122509-72-2

Basic information

• Product Name: 6-Chloro-5-fluoroindole
• Synonyms: 6-CHLORO-5-FLUOROINDOLE;6-Chloro-5-fluoroindole ,98%;6-Chloro-5-fluoro-1H-indole;- 6-chloro-5-fluroindole;1H-Indole,6-chloro-5-fluoro-
• CAS NO: 122509-72-2
• Molecular Formula: C₈H₅ClFN
• Molecular Weight: 169.58
• EINECS: 1312995-182-4
• Product Categories: Indoles and derivatives;Indole
• Mol File: 122509-72-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 105-107°C
• Boiling Point: 299.8 °C at 760 mmHg
• Flash Point: 135.1 °C
• Appearance: /
• Density: 1.436 g/cm³
• Vapor Pressure: 0.0122mmHg at 25°C
• Refractive Index: 1.432
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.26±0.30(Predicted)
• CAS DataBase Reference: 6-Chloro-5-fluoroindole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-5-fluoroindole(122509-72-2)
• EPA Substance Registry System: 6-Chloro-5-fluoroindole(122509-72-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-39-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 122509-72-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C7H10F2O2/c8-7(9)3-1-5(2-4-7)6(10)11/h5H,1-4H2,(H,10,11)

Upstream product

• 1027185-20-1 1-(6-Chloro-5-fluoro-indol-1-yl)-2,2,2-trifluoro-ethanone 
• 496916-77-9 3-chloro-4-fluoro-6-vinylaniline 
• 709007-52-3 [2-(4-chloro-5-fluoro-2-nitrophenyl)vinyl]dimethylamine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 118664-99-6 1-chloro-2-fluoro-4-methyl-5-nitrobenzene 
• 452-80-2 2-fluoro-4-methylaniline 
• 259860-00-9 2-fluoro-4-methyl-5-nitro-phenylamine 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 85462-59-5 2-bromo-5-chloro-4-fluoroaniline 
• 1026638-79-8 (R,S)-1-(trifluoroacetyl)-6-chloro-5-fluoro-3-hydroxy-2,3-dihydro-1H-indole 
• 100487-74-9 6-Chloro-5-fluoro-1,3-dihydro-2H-indol-2-one 
• 96202-57-2 6-Chloro-5-fluoro-1H-indole-2,3-dione 

Downstream Products

• 172078-39-6 6-Chloro-5-nitro-indole 
• 920023-30-9 6-chloro-5-fluoro-1H-indole-3-carboxylic acid 
• 205584-67-4 2,3-dihydro-6-chloro-5-fluoro-1H-indole 
• 1193314-23-6 cipargamin 

Relevant articles and documents

Novel agonists of 5HT2C receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder.

The syntheses of a series of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2- b]pyrrol-1-yl)-1-methylethylamines are reported. The binding affinities of the compounds at 5HT2C and 5HT2A receptors (79% homology in the transmembrane domain)

Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives

The present invention relates to Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the residues R1 to R7 are as defined herein. The invention

Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole

An efficient synthesis of the title indole, the heterocyclic core of the standard 5-HT2C receptor agonist Ro 60-0175, via a modified Leimgruber-Batcho indole synthesis is presented. The process can be used to make > 100 g quantities of the targ