113525-91-0

Basic information

• Product Name: (2S,3S)-methyl 2-[(tert-butoxycarbonyl)amino]-3-hydroxybutanoate
• Synonyms: (2S,3S)-methyl 2-[(tert-butoxycarbonyl)amino]-3-hydroxybutanoate
• CAS NO: 113525-91-0
• Molecular Weight: 233.265
• Mol File: 113525-91-0.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: (2S,3S)-methyl 2-[(tert-butoxycarbonyl)amino]-3-hydroxybutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-methyl 2-[(tert-butoxycarbonyl)amino]-3-hydroxybutanoate(113525-91-0)
• EPA Substance Registry System: (2S,3S)-methyl 2-[(tert-butoxycarbonyl)amino]-3-hydroxybutanoate(113525-91-0)

Safety Data

• Hazardous Substances Data: 113525-91-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 72-19-5 L-threonine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2592-18-9 Boc-Thr-OH 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 137719-70-1 Boc-L-Thr(Bn)-OMe 
• 3373-59-9 L-threonine methyl ester 
• 77-78-1 dimethyl sulfate 
• 22038-72-8 methyldiazene 
• 83791-43-9 methyl (4S,5R)-5-methyl-2-carbonyloxazolidine-4-carboxylate 
• 74-88-4 methyl iodide 
• 113525-85-2 methyl N-Boc-(4S,5R)-5-methyl-2-oxazolidinone-4-carboxylate 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 

Downstream Products

• 1027489-76-4 (2S,3R)-3-[Bis-(4-chloro-benzyloxy)-phosphanyloxy]-2-tert-butoxycarbonylamino-butyric acid methyl ester 
• 56776-41-1 methyl 2-(N-(1,1-dimethylethoxy)methanamido)butenoate 
• 63658-16-2 (Z)-methyl 2-((tertbutoxycarbonyl)amino)but-2-enoate 
• 56776-41-1 (E)-2-N-(tert-butyloxycarbonyl)dehydroaminobutyric acid methyl ester 
• 39994-75-7 L-threonine methyl ester hydrochloride 
• 99216-67-8 2-<<(tert-butoxy)carbonyl>amino>butane-1,3-diol 
• 112380-21-9 N-[(1,1-dimethylethoxy)carbonyl]-O-[(4-methylphenyl)sulfonyl]-L-threonine methyl ester 
• 108149-61-7 3-(tert-butyl) 4-methyl (4S,5R)-2,2,5-trimethyloxazolidine-3,4-dicarboxylate 
• 159846-15-8 N-(tert-Butoxycarbonyl)-O-(tert-butyldiphenylsilyl)-L-threonine methyl ester 
• 137719-70-1 Boc-L-Thr(Bn)-OMe 
• 80082-48-0 t-butyloxycarbonyl-L-threonine amide 
• 552888-37-6 N-(tert-butoxycarbonyl)-O-(3,4,6-tri-O-benzyl-2-deoxy-2-nitro-α-D-galactopyranosyl)-L-threonine methyl ester 
• 695177-56-1 (2S,3R)-3-[(2S,3R,4R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-nitro-4-((2R,3R,4S,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-tert-butoxycarbonylamino-butyric acid methyl ester 
• 108149-62-8 (4S,5R)-3-(tert-Butoxycarbonyl)-4-formyl-2,2,5-trimethyloxazolidine 

Relevant articles and documents

Synthesis and Biological Evaluation of CF3Se-Substituted α-Amino Acid Derivatives

Several CF3Se-substituted α-amino acid derivatives, such as (R)-2-amino-3-((trifluoromethyl)selanyl)propanoates (5 a/6 a), (S)-2-amino-4-((trifluoromethyl)selanyl)butanoates (5 b/6 b), (2R,3R)-2-amino-3-((trifluoromethyl)selanyl)butanoates (5 c/6 c), (R)-2-((S)-2-amino-3-phenylpropanamido)-3-((trifluoromethyl)selanyl)propanoates (11 a/12 a), and (R)-2-(2-aminoacetamido)-3-((trifluoromethyl)selanyl)propanoates (11 b/12 b), were readily synthesized from natural amino acids and [Me4N][SeCF3]. The primary in vitro cytotoxicity assays revealed that compounds 6 a, 11 a and 12 a were more effective cell growth inhibitors than the other tested CF3Se-substituted derivatives towards MCF-7, HCT116, and SK-OV-3 cells, with their IC50 values being less than 10 μM for MCF-7 and HCT116 cells. This study indicated the potentials of CF3Se moiety as a pharmaceutically relevant group in the design and synthesis of novel biologically active molecules.

Synthesis method of aztreonam monocyclic mother nucleus

The invention discloses a synthesis method of an aztreonam monocyclic mother nucleus, and mainly relates to the technical field of pharmaceutical and chemical industry. The method comprises the stepsthat L-threonine is subjected to methyl esterification; terbutyloxycarbonyl anhydride is used for performing amino BOC protection; ammonia water is subjected to ammonolysis; under the catalysis of a solid basic catalyst, methyl-sulfuric-acyl reaction and sulfonation are performed; cyclization, deprotection and acidification are performed to obtain the aztreonam monocyclic mother nucleus. The raw materials are cheap and can be easily obtained; the yield is high; the cost is low; the synthesis method belongs to a green, energy-saving and environment-friendly practical technology.

Preparation method of O-methyl-threonine/tyrosine

The invention relates to a preparation method of O-methyl-threonine/tyrosine. The preparation method mainly overcomes the disadvantages of the existing method that a toxic reagent is volatile, the reagent is dangerous, the steps are long, the yield is low, and the like. The preparation method of the O-methyl-threonine/tyrosine comprises the following steps: N-t-butyloxycarboryl-threonine/tyrosineis catalyzed by sodium hydroxide and reacts with dimethyl sulfate to generate N-t-butyloxycarboryl-O-methyl-threonine/tyrosine, and then t-butyloxycarboryl is removed from the N-t-butyloxycarboryl-O-methyl-threonine/tyrosine through acid substances to obtain the product O-methyl-threonine/tyrosine. The product has important application in the fields of antibiotics and polypeptide drugs.