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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Eltoprazine

Cas:98224-03-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Eltoprazine 98224-03-4

Cas:98224-03-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE CAS: 98224-03-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates,

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE CAS: 98224-03-4

Cas:98224-03-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Eltoprazine

Cas:98224-03-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Eltoprazine

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Eltoprazinehydrochloride

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine hydrochloride

Cas:98224-03-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE Synonyms: 1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE;ELTOPRAZINE HYDROCHLORIDE;1-[(2,3-Dihydro-1,4-benzodioxin)-5-yl]piperazine;5-(Piperazin-1-yl)-2,

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine hydrochloride

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Eltoprazine

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine hydrochloride

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Eltoprazine

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.Appearanc

Eltoprazine

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Eltoprazine

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

98224-03-4

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine hydrochloride

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine hydrochloride 98224-03-4

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine hydrochloride

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

1-(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)piperazine hydrochloride

Cas:98224-03-4

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

HENAN SUNLAKE ENTERPRISE CORPORATION Our company advantages: 1. The highest quality with the competitive price. 2. Professional human services. 3. The fastest and safest delivery service. 4. The faster and safest delivery service. 5. Th

1-(2,3-DIHYDRO-1,4-BENZODIOXIN-5-YL)-PIPERAZINE HYDROCHLORIDE

Cas:98224-03-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

Zhengzhou Kingorgchem Chemical Technology Co., Ltd. was founded on the basis of Organophosphorus Chemistry Lab of Institute of Chemistry Henan Academy of Sciences in 2015. The laboratory covers 600 m2 and the pilot plant covers 2000 m2. Kingorgchem i

National Research Platform ISO 9001 98224-03-4

Cas:98224-03-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

1-(2,3-DIHYDROBENZO[B[1,4DIOXIN-5-YL)PIPERAZINE

Cas:98224-03-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

piperazine
110-85-0

piperazine

5-bromo-2,3-dihydrobenzo[1,4]dioxin
58328-39-5

5-bromo-2,3-dihydrobenzo[1,4]dioxin

eltoprazine
98224-03-4

eltoprazine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 100℃; for 4h; Sealed tube;59%
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

1,4-benzodioxan-5-amine
16081-45-1

1,4-benzodioxan-5-amine

eltoprazine
98224-03-4

eltoprazine

Conditions
ConditionsYield
In chlorobenzene Reflux;51%
With potassium carbonate In chlorobenzene for 24h; Heating;
With sodium hydroxide In chlorobenzene
In sodium hydroxide; chlorobenzene
In sodium hydroxide; chlorobenzene
4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester

eltoprazine
98224-03-4

eltoprazine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane Ambient temperature; Yield given;
5-bromo-2,3-dihydrobenzo[1,4]dioxin
58328-39-5

5-bromo-2,3-dihydrobenzo[1,4]dioxin

eltoprazine
98224-03-4

eltoprazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tri(o-tolyl)phosphine, bis(dibenzylideneacetone)palladium(O), sodium tert-butoxide / toluene / 100 °C
2: trifluoroacetic acid / CH2Cl2 / Ambient temperature
View Scheme
2,3-dihydro-1,4-benzodioxine-5-carboxylic acid
4442-53-9

2,3-dihydro-1,4-benzodioxine-5-carboxylic acid

eltoprazine
98224-03-4

eltoprazine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / water; acetone / 0 °C
2.1: sodium azide / water; acetone
2.2: Heating
3.1: hydrogenchloride / water / Reflux
4.1: chlorobenzene / Reflux
View Scheme
C12H12O6

C12H12O6

eltoprazine
98224-03-4

eltoprazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium azide / water; acetone
1.2: Heating
2.1: hydrogenchloride / water / Reflux
3.1: chlorobenzene / Reflux
View Scheme
C9H7NO3
1155139-88-0

C9H7NO3

eltoprazine
98224-03-4

eltoprazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / Reflux
2: chlorobenzene / Reflux
View Scheme
2-bromoindanone
1775-27-5

2-bromoindanone

eltoprazine
98224-03-4

eltoprazine

2-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl]-1-indanone

2-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl]-1-indanone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h;100%
3-(2-bromoethyl)-1H-indole
3389-21-7

3-(2-bromoethyl)-1H-indole

eltoprazine
98224-03-4

eltoprazine

3-[2-[4-(1,4-Benzodioxan-5-yl)piperazin-1-yl]ethyl]-1H-indole

3-[2-[4-(1,4-Benzodioxan-5-yl)piperazin-1-yl]ethyl]-1H-indole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; potassium iodide In acetonitrile Heating;99%
formaldehyd
50-00-0

formaldehyd

eltoprazine
98224-03-4

eltoprazine

6,7,8,8a-tetrahydro-5H-imidazo[1,5-a]pyridine-1,3(2H,5H)-dione
4705-52-6

6,7,8,8a-tetrahydro-5H-imidazo[1,5-a]pyridine-1,3(2H,5H)-dione

2-[[4-(2,3-dihydro-1,4-benzodioxan-5-yl)piperazin-1-yl]methyl]-1,3-dioxoperhydroimidazo[1,5-a]pyridine

2-[[4-(2,3-dihydro-1,4-benzodioxan-5-yl)piperazin-1-yl]methyl]-1,3-dioxoperhydroimidazo[1,5-a]pyridine

Conditions
ConditionsYield
In methanol; water Mannich reaction; Heating;88%
eltoprazine
98224-03-4

eltoprazine

7-bromo-3-(4-chlorobutyl)-4-fluorobenzo[b]thiophene
522648-64-2

7-bromo-3-(4-chlorobutyl)-4-fluorobenzo[b]thiophene

1-[4-(7-bromo-4-fluorobenzo[b]thiophen-3-yl)butyl]-4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)piperazine
522649-03-2

1-[4-(7-bromo-4-fluorobenzo[b]thiophen-3-yl)butyl]-4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)piperazine

Conditions
ConditionsYield
With potassium carbonate; sodium iodide In acetonitrile at 80℃; for 18h;86%
eltoprazine
98224-03-4

eltoprazine

7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone
129722-34-5

7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone

7-(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one
1354030-74-2

7-(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone With sodium iodide In acetonitrile for 0.5h; Reflux;
Stage #2: eltoprazine With potassium carbonate In acetonitrile for 4h; Reflux;
83%
4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yloxy)butyl methanesulfonate
1354030-18-4

4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yloxy)butyl methanesulfonate

eltoprazine
98224-03-4

eltoprazine

7-(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)butoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

7-(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)butoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

Conditions
ConditionsYield
Stage #1: 4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yloxy)butyl methanesulfonate With sodium iodide In acetonitrile for 0.5h; Reflux;
Stage #2: eltoprazine With potassium carbonate In acetonitrile for 4h; Reflux;
83%
n-decanoyl chloride
112-13-0

n-decanoyl chloride

eltoprazine
98224-03-4

eltoprazine

1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(1-oxodecyl)piperazine
151143-81-6

1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(1-oxodecyl)piperazine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 2h;80%
chloroacetonitrile
107-14-2

chloroacetonitrile

eltoprazine
98224-03-4

eltoprazine

1-(cyanomethyl)-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine
161312-72-7

1-(cyanomethyl)-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; sodium iodide In N,N-dimethyl-formamide for 2h; Heating;78%
With triethylamine In 1-methyl-pyrrolidin-2-one
eltoprazine
98224-03-4

eltoprazine

2-chloro-ethanol
107-07-3

2-chloro-ethanol

4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazineethanol

4-(2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazineethanol

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; sodium iodide In acetonitrile for 16h; Heating;78%
tert-butyl (2R)-2-(2-oxoethyl)pyrrolidine-1-carboxylate
916263-26-8

tert-butyl (2R)-2-(2-oxoethyl)pyrrolidine-1-carboxylate

eltoprazine
98224-03-4

eltoprazine

(R)-tert-butyl 2-{2-[4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl]ethyl}pyrrolidine-1-carboxylate

(R)-tert-butyl 2-{2-[4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl]ethyl}pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; for 4h;78%
n-octanoic acid chloride
111-64-8

n-octanoic acid chloride

eltoprazine
98224-03-4

eltoprazine

1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(1-oxooctyl)piperazine

1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(1-oxooctyl)piperazine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 2h;77%
(S)-4,5-dihydro-5-methyl-3-(2-pyridyl)-3H-[1,2,3]-oxathiazole-2,2-dioxide
174854-87-6

(S)-4,5-dihydro-5-methyl-3-(2-pyridyl)-3H-[1,2,3]-oxathiazole-2,2-dioxide

eltoprazine
98224-03-4

eltoprazine

{(R)-2-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl]propyl}pyridin-2-ylamine
187795-96-6

{(R)-2-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl]propyl}pyridin-2-ylamine

Conditions
ConditionsYield
Stage #1: (S)-4,5-dihydro-5-methyl-3-(2-pyridyl)-3H-[1,2,3]-oxathiazole-2,2-dioxide; eltoprazine With potassium carbonate In acetonitrile at 55 - 60℃; for 72h;
Stage #2: With hydrogenchloride at 50℃; for 6h;
77%
3-(1H-indol-3-yl)propyl methanesulfonate
116578-61-1

3-(1H-indol-3-yl)propyl methanesulfonate

eltoprazine
98224-03-4

eltoprazine

3-{3-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-1H-indole

3-{3-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-1H-indole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; potassium iodide In acetonitrile for 18h; Heating;77%
With N-ethyl-N,N-diisopropylamine; potassium iodide In acetonitrile for 18h; Heating / reflux;77%
eltoprazine
98224-03-4

eltoprazine

2-[4-(2,3-Dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]-6-methoxy-indan-1-one
222991-98-2

2-[4-(2,3-Dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]-6-methoxy-indan-1-one

Conditions
ConditionsYield
With potassium carbonate In N-methyl-acetamide; 2-bromo-6-methoxy-2,3-dihydro-1H-inden-1-one; water74%
eltoprazine
98224-03-4

eltoprazine

3-chloro-1-(5-nitro-benzo[b]thiophen-3-yl)-propan-1-one
219907-04-7

3-chloro-1-(5-nitro-benzo[b]thiophen-3-yl)-propan-1-one

1-(5-nitrobenzo[b]thiophen-3-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]propan-1-one
433303-53-8

1-(5-nitrobenzo[b]thiophen-3-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]propan-1-one

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 72h;72%
eltoprazine
98224-03-4

eltoprazine

tert-butyl (2S)-2-(2-oxoethyl)pyrrolidine-1-carboxylate
198493-30-0

tert-butyl (2S)-2-(2-oxoethyl)pyrrolidine-1-carboxylate

(S)-tert-butyl 2-{2-[4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl]ethyl}pyrrolidine-1-carboxylate

(S)-tert-butyl 2-{2-[4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl]ethyl}pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; for 4h;72%
(R)-4,5-dihydro-5-methyl-3-(2-pyridyl)-3H-[1,2,3]-oxathiazole-2,2-dioxide

(R)-4,5-dihydro-5-methyl-3-(2-pyridyl)-3H-[1,2,3]-oxathiazole-2,2-dioxide

eltoprazine
98224-03-4

eltoprazine

{(S)-2-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl]propyl}pyridin-2-ylamine
603992-48-9

{(S)-2-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl]propyl}pyridin-2-ylamine

Conditions
ConditionsYield
Stage #1: (R)-4,5-dihydro-5-methyl-3-(2-pyridyl)-3H-[1,2,3]-oxathiazole-2,2-dioxide; eltoprazine With potassium carbonate In acetonitrile at 55 - 60℃; for 72h;
Stage #2: With hydrogenchloride at 50℃; for 6h;
70%
eltoprazine
98224-03-4

eltoprazine

3-chloro-1-(5-methylbenzo[b]thiophen-3-yl)-1-propanone
391669-08-2

3-chloro-1-(5-methylbenzo[b]thiophen-3-yl)-1-propanone

1-(5-methylbenzo[b]thiophen-3-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]propan-1-one

1-(5-methylbenzo[b]thiophen-3-yl)-3-[4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazin-1-yl]propan-1-one

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 72h;62%
5-(4-bromobutoxy)-2-methylbenzo[d]thiazole

5-(4-bromobutoxy)-2-methylbenzo[d]thiazole

eltoprazine
98224-03-4

eltoprazine

5-(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)-butoxy)-2-methylbenzo[d]thiazole

5-(4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazin-1-yl)-butoxy)-2-methylbenzo[d]thiazole

Conditions
ConditionsYield
Stage #1: 5-(4-bromobutoxy)-2-methylbenzo[d]thiazole With sodium iodide In acetonitrile for 0.5h; Reflux;
Stage #2: eltoprazine In acetonitrile for 6h; Reflux;
61%
benzoyl chloride
98-88-4

benzoyl chloride

eltoprazine
98224-03-4

eltoprazine

1-benzoyl-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

1-benzoyl-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 0.5h;59%
n-valeryl chloride
638-29-9

n-valeryl chloride

eltoprazine
98224-03-4

eltoprazine

1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(1-oxopentenyl)piperazine

1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(1-oxopentenyl)piperazine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 2h;57%
2-(chloromethyl)benzimidazole-4-carboxylic acid hydrochloride salt

2-(chloromethyl)benzimidazole-4-carboxylic acid hydrochloride salt

eltoprazine
98224-03-4

eltoprazine

2-[[4-(2,3-dihydro-1,4-benzodioxan-5-yl)piperazin-1-yl]methyl]benzimidazole-4-carboxylic acid
620950-02-9

2-[[4-(2,3-dihydro-1,4-benzodioxan-5-yl)piperazin-1-yl]methyl]benzimidazole-4-carboxylic acid

Conditions
ConditionsYield
With triethylamine In acetonitrile at 60℃; for 20h;57%
eltoprazine
98224-03-4

eltoprazine

cyclohexanylcarbonyl chloride
2719-27-9

cyclohexanylcarbonyl chloride

1-(1-cyclohexylcarbonyl)-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

1-(1-cyclohexylcarbonyl)-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 2h;54%
cyclohexylacetic acid chloride
23860-35-7

cyclohexylacetic acid chloride

eltoprazine
98224-03-4

eltoprazine

1-(cyclohexylacetyl)-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

1-(cyclohexylacetyl)-4-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 2h;53%
eltoprazine
98224-03-4

eltoprazine

4-(5-Fluoro-1H-3-indolyl)-cyclohexanone
185383-64-6

4-(5-Fluoro-1H-3-indolyl)-cyclohexanone

3-{(1,4-cis)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-5-fluoro-1H-indole

3-{(1,4-cis)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-5-fluoro-1H-indole

3-{(1,4-trans)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-5-fluoro-1H-indole

3-{(1,4-trans)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-5-fluoro-1H-indole

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 12h;A 53%
B 27%
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane
4-(4-fluoro-1H-indol-3-yl)-cyclohexanone
282547-09-5

4-(4-fluoro-1H-indol-3-yl)-cyclohexanone

eltoprazine
98224-03-4

eltoprazine

3-{(1,4-cis)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-4-fluoro-1H-indole

3-{(1,4-cis)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-4-fluoro-1H-indole

3-{(1,4-trans)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-4-fluoro-1H-indole

3-{(1,4-trans)-4-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-cyclohexyl}-4-fluoro-1H-indole

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 12h;A 53%
B 14%
1,2-epoxy-6-nitroindane
124369-38-6

1,2-epoxy-6-nitroindane

eltoprazine
98224-03-4

eltoprazine

trans-1-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperid-1-yl] 6-nitroindan-2-ol

trans-1-[4-(2,3-dihydrobenzo[1,4]dioxin-5-yl)piperid-1-yl] 6-nitroindan-2-ol

Conditions
ConditionsYield
In acetonitrile for 4h; Heating;52%

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