6318-30-5

Basic information

• Product Name: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL
• Synonyms: 2,2-dimethyl-1,3-Dioxolane-4-propanol
• CAS NO: 6318-30-5
• Molecular Formula: C₈H₁₆O₃
• Molecular Weight: 160.21084
• Mol File: 6318-30-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 221°Cat760mmHg
• Flash Point: 103.7°C
• Appearance: /
• Density: 0.996g/cm³
• Vapor Pressure: 0.0227mmHg at 25°C
• Refractive Index: 1.433
• PKA: 15.04±0.10(Predicted)
• CAS DataBase Reference: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL(6318-30-5)
• EPA Substance Registry System: (S)-4,5-ISOPROPYLIDENE-1-PENTANOL(6318-30-5)

Safety Data

• Hazardous Substances Data: 6318-30-5(Hazardous Substances Data)

Usage

General Description

(S)-4,5-ISOPROPYLIDENE-1-PENTANOL, also known as isopropylidene pentanol, is a chemical compound with a molecular formula of C8H18O. It is a colorless liquid with a pleasant odor and is commonly used in the pharmaceutical and chemical industries as a building block for the synthesis of various compounds. It is also used as a solvent and a fragrance ingredient in cosmetic products. (S)-4,5-ISOPROPYLIDENE-1-PENTANOL is known for its high purity and stability, making it a versatile and valuable chemical in various applications. Additionally, it is considered to be safe for use and is not known to pose any significant health risks when handled and used properly.

InChI:InChI=1/C8H16O3/c1-8(2)10-6-7(11-8)4-3-5-9/h7,9H,3-6H2,1-2H3

Upstream product

• 14697-46-2 1,2,5-pentanetriol 
• 67-64-1 acetone 
• 173152-85-7 (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionic acid 
• 77-76-9 2,2-dimethoxy-propane 
• 5470-86-0 1,2,5-triacetoxypentane 
• 110-87-2 3,4-dihydro-2H-pyran 
• 96392-13-1 (2R)-4-Bromo-1,2-O-isopropylidenebutane-1,2-diol 
• 36326-39-3 Ethyl 4,5-O-isopropylidene-(S)-4,5-dihydroxypentanoate 
• 173152-84-6 ethyl (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionate 
• 56-86-0 L-glutamic acid 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 

Downstream Products

• 69380-64-9 rac-2,2-dimethyl-4-(3'-hydroxypropyl)-1,3-dioxolan toluene-p-sulphonate 
• 4568-67-6 (+/-)-5-benzyloxy-1,2-isopropylidenedioxypentane 
• 106681-49-6 5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate 
• 197365-59-6 1-(pent-4-en-1-yl)-1H-pyrrole 
• 185627-00-3 4,5-dihydroxypentyl benzoate 
• 83458-88-2 (+/-)-5-benzyloxy-1,2-pentanediol 
• 186090-99-3 [3-(3-Benzyloxy-propyl)-3H-diazirin-3-yl]-methanol 
• 186090-98-2 5-benzyloxy-1-hydroxypentan-2-one 
• 186090-97-1 5-benzyloxy-1-triphenylmethyloxy-2-pentanone 
• 186090-96-0 (+/-)-5-benzyloxy-1-triphenylmethyloxy-2-pentanol 
• 186091-01-0 2-azi-1-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyloxy)-5-pentanol 
• 186091-02-1 2-azi-1-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyloxy)-6-oxa-8-thianonane 
• 186091-00-9 2-azi-5-benzyloxy-1-(2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyloxy)pentane 
• 177411-59-5 5-Benzylsulfanyl-pentane-1,2-diol 

Relevant articles and documents

Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule

Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5-and 3′-position have been extensively investigated, but the impact of substituents in 5′-position is not equally well-studied. Here, we report the synthesis of new indirubin 3′-and 5′-derivatives in the search of water-soluble indirubins by introducing basic centers. Antiproliferative activity of all compounds in tumor cells was evaluated along with kinase inhibition of selected compounds. The results show the 3′-position to tolerate large substituents without compromising activity, whereas bulk and rigid substituents in 5′-position appear unfavorable. Screening molecular targets of water-soluble 3′-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells. Consistently, 6ha inhibited tumor cell growth in the NCI 60 cell line panel and induced apoptosis. The results indicate that the 5′-position provides limited space for chemical modifications and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.

Substituted oxygen alicyclic compounds, including methods for synthesis thereof

The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.

Deprotection of tetrahydropyranyl ethers with montmorillonite K-10 clay in methanol

A variety of tetrahydropyranyl (THP) ethers are removed by Montmorillonite K-10 clay in methanol at room temperature to give alcohols. It has been shown that the THP ethers carrying epoxy, methoxymethoxy (MOMO), tertbutyldiphenylsiloxy (TBDP-SO-), acetoxy (AcO-) and benzoyloxy (BzO-) functionalities are stable under the conditions, while the ethers carrying ketal, tertbutyldimethylsioxy (TBSO-) and β,β,β-trichloroethylimidoxy [CCl3C(=NH)O-] functionalities are unstable.