50438-47-6

Basic information

• Product Name: CHEMBRDG-BB 5304453
• Synonyms: CHEMBRDG-BB 5304453;N-(4-BROMOPHENYL)-N-METHYLACETAMIDE;N-(4-bromophenyl)-N-methylacetamide(SALTDATA: FREE);4'-BroMo-N-Methylacetanilide;N-(4-bromophenyl)-N-methyl-ethanamide
• CAS NO: 50438-47-6
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 228.1
• Mol File: 50438-47-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 298.7°C at 760 mmHg
• Flash Point: 134.5°C
• Appearance: /
• Density: 1.45g/cm³
• Vapor Pressure: 0.00124mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: CHEMBRDG-BB 5304453(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5304453(50438-47-6)
• EPA Substance Registry System: CHEMBRDG-BB 5304453(50438-47-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 50438-47-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H10BrNO/c1-7(12)11(2)9-5-3-8(10)4-6-9/h3-6H,1-2H3

Upstream product

• 579-10-2 N-acetyl-N-methylaniline 
• 108-24-7 acetic anhydride 
• 937-23-5 4-bromo-N-nitroso-N-methylaniline 
• 103-88-8 4-bromoacetanilide 
• 74-88-4 methyl iodide 
• 106-40-1 4-bromo-aniline 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 75-91-2 tert.-butylhydroperoxide 
• 64-19-7 acetic acid 

Downstream Products

• 83670-37-5 acetic acid-(2,4,6-tribromo-N-methyl-anilide) 
• 99071-56-4 N-(4-cyanophenyl)-N-methylacetamide 
• 4714-62-9 4-cyano-N-methylaniline 
• 806632-62-2 4-methylamino-benzamidine 
• 553631-79-1 N-methyl-N-(4-piperazin-1-ylphenyl)-acetamide 
• 941588-04-1 7-deoxy-7-epi-7-(4-(N-methylacetamido)phenylthio)lincomycin 
• 119-63-1 4-(N-methylacetamido)aniline 
• 1446428-13-2 N-(4-((diphenylmethylene)amino)phenyl)-N-methylacetamide 
• 6911-87-1 4-bromo-N-methylaniline 
• 67274-54-8 4-bromo-N-methyl-N-ethylaniline 

Relevant articles and documents

Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions

A series of catalysts based on supported copper nanoparticles have been prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-butyl hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some commercially available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodology has been successfully scaled-up to a gram scale with no detriment to the yield.

A para-C–H Functionalization of Aniline Derivatives via In situ Generated Bulky Hypervalent Iodinium Reagents

A practical para-C-H functionalization of aniline derivatives has been developed using an in situ generated bulky hypervalent iodinium reagent. Para-iodo, bromo, chloro, nitro, trifluormethyl aniline derivatives can be obtained efficiently, in many cases in 10 min in a transition metal-free manner. Medicinal chemicals or intermediates can be purified without column chromatography or recrystallization, which significantly reduces the waste and simplifies the work-up process.

Combining Eosin y with Selectfluor: A Regioselective Brominating System for Para-Bromination of Aniline Derivatives

A mild, metal-free, and absolutely para-selective bromination of aniline derivatives has been developed in excellent yields, wherein the organic dye Eosin Y is employed as the bromine source in company with Selectfluor. Neither air nor moisture sensitive, this facile reaction proceeds smoothly at room temperature and completes within a short time. Mechanistic studies indicate a radical pathway; therefore, the existence of an in situ generated brominating reagent, "Selectbrom", is postulated, which may reasonably account for the unique regioselectivity for the para-bromination of N-acyl- as well as N-sulfonylanilines.