108644-83-3

Basic information

• Product Name: (R)-(+)-1,1,1-trifluoro-4-phenyl-2-butanol
• Synonyms: (R)-(+)-1,1,1-trifluoro-4-phenyl-2-butanol
• CAS NO: 108644-83-3
• Molecular Weight: 204.192
• Mol File: 108644-83-3.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: (R)-(+)-1,1,1-trifluoro-4-phenyl-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1,1,1-trifluoro-4-phenyl-2-butanol(108644-83-3)
• EPA Substance Registry System: (R)-(+)-1,1,1-trifluoro-4-phenyl-2-butanol(108644-83-3)

Safety Data

• Hazardous Substances Data: 108644-83-3(Hazardous Substances Data)

Upstream product

• 86571-26-8 1,1,1-trifluoro-4-phenylbutan-2-one 
• 108535-36-0 1,1,1-trifluoro-4-phenyl-2-butanol acetate 
• 100-42-5 styrene 
• 75-89-8 2,2,2-trifluoroethanol 
• 104-53-0 3-phenyl-propionaldehyde 
• 2708-87-4 diethoxytrifluoromethylphosphonate 
• 3108-32-5 (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one 
• 122920-70-1 (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 
• 89524-14-1 (Z)-1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butene 
• 89524-12-9 1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butyne 
• 80768-54-3 (+/-)-E-1,1,1-trifluoro-4-phenylbut-3-en-2-ol 
• 108535-32-6 Toluene-4-sulfonic acid (R)-4,4,4-trifluoro-3-(tetrahydro-pyran-2-yloxy)-butyl ester 
• 128779-60-2 (Z)-1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 
• 108644-85-5 (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol 

Relevant articles and documents

Decarboxylative Borylation of Stabilized and Activated Carbon Radicals

Redox-active esters (RAEs) as active radical precursors have been extensively studied for C?B bond formations. However, the analogous transformations of stabilized radicals from the corresponding acid precursors remain challenging owing to the strong preference towards single-electron oxidation to the stable carbocations. This work describes a general strategy for rapid access to various aliphatic and aromatic boronic esters by mild photoinduced decarboxylative borylation. Both aryl and alkyl radicals could be generated from the leaving group-assisted N-hydroxybenzimidoyl chloride esters, even α-CF3 substituted substrates could be activated for further elaboration.

Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl

Nickel-Catalyzed Alkyl-Alkyl Cross-Couplings of Fluorinated Secondary Electrophiles: A General Approach to the Synthesis of Compounds having a Perfluoroalkyl Substituent

Fluorinated organic molecules are of interest in fields ranging from medicinal chemistry to polymer science. Described herein is a mild, convenient, and versatile method for the synthesis of compounds bearing a perfluoroalkyl group attached to a tertiary carbon atom by using an alkyl-alkyl cross-coupling. A nickel catalyst derived from NiCl2 glyme and a pybox ligand achieves the coupling of a wide range of fluorinated alkyl halides with alkylzinc reagents at room temperature. A broad array of functional groups is compatible with the reaction conditions, and highly selective couplings can be achieved on the basis of differing levels of fluorination. A mechanistic investigation has established that the presence of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) inhibits cross-coupling under these conditions and that a TEMPO-electrophile adduct can be isolated.