1138324-48-7

Basic information

• Product Name: (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxyMethylpyrrolidine
• Synonyms: (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxyMethylpyrrolidine;tert-butyl (2S,4R)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate;(2S,4R)-tert-Butyl 4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate
• CAS NO: 1138324-48-7
• Molecular Formula: C10H18FNO3
• Molecular Weight: 219.2532232
• Mol File: 1138324-48-7.mol
• Article Data: 48

Chemical Properties

• Boiling Point: 298.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.77±0.10(Predicted)
• CAS DataBase Reference: (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxyMethylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxyMethylpyrrolidine(1138324-48-7)
• EPA Substance Registry System: (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxyMethylpyrrolidine(1138324-48-7)

Safety Data

• Hazardous Substances Data: 1138324-48-7(Hazardous Substances Data)

Usage

General Description

The chemical (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxyMethylpyrrolidine is a compound with a molecular formula of C10H18FNO3. It is a derivative of pyrrolidine with a tert-butoxycarbonyl (Boc) protecting group at the 1-position and a fluoro and hydroxymethyl group at the 4-position. (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-hydroxyMethylpyrrolidine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its specific stereochemistry and functional groups make it a versatile building block for the production of various biologically active compounds. Additionally, the presence of the fluoro group can impart unique properties to these compounds, making them potential candidates for drug development or biological research.

Upstream product

• 203866-18-6 methyl (2S,4R)-N-(tert-butyloxy)carbonyl-4-fluoropyrrolidine-2-carboxylate 
• 203866-14-2 (2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 121147-94-2 1-tert-butyl 2-methyl (2S,4S)-4-((benzoyl)oxy)-1,2-pyrrolidinedicarboxylate 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 203866-16-4 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate 
• 203866-13-1 (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 647857-43-0 (2R,4R)-1-tert-butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate 
• 647857-39-4 1-(tert-butyl) 2-methyl (2R,4S)-4-fluoropyrrolidine-1,2-dicarboxylate 
• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1283146-14-4 ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol 
• 1283146-15-5 2-((2R,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)acetonitrile 
• 1283142-63-1 2-((2R,4S)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt 

Relevant articles and documents

Synthesis and pharmacological evaluation of α4β2 nicotinic ligands with a 3-fluoropyrrolidine nucleus

Abstract Nicotinic acetylcholine receptors (nAChRs) play an important role in many central nervous system disorders such as Alzheimer's and Parkinson's diseases, schizophrenia, and mood disorders. The α4β2 subtype has emerged as an important target for the early diagnosis and amelioration of Alzheimer's disease symptoms. Herein we report a new class of α4β2 receptor ligands characterized by a basic pyrrolidine nucleus, the basicity of which was properly decreased through the insertion of a fluorine atom at the 3-position, and a pyridine ring carrying at the 3-position substituents known to positively affect affinity and selectivity toward the α4β2 subtype. Derivatives 3-(((2S,4R)-4-fluoropyrrolidin-2-yl)methoxy)-5-(phenylethynyl)pyridine (11) and 3-((4-fluorophenyl)ethynyl)-5-(((2S,4R)-4-fluoropyrrolidin-2-yl)methoxy)pyridine (12) were found to be the most promising ligands identified in this study, showing good affinity and selectivity for the α4β2 subtype and physicochemical properties predictive of a relevant central nervous system penetration. Basicity tuned by F: By combining structural features of niodene and compound B, we developed new α4β2 receptor ligands characterized by the 3-fluoropyrrolidine nucleus. Derivatives (2S,4R)-11 and (2S,4R)-12 were highlighted as the most promising ligands identified in this study, showing good affinity and selectivity for the α4β2 subtype and physicochemical properties predictive of good central nervous system penetration.

COMPOUNDS TARGETING RNA-BINDING PROTEINS OR RNA-MODIFYING PROTEINS

The invention relates to a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, compositions comprising the same and methods of preparing and using the same. The variables are described herein.

POTENT HUMAN NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS

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BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST

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