119-63-1

Basic information

• Product Name: 4'-Amino-N-methylacetanilide
• Synonyms: n-(4-aminophenyl)-n-methyl-acetamid;4-(N-methylacetamido)aniline;p-Amino-N-methylacetanilide;N-(4-aminophenyl)-N-methylacetamide;4''-AMINO-N-METHYLACETANILINE;N-Acetyl-N-methyl-p-phenylendiamin;N-Acetyl-N-methyl-p-phenylene diamine;N1-(4-Aminophenyl)-N1-methylacetamide, Tech.
• CAS NO: 119-63-1
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• EINECS: 204-339-7
• Mol File: 119-63-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 70 °C
• Boiling Point: 323.111 °C at 760 mmHg
• Flash Point: 149.212 °C
• Appearance: /
• Density: 1.146 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 3.73±0.10(Predicted)
• CAS DataBase Reference: 4'-Amino-N-methylacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Amino-N-methylacetanilide(119-63-1)
• EPA Substance Registry System: 4'-Amino-N-methylacetanilide(119-63-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36/37/39-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 119-63-1(Hazardous Substances Data)

Usage

Uses

4''-Amino-N-methylacetanilide is one of the micropollutatnts used to study elimination of organic micropollutants in a municipal wastewater treatment plant.

Upstream product

• 121-95-9 N-methyl-4-nitroacetanilide 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 579-10-2 N-acetyl-N-methylaniline 
• 100-61-8 N-methylaniline 
• 100-15-2 N-methyl(p-nitroaniline) 
• 50438-47-6 N-(4-bromo-phenyl)-N-methylacetamide 
• 103-88-8 4-bromoacetanilide 
• 1446428-13-2 N-(4-((diphenylmethylene)amino)phenyl)-N-methylacetamide 
• 373-68-2 tetramethylammonium fluoride 
• 122-80-5 N-acetyl-p-phenylenediamine 

Downstream Products

• 114302-68-0 N-(2,3-diphenyl-indol-5-yl)-N-methyl-acetamide 
• 114224-23-6 1,3-bis-[4-(N-methyl-acetylamino)-phenyl]-triazene 
• 52177-54-5 p-(Bis-2-hydroxyethylamino)-N-methylacetanilid 
• 65488-11-1 4'-(N-Acetyl-methylamino)-phenyldiazo-4-tolylsulfon 
• 99071-56-4 N-(4-cyanophenyl)-N-methylacetamide 
• 178100-44-2 p-(acetyl-N-methyl)aminophenyl azide 
• 5369-36-8 4-(N-methylacetamido)-NN-dimethylaniline 
• 4714-62-9 4-cyano-N-methylaniline 
• 806632-62-2 4-methylamino-benzamidine 
• 741668-11-1 N,N-Bis-2-chlorethyl-N'-methyl-p-phenylendiamin 
• 52177-56-7 p-(Bis-2-chlorethylamino)-N-methylacetanilid 
• 52177-57-8 N-Methyl-N-[4-(2-oxo-2λ⁴-[1,3,2,6]dioxathiazocan-6-yl)-phenyl]-acetamide 
• 297756-29-7 N-methyl-N-(4-{(Z)-[(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}phenyl)acetamide 

Relevant articles and documents

Hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis

The invention relates to a hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis. According to the method, triethyl boron and potassium tert-butoxide are used as catalysts for the first time, and an aromatic nitro compound and pinacol borane which is low in price and easy to obtain can be conveniently catalyzed to be subjected to a hydroboration reduction reaction under mild conditions to prepare aromatic amine products. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective hydroboration reduction reaction of the non-transition metal reagent catalyzed aromatic nitro compound and pinacol borane is realized for the first time, and a practical new reaction strategy is provided for laboratory preparation or industrial production of aromatic amine products.

Silver-mediated trifluoromethylation of aryldiazonium salts: Conversion of amino group into trifluoromethyl group

A novel strategy for aromatic trifluoromethylation by converting aromatic amino group into CF3 group is reported herein. This method, which can be considered as trifluoromethylation variation of the classic Sandmeyer reaction, uses readily available aromatic amines as starting materials and is performed under mild conditions.

AMIDE COMPOUND

There is provided a FAAH inhibitor and a prophylactic or therapeutic agent for cerebrovascular disorders or sleep disorders comprising it. The prophylactic or therapeutic agent comprises a compound of the formula (I0): wherein Z is oxygen or sulfur; R1 is aryl which may be substituted, or a heterocyclic group which may be substituted; R1a is a hydrogen atom, a hydrocarbon group which may be substituted, hydroxyl, etc.; R2 is piperidin-1,4-diyl which may be substituted, or piperazin-1,4-diyl which may be substituted; R3 is a group formed by eliminating two hydrogen atoms from a 5-membered aromatic heterocyclic group having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, which may be further substituted, -CO-, etc.; and R4 is a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; or a salt thereof.