121148-04-7

Basic information

• Product Name: 1-tert-butyl 2-methyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate
• Synonyms: 1-tert-butyl 2-methyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate
• CAS NO: 121148-04-7
• Molecular Weight: 418.898
• Mol File: 121148-04-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-tert-butyl 2-methyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 2-methyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate(121148-04-7)
• EPA Substance Registry System: 1-tert-butyl 2-methyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-1,2-pyrrolidinedicarboxylate(121148-04-7)

Safety Data

• Hazardous Substances Data: 121148-04-7(Hazardous Substances Data)

Upstream product

• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 121148-00-3 1-(1,1-dimethylethyl) 2-methyl (2S,4R)-4-amino-1,2-pyrrolidinedicarboxylate 
• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 121147-97-5 1-tert-butyl 2-methyl (2S,4R)-4-azido-1,2-pyrrolidinedicarboxylate 
• 121147-94-2 1-tert-butyl 2-methyl (2S,4S)-4-((benzoyl)oxy)-1,2-pyrrolidinedicarboxylate 
• 121147-93-1 (2S,4S)-2-methyl N-Boc-4-((methylsulfonyl)oxy)pyrrolidine-2-carboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 121148-09-2 tert-butyl (2S,4R)-2-formyl-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidine-1-carboxylate 
• 121147-01-1 (2S,4R)-1-(4-Chlorophenylsulfonyl)-4-(4-chlorophenylsulfonylamino)-2-[(E)-2-(4-methoxycarbonylphenyl)vinyl]pyrrolidine 
• 121147-42-0 (2S,4R)-1-(4-chlorophenylsulfonyl)-4-(4-chlorophenylsulfonylamino)-2-[(Z)-2-(4-methoxycarbonylphenyl)vinyl]pyrrolidine 
• 121147-44-2 (2S,4R)-1-(4-Chlorophenylsulfonyl)-4-(4-chlorophenylsulfonylamino)-2-[(E)-2-(3-methoxycarbonylphenyl)vinyl]pyrrolidine 
• 121147-43-1 methyl 3-((Z)-2-((2S,4R)-1-((4-chlorophenyl)sulfonyl)-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidin-2-yl)ethenyl)benzoate 
• 121147-49-7 (5Z)-6-((2S,4R)-1-((4-chlorophenyl)sulfonyl)-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidin-2-yl)-5-hexenoic acid 
• 121147-51-1 tert-butyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-2-((E)-2-(3-(methoxycarbonyl)phenyl)ethenyl)-1-pyrrolidinecarboxylate 
• 121147-38-4 tert-butyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-2-((Z)-2-(3-(methoxycarbonyl)phenyl)ethenyl)-1-pyrrolidinecarboxylate 
• 121147-35-1 tert-butyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-2-((E)-2-(4-(methoxycarbonyl)phenyl)ethenyl)-1-pyrrolidinecarboxylate 
• 121147-37-3 tert-butyl (2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)-2-((Z)-2-(4-(methoxycarbonyl)phenyl)ethenyl)-1-pyrrolidinecarboxylate 
• 454474-28-3 (5E/Z)-6-((2S,4R)-1-(tert-butoxycarbonyl)-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidin-2-yl)-5-hexenoic acid 
• 121147-58-8 methyl 4-((E)-2-((2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidin-2-yl)ethenyl)benzoate 
• 121147-39-5 methyl 4-((Z)-2-((2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidin-2-yl)ethenyl)benzoate 
• 121147-41-9 methyl 3-((E)-2-((2S,4R)-4-(((4-chlorophenyl)sulfonyl)amino)pyrrolidin-2-yl)ethenyl)benzoate 

Relevant articles and documents

Synthesis and biological activity of 1-phenylsulfonyl-4-phenylsulfonylaminopyrrolidine derivatives as thromboxane A2 receptor antagonists

The synthesis and biological activity of novel 1-phenylsulfonyl-4- phenylsulfonylaminopyrrolidine analogues are described. All compounds were produced through modification of the substituent formally corresponding to the 1,3-dioxane ring system and the ω-octenol side chain of thromboxane A2 (TXA2), in reference to the structure of Daltroban. Several compounds were found to be potent TXA2 receptor antagonists. Compound 51a was the most effective inhibitor of 9,11-epoxymethano PGH2 (U-46619)-induced rat aortic strip contraction (IC50 = 0.48 nM).