113416-61-8Relevant articles and documents
Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment
Johansson, Niklas G.,Turku, Ainoleena,Vidilaseris, Keni,Dreano, Lo?c,Khattab, Ayman,Ayuso Pérez, Daniel,Wilkinson, Aaron,Zhang, Yuezhou,Tamminen, Matti,Grazhdankin, Evgeni,Kiriazis, Alexandros,Fishwick, Colin W. G.,Meri, Seppo,Yli-Kauhaluoma, Jari,Goldman, Adrian,Boije Af Genn?s, Gustav,Xhaard, Henri
supporting information, p. 605 - 610 (2020/03/10)
Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. Here, w
FIVE-MEMBERED 2,3-DIOXOHETEROCYCLES. V. SYNTHESIS OF 1-ARYL-4-AROYL-5-METHOXYCARBONYL-2,3-DIHYDRO-2,3-PYRROLEDIONES AND THEIR REACTIONS WITH WATER AND ALCOHOLS
Andreichikov, Yu. S.,Maslivets, A. N.,Smirnova, L. I.,Krasnykh, O. P.,Kozlov, A. P.,Perevozchikov, L. A.
, p. 1378 - 1387 (2007/10/02)
1-Aryl-4-aroyl-5-methoxycarbonyl-2,3-dihydro-2,3-pyrrolediones were obtained from oxalyl chloride and methyl 4-aryl-2-arylamino-4-oxo-2-butenoates.They add water and alcohols reversibly with the formation of substituted 3,5-dihydroxy- and 5-alkoxy-3-hydro