121148-00-3Relevant articles and documents
Design and synthesis of fluorinated peptides for analysis of fluorous effects on the interconversion of polyproline helices
Li, Meng-Che,Liu, Ying-Jie,Hsu, Kuang-Cheng,Lin, Tse-Hsueh,Lin, Chih-Wei,Horng, Jia-Cherng,Wang, Sheng-Kai
, (2021/11/30)
The unique interaction between fluorine atoms has been exploited to alter protein structures and to develop synthetic and analytical applications. To expand such fluorous interaction for novel applications, polyproline peptides represent an excellent molecular nanoscaffold for controlling the presentation of perfluoroalkyl groups on their unique secondary structure. We develop approaches to synthesis fluorinated peptides to systematically investigate how the number, location and types of the fluorous groups on polyproline affect the conformation by monitoring the transition between the two major polyproline structures PPI and PPII. This work provides valuable information on how fluorous interaction affects the peptide structure and also benefits the design of functional fluorous molecules.
HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF
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, (2016/05/02)
Disclosed are heteroaryl derivatives, pharmaceutical composition and uses in the manufacture of a medicine for treating respiratory diseases, especially for chronic obstructive pulmonary disease (COPD).
Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands
Nomura, Wataru,Aikawa, Haruo,Taketomi, Shohei,Tanabe, Miho,Mizuguchi, Takaaki,Tamamura, Hirokazu
, p. 6967 - 6973 (2015/11/11)
We have previously used poly-l-proline linkers for the development of bivalent-type ligands for the chemokine receptor, CXCR4. The bivalent ligands with optimum linkers showed specific binding to CXCR4, suggesting the existence of CXCR4 possibly as a dime