122509-72-2

Basic information

• Product Name: 6-Chloro-5-fluoroindole
• Synonyms: 6-CHLORO-5-FLUOROINDOLE;6-Chloro-5-fluoroindole ,98%;6-Chloro-5-fluoro-1H-indole;- 6-chloro-5-fluroindole;1H-Indole,6-chloro-5-fluoro-
• CAS NO: 122509-72-2
• Molecular Formula: C₈H₅ClFN
• Molecular Weight: 169.58
• EINECS: 1312995-182-4
• Product Categories: Indoles and derivatives;Indole
• Mol File: 122509-72-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 299.8 °C at 760 mmHg
• Flash Point: 135.1 °C
• Appearance: /
• Density: 1.436 g/cm³
• Vapor Pressure: 0.0122mmHg at 25°C
• Refractive Index: 1.432
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.26±0.30(Predicted)
• CAS DataBase Reference: 6-Chloro-5-fluoroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-fluoroindole(122509-72-2)
• EPA Substance Registry System: 6-Chloro-5-fluoroindole(122509-72-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-39-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 122509-72-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C7H10F2O2/c8-7(9)3-1-5(2-4-7)6(10)11/h5H,1-4H2,(H,10,11)

Upstream product

• 1027185-20-1 1-(6-Chloro-5-fluoro-indol-1-yl)-2,2,2-trifluoro-ethanone 
• 496916-77-9 3-chloro-4-fluoro-6-vinylaniline 
• 709007-52-3 [2-(4-chloro-5-fluoro-2-nitrophenyl)vinyl]dimethylamine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 118664-99-6 1-chloro-2-fluoro-4-methyl-5-nitrobenzene 
• 452-80-2 2-fluoro-4-methylaniline 
• 259860-00-9 2-fluoro-4-methyl-5-nitro-phenylamine 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 85462-59-5 2-bromo-5-chloro-4-fluoroaniline 
• 1026638-79-8 (R,S)-1-(trifluoroacetyl)-6-chloro-5-fluoro-3-hydroxy-2,3-dihydro-1H-indole 
• 100487-74-9 6-Chloro-5-fluoro-1,3-dihydro-2H-indol-2-one 
• 96202-57-2 6-Chloro-5-fluoro-1H-indole-2,3-dione 

Downstream Products

• 172078-39-6 6-Chloro-5-nitro-indole 
• 920023-30-9 6-chloro-5-fluoro-1H-indole-3-carboxylic acid 
• 205584-67-4 2,3-dihydro-6-chloro-5-fluoro-1H-indole 
• 1193314-23-6 cipargamin 

Relevant articles and documents

Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.

The syntheses of a series of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2- b]pyrrol-1-yl)-1-methylethylamines are reported. The binding affinities of the compounds at 5HT2C and 5HT2A receptors (79% homology in the transmembrane domain)

INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS

The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole

An efficient synthesis of the title indole, the heterocyclic core of the standard 5-HT2C receptor agonist Ro 60-0175, via a modified Leimgruber-Batcho indole synthesis is presented. The process can be used to make > 100 g quantities of the targ