99071-56-4

Basic information

• Product Name: Acetamide, N-(4-cyanophenyl)-N-methyl-
• CAS NO: 99071-56-4
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• Mol File: 99071-56-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(4-cyanophenyl)-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(4-cyanophenyl)-N-methyl-(99071-56-4)
• EPA Substance Registry System: Acetamide, N-(4-cyanophenyl)-N-methyl-(99071-56-4)

Safety Data

• Hazardous Substances Data: 99071-56-4(Hazardous Substances Data)

Upstream product

• 79-16-3 N-methyl-acetamide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 579-10-2 N-acetyl-N-methylaniline 
• 201230-82-2 carbon monoxide 
• 1197-19-9 4-cyano-N,N-dimethylaniline 
• 75-91-2 tert.-butylhydroperoxide 
• 108-24-7 acetic anhydride 
• 121-95-9 N-methyl-4-nitroacetanilide 
• 873-74-5 4-Aminobenzonitrile 
• 35704-19-9 N-(4-cyanophenyl)acetamide 
• 74-88-4 methyl iodide 
• 119-63-1 4-(N-methylacetamido)aniline 
• 151-50-8 potassium cyanide 
• 50438-47-6 N-(4-bromo-phenyl)-N-methylacetamide 

Downstream Products

• 4714-62-9 4-cyano-N-methylaniline 
• 806632-62-2 4-methylamino-benzamidine 
• 579-10-2 N-acetyl-N-methylaniline 

Relevant articles and documents

Carbonylation of C?N Bonds in Tertiary Amines Catalyzed by Low-Valent Iron Catalysts

The first iron catalysts able to promote the formal insertion of CO into the C?N bond of amines are reported. Using low-valent iron complexes, including K2[Fe(CO)4], amides are formed from aromatic and aliphatic amines, in the presence of an iodoalkane promoter. Inorganic Lewis acids, such as AlCl3 and Nd(OTf)3, have a positive influence on the catalytic activity of the iron salts, enabling the carbonylation at a low pressure of CO (6 to 8 bars).

Amide bond formation through iron-catalyzed oxidative amidation of tertiary amines with anhydrides

A general and efficient method for amide bond synthesis has been developed. The method allows for synthesis of tertiary amides from readily available tertiary amines and anhydrides in the presence of FeCl2 as catalyst and tert-butyl hydroperoxide in water (T-Hydro) as oxidant. Mechanistic studies indicated that the in situ-generated α-amino peroxide of tertiary amine and iminium ion act as key intermediates in this oxidative transformation.

Pd-catalyzed intermolecular amidation of aryl halides: The discovery that xantphos can be trans-chelating in a palladium complex

A general method for the intermolecular coupling of aryl halides and amides using a Xantphos/ Pd catalyst is described. This system displays good functional group compatibility, and the desired C-N bond forming process proceeds in good to excellent yields with 1-4 mol % of the Pd catalyst. Additionally, the arylation of sulfonamides, oxazolidinones, and ureas is reported. The efficiency of these transformations was found to be highly dependent on reaction concentrations and catalyst loadings. A Pd complex resulting from oxidative addition of 4-bromobenzonitrile, (Xantphos)Pd(4-cyanophenyl)(Br) (II), was prepared in one step from Xantphos, Pd2(dba)3, and the aryl bromide. Complex II proved to be an active catalyst for the coupling between 4-bromobenzonitrile and benzamide. X-ray crystallographic analysis of II revealed a rare trans-chelating bisphosphine-Pd(II) structure with a large bite angle of 150.7°.