107793-07-7

Basic information

• Product Name: methyl 2-((trimethylsilyl)ethynyl)benzoate
• Synonyms: methyl 2-((trimethylsilyl)ethynyl)benzoate;Methyl 2-[2-(trimethylsilyl)ethynyl]benzoate
• CAS NO: 107793-07-7
• Molecular Formula: C₁₃H₁₆O₂Si
• Molecular Weight: 232.35044
• Mol File: 107793-07-7.mol
• Article Data: 52

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 2-((trimethylsilyl)ethynyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-((trimethylsilyl)ethynyl)benzoate(107793-07-7)
• EPA Substance Registry System: methyl 2-((trimethylsilyl)ethynyl)benzoate(107793-07-7)

Safety Data

• Hazardous Substances Data: 107793-07-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-((trimethylsilyl)ethynyl)benzoate is a chemical compound that belongs to the category of organic compounds. It is commonly used as an intermediate in the synthesis of other chemical compounds, such as pharmaceuticals and agrochemicals. methyl 2-((trimethylsilyl)ethynyl)benzoate is characterized by the presence of a benzoate ester group, a ethynyl group, and a trimethylsilyl group. It is a clear, colorless liquid with a slightly fruity odor. Methyl 2-((trimethylsilyl)ethynyl)benzoate is primarily used in research and development, as well as in various industrial applications. It should be handled and stored with caution, following proper safety protocols and regulations.

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 1066-54-2 trimethylsilylacetylene 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 110-89-4 piperidine 
• 88-67-5 2-Iodobenzoic acid 
• 6224-91-5 trimethyl(prop-1-ynyl)silane 
• 970-93-4 dimethyl 2,2'-(ethyne-1,2-diyl)dibenzoate 
• 88-65-3 2-bromobenzoic-acid 
• 33577-99-0 2-ethynyl-benzoic acid methyl ester 

Downstream Products

• 33577-99-0 2-ethynyl-benzoic acid methyl ester 
• 952594-51-3 methyl 2-((3-fluorophenyl)ethynyl)benzoate 
• 952594-61-5 2-((3-fluorophenyl)ethynyl)benzoic acid 
• 952594-53-5 methyl 2-((2-ethyl-6-methylphenyl)ethynyl)benzoate 
• 952594-63-7 2-((2-ethyl-6-methylphenyl)ethynyl)benzoic acid 
• 4809-08-9 3-phenyl-isocoumarin 
• 29910-92-7 3-(4-methoxyphenyl)-1H-isochromen-1-one 
• 33578-00-6 (2-ethynyl)benzoic acid 
• 33578-05-1 methyl 2-(phenylethynyl)benzoate 
• 130818-18-7 2'-Methyl-2-methoxycarbonylacetylene 
• 130818-20-1 2-(2-(4-methoxyphenyl)ethynyl)benzoic acid methyl ester 
• 221351-33-3 3-(3-fluorophenyl)-1H-isochromen-1-one 
• 169170-37-0 2-(2'-aminophenylethynyl)benzoic acid methyl ester 
• 1044518-10-6 methyl 2-[1H-indol-2-yl]benzoate 

Relevant articles and documents

Improved procedures for the palladium-catalyzed coupling of terminal alkynes with aryl bromides (Sonogashira coupling)

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Palladium cross-coupling reactions on solid support using a new silylated linker

The synthesis and the use in palladium cross-coupling reactions of a new silylated stable resin were described. The products have been cleaved from the support using mild conditions and purified with a scavenger ionic resin. A small library of coupling pr

Cyclopentadienones as intermediates for the synthesis of highly functionalized biaryls

A new approach to the synthesis of substituted biaryls, via Diels-Alder reaction between cyclopentadienones and arylacetylenes, is described.

Cys–Cys and Cys–Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents

Easy access to a wide range of structurally diverse stapled peptides is crucial for the development of inhibitors of protein-protein interactions. Herein, we report bis-functional hypervalent iodine reagents for two-component cysteine-cysteine and cysteine-lysine stapling yielding structurally diverse thioalkyne linkers. This stapling method works with unprotected natural amino acid residues and does not require pre-functionalization or metal catalysis. The products are stable to purification and isolation. Post-stapling modification can be accessed via amidation of an activated ester, or via cycloaddition onto the formed thioalkyne group. Increased helicity and binding affinity to MDM2 was obtained for a i,i+7 stapled peptide.

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Tertiary amines acting as Alkyl radical equivalents enabled by a P/N heteroleptic Cu(I) photosensitizer

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