1138324-46-5

Basic information

• Product Name: tert-butyl (2S,4R)-2-(aMinoMethyl)-4-fluoro-1-pyrrolidinecarboxylate
• Synonyms: tert-butyl (2S,4R)-2-(aMinoMethyl)-4-fluoro-1-pyrrolidinecarboxylate;tert-butyl (2S,4R)-2-(aminomethyl)-4-fluoropyrrolidine-1-carboxylate;(2S,4R)-tert-Butyl 2-(aminomethyl)-4-fluoropyrrolidine-1-carboxylate
• CAS NO: 1138324-46-5
• Molecular Formula: C₁₀H₁₉FN₂O₂
• Molecular Weight: 218.2684632
• Mol File: 1138324-46-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: tert-butyl (2S,4R)-2-(aMinoMethyl)-4-fluoro-1-pyrrolidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2S,4R)-2-(aMinoMethyl)-4-fluoro-1-pyrrolidinecarboxylate(1138324-46-5)
• EPA Substance Registry System: tert-butyl (2S,4R)-2-(aMinoMethyl)-4-fluoro-1-pyrrolidinecarboxylate(1138324-46-5)

Safety Data

• Hazardous Substances Data: 1138324-46-5(Hazardous Substances Data)

Usage

General Description

Tert-butyl (2S,4R)-2-(aminomethyl)-4-fluoro-1-pyrrolidinecarboxylate, also known as Fmoc-L-pyroglutamic acid, is a chemical compound with the molecular formula C12H20FNO2. It is commonly used as a peptide intermediate in the synthesis of pharmaceuticals and research chemicals. tert-butyl (2S,4R)-2-(aMinoMethyl)-4-fluoro-1-pyrrolidinecarboxylate is a pyrrolidine derivative with a fluoro-substituted carboxylic acid. It is often used in solid-phase peptide synthesis and is known for its stability and compatibility with a wide range of chemical reactions. Its tert-butyl protecting group protects the chiral center on the amino group, making it a valuable tool for the synthesis of complex peptides and bioactive molecules.

Upstream product

• 1138324-45-4 tert-butyl (2S,4R)-2-(azidomethyl)-4-fluoropyrrolidine-1-carboxylate 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 203866-18-6 methyl (2S,4R)-N-(tert-butyloxy)carbonyl-4-fluoropyrrolidine-2-carboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 1138324-48-7 (2S,4R)-tert-butyl 4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 1138324-44-3 tert-butyl (2S,4R)-4-fluoro-2-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate 

Downstream Products

• 1307831-81-7 C₃₆H₄₂FN₇O₄ 
• 1272598-94-3 C₂₉H₃₀ClFN₆O 
• 1272598-96-5 C₂₉H₃₀ClFN₆O 
• 1272598-99-8 C₃₁H₃₃FN₆O 
• 1272599-02-6 C₂₈H₂₉FN₆O 
• 1272599-04-8 C₂₄H₂₇FN₆O₃ 
• 1272599-06-0 C₂₄H₂₉FN₆O₂ 
• 1272599-08-2 C₃₀H₃₁FN₆O₃ 
• 1272599-10-6 C₃₁H₃₄FN₇O₂ 
• 1272598-79-4 C₂₂H₂₅FN₆O 
• 1272598-82-9 C₂₃H₂₇FN₆O 
• 1272598-85-2 C₂₄H₂₉FN₆O 
• 1272598-88-5 C₂₅H₃₁FN₆O 

Relevant articles and documents

4-Fluoro and 4-hydroxy pyrrolidine-thioxotetrahydropyrimidinones: Organocatalysts for green asymmetric transformations in brine

The synthesis of both trans- and cis-diastereomers of pyrrolidinine-thioxotetrahydropyrimidinone bearing either a fluorine or a hydroxyl group was accomplished. The new compounds were tested for their catalytic properties in a variety of asymmetric organic transformations and compared with the first generation catalyst. It was found that the new catalysts could efficiently catalyze the reactions in brine, without the use of organic solvent, and by employing an almost stoichiometric amount of reagents. Thus, the products were isolated by simple extractions, avoiding the use of chromatography in excellent yields, diastereoselectivities, and enantioselectivities.