106681-49-6

Basic information

• Product Name: 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate
• Synonyms: 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate
• CAS NO: 106681-49-6
• Molecular Weight: 323.413
• Mol File: 106681-49-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate(106681-49-6)
• EPA Substance Registry System: 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate(106681-49-6)

Safety Data

• Hazardous Substances Data: 106681-49-6(Hazardous Substances Data)

Upstream product

• 98095-34-2 5-iodo-1,2-O-isopropylidenepentane-1,2-diol 
• 69380-64-9 rac-2,2-dimethyl-4-(3'-hydroxypropyl)-1,3-dioxolan toluene-p-sulphonate 
• 6318-30-5 2,2-dimethyl-4-(3-hydroxypropyl)-1,3-dioxolane 
• 106681-43-0 5-N-pyrrolylpentane-1,2-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 5470-86-0 1,2,5-triacetoxypentane 
• 14697-46-2 1,2,5-pentanetriol 
• 106681-39-4 1,2-O-isopropylidene-5-N-pyrrolylpentane-1,2-diol 

Downstream Products

• 197365-59-6 1-(pent-4-en-1-yl)-1H-pyrrole 

Relevant articles and documents

A synthesis of (-)-tashiromine and formal synthesis of (+)-tashiromine utilizing a highly enantioselective pyrrole/cobaloxime π-cation cyclization

Cyclization of (5-N-pyrrolyl-2-hydroxypentyl)cobaloxime (13) proceeds by intramolecular electrophilic aromatic substitution of a cobaloxime π-cation onto the pyrrole ring to provide 6-exo cyclization product (14) in 95% yield. This cyclization is highly enantioselective. It is applied to a synthesis of highly enantioenriched (-)-tashiromine, (-)-21, and a formal synthesis of (+)-tashiromine.