730964-78-0

Basic information

• Product Name: 2-ISOCYANO-2-(4-FLUOROPHENYL) ACETIC ACID METHYL ESTER
• Synonyms: 2-ISOCYANO-2-(4-FLUOROPHENYL) ACETIC ACID METHYL ESTER
• CAS NO: 730964-78-0
• Molecular Formula: C₁₀H₈FNO₂
• Molecular Weight: 193.17
• Mol File: 730964-78-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-ISOCYANO-2-(4-FLUOROPHENYL) ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOCYANO-2-(4-FLUOROPHENYL) ACETIC ACID METHYL ESTER(730964-78-0)
• EPA Substance Registry System: 2-ISOCYANO-2-(4-FLUOROPHENYL) ACETIC ACID METHYL ESTER(730964-78-0)

Safety Data

• Hazardous Substances Data: 730964-78-0(Hazardous Substances Data)

Upstream product

• 616-38-6 carbonic acid dimethyl ester 
• 148890-53-3 4-fluorobenzyl isocyanide 
• 140-75-0 para-fluorobenzylamine 
• 84174-25-4 p-fluorobenzylamine formamide 
• 1012886-64-4 methyl 2-(4-fluorophenyl)-2-formamidoacetate 
• 42718-18-3 dl-α-4-fluorophenylglycine methyl ester hydrochloride 
• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 

Relevant articles and documents

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.