106345-32-8

Basic information

• Product Name: 1H-Indole, 2-phenyl-3-(phenylthio)-
• CAS NO: 106345-32-8
• Molecular Formula: C20H15NS
• Molecular Weight: 301.412
• Mol File: 106345-32-8.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-phenyl-3-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-phenyl-3-(phenylthio)-(106345-32-8)
• EPA Substance Registry System: 1H-Indole, 2-phenyl-3-(phenylthio)-(106345-32-8)

Safety Data

• Hazardous Substances Data: 106345-32-8(Hazardous Substances Data)

Upstream product

• 948-65-2 2-phenyl-indole 
• 194720-38-2 2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate 
• 13141-38-3 2-phenylethynylaniline 
• 1192-40-1 copper(I) thiophenolate 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 4831-18-9 N-phenacyl-p-toluidine 
• 32119-53-2 N-methyl-N-phenacylaniline 
• 62-53-3 aniline 
• 882-33-7 diphenyldisulfane 
• 5883-81-8 2-anilinoacetophenone 
• 2727-71-1 N-(2-bromophenyl)-2,2,2-trifluoroacetamide 
• 536-74-3 phenylacetylene 
• 143360-89-8 o-(phenylethynyl)trifluoroacetanilide 
• 1024-38-0 N-(2-bromophenyl)-4-methylbenzenesulfonamide 

Downstream Products

• 1613218-93-1 C₂₇H₂₁NS 
• 82946-84-7 1-methyl-2-phenyl-3-(phenylthio)-1H-indole 
• 948-65-2 2-phenyl-indole 

Relevant articles and documents

Sulfanyl radical addition to alkynyl azides: An insight into vinyl radical cyclization onto the azido function

5-Exo-Cyclization of 2-sulfanylvinyl radicals 16 and 21 is a fast process which prevents intramolecular addition to the sulfanyl aromatic ring and hydrogen abstraction. In contrast, the 2-sulfanylvinyl radicals 3 and 9 are reluctant to add to their alipha

Aniline-initiated and Br?nsted acid-catalyzed one-pot reaction toward 2-aryl-3-sulfenylindoles by using α-aminocarbonyl compounds and primary amines with RSSR

A highly novel method of direct synthesis of 2-aryl-3-sulfenylindoles in moderate to good yields was developed via one-pot tandem reaction of readily available α-aminocarbonyl compounds and catalytic amount of benzenamines with RSSR.

Synthesis of Polysubstituted 3-Chalcogenated Indoles through Copper(I) Iodide-Catalyzed Three-Component Domino Reactions

Polysubstituted 3-chalcogenated indoles were synthesized by a three-component, one-pot, domino reaction of a N -(2-bromophenyl)trifluoroacetamide, a 1-alkyne, a disulfides or diselenides, CuI, and proline in DMF. In this process, tandem Sonogashira coupling, N-cyclization, and sulfenyl/selenyl electrophilic substitution occurred sequentially and smoothly to form the anticipated products in good to excellent yields (20 examples; 65-96%). Notably, no palladium catalyst was used in this catalytic system, supporting its cost effectiveness and potential industrial application.

Method for directly synthesizing indole by using nitrile

The invention discloses a method for directly synthesizing indole by using nitrile. The method is characterized in that a 2-iodotoluene derivative is served as a substrate, anhydrous copper sulfate, potassium tert-butoxide, a cyanophenyl derivative and the 2-iodophene derivative are mixed according to the molar ratio of (0.02-0.1): (2-4): (5-20):1, reaction is carried out for 4-48 hours at 60-105DEG C in a solvent, petroleum ether/dichloromethane/ethyl acetate are mixed according to the volume ratio of (20-5):10:1 so as to be served as an eluent, and separation is carried out by using a silica gel column so as to obtain a target product. The method has the advantages that the operation is simple, the conditions are mild, the yield is high, and the method is a green and novel synthetic method.