118520-71-1

Basic information

• Product Name: 2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester
• Synonyms: 2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester
• CAS NO: 118520-71-1
• Molecular Weight: 270.715
• Mol File: 118520-71-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester(118520-71-1)
• EPA Substance Registry System: 2-(2-(4-chlorophenyl)ethynyl)benzoic acid methyl ester(118520-71-1)

Safety Data

• Hazardous Substances Data: 118520-71-1(Hazardous Substances Data)

Upstream product

• 78704-49-1 1-(4-chlorophenyl)-2-trimethylsilylacetylene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 33577-99-0 2-ethynyl-benzoic acid methyl ester 
• 107793-07-7 methyl 2-(2-trimethylsilyl-1-ethynyl)benzoate 
• 873-73-4 4-n-chlorophenylacetylene 
• 106-39-8 bromochlorobenzene 
• 88-67-5 2-Iodobenzoic acid 
• 49748-64-3 1-copper(I) (4-chlorophenyl)ethyne 

Downstream Products

• 1314961-15-3 3-(4-chlorophenyl)-4-(phenylselenyl)-1H-isochromen-1-one 
• 1452790-30-5 3-(4-chlorophenyl)-4-(3-oxobutyl)-1H-isochromen-1-one 
• 62827-72-9 3-(p-chlorophenyl)-1H-isochromen-1-one 
• 20526-97-0 3-(4-chlorobenzylidene)-2-benzofuran-1(3H)-one 
• 1647071-81-5 3-(4-chlorophenyl)-4-[(trifluoromethyl)thio]-1H-isochromen-1-one 
• 1356456-53-5 3-(4-chlorophenyl)-4-(p-tolylthio)-1H-isochromen-1-one 
• 1361132-15-1 3-(4-chlorophenyl)-1',3'-dimethyl-3,4-dihydro-1H,1'H-spiro[naphthalene-2,5'-pyrimidine]-2',4',6'(3'H)-trione 
• 1175028-73-5 C₁₅H₁₃ClO 
• 1175028-75-7 C₁₅H₁₅ClO 
• 88733-63-5 C₁₆H₁₅ClO₂ 

Relevant articles and documents

Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.

Metal-Free Synthesis of 4-Chloroisocoumarins by TMSCl-Catalyzed NCS-Induced Chlorinative Annulation of 2-Alkynylaryloate Esters

4-Chloroisocoumarins can be conveniently prepared from 2-alkynylaryloate esters via the activation of alkynes by electrophilic chlorine, generated in situ from N-chlorosuccinimide (NCS) in the presence of 10 mol % trimethylsilyl chloride (TMSCl), which leads to 6-endo-dig-selective chlorinative annulation to give the desired products in moderate to quantitative yields. The procedure employs readily available reagents and can be conveniently carried out on a wide scope of substrates under mild conditions (0 °C to rt). Furthermore, the reaction is scalable for gram-scale preparation of 4-chloroisocoumarins. Additionally, 4-bromo- and 4-iodoisocoumarins can be prepared in moderate to good yields by replacing NCS with N-bromosuccinimide (NBS) and N-iodosuccinimide (NIS), respectively.

Boron Trichloride-Mediated Synthesis of Indoles via the Aminoboration of Alkynes

We describe an efficient catalyst- and metal-free aminoboration of alkynes to 3-borylated indoles using one of the least expensive boron sources, BCl3. The major dichloro(indolyl)borane products can be used for the in situ construction of usefu