118664-99-6Relevant articles and documents
Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole
Bentley, Jon M.,Davidson, James E.,Duncton, Matthew A. J.,Giles, Paul R.,Pratt, Robert M.
, p. 2295 - 2300 (2004)
An efficient synthesis of the title indole, the heterocyclic core of the standard 5-HT2C receptor agonist Ro 60-0175, via a modified Leimgruber-Batcho indole synthesis is presented. The process can be used to make > 100 g quantities of the targ
ANTITUMOR-EFFECT ENHANCER USING PYRAZOLO[3,4-D]PYRIMIDINE COMPOUND
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Paragraph 0361, (2020/01/22)
To provide a method for treating cancer using a pyrazolo[3,4-d]pyrimidine compound or a salt thereof. The present invention provides an antitumor agent comprising a pyrazolo[3,4-d]pyrimidine compound of formula (I) wherein X, Y, Z1, Z2/su
Indoline derivatives as 5-HT2C receptor agonists
Bentley,Adams,Bebbington,Benwell,Bickerdike,Davidson,Dawson,Dourish,Duncton,Gaur,George,Giles,Hamlyn,Kennett,Knight,Malcolm,Mansell,Misra,Monck,Pratt,Quirk,Roffey,Vickers,Cliffe
, p. 2367 - 2370 (2007/10/03)
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT2C receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand