42718-18-3

Basic information

• Product Name: Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride
• Synonyms: Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride;RS-4-Fluorophenylglycine methyl ester hydrochloride
• CAS NO: 42718-18-3
• Molecular Formula: C9H11ClFNO2
• Molecular Weight: 219.6405432
• Mol File: 42718-18-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride(42718-18-3)
• EPA Substance Registry System: Methyl 2-aMino-2-(4-fluorophenyl)acetate hydrochloride(42718-18-3)

Safety Data

• Hazardous Substances Data: 42718-18-3(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-2-(4-fluorophenyl)acetate hydrochloride is a chemical compound with the molecular formula C9H11ClFNO2. It is commonly used as a precursor in the synthesis of various pharmaceuticals, especially those related to the treatment of neurological disorders and psychiatric conditions. It is a crystalline solid that is soluble in water, and it is typically synthesized through organic chemical reactions. The compound has been studied for its potential use in the development of new drugs due to its structural and functional properties. However, it is important to handle and use this chemical with care, as it can pose risks to human health and the environment if not properly handled and disposed of.

Upstream product

• 67-56-1 methanol 
• 19883-57-9 (S)-2-amino-2-(4-fluorophenyl)acetic acid 
• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 
• 185994-15-4 (S)-α-amino-α-(4-fluorophenyl)acetic acid hydrochloride 
• 93939-74-3 (R)-2-(4-fluorophenyl)glycine 

Downstream Products

• 1587732-42-0 (S)-2-amino-2-(4-fluorophenyl)acetohydrazide 
• 888028-36-2 (1S)-1-amino-1-(4-fluorophenyl)-2-methylpropan-2-ol 
• 1012886-64-4 methyl 2-(4-fluorophenyl)-2-formamidoacetate 
• 730964-78-0 methyl 2-isocyano-2-(4-fluorophenyl)acetate 
• 174770-74-2 (R)-2-amino-2-(4-fluorophenyl)ethanol 
• 1456506-65-2 (S)-methyl 2-((4-((tert-butoxycarbonyl)amino)cyclohexyl)amino)-2-(4-fluorophenyl)acetate 
• 19883-57-9 (S)-2-amino-2-(4-fluorophenyl)acetic acid 

Relevant articles and documents

Cobalt-Catalyzed, Directed C-H Functionalization/Annulation of Phenylglycinol Derivatives with Alkynes

A new method for cobalt-catalyzed C(sp2)-H functionalization of phenylglycinol derivatives with terminal and internal alkynes directed by picolinamide auxiliary has been developed. This method offers an efficient and highly regioselective route for the synthesis of 1-hydroxymethyltetrahydroisoquinolines. The reaction employs commercially available Co(II) catalyst in the presence of Mn(III) cooxidant and oxygen as a terminal oxidant and proceeds with full preservation of original stereochemistry.

((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies

The emergence and global spread of metallo-β-lactamase (MBL) mediated resistance to almost all β-lactam antibacterials poses a serious threat to public health. Since no clinically useful MBL inhibitors have been reported, there is an urgent need to develop new potent broad-spectrum MBL inhibitors effective against antibacterial resistance. Herein, we synthesized a set of 2-substituted ((S)-3-mercapto-2-methylpropanamido) acetic acid derivatives, some of which displayed potent inhibition with high ligand efficiency to the clinically relevant MBL subtypes, Verona Integron-encoded MBL (VIM)-2 and New Delhi MBL (NDM)-1. Kinetic studies revealed that the inhibitors are not strong zinc chelators in solution, and they bind reversibly to VIM-2 but dissociate very slowly. Crystallographic analyses revealed that they inhibit VIM-2 via chelating the active site zinc ions and interacting with catalytically important residues. Further cell- and zebrafish-based assays revealed that the inhibitors slightly increase susceptibility of E. coli cells expressing VIM-2 to meropenem, and they have no apparent toxicity to the viability of HEK293T cells and the zebrafish embryogenesis.

SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES

The invention relates to new piperidino-dihydrothienopyrimidines of formula 1, as well as pharmacologically acceptable salts thereof, wherein X is SO or SO2, but preferably SO, and wherein R1, R2, R3 and R4 may have the meanings given in claim 1, as well as pharmaceutical compositions which contain these compounds. These new piperidino-dihydrothienopyrimidines are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers.