103994-82-7

Basic information

• Product Name: ethyl 3-ethoxy-2-(2,3,4,5-tetra-fluorobenzoyl)-acrylate
• Synonyms: ethyl 3-ethoxy-2-(2,3,4,5-tetra-fluorobenzoyl)-acrylate
• CAS NO: 103994-82-7
• Molecular Weight: 320.24
• Mol File: 103994-82-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-ethoxy-2-(2,3,4,5-tetra-fluorobenzoyl)-acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-ethoxy-2-(2,3,4,5-tetra-fluorobenzoyl)-acrylate(103994-82-7)
• EPA Substance Registry System: ethyl 3-ethoxy-2-(2,3,4,5-tetra-fluorobenzoyl)-acrylate(103994-82-7)

Safety Data

• Hazardous Substances Data: 103994-82-7(Hazardous Substances Data)

Upstream product

• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 158585-86-5 ethyl 6,8-difluoro-1,4-dihydro-1-(N-methylformamido)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylate 
• 100276-65-1 6,7,8-Trifluor-1-(formylmethylamino)-1,4-dihydro-4-oxo-3-chinolincarbonsaeure-ethylester 
• 113933-52-1 ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-(1-hydroxyprop-2-ylamino)acrylate 

Relevant articles and documents

Process for the manufacture of a tricyclic compound

A process for preparing a compound of formula (I) or a phamaceutically-acceptable salt thereof, comprising: 1) reacting a compound. of formula (III), in which R is a straight or branched chain alkyl having from one to four carbon atoms, with an alkali metal hydroxide in an aqueous medium at a temperature of about 80° to 120° C. and time of about 20 to 100 hours to form a reaction product; 2) cyclizing the reaction product of step 1) with formic acid and formaldehyde to form a formiate compound; and 3) neutralizing the formiate compound of step 2) with an aqueous base.