116714-46-6

Basic information

• Product Name: Novaluron
• Synonyms: RIMON;NOVALURON;Benzamide, N-3-chloro-4-1,1,2-trifluoro-2-(trifluoromethoxy)ethoxyphenylaminocarbonyl-2,6-difluoro-;novaluron (bsi, pa e-iso);N-[[3-Chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl]carbamoyl]-2,6-difluorobenzamide;Hsdb 7004;Novaluron [iso];Novaluron 100mg [116714-46-6]
• CAS NO: 116714-46-6
• Molecular Formula: C₁₇H₉ClF₈N₂O₄
• Molecular Weight: 492.7
• Mol File: 116714-46-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 172-174°
• Flash Point: 202℃
• Appearance: white
• Density: 1.601 g/cm³
• Refractive Index: 1.513
• Storage Temp.: 0-6°C
• PKA: 8.68±0.46(Predicted)
• BRN: 5465888
• CAS DataBase Reference: Novaluron(CAS DataBase Reference)
• NIST Chemistry Reference: Novaluron(116714-46-6)
• EPA Substance Registry System: Novaluron(116714-46-6)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 2
• Hazardous Substances Data: 116714-46-6(Hazardous Substances Data)

Usage

Description

Novaluron is an insect growth regulator that effectively targets and controls various larvae of the genus Lepidoptera, Coleoptera, Hemiptera, and Diptera. It is a potent insecticide that disrupts the growth and development of insects, leading to their death.

Uses

Used in Agriculture:
Novaluron is used as an insecticide for controlling and eliminating various larvae of the genus Lepidoptera, Coleoptera, Hemiptera, and Diptera. It is particularly effective in protecting crops from these pests, ensuring a healthy and productive agricultural yield.
Used in Insect Control:
Novaluron is used as an insect growth regulator for managing insect populations in various settings, such as gardens, parks, and other outdoor areas. Its ability to target and kill a wide range of larvae makes it a versatile and effective tool for insect control.

InChI:InChI=1/C17H9ClF8N2O4/c18-8-6-7(4-5-11(8)31-16(22,23)14(21)32-17(24,25)26)27-15(30)28-13(29)12-9(19)2-1-3-10(12)20/h1-6,14H,(H2,27,28,29,30)

Synthetic route

2,6-difluorobenzoyl isocyanate (60731-73-9) + 3-chloro-4-[ 1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy] aniline (116714-47-7) → 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea (116714-46-6)

Conditions	Yield
Heating;	82%

2-chloro 4-aminophenol (3964-52-1) → 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea (116714-46-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / KOH / toluene; dimethylsulfoxide / 3 h / 0 °C 2: 82 percent / Heating View Scheme

2,6-difluorobenzoyl isocyanate (60731-73-9) + 3-chloro-4-[ 1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy] aniline (116714-47-7) → 1-benzoylurea (614-22-2) + 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea (116714-46-6)

Conditions	Yield
In chlorobenzene

chloromethyl methyl ether (107-30-2) + 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea (116714-46-6) → 1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethyl)phenyl]-3-(2,6-difluorobenzoyl)-1,3-bis(methoxymethyl)urea

Conditions	Yield
With sodium hydride In 1-methyl-pyrrolidin-2-one at 0 - 2℃; for 4h;

Upstream product

• 60731-73-9 2,6-difluorobenzoyl isocyanate 
• 116714-47-7 3-chloro-4-[ 1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy] aniline 
• 3964-52-1 2-chloro 4-aminophenol 

Related news

Toxicity of the insect growth regulator Novaluron (cas 116714-46-6) to the non-target predatory bug Podisus maculiventris (Heteroptera: Pentatomidae)08/24/2019

Novaluron is a novel insect growth regulator that exhibits potent insecticidal activity against the Colorado potato beetle, Leptinotarsa decemlineata (Say). The predatory bug Podisus maculiventris (Say) is a natural enemy of the potato beetle found throughout North America, and is widely availab...detailed

Susceptibility of Rhipicephalus (Boophilus) microplus to fluazuron (2.5 mg/kg) and a combination of Novaluron (cas 116714-46-6) (2.0 mg/kg) + eprinomectin (0.36 mg/kg) in field studies in Brazil08/23/2019

The present study aimed to determine the susceptibility of 32 R. (B.) microplus populations from Southeast, Midwest and South regions of Brazil, to fluazuron (2.5 mg/kg), administered topically (pour-on). Additionally, five populations (Southeast and Midwest regions) of the southern cattle tick ...detailed

Vertical distribution in soil column and dissipation in soil of benzoylurea insecticides diflubenzuron, flufenoxuron and Novaluron (cas 116714-46-6) and effect on the bacterial community08/22/2019

Benzoylurea insecticides are used for prevention and eradication of household or field pests. However, few studies have investigated their distribution and dissipation in soils and the effects on the soil microbial community. We examined the dissipation and vertical distribution of diflubenzuron...detailed

Effect of the insect growth regulator Novaluron (cas 116714-46-6) on diamondback moth, Plutella xylostella L. (Lepidoptera: Plutellidae), and its indigenous parasitoids08/21/2019

Research to evaluate effective and selective insecticides through periodic screening is needed to strengthen diamondback moth (DBM) (Plutella xylostella L.) management. The efficacy of the insect growth regulator novaluron on DBM and effects on the parasitoids Diadegma sp. (Hym.: Ichneumonidae),...detailed

Field efficacy of Novaluron (cas 116714-46-6) for control of Colorado potato beetle (Coleoptera: Chrysomelidae) on potato08/20/2019

Field trials were conducted in 2003 and 2004 to assess the effectiveness of novaluron (Rimon 10EC), a benzoylphenyl urea chitin synthesis inhibitor, for Colorado potato beetle, Leptinotarsa decemlineata (Say), management on potato. Foliar applications of novaluron did not significantly reduce nu...detailed

Novaluron (cas 116714-46-6) nanoparticles: Formation and potential use in controlling agricultural insect pests08/19/2019

Nanoparticles of novaluron, a water-insoluble insecticide, were prepared by a novel method, based on a direct conversion of O/W microemulsions containing pesticide and volatile solvents, into powders. The conversion of nanoparticles into powder was achieved by rapid evaporation of all the liquid...detailed

Novaluron (cas 116714-46-6) ingestion causes larval lethality and inhibits chitin content in Leptinotarsa decemlineata fourth-instar larvae08/17/2019

To accomplish consistent, long-term, integrated management (IPM) of the Colorado potato beetle, Leptinotarsa decemlineata (Say), research assessing the potential of novel, IPM-compatible insecticides is essential. Novaluron is a potent benzoylurea insecticide. In the present paper, we found that...detailed

Negative impact of Novaluron (cas 116714-46-6) on the nontarget insect Bombyx mori (Lepidoptera: Bombycidae)☆08/16/2019

Due to increased use of agrochemicals and growing concerns about ecotoxicology, the development of new insecticides, moving away from those with neurotoxic and broad spectrum effects towards insecticides that are safer for the environment and nontarget beneficial species, has been a research pri...detailed

Relevant articles and documents

Method for exterminating termites

A method for exterminating termites comprising using an entomopathogenic nematode together with an inset-growth regulator or a slow-acting insecticide, wherein insecticidal effects are reinforced compared with the cases using singly the entomopathogenic nematode and the insect-growth regulator or the slow-acting insecticide, respectively, and a bait station for exterminating termites that contains an entomopathogenic nematode with an insect-growth regulator or a slow-acting insecticide. According to the invention, emission of harmful chemicals to environment can be suppressed. The invention is nonpoisonous for human being and livestock, and is useful for indoor or outdoor extermination of termites.

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