33577-99-0

Basic information

• Product Name: methyl 2-ethynylbenzoate
• Synonyms: methyl 2-ethynylbenzoate;2-Ethynyl-benzoic acid Methyl ester;OrthoMethoxycarbonylphenylacetylene;NSC 649436;o-Methoxycarbonylphenylacetylene;Methyl o-ethynylbenzoate;Benzoic acid, 2-ethynyl-, methyl ester
• CAS NO: 33577-99-0
• Molecular Formula: C₁₀H₈O₂
• Molecular Weight: 160.16932
• Mol File: 33577-99-0.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 80-85 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: methyl 2-ethynylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-ethynylbenzoate(33577-99-0)
• EPA Substance Registry System: methyl 2-ethynylbenzoate(33577-99-0)

Safety Data

• Hazardous Substances Data: 33577-99-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-ethynylbenzoate is an organic chemical compound with the formula C11H8O2. Its molecular weight is 172.18 g/mol. It is a derivative of benzoic acid, characterized by the presence of a methyl ester group (-COOCH3) and an ethynyl group (-C≡CH) on the benzene ring. It shows similar characteristics to other esters, being typically low in toxicity and having a pleasant odor. It is commonly utilized in the synthesis of complex molecules in the fields of pharmaceuticals and organic chemistry. The substance is typically stored in a cool, dry place to maintain its stability and prevent its decomposition. It can be identified with its CAS number 7696-37-5.

Upstream product

• 1077-79-8 methyl 2-acetylbenzoate 
• 33577-96-7 methyl 2-(2-hydroxy-2-methyl-3-butyn-4-yl)benzoate 
• 103606-72-0 methyl 2-(3-hydroxyprop-1-yn-1-yl)benzoate 
• 107793-07-7 methyl 2-(2-trimethylsilyl-1-ethynyl)benzoate 
• 278175-48-7 methyl 2-(perfluoro-1-butanesulfonyloxy)benzoate 
• 4301-14-8 acetylenemagnesium bromide 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 74-86-2 acetylene 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 1066-54-2 trimethylsilylacetylene 
• 229028-09-5 Methyl 2-[2-(triisopropylsilyl)ethyn-1-yl]benzoate 
• 1351067-13-4 N-(quinolin-8-yl)-2-((triisopropylsilyl)ethynyl)benzamide 
• 88-65-3 2-bromobenzoic-acid 
• 88-67-5 2-Iodobenzoic acid 

Downstream Products

• 142458-70-6 2-ethynyl-α-diazoacetophenone 
• 151589-37-6 methyl 2-cyanoethynylbenzoate 
• 147298-34-8 Methyl 2-<4-<2-(2-Propenyl)phenyl>buta-1,3-diynyl>benzoate 
• 27326-44-9 methyl o-vinylbenzoate 
• 147298-29-1 methyl 2-(2-bromoethynyl)benzoate 
• 107793-06-6 2,2'-(1,3-butadiyne-1,4-diyl)bisbenzoic acid dimethyl ester 
• 166756-98-5 Methyl 2-<2-<2-(hydroxymethyl)phenyl>ethynyl>benzoate 
• 160301-04-2 2-(1-Oxo-isochroman-3-ylethynyl)-benzoic acid methyl ester 
• 179007-65-9 2-[3-Hydroxy-4-(1-trifluoromethanesulfonyloxy-naphthalen-2-yl)-but-1-ynyl]-benzoic acid methyl ester 
• 213991-96-9 methyl 1-[2-(2-methoxycarbonylphenyl)-1-ethynyl]-2-naphthoate 
• 69976-43-8 2-(2-(methoxycarbonyl)phenyl)benzo[b]furan 
• 169170-37-0 2-(2'-aminophenylethynyl)benzoic acid methyl ester 
• 676443-74-6 2-[3-(2,4-diamino-pyrimidin-5-ylmethyl)-4-methoxy-phenylethynyl]-benzoic acid methyl ester 
• 54784-10-0 4-butoxy-1-naphthaldehyde 

Relevant articles and documents

Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate

The potential of (2-bromoethyl)diphenylsulfonium triflate to be a powerful vinylation reagent was determined by the Sonogashira cross-coupling reactions with terminal alkynes. The vinylation proceeded smoothly at 25 °C under Pd/Cu catalysis to afford a variety of 1- and 2-unsubstituted 1,3-enynes in moderate to excellent yields. This protocol represents the first application of (2-haloethyl)diphenylsulfonium triflate as a CH═CH2 transfer source in organic synthesis.

Tertiary amines acting as Alkyl radical equivalents enabled by a P/N heteroleptic Cu(I) photosensitizer

An unprecedented exploration of tertiary amines as alkyl radical equivalents for cross-coupling with aromatic alkynes to access allylarenes has been achieved by a P/N heteroleptic Cu(I)based photosensitizer under photoredox catalysis conditions. Mechanist

COMPLEX COMPOUND, METHOD FOR PRODUCING COMPOUND HAVING CARBON-CARBON TRIPLE BOND, METHOD FOR PRODUCING INTERMEDIATE IN THE METHOD, AND KIT FOR USE IN THESE METHODS

PROBLEM TO BE SOLVED: To provide a method for introducing a dicobalt cationic complex into a raw material compound under a milder condition, and a novel compound useful for conducting a method for introducing a carbon-carbon triple bond such as a propargyl group into the raw material compound. SOLUTION: The present invention provides a dicobalt cationic complex compound represented by the formula 23a or a salt thereof. Using the compound makes it possible to introduce a C3 dicobalt cationic complex portion into methoxy naphthalene or the like, and further, removing Co makes it possible to introduce a propargyl group. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT