100276-37-7 Usage
Description
6,8-Difluoro-1,4-dihydro-1-(MethylaMino)-7-(4-Methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Sulfate is a complex organic compound that serves as a crucial intermediate in the pharmaceutical industry. It is characterized by its unique molecular structure, which includes fluorine atoms, a quinoline ring, and various functional groups such as amines and piperazinyl moieties. 6,8-Difluoro-1,4-dihydro-1-(MethylaMino)-7-(4-Methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Sulfate plays a significant role in the development of antibiotics, particularly in the synthesis of fluorinated quinolones.
Uses
Used in Pharmaceutical Industry:
6,8-Difluoro-1,4-dihydro-1-(MethylaMino)-7-(4-Methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Sulfate is used as an intermediate in the synthesis of Marbofloxacin (M197000), a fluorinated quinolone antibacterial agent. It contributes to the development of this antibiotic by providing the necessary structural framework for the final product. Marbofloxacin is effective against a wide range of bacterial infections, making it a valuable addition to the arsenal of antibiotics used in both human and veterinary medicine.
The compound's role in the synthesis of Marbofloxacin highlights its importance in the pharmaceutical industry, as it enables the production of a potent and widely used antibiotic. The fluorination of the quinolone structure enhances the drug's activity against bacterial pathogens, making it a preferred choice for treating various infections. Furthermore, the presence of the methylamino and piperazinyl groups in the molecule contributes to its overall effectiveness and pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 100276-37-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,2,7 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 100276-37:
(8*1)+(7*0)+(6*0)+(5*2)+(4*7)+(3*6)+(2*3)+(1*7)=77
77 % 10 = 7
So 100276-37-7 is a valid CAS Registry Number.
100276-37-7Relevant articles and documents
A PROCESS FOR A PREPARATION OF MARBOFLOXACIN AND INTERMEDIATE THEREOF
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Page/Page column 28, (2011/06/19)
The present invention describes a novel process for the preparation of marbof loxacin and intermediate thereof comprising reaction of ammonium hydroxide of formula (III), NR1R2R3R4, wherein R1, R2, R3 and R4 are independently selected from the group of H, alkyl, alkylaryl, aryl and/or heteroaryl, with compound of formula (II), wherein R is selected from H, alkyl, arylalkyl, alkali metal cation,, NH4 cation, NR1R2R3R4cation; X is halogen, such as chloro, bromo, fluoro, piperazinyl, which may be substituted or unsubstituted, and R' is selected from H, formyl or COOAlkyl.
Cycloaracylation of Enamines,II. - Synthesis of 1-Amino-4-quinolone-3-carboxylic Acids
Grohe, Klaus,Heitzer, Helmut
, p. 871 - 880 (2007/10/02)
The 2-benzoyl-3-hydrazinoacrylic esters 3, 11, 17, and 23 are obtained by the reactions of 2-chloro-5-nitrobenzoyl chloride (1) with the enehydrazinocarboxylic esters 2 and 2-benzoyl-3-ethoxyacrylic esters 9 with hydrazine derivatives 10, 16, and 22.After cyclocondensation, the above esters afford 1-aminoquinolonecarboxylic esters 4, 12, 18, and 24, which are hydrolyzed to give the corresponding 1-aminoquinolonecarboxylic acids 5, 13, 19, and 26.The 1-amino-7-haloquinolonecarboxylic acids 13a-f, 19a-f, and 26b react with aliphatic amines to afford 1,7-diaminoquinolonecarboxylic acids 30c-m, which possess a high level of bactericidal activity.
