1003316-10-6 Usage
Description
N-[3-[[4-(ChloroMethyl)benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is a complex organic compound characterized by its white solid appearance. It is a reactant utilized in the synthesis of carboxybenzylamino biaryls, which are known to act as histone deacetylase inhibitors. N-[3-[[4-(ChloroMethyl)benzoyl]aMino][1,1'-biphenyl]-4-yl]carbaMic Acid tert-Butyl Ester plays a significant role in the development and optimization of biaryl selective HDAC1&2 inhibitors, contributing to advancements in the field of epigenetic research and therapeutics.
Uses
Used in Pharmaceutical Industry:
N-[3-[[4-(ChloroMethyl)benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is used as a reactant for the preparation of carboxybenzylamino biaryls, which serve as histone deacetylase inhibitors. These inhibitors are crucial in the development of novel therapeutics targeting various diseases, including cancer, neurological disorders, and cardiovascular conditions. The compound's role in optimizing biaryl selective HDAC1&2 inhibitors highlights its importance in the pharmaceutical industry for creating more effective and targeted treatments.
Used in Epigenetic Research:
In the field of epigenetic research, N-[3-[[4-(ChloroMethyl)benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is employed as a key reactant in the synthesis of carboxybenzylamino biaryls. These biaryls are essential for studying the role of histone deacetylases in gene regulation and their potential as therapeutic targets. The compound's involvement in the optimization of biaryl selective HDAC1&2 inhibitors aids researchers in understanding the epigenetic mechanisms underlying various diseases and conditions, paving the way for the development of innovative treatments and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1003316-10-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,3,3,1 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1003316-10:
(9*1)+(8*0)+(7*0)+(6*3)+(5*3)+(4*1)+(3*6)+(2*1)+(1*0)=66
66 % 10 = 6
So 1003316-10-6 is a valid CAS Registry Number.
1003316-10-6Relevant articles and documents
Design and Synthesis of Novel N-(2-aminophenyl)benzamide Derivatives as Histone Deacetylase Inhibitors and Their Antitumor Activity Study
La, Minh Thanh,Jeong, Byung-Hoon,Kim, Hee-Kwon
, p. 740 - 743 (2021/03/16)
Histone deacetylases (HDACs) are promising therapeutic targets for cancer therapy because inhibition of HDACs triggers growth arrest or apoptosis of tumor cells. In the present study, a new series of fluorinated N-(2-aminophenyl)benzamide derivatives were synthesized to investigate potential inhibition of HDACs and associated anticancer activity. Among the synthesized derivatives, compound 24a showed potent inhibitory activity of HDACs and higher antitumor efficacy in human cancer cell lines (HCT-116, MCF-7, and A549) compared with SAHA. Moreover, animal studies demonstrated that compound 24a showed potent in vivo antitumor efficacy in an HCT-116 colon cancer xenograft mouse model.
SILICON DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
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Page/Page column 54-55, (2009/04/25)
The present invention relates to a novel class of Silicon derivatives. The Silicon compounds can be used to treat cancer. The Silicon compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation,
Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)
Witter, David J.,Harrington, Paul,Wilson, Kevin J.,Chenard, Melissa,Fleming, Judith C.,Haines, Brian,Kral, Astrid M.,Secrist, J. Paul,Miller, Thomas A.
, p. 726 - 731 (2008/12/23)
A class of biaryl benzamides was identified and optimized as selective HDAC1&2 inhibitors (SHI-1:2). These agents exhibit selectivity over class II HDACs 4-7, as well as class I HDACs 3 and 8; providing examples of selective HDAC inhibitors for the HDAC i
