103496-86-2Relevant articles and documents
Selective fluorodenitration of chloronitroaromatics
Beaumont, Andrew J.,Clark, James H.,Boechat, Nubia A.
, p. 25 - 30 (1993)
Nucleophilic fluorination of chloronitrobenzenes shows a strong bias for fluorodenitration rather than halogen exchange.
Mild and general methods for the palladium-catalyzed cyanation of aryl and heteroaryl chlorides
Littke, Adam,Soumeillant, Maxime,Kaltenbach III, Robert F.,Cherney, Robert J.,Tarby, Christine M.,Kiau, Susanne
, p. 1711 - 1714 (2007)
New methods for the palladium-catalyzed cyanation of aryl and heteroaryl chlorides have been developed, featuring sterically demanding, electron-rich phosphines. Highly challenging electron-rich aryl chlorides, in addition to electron-neutral and electron-deficient substrates, as well as nitrogen- and sulfur-containing heteroaryl chlorides can all undergo efficient cyanation under relatively mild conditions using readily available materials. In terms of substrate scope and temperature, these methods compare very favorably with the state-of-the-art cyanations of aryl chlorides.
Catalytic Hydrodefluorination via Oxidative Addition, Ligand Metathesis, and Reductive Elimination at Bi(I)/Bi(III) Centers
Cornella, Josep,Katzenburg, Felix,Leutzsch, Markus,N?thling, Nils,Pang, Yue
supporting information, p. 12487 - 12493 (2021/08/30)
Herein, we report a hydrodefluorination reaction of polyfluoroarenes catalyzed by bismuthinidenes, Phebox-Bi(I) and OMe-Phebox-Bi(I). Mechanistic studies on the elementary steps support a Bi(I)/Bi(III) redox cycle that comprises C(sp2)-F oxidative addition, F/H ligand metathesis, and C(sp2)-H reductive elimination. Isolation and characterization of a cationic Phebox-Bi(III)(4-tetrafluoropyridyl) triflate manifests the feasible oxidative addition of Phebox-Bi(I) into the C(sp2)-F bond. Spectroscopic evidence was provided for the formation of a transient Phebox-Bi(III)(4-tetrafluoropyridyl) hydride during catalysis, which decomposes at low temperature to afford the corresponding C(sp2)-H bond while regenerating the propagating Phebox-Bi(I). This protocol represents a distinct catalytic example where a main-group center performs three elementary organometallic steps in a low-valent redox manifold.
A process for preparing 2, 4 - difluoro phenyl nitrile (by machine translation)
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Paragraph 0039; 0046; 0047; 0050; 0053, (2019/01/08)
The invention discloses a 2, 4 - difluoro phenyl nitrile preparation process, steps are as follows: (1) to 2, 4 - difluoro-benzoic acid and thionyl chloride as the raw material, produced by the reaction of 2, 4 - difluoro-benzoyl chloride; (2) the 2, 4 - difluoro-benzoyl chloride with ammonia water reaction, generating 2, 4 - difluoro-benzamide; (3) the 2, 4 - difluoro-benzamide with trifluoroacetic anhydride reaction, namely the preparation of the 2, 4 - difluoro phenyl nitrile. The invention relates to 2, 4 - difluoro phenyl nitrile synthetic reaction raw materials and synthetic route optimized design, the present invention adopted in the reaction raw material is cheap, it is safe to use; mild reaction conditions, does not need high temperature reaction, low requirements on the equipment, the yield of the product is high, high purity, easy to realize industrial production. (by machine translation)