1012886-64-4

Basic information

• Product Name: methyl 2-(4-fluorophenyl)-2-formamidoacetate
• Synonyms: methyl 2-(4-fluorophenyl)-2-formamidoacetate
• CAS NO: 1012886-64-4
• Molecular Weight: 211.193
• Mol File: 1012886-64-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-fluorophenyl)-2-formamidoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-fluorophenyl)-2-formamidoacetate(1012886-64-4)
• EPA Substance Registry System: methyl 2-(4-fluorophenyl)-2-formamidoacetate(1012886-64-4)

Safety Data

• Hazardous Substances Data: 1012886-64-4(Hazardous Substances Data)

Upstream product

• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 
• 42718-18-3 dl-α-4-fluorophenylglycine methyl ester hydrochloride 
• 109-94-4 formic acid ethyl ester 
• 64-18-6 formic acid 
• 1012886-60-0 methyl 2-(4-fluorophenyl)-2-((4-methoxyphenyl)amino)acetate 

Downstream Products

• 730964-78-0 methyl 2-isocyano-2-(4-fluorophenyl)acetate 

Relevant articles and documents

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.