C 6.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C 6.3: 90 percent / H2O / -50 °C 7.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 8.1: TFA; anisole / CH2Cl2 / 0 - 5 °C 9.1: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: ethyl acetate / 1 h / 20 °C 2.1: PBr / tetrahydrofuran / 0.33 h / -5 °C 3.1: ethyl acetate / 5 h / 20 °C 4.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C 5.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C 5.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C 5.3: 90 percent / H2O / -50 °C 6.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 7.1: TFA; anisole / CH2Cl2 / 0 - 5 °C 8.1: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
3-hydroxymethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: ethyl acetate / 1 h / 20 °C 2.1: PBr / tetrahydrofuran / 0.33 h / -5 °C 3.1: ethyl acetate / 5 h / 20 °C 4.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C 5.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C 5.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C 5.3: 90 percent / H2O / -50 °C 6.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 7.1: TFA; anisole / CH2Cl2 / 0 - 5 °C 8.1: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 2: TFA; anisole / CH2Cl2 / 0 - 5 °C 3: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
(Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 52.2 percent / TEA / CHCl3 / 1.5 h / 20 °C 2: 97.6 percent / aq. NaOH / dioxane / 2 h / 100 - 110 °C 3: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 4: TFA; anisole / CH2Cl2 / 0 - 5 °C 5: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
(6R,7R)-3-Bromomethyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: ethyl acetate / 5 h / 20 °C 2.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C 3.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C 3.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C 3.3: 90 percent / H2O / -50 °C 4.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 5.1: TFA; anisole / CH2Cl2 / 0 - 5 °C 6.1: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 2: TFA; anisole / CH2Cl2 / 0 - 5 °C 3: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
diphenylmethyl 7β-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-tritylhydroxyimino]-3-vinyl-3-cephem-4-carboxylate
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: TFA; anisole / CH2Cl2 / 0 - 5 °C 2: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
cefdinir
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: 4.04 g / aq. Na2CO3 / CH2Cl2 / 1.5 h / 20 °C 2.1: PCl5; pyridine / CH2Cl2 / 1.5 h / 8 - 10 °C 2.2: MeOH / CH2Cl2 / 1.25 h / -20 - -10 °C 2.3: 90 percent / H2O / -50 °C 3.1: 92.4 percent / N,N-dimethylaniline; POCl3 / CH2Cl2 / 1.5 h / -15 - -10 °C 4.1: TFA; anisole / CH2Cl2 / 0 - 5 °C 5.1: 2.54 g / aq. HCOOH / 3 h / 20 °C View Scheme |
(6R,7R)-7-amino-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
cefdinir
Conditions | Yield |
---|---|
With N,O-bis-(trimethylsilyl)-acetamide In dichloromethane at 0 - 20℃; for 3.5h; |
potassium 7-(Z)-[2-(2-aminothiazol-4-yl)-2-hydroxylminoacetimido]-3-vinyl-3-cephem-4-carboxylate
cefdinir
Conditions | Yield |
---|---|
With hydrogenchloride In water at 3 - 4℃; for 5 - 6h; pH=2.4 - 2.6; Purification / work up; | |
With hydrogenchloride In methanol; water at 0 - 14℃; for 5 - 6h; pH=2.2 - 2.3; Product distribution / selectivity; | |
With ethylenediaminetetraacetic acid In water at 25 - 30℃; for 0.25 - 0.5h; pH=1.8 - 2.4; Product distribution / selectivity; Active carbon; | |
With ethylenediaminetetraacetic acid In water at 8 - 30℃; for 0.25 - 0.5h; pH=1.8 - 2.4; Product distribution / selectivity; Active carbon; |
N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid
cefdinir
Conditions | Yield |
---|---|
Stage #1: N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid With hydrogenchloride In water; acetone at 35 - 38℃; for 0.0833333 - 0.166667h; pH=1.2 - 1.8; Stage #2: With ammonia; pyrographite In water; acetone at 35 - 38℃; for 0.5h; pH=6.0; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; | |
Stage #1: N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid With hydrogenchloride In water; ethyl acetate at 35 - 38℃; for 0.0833333 - 0.166667h; pH=1.2 - 1.8; Stage #2: With ammonia; pyrographite In water; ethyl acetate at 35 - 38℃; for 0.5h; pH=6.0; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; | |
Stage #1: N,N'-dicyclohexylethane-1,2-diamine salt of 7β-[2-(2-amino-4-thiazolyl)-2-((Z)-hydroxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid With hydrogenchloride In water; isopropyl alcohol at 35 - 38℃; for 0.0833333 - 0.166667h; pH=1.2 - 1.8; Stage #2: With ammonia; pyrographite In water; isopropyl alcohol at 35 - 38℃; for 0.5h; pH=6.0; Stage #3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages; |
benzhydryl 7-[2-(-aminothiazaol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrobromide (syn isomer)
cefdinir
Conditions | Yield |
---|---|
With trifluoroacetic acid In methoxybenzene at 5℃; for 1h; Product distribution / selectivity; | |
With boron trifluoride diethyl etherate In acetic acid; methoxybenzene at 10℃; for 0.333333h; Product distribution / selectivity; | |
Stage #1: benzhydryl 7-[2-(-aminothiazaol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrobromide (syn isomer) With trifluoroacetic acid In methoxybenzene at 5 - 7℃; for 1h; Stage #2: With hydrogenchloride In tetrahydrofuran; water; ethyl acetate at 0℃; for 1h; pH=2.2; Product distribution / selectivity; | |
Stage #1: benzhydryl 7-[2-(-aminothiazaol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylate hydrobromide (syn isomer) With boron trifluoride diethyl etherate; acetic acid In methoxybenzene at 10℃; for 0.333333h; Stage #2: With hydrogenchloride In water pH=2.0; Product distribution / selectivity; | |
With trifluoroacetic acid In methoxybenzene at 5 - 7℃; for 1h; Product distribution / selectivity; |
p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate
cefdinir
Conditions | Yield |
---|---|
Stage #1: p-methoxybenzyl (Z)-7-((2-tritylamino-thiazol-4-yl)-2-trityloxyimino-acetamido)-3-vinyl-3-cephem-4-carboxylate With trifluoroacetic acid In toluene at 5 - 20℃; for 3.5h; Stage #2: With water In toluene at 0 - 5℃; for 0.75 - 1h; |
cefdinir
Conditions | Yield |
---|---|
Stage #1: C55H49N5O5S2Si With trifluoroacetic acid In toluene at 5 - 20℃; for 3.5h; Stage #2: With water In toluene at 0 - 50℃; Product distribution / selectivity; |
cefdinir
Conditions | Yield |
---|---|
With water for 0.0833333h; | |
In methanol Purification / work up; | |
Stage #1: 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) monohydrate at -20℃; freezing; Stage #2: at 20℃; under 0.01 Torr; for 158h; Product distribution / selectivity; vacuum drying; | |
With phosphorus pentoxide at 60℃; for 1h; Product distribution / selectivity; |
cefdinir
Conditions | Yield |
---|---|
Stage #1: cefdinir With sulfuric acid In methanol Cooling with ice; Stage #2: With sodium methylate In methanol for 0.25h; Product distribution / selectivity; | 99% |
With sulfuric acid; sodium methylate In methanol for 0.25h; Product distribution / selectivity; Cooling with ice; | 99% |
cefdinir
Conditions | Yield |
---|---|
With sulfuric acid; potassium propylate In ethanol for 0.25h; Product distribution / selectivity; | 98.3% |
cefdinir
Conditions | Yield |
---|---|
Stage #1: cefdinir With phosphoric acid In ethanol Stage #2: With sodium t-butanolate In ethanol for 0.25h; Product distribution / selectivity; | 98.1% |
With phosphoric acid; sodium t-butanolate In ethanol for 0.25h; Product distribution / selectivity; | 98.1% |
cefdinir
Conditions | Yield |
---|---|
With sulfuric acid; sodium methylate In ethanol for 0.25h; Product distribution / selectivity; Cooling with ice; | 98.1% |
cefdinir
Conditions | Yield |
---|---|
Stage #1: cefdinir With sulfuric acid In methanol Cooling with ice; Stage #2: With potassium methanolate In methanol for 0.25h; Product distribution / selectivity; | 98% |
With sulfuric acid; sodium methylate In metahanol for 0.25h; Product distribution / selectivity; Cooling with ice; | 98% |
cefdinir
Conditions | Yield |
---|---|
With ammonium bisulphate In methanol Product distribution / selectivity; | 98% |
With ammonium bisulphate In methanol Product distribution / selectivity; | 98% |
cefdinir
Conditions | Yield |
---|---|
Stage #1: cefdinir With phosphoric acid In methanol Stage #2: With potassium isopropoxide In methanol for 0.25h; Product distribution / selectivity; | 97.5% |
With phosphoric acid; potassium isopropoxide In methanol for 0.25h; Product distribution / selectivity; | 97.5% |
cefdinir
Conditions | Yield |
---|---|
Stage #1: cefdinir With sulfuric acid In acetone Stage #2: With cesium butoxide In acetone for 0.25h; Product distribution / selectivity; | 97.3% |
With sulfuric acid; cesium butoxide In acetone for 0.25h; Product distribution / selectivity; | 97.3% |
cefdinir
Conditions | Yield |
---|---|
Stage #1: cefdinir With phosphoric acid In ethanol Stage #2: With cesium butoxide In ethanol for 0.25h; Product distribution / selectivity; | 96.8% |
With phosphoric acid; cesium butoxide In ethanol for 0.25h; Product distribution / selectivity; | 96.8% |
cefdinir
Conditions | Yield |
---|---|
With sulfuric acid; ammonia In ethanol for 0.25h; Product distribution / selectivity; Cooling with ice; | 96.7% |
cefdinir
Conditions | Yield |
---|---|
With ammonium dihydrogen phosphate In ethanol Product distribution / selectivity; | 96.4% |
With ammonium dihydrogen phosphate In ethanol Product distribution / selectivity; | 96.4% |
cefdinir
Conditions | Yield |
---|---|
With water; potassium acetate In acetone at 10 - 30℃; for 5h; Product distribution / selectivity; | 94.5% |
Conditions | Yield |
---|---|
at 60℃; for 0.025h; Microwave irradiation; Alcohol solution; | 72.9% |
cefdinir
Conditions | Yield |
---|---|
Stage #1: cefdinir With N-Trimethylsilylacetamide In dichloromethane for 0.5h; Stage #2: With triethylamine In dichloromethane at 25 - 30℃; for 24h; Stage #3: With sulfuric acid at 2 - 5℃; for 2h; pH=3.0; Further stages.; | 48% |
cefdinir
Conditions | Yield |
---|---|
With trifluoroacetic acid In water at 35 - 40℃; for 1h; | 1% |
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