121147-94-2

Basic information

• Product Name: (2S,4S)-1-tert-butyl 2-Methyl 4-(benzoylo×y)pyrrolidine-1,2-dicarbo×ylate
• Synonyms: (2S,4S)-1-tert-butyl 2-Methyl 4-(benzoylo×y)pyrrolidine-1,2-dicarbo×ylate;(2S,4S)-1-tert-Butyl 2-Methyl 4-(benzoyloxy)pyrrolidine-1,2-dicarboxylate
• CAS NO: 121147-94-2
• Molecular Formula: C₁₈H₂₃NO₆
• Molecular Weight: 349.37832
• Mol File: 121147-94-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 438.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -5.20±0.60(Predicted)
• CAS DataBase Reference: (2S,4S)-1-tert-butyl 2-Methyl 4-(benzoylo×y)pyrrolidine-1,2-dicarbo×ylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-1-tert-butyl 2-Methyl 4-(benzoylo×y)pyrrolidine-1,2-dicarbo×ylate(121147-94-2)
• EPA Substance Registry System: (2S,4S)-1-tert-butyl 2-Methyl 4-(benzoylo×y)pyrrolidine-1,2-dicarbo×ylate(121147-94-2)

Safety Data

• Hazardous Substances Data: 121147-94-2(Hazardous Substances Data)

Usage

General Description

(2S,4S)-1-tert-butyl 2-Methyl 4-(benzoyloxy)pyrrolidine-1,2-dicarboxylate is a chemical compound with the molecular formula C21H25NO6. It is a derivative of pyrrolidine and contains a tert-butyl group and a benzoyloxy group. (2S,4S)-1-tert-butyl 2-Methyl 4-(benzoylo×y)pyrrolidine-1,2-dicarbo×ylate is often used in organic synthesis as a building block for creating more complex molecules. It has a wide range of potential applications in the pharmaceutical industry, particularly in the development of new drugs and pharmaceutical ingredients. Additionally, it has been studied for its potential biological and pharmacological properties, making it a valuable compound for further research and development.

Upstream product

• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 65-85-0 benzoic acid 
• 532-32-1 sodium benzoate 
• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 191280-88-3 (2S,4S)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 121148-00-3 1-(1,1-dimethylethyl) 2-methyl (2S,4R)-4-amino-1,2-pyrrolidinedicarboxylate 
• 121147-97-5 1-tert-butyl 2-methyl (2S,4R)-4-azido-1,2-pyrrolidinedicarboxylate 
• 121148-10-5 tert-butyl (2S,4R)-2-formyl-4-((phenylsulfonyl)amino)-pyrrolidine-1-carboxylate 
• 121148-21-8 tert-butyl (2S,4R)-2-formyl-4-(((4-methylphenyl)sulfonyl)amino)pyrrolidine-1-carboxylate 
• 121148-09-2 tert-butyl (2S,4R)-2-formyl-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidine-1-carboxylate 
• 121148-22-9 tert-butyl (2S,4R)-2-formyl-4-(((4-methoxyphenyl)sulfonyl)amino)pyrrolidine-1-carboxylate 
• 121148-05-8 4(R)-[(phenylsulfonyl)amino]-1,2(S)-pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl)-2-methyl ester 
• 121148-18-3 1-tert-butyl 2-methyl (2S,4R)-4-(((4-methylphenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate 
• 121148-04-7 1-tert-butyl 2-methyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate 
• 121148-19-4 1-tert-butyl 2-methyl (2S,4R)-4-(((4-methoxyphenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate 
• 121148-23-0 tert-butyl (2S,4R)-2-formyl-4-(((4-(trifluoromethyl)phenyl)sulfonyl)amino)pyrrolidine-1-carboxylate 
• 121147-40-8 methyl 3-((Z)-2-((2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidin-2-yl)ethenyl)benzoate 

Relevant articles and documents

Conformationally restrained chiral analogues of spermine: Chemical synthesis and improvements in DNA triplex stability

The synthesis of novel chiral analogues of spermine, 11 (2R,4S) and 14 (2S,4R), is reported starting from trans-4-hydroxy-L-proline 3. These cyclic analogues are generated from linear, achiral spermine by incorporating a pyrrolidine ring on the backbone t

NOVEL AMINO PYRIMIDINE DERIVATIVES

The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel amino pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.

Part 2: Design, synthesis and evaluation of hydroxyproline-derived α2δ ligands

Conformational constraint has been used to design a potent series of α2δ ligands derived from the readily available starting material (2S,4R)-hydroxy-l-proline. The ligands have improved physicochemistry and potency compared to their linear counterparts (described in our earlier publication) and the lead compound has been progressed to clinical development.