158585-86-5 Usage
Description
6,8-Difluoro-1-(formylmethylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester is a complex organic compound with a quinoline core structure. It is characterized by the presence of fluorine atoms at the 6 and 8 positions, a formylmethylamino group, and a 4-methylpiperazin-1-yl substituent. This molecule is known for its potential applications in the pharmaceutical industry due to its unique structural features and properties.
Uses
Used in Pharmaceutical Industry:
6,8-Difluoro-1-(formylmethylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester is used as an intermediate in the synthesis of Marbofloxacin (M197000), a fluorinated quinolone antibacterial agent. Marbofloxacin is effective against a wide range of bacterial infections, making it a valuable compound in the development of new antibiotics to combat drug-resistant bacteria.
Application Reason:
The unique structural features of this compound, including the presence of fluorine atoms and the formylmethylamino group, contribute to its ability to act as a key intermediate in the synthesis of Marbofloxacin. These structural elements are crucial for the compound's antibacterial properties and its potential to be used in the development of new antibiotics.
Check Digit Verification of cas no
The CAS Registry Mumber 158585-86-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,5,8 and 5 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 158585-86:
(8*1)+(7*5)+(6*8)+(5*5)+(4*8)+(3*5)+(2*8)+(1*6)=185
185 % 10 = 5
So 158585-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H22F2N4O4/c1-4-29-19(28)13-10-25(23(3)11-26)16-12(18(13)27)9-14(20)17(15(16)21)24-7-5-22(2)6-8-24/h9-11H,4-8H2,1-3H3
158585-86-5Relevant articles and documents
A PROCESS FOR A PREPARATION OF MARBOFLOXACIN AND INTERMEDIATE THEREOF
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Page/Page column 43-44, (2011/06/19)
The present invention describes a novel process for the preparation of marbof loxacin and intermediate thereof comprising reaction of ammonium hydroxide of formula (III), NR1R2R3R4, wherein R1, R2, R3 and R4 are independently selected from the group of H, alkyl, alkylaryl, aryl and/or heteroaryl, with compound of formula (II), wherein R is selected from H, alkyl, arylalkyl, alkali metal cation,, NH4 cation, NR1R2R3R4cation; X is halogen, such as chloro, bromo, fluoro, piperazinyl, which may be substituted or unsubstituted, and R' is selected from H, formyl or COOAlkyl.
Process for the manufacture of a tricyclic compound
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, (2008/06/13)
A process for preparing a compound of formula (I) or a phamaceutically-acceptable salt thereof, comprising: 1) reacting a compound. of formula (III), in which R is a straight or branched chain alkyl having from one to four carbon atoms, with an alkali metal hydroxide in an aqueous medium at a temperature of about 80° to 120° C. and time of about 20 to 100 hours to form a reaction product; 2) cyclizing the reaction product of step 1) with formic acid and formaldehyde to form a formiate compound; and 3) neutralizing the formiate compound of step 2) with an aqueous base.
