115665-76-4

Basic information

• Product Name: Benzene, 1-[(1E)-2-bromoethenyl]-4-fluoro-
• CAS NO: 115665-76-4
• Molecular Formula: C8H6BrF
• Molecular Weight: 201.038
• Mol File: 115665-76-4.mol
• Article Data: 38

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(1E)-2-bromoethenyl]-4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(1E)-2-bromoethenyl]-4-fluoro-(115665-76-4)
• EPA Substance Registry System: Benzene, 1-[(1E)-2-bromoethenyl]-4-fluoro-(115665-76-4)

Safety Data

• Hazardous Substances Data: 115665-76-4(Hazardous Substances Data)

Upstream product

• 75-25-2 Bromoform 
• 401514-49-6 [(4-fluorophenyl)methylidene]hydrazine 
• 459-46-1 4-Fluorobenzyl bromide 
• 74-95-3 1,1-dibromomethane 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 405-99-2 para-fluorostyrene 
• 459-57-4 4-fluorobenzaldehyde 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 459-32-5 4-fluorocinnamic acid 
• 870122-74-0 2-bromo-1-(4-fluorophenyl)ethylene 

Downstream Products

• 1042728-04-0 (E)-1-(4-fluorostyryl)-1H-imidazole 
• 1042728-08-4 (E)-1-(4-fluorostyryl)-1H-benzo[d]imidazole 
• 119869-92-0 C₁₄H₁₁FO 
• 1607020-79-0 N-(4-methylphenyl)-3-exo-(4-fluorobenzylidene)tricyclo[3.2.1.02,4]octane-6,7-endo-dicarboximide 
• 1607020-89-2 3-exo-(4-fluorobenzylidene)tricyclo[3.2.1.02,4]octane 
• 1380341-57-0 (E)-ethyl 4-(4-fluorophenyl)-2-methylbut-3-enoate 
• 405-69-6 (E)‐1‐(buta‐1,3‐dien‐1‐yl)‐4‐fluorobenzene 
• 1427026-26-3 1-(4-methylbenzenesulfonyl)-4-(4-fluorobenzene)-1H-1,2,3-triazole 

Relevant articles and documents

Illuminatinganti-hydrozirconation: controlled geometric isomerization of an organometallic species

A general strategy to enable the formalanti-hydrozirconation of arylacetylenes is reported that mergescis-hydrometallation using the Schwartz Reagent (Cp2ZrHCl) with a subsequent light-mediated geometric isomerization atλ= 400 nm. Mechanistic delineation of thecontra-thermodynamic isomerization step indicates that a minor reaction product functions as an efficientin situgenerated photocatalyst. Coupling of theE-vinyl zirconium species with an alkyne unit generates a conjugated diene: this has been leveraged as a selective energy transfer catalyst to enableE→Zisomerization of an organometallic species. Through anUmpolungmetal-halogen exchange process (Cl, Br, I), synthetically useful vinyl halides can be generated (up toZ?:?E= 90?:?10). This enabling platform provides a strategy to access nucleophilic and electrophilic alkene fragments in both geometric forms from simple arylacetylenes.

Iron-Catalyzed Regioselective Alkenylboration of Olefins

The first examples of an iron-catalyzed three-component synthesis of homoallylic boronates from regioselective union of bis(pinacolato)diboron, an alkenyl halide (bromide, chloride or fluoride), and an olefin are disclosed. Products that bear tertiary or quaternary carbon centers could be generated in up to 87 % yield as single regioisomers with complete retention of the olefin stereochemistry. With cyclopropylidene-containing substrates, ring cleavage leading to trisubstituted E-alkenylboronates were selectively obtained. Mechanistic studies revealed reaction attributes that are distinct from previously reported alkene carboboration pathways.

Method for synthesizing beta-bromostyrene through metal-free catalysis

The invention discloses a method for synthesizing beta-bromostyrene through metal-free catalysis, and belongs to the technical field of organic chemistry. Substituted styrene 1 is used as a raw material and is reacted in the presence of a bromination reagent, sodium persulfate and dichloroethane, and the beta-bromostyrene compound 2 can be obtained in one step. The method is capable of solving thetechnical problem that in the traditional synthesis method, conversion into alkenyl boron, alkenyl silicon and other intermediates under the catalysis of noble metals and then further halogenation are needed; the defects of expensive reaction reagent, high catalytic cost, complex operation, incapability of large-scale preparation and the like in the traditional preparation method are avoided; byadopting the method, a series of beta-bromostyrene compounds can be obtained, and the method has a potential application prospect.