203866-18-6 Usage
Description
BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER is a chemical compound that serves as an intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries. It is characterized by its unique structure, which includes a Boc-protected trans-4-fluoro-L-proline moiety and a methyl ester functional group. BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER is essential for the preparation of specific target molecules through chemical reactions.
Uses
Used in Pharmaceutical Industry:
BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER is used as a key intermediate in the synthesis of (S)-2-[N-(N'-benzyl-(S)-4-fluoro-L-prolyl)amino]benzophenone. BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER is prepared by reacting BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER with 2-aminobenzophenone in the presence of potassium tert-butoxide. The resulting product has potential applications in the development of pharmaceuticals, particularly those targeting specific biological pathways or diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 203866-18-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,3,8,6 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 203866-18:
(8*2)+(7*0)+(6*3)+(5*8)+(4*6)+(3*6)+(2*1)+(1*8)=126
126 % 10 = 6
So 203866-18-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H18FNO4/c1-11(2,3)17-10(15)13-6-7(12)5-8(13)9(14)16-4/h7-8H,5-6H2,1-4H3/t7-,8+/m1/s1
203866-18-6Relevant articles and documents
Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor
González-Esguevillas, María,Miró, Javier,Jeffrey, Jenna L.,MacMillan, David W.C.
, p. 4222 - 4227 (2019/06/13)
Herein we disclose a deoxyfluorination of alcohols with an electrophilic fluorine source via visible-light photoredox catalysis. This radical-mediated C–F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing previously reported nucleophilic deoxyfluorination protocols.
Practical synthesis of Boc and Fmoc protected 4-fluoro and 4-difluoroprolines from trans-4-hydroxyproline
Demange, Luc,Menez, Andre,Dugave, Christophe
, p. 1169 - 1172 (2007/10/03)
Boc-cis-4-fluoro-L-proline and 4-difluoro-L-proline, usable in classical peptide synthesis, were obtained in respectively 71% (3 steps) and 65% (4 steps) overall yields from the readily available trans-4-hydroxy-L-proline methyl ester. The corresponding fluorinated trans-isomer was isolated in 24% yield (5 steps). Transformation of Boc-protected compounds to their Fmoc-equivalents was performed in high yields.