1003316-11-7

Basic information

• Product Name: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester
• Synonyms: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester;N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic acid 1,1-dimethylethyl ester
• CAS NO: 1003316-11-7
• Molecular Formula: C₃₃H₂₉N₃O₅
• Molecular Weight: 547.60046
• Mol File: 1003316-11-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester(1003316-11-7)
• EPA Substance Registry System: N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester(1003316-11-7)

Safety Data

• Hazardous Substances Data: 1003316-11-7(Hazardous Substances Data)

Usage

Description

N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is a complex organic compound characterized by its white solid appearance. It is a reactant used in the synthesis of carboxybenzylamino biaryls, which are known for their histone deacetylase inhibitory properties.

Uses

Used in Pharmaceutical Industry:
N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is used as a reactant for the preparation of carboxybenzylamino biaryls, which serve as histone deacetylase inhibitors. These inhibitors play a crucial role in the development of drugs targeting various diseases, including cancer, by regulating gene expression and cellular processes.
Used in Chemical Research:
In the field of chemical research, N-[3-[[4-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoyl]amino][1,1'-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester is utilized as a key intermediate in the synthesis of novel compounds with potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals. Its unique structure allows for further modification and exploration of its properties and potential uses.

Upstream product

• 1003316-10-6 tert-butyl 3-(4-(chloromethyl)benzamido)biphenyl-4-ylcarbamate 
• 1074-82-4 potassium phtalimide 
• 136918-14-4 phthalimide 
• 335255-33-9 tert-butyl (3-amino-4-biphenylyl)carbamate 
• 875-51-4 4-Bromo-2-nitroaniline 
• 327046-79-7 tert-butyl (4-bromo-2-nitrophenyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 335254-77-8 tert-butyl (3-nitro-[1, 1'-biphenyl]-4-yl)carbamate 

Downstream Products

• 1003316-12-8 tert-butyl (3-(4-(aminomethyl)benzamido)-[1,1'-biphenyl]-4-yl)carbamate 
• 1013330-69-2 1,1-dimethylethyl [3-({[4-({[(methyloxy)carbonyl]amino}methyl)phenyl]carbonyl}amino)biphenyl-4-yl]carbamate 

Relevant articles and documents

Design and Synthesis of Novel N-(2-aminophenyl)benzamide Derivatives as Histone Deacetylase Inhibitors and Their Antitumor Activity Study

Histone deacetylases (HDACs) are promising therapeutic targets for cancer therapy because inhibition of HDACs triggers growth arrest or apoptosis of tumor cells. In the present study, a new series of fluorinated N-(2-aminophenyl)benzamide derivatives were synthesized to investigate potential inhibition of HDACs and associated anticancer activity. Among the synthesized derivatives, compound 24a showed potent inhibitory activity of HDACs and higher antitumor efficacy in human cancer cell lines (HCT-116, MCF-7, and A549) compared with SAHA. Moreover, animal studies demonstrated that compound 24a showed potent in vivo antitumor efficacy in an HCT-116 colon cancer xenograft mouse model.

4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selecti

PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS

The present invention relates to a novel class of phosphorus derivatives. The phosphorus compounds can be used to treat cancer. The phosphorus compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differe