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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (4-chloro-2-fluoro-3-methoxyphenyl)boronic acid

Cas:944129-07-1

Min.Order:1

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Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 944129-07-1 with competitive price

Cas:944129-07-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-Chloro-2-fluoro-3-methoxyphenylboronic acid CAS:944129-07-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

4-Chloro-2-fluoro-3-methoxyphenylboronic acid CAS:944129-07-1

Cas:944129-07-1

Min.Order:1 Gram

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 200.0

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

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Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-Chloro-2-fluoro-3- methoxy phenylboronic acid

Cas:944129-07-1

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid CAS NO.944129-07-1

Cas:944129-07-1

Min.Order:10 Gram

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Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:944129-07-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:944129-07-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

Hangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting 4-Chloro-2-fluoro-3-methoxyphenylboronic acid 99%,cas944129-07-1, Please contact us by email freely. We are leading exporter in China. If you really ne

4-Chloro-2-fluoro-3-methoxyphenylboronic acid 99%,cas944129-07-1 from fandachem

Cas:944129-07-1

Min.Order:0 Metric Ton

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Type:Other

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:944129-07-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

944129-07-1

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:944129-07-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Chloro-2-fluoro-3-methoxyphenylboronic acid cas no. 944129-07-1 97%

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Manufacturers

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

(4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

TIANFU CHEM--4-Chloro-2-fluoro-3-methoxyphenylboronic acidAppearance:White solid Storage:Store in dry, dark and ventilated place Package:as per buyer's request Application:Multipurpose intermediate Transportation:By sea , by air or express

TIANFU CHEM--4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

(4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID Application:4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID

4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Other

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4-Chloro-2-fluoro-3-methoxyphenylboronic acid

Cas:944129-07-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

4-CHLORO-2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:944129-07-1

Min.Order:0

Negotiable

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Synthetic route

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

Conditions
ConditionsYield
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In 1,2-dimethoxyethane at -78 - -70.1℃; for 1.75h;
Stage #2: With Trimethyl borate In 1,2-dimethoxyethane at -67 - 20℃; Time; Temperature; Further stages;
93%
Multi-step reaction with 2 steps
1.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 1.75 h / -77 - -70.1 °C / Inert atmosphere
1.2: 1.37 h / -74.1 - 23.1 °C
2.1: potassium hydroxide; water / 1,2-dimethoxyethane / 2 h / 30 °C / Cooling
View Scheme
Trimethyl borate
121-43-7

Trimethyl borate

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane; cyclohexane at -50℃; Flow reactor;92%
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In 1,2-dimethoxyethane at -65℃; Inert atmosphere;
Stage #2: Trimethyl borate In 1,2-dimethoxyethane at -65 - 30℃; Time; Inert atmosphere;
Trimethyl borate
121-43-7

Trimethyl borate

6-chloro-2-fluoro-3-lithioanisole

6-chloro-2-fluoro-3-lithioanisole

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

Conditions
ConditionsYield
Stage #1: Trimethyl borate; 6-chloro-2-fluoro-3-lithioanisole In 1,2-dimethoxyethane; hexane at -70 - -45℃; for 0.25h; Cooling with dry ice bath;
Stage #2: With hydrogenchloride; water In 1,2-dimethoxyethane; hexane Product distribution / selectivity;
Stage #1: Trimethyl borate; 6-chloro-2-fluoro-3-lithioanisole In hexanes; 1,2-dimethoxyethane at -65 - 20℃;
Stage #2: With potassium hydroxide; water In hexanes; 1,2-dimethoxyethane at 23.1℃; for 1.11667h;
Stage #3: With hydrogenchloride In water; acetonitrile Product distribution / selectivity;
Stage #1: Trimethyl borate; 6-chloro-2-fluoro-3-lithioanisole In hexanes; 1,2-dimethoxyethane at -65 - 20℃;
Stage #2: With potassium hydroxide; water In hexanes; 1,2-dimethoxyethane at 23.3℃; for 1.43333h;
Stage #3: With hydrogenchloride In water Product distribution / selectivity;
4-chloro-2-fluoro-3-methoxyphenyl dimethylboronate
1426539-30-1

4-chloro-2-fluoro-3-methoxyphenyl dimethylboronate

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

Conditions
ConditionsYield
Stage #1: 4-chloro-2-fluoro-3-methoxyphenyl dimethylboronate With water; potassium hydroxide at 16 - 20℃; for 0.25h;
Stage #2: With hydrogenchloride In water for 0.25h;
With water; potassium hydroxide In 1,2-dimethoxyethane at 30℃; for 2h; Cooling;
2,3-dimethyl-2,3-butane diol
76-09-5

2,3-dimethyl-2,3-butane diol

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1126321-06-9

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
In ethyl acetate at 23.1℃; for 2h; Inert atmosphere;99%
methyl 4-amino-3,6-dichloro-5-fluoropicolinate
496850-09-0

methyl 4-amino-3,6-dichloro-5-fluoropicolinate

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropyridine-2-carboxylic acid methyl ester

4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropyridine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In methanol; water; acetonitrile at 60℃; for 7h; Suzuki Coupling;88.1%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

C14H18Cl3NO2

C14H18Cl3NO2

C21H23Cl3FNO3

C21H23Cl3FNO3

Conditions
ConditionsYield
With dichloro[9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene]palladium (II); triethylamine In water; toluene at 55℃; for 24h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Suzuki-Miyaura Coupling; Inert atmosphere;85%
methyl 4-amino-3,6-dichloropyridine-2-carboxylate
350601-39-7

methyl 4-amino-3,6-dichloropyridine-2-carboxylate

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

halauxifen methyl ester

halauxifen methyl ester

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In water; acetonitrile at 50℃; for 22h; Concentration; Reagent/catalyst; Suzuki Coupling; Inert atmosphere;81.4%
With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride In water; acetonitrile for 4h; Reflux;
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

benzyl 4,5,6-trichloropicolinate
1390662-56-2

benzyl 4,5,6-trichloropicolinate

benzyl 4,5-dichloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate
1390662-58-4

benzyl 4,5-dichloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate

Conditions
ConditionsYield
With dichloro[9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene]palladium (II); triethylamine In water; toluene at 35℃; for 18h; Catalytic behavior; Reagent/catalyst; Temperature; Solvent; Suzuki-Miyaura Coupling; Inert atmosphere;79%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

methyl 6-amino-2-chloro-5-methoxy-pyrimidine-4-carboxylate
1126320-49-7

methyl 6-amino-2-chloro-5-methoxy-pyrimidine-4-carboxylate

methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate
1126318-85-1

methyl 6-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidine-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; potassium hydrogencarbonate; triphenylphosphine In methanol; water; acetonitrile at 50℃; for 22h; Suzuki Coupling; Inert atmosphere;75.6%
With cesium fluoride; bis-triphenylphosphine-palladium(II) chloride In 1,2-dimethoxyethane; water at 100℃; for 0.25h; Microwave irradiation;51.1%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

4,5,6-trichloropicolinic acid
496849-77-5

4,5,6-trichloropicolinic acid

A

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-2-pyridinecarboxylic acid
1546765-39-2

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-2-pyridinecarboxylic acid

B

5-chloro-4,6-bis(4-chloro-2-fluoro-3-methoxyphenyl)picolinic acid

5-chloro-4,6-bis(4-chloro-2-fluoro-3-methoxyphenyl)picolinic acid

Conditions
ConditionsYield
Stage #1: 4,5,6-trichloropicolinic acid With palladium diacetate; triethylamine In water; acetonitrile for 0.5h; Inert atmosphere;
Stage #2: (4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid With triethylamine In water; acetonitrile at 65℃; for 24.5h; Reagent/catalyst; Inert atmosphere;
A 74%
B 6%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

[(3-methoxyphenyl)methylidene]hydrazine
108087-83-8

[(3-methoxyphenyl)methylidene]hydrazine

C15H14ClFO2

C15H14ClFO2

Conditions
ConditionsYield
With manganese(IV) oxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; under 5171.62 Torr; Flow reactor;71%
6-amino-2,5-dichloro-pyrimidine-4-carboxylic acid methyl ester
502142-81-6

6-amino-2,5-dichloro-pyrimidine-4-carboxylic acid methyl ester

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

methyl 6-amino-5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)pyrimidine-4-carboxylate

methyl 6-amino-5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)pyrimidine-4-carboxylate

Conditions
ConditionsYield
With palladium diacetate; potassium hydrogencarbonate; triphenylphosphine In methanol; water; acetonitrile at 50℃; for 22h; Suzuki Coupling; Inert atmosphere;68.1%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

benzyl 4-amino-3,6-dichloro-5-fluoropicolinate

benzyl 4-amino-3,6-dichloro-5-fluoropicolinate

benzyl ester of 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid
1390661-72-9

benzyl ester of 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; triphenylphosphine In methanol; water; acetonitrile at 60℃; for 4h; Suzuki Coupling;67.9%
methyl 5-chloropyridine-2-carboxylate
132308-19-1

methyl 5-chloropyridine-2-carboxylate

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

5-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid

5-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid

Conditions
ConditionsYield
Stage #1: methyl 5-chloropyridine-2-carboxylate; (4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; triphenylphosphine In N,N-dimethyl-formamide at 85 - 90℃; for 24h; Suzuki Coupling; Inert atmosphere;
Stage #2: With water; lithium hydroxide In tetrahydrofuran at 25 - 30℃; for 3h; Inert atmosphere;
60%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

4-(4-chloro-2-fluoro-3-methoxy-phenyl)-1-tetrahydropyran-2-yl-pyrazole

4-(4-chloro-2-fluoro-3-methoxy-phenyl)-1-tetrahydropyran-2-yl-pyrazole

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 110℃; for 2h; Suzuki Coupling;54%
methyl 6-amino-2-chloropyrimidine-4-carboxylate
944129-00-4

methyl 6-amino-2-chloropyrimidine-4-carboxylate

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

6-amino-2-(4-chloro-2-fluoro-3-methoxy-phenyl)-pyrimidine-4-carboxylic acid methyl ester
944129-05-9

6-amino-2-(4-chloro-2-fluoro-3-methoxy-phenyl)-pyrimidine-4-carboxylic acid methyl ester

Conditions
ConditionsYield
bis-triphenylphosphine-palladium(II) chloride In 1,2-dimethoxyethane; water at 80℃; for 2h;53.3%
bis-triphenylphosphine-palladium(II) chloride In 1,2-dimethoxyethane; water at 80℃; for 2h;53.5%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

C11H7Cl3N4O2

C11H7Cl3N4O2

C18H12Cl3FN4O3

C18H12Cl3FN4O3

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; cesium fluoride In 1,4-dioxane; water at 120℃; for 12h; Inert atmosphere;51%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

4-amino-2-chloro-6-methoxycarbonyl-5-prop-1-ynyl-pyrimidine
1240313-17-0

4-amino-2-chloro-6-methoxycarbonyl-5-prop-1-ynyl-pyrimidine

4-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-methoxycarbonyl-5-prop-1-ynyl-pyrimidine
1240312-70-2

4-amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-methoxycarbonyl-5-prop-1-ynyl-pyrimidine

Conditions
ConditionsYield
With cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,2-dimethoxyethane; water at 140℃; for 0.333333h; Haller-Bauer Reaction; Inert atmosphere; microwave irradiation;11%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

4,5,6-trichloro-pyridine-2-carboxylic acid methyl ester
496849-76-4

4,5,6-trichloro-pyridine-2-carboxylic acid methyl ester

C14H9Cl3FNO3

C14H9Cl3FNO3

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride In water; ethyl acetate at 45℃; for 18h; Suzuki-Miyaura Coupling; Inert atmosphere;5%
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

trimethyleneglycol
504-63-2

trimethyleneglycol

1,3-propanediyl 4-chloro-2-fluoro-3-methoxyphenylboronate

1,3-propanediyl 4-chloro-2-fluoro-3-methoxyphenylboronate

Conditions
ConditionsYield
In 1,2-dimethoxyethane; hexane
In toluene for 2h; Heating / reflux;
4-acetylamino-3-benzyloxy-6-bromo-pyridine-2-carboxylic acid methyl ester
851442-71-2

4-acetylamino-3-benzyloxy-6-bromo-pyridine-2-carboxylic acid methyl ester

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

methyl 4-acetamido-3-(benzyloxy)-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate
1417332-47-8

methyl 4-acetamido-3-(benzyloxy)-6-(4-chloro-2-fluoro-3-methoxyphenyl)picolinate

Conditions
ConditionsYield
With cesium fluoride; bis-triphenylphosphine-palladium(II) chloride In 1,2-dimethoxyethane; water at 100℃; for 0.25h; microwave irradiation;
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

methyl 4-acetamido-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-hydroxypicolinate
1417332-44-5

methyl 4-acetamido-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-hydroxypicolinate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / microwave irradiation
2: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 24 h
View Scheme
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

methyl 4-acetamido-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate
1417331-18-0

methyl 4-acetamido-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / microwave irradiation
2: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 24 h
3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h
View Scheme
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate
1417331-20-4

methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-3-methoxypicolinate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.25 h / 100 °C / microwave irradiation
2: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 24 h
3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 24 h
4: methanol / 25 °C
View Scheme
methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate

methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate
943831-44-5

methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

Conditions
ConditionsYield
Stage #1: methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate; (4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid With palladium diacetate; triphenylphosphine In 1,2-dimethoxyethane; acetonitrile Inert atmosphere;
Stage #2: With potassium carbonate In 1,2-dimethoxyethane; water; acetonitrile at 50℃; for 2.5h;
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

4,5,6-trichloropicolinic acid
496849-77-5

4,5,6-trichloropicolinic acid

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-2-pyridinecarboxylic acid
1546765-39-2

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-2-pyridinecarboxylic acid

Conditions
ConditionsYield
Stage #1: 4,5,6-trichloropicolinic acid With bis-triphenylphosphine-palladium(II) chloride; triethylamine In water; acetonitrile at 50℃; for 0.25h; Inert atmosphere;
Stage #2: (4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid In 1,2-dimethoxyethane; water; acetonitrile at 50℃; for 5h; Inert atmosphere;
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-2-pyridinecarbonyl chloride
1546765-42-7

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-2-pyridinecarbonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.25 h / 50 °C / Inert atmosphere
1.2: 5 h / 50 °C / Inert atmosphere
2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 75 °C
View Scheme
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

C13H6ClF4NO2
1546765-44-9

C13H6ClF4NO2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / water; acetonitrile / 0.25 h / 50 °C / Inert atmosphere
1.2: 5 h / 50 °C / Inert atmosphere
2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 75 °C
3.1: potassium fluoride / sulfolane / 20 - 130 °C
View Scheme
(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

5,6-dichloro-2-pyridinecarboxylic acid
88912-24-7

5,6-dichloro-2-pyridinecarboxylic acid

C13H8Cl2FNO3

C13H8Cl2FNO3

Conditions
ConditionsYield
Stage #1: 5,6-dichloro-2-pyridinecarboxylic acid With triethylamine In water; acetonitrile for 0.5h;
Stage #2: (4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate In water; acetonitrile at 55℃; for 22h;

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